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Resistance Evaluation of Part of Leading Rice Varieties to Rice Blast in Guangxi Province
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作者 颜群 罗志勇 +3 位作者 张晋 高利军 陈小林 高汉亮 《Agricultural Science & Technology》 CAS 2015年第3期518-522,共5页
In order to determine the resistance of leading rice varieties to rice blast in Guangxi, three natural induction rice blast nurseries were established in Cenxi, Sanjiang and Yongfu. The resistance of the 45 leading ri... In order to determine the resistance of leading rice varieties to rice blast in Guangxi, three natural induction rice blast nurseries were established in Cenxi, Sanjiang and Yongfu. The resistance of the 45 leading rice varieties in Guangxi to rice blast was determined under conditions of spray inoculation and natural induction at seedling stage. The results showed that resistance frequencies of the 45 leading rice varieties ranged from 8.33% to 94.44%. Among the 45 tested varieties, there were 8 varieties of which the resistance frequencies were all higher than 80%, accounting for 17.78%; there were 11 varieties of which the resistance frequencies ranged from 50% to 80%, accounting for 24.44%; the resistance frequencies of the remaining varieties were all lower than 50%, accounting for 57.78% of the total tested varieties. The twoconsecutive-year determination results showed none of the 45 leading rice varieties showed resistance to rice blast. In 2010, there were 26, 12 and 7 varieties that were moderately sensitive, sensitive and greatly sensitive to rice blast respectively, accounting for 57.78%, 26.67% and 15.56% of the total tested varieties. In 2011, there were 16, 23 and 12 varieties that were moderately sensitive, sensitive and greatly sensitive to rice blast respectively, accounting for 35.56%, 51.11% and 13.33%. The overall resistance of the 45 leading rice varieties trended to be decreased year by year. So in rice production, they should be selected properly. 展开更多
关键词 leading rice varieties Rice blast Resistance evaluation GUANGXI
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PHOTOREALISTIC COMPUTER GRAPHICS FORENSICS BASED ON LEADING DIGIT LAW 被引量:3
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作者 Xu Bo Wang Junwen Liu Guangjie Dai Yuewei 《Journal of Electronics(China)》 2011年第1期95-100,共6页
As the advent and growing popularity of image rendering software,photorealistic computer graphics are becoming more and more perceptually indistinguishable from photographic images.If the faked images are abused,it ma... As the advent and growing popularity of image rendering software,photorealistic computer graphics are becoming more and more perceptually indistinguishable from photographic images.If the faked images are abused,it may lead to potential social,legal or private consequences.To this end,it is very necessary and also challenging to find effective methods to differentiate between them.In this paper,a novel leading digit law,also called Benford's law,based method to identify computer graphics is proposed.More specifically,statistics of the most significant digits are extracted from image's Discrete Cosine Transform(DCT) coefficients and magnitudes of image's gradient,and then the Support Vector Machine(SVM) based classifiers are built.Results of experiments on the image datasets indicate that the proposed method is comparable to prior works.Besides,it possesses low dimensional features and low computational complexity. 展开更多
关键词 leading digit law Benford’s law Digital image forensic Computer graphics
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Transition from the Southern Mode of the Mei-yu Front Cloud System to Other Leading Modes 被引量:1
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作者 QIN Danyu LI Bo HUANG Yong 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2014年第4期948-961,共14页
Based on normalized six-hourly black body temperature (TBB) data of three geostationary meteorological satellites,the leading modes of the mei-yu cloud system between 1998 and 2008 were extracted by the Empirical Or... Based on normalized six-hourly black body temperature (TBB) data of three geostationary meteorological satellites,the leading modes of the mei-yu cloud system between 1998 and 2008 were extracted by the Empirical Orthogonal Function (EOF) method,and the transition processes from the first typical leading mode to other leading modes were discussed and compared.The analysis shows that,when the southern mode (EOF1) transforms to the northeastern mode (EOF3),in the mid-troposphere,a low trough develops and moves southeastward over central and eastern China.The circulation pattern is characterized by two highs and one low in the lower troposphere.A belt of low pressure is sandwiched between the weak high over central and western China and the strong western North Pacific subtropical high (WNPSH).Cold air moves southward along the northerly flow behind the low,and meets the warm and moist air between the WNPSH and the forepart of the low trough,which leads to continuous convection.At the same time,the central extent of the WNPSH increases while its ridge extends westward.In addition,transitions from the southern mode to the dual centers mode and the tropical-low-influenced mode were found to be atypical,and so no common points could be concluded.Furthermore,the choice of threshold value can affect the number of samples discussed. 展开更多
关键词 black body temperature mei-yu front cloud system leading modes mode transition
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Research on Aerodynamic Characteristics of Hovering Rotor Based on Leading Edge Droop 被引量:1
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作者 LI Congcong SHI Yongjie +1 位作者 XU Guohua MA Taihang 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2021年第S01期10-16,共7页
In view of the reduction of hovering efficiency near high tension when a helicopter rotor hovers,a numerical simulation method of lifting rotor hovering aerodynamic characteristics based on leading edge droop is estab... In view of the reduction of hovering efficiency near high tension when a helicopter rotor hovers,a numerical simulation method of lifting rotor hovering aerodynamic characteristics based on leading edge droop is established in this paper. It is dominated by Reynolds average N-S equation in integral form. Firstly,VR-12 airfoil is taken as the research object,and the influence of leading edge droop angle on the aerodynamic characteristics of two-dimensional airfoil is studied. Secondly,the modified 7 A rotor is taken as the research object,and the effects of different leading edge droop angles at the position of blade r/R=0.75—1 on the aerodynamic characteristics in hover are explored. It is found that the leading edge droop can significantly improve the aerodynamic characteristics of two-dimensional airfoil and three-dimensional hovering rotor near high angle of attack,and can effectively inhibit the generation of stall vortex. 展开更多
关键词 helicopter rotor hovering leading edge droop aerodynamic characteristics
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Numerical Study on the Duct Noise Control of Single-Stage Axial Flow Fan with Wave Leading Edge Stator Blade Configurations 被引量:1
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作者 Jianxin Lian Hang Tong +2 位作者 Liangji Zhang Weiyang Qiao Weijie Chen 《Journal of Applied Mathematics and Physics》 2023年第8期2503-2514,共12页
This study focuses on a single-stage axial flow fan, investigating the effect of three kinds of wave leading edge stator blades on its noise reduction. The DDES method and the duct acoustic analogy theory based on the... This study focuses on a single-stage axial flow fan, investigating the effect of three kinds of wave leading edge stator blades on its noise reduction. The DDES method and the duct acoustic analogy theory based on the penetrable data surface were used for noise prediction. The results showed that the three kinds of wave leading edge blades were effective in reducing the rotor-stator interaction tonal noise and also have a certain inhibitory effect on broadband noise. The A10W15 stator blade can effectively reduce broadband noise in the frequency range of 2200 - 4200 Hz. When the amplitude is increased to 20, the noise reduction effect is further enhanced. However, when the amplitude is increased to 30, the broadband noise reduction effect is no longer significant. Further research shows that the wave leading edge stator blades can significantly change the pressure fluctuation distribution on the leading edge and suction surface, which control the modal energy distribution. Finally, this paper analyzed multiple factors affecting the broadband noise reduction, such as the noise source cut-off and cut-on effect and correlation. The purpose of this paper is to explore the laws of the influence of wave leading edge blades on the duct noise of real fan, and to reveal its noise control mechanism. . 展开更多
关键词 FAN Wave leading Edge Blade Duct Noise Broadband Noise Noise Source Analysis
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CHARACTER OF SIMPLIFIED NAVIER-STOKES EQUATIONS FOR NEAR THE LEADING EDGE PART OF TWO-DIMENSIONAL LAMINAR FLOW PAST A FLAT PLATE
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作者 田纪伟 王新生 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 1994年第4期351-360,共10页
Starting from the Simplified Navier-Stokes(SNS)equations presented at first by Godovachev-Kuzmin-Tsopov,and Gao Zhi,Davis,the authors analyze the character of the SNS equations for the laminarflow near the leading edg... Starting from the Simplified Navier-Stokes(SNS)equations presented at first by Godovachev-Kuzmin-Tsopov,and Gao Zhi,Davis,the authors analyze the character of the SNS equations for the laminarflow near the leading edge of a flat plate and far away from the plate by using the Weiner—Hopf meth-od and Fourier transform.It is proved that the solution of the SNS equations agree with the solution of the Navier-Stokes equations for flow near the leading edge of the plate and far away from the plate.How to match the solution of the SNS equations to the Blasius solution of the boundary layer equationsis also discussed. 展开更多
关键词 simplified NAVIER-StoKES equations Weiner-Hope method leading edge of a flat plate
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Recognition of an additional mechanism leading to myocardial abnormalities
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作者 Yongming YU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2004年第2期71-72,共2页
A growing body of evidence explicitly suggests the significant role of inflammatory processes in the development and progressive deterioration of vascular diseases and cardiomyopathies.1-3 In recent years, a large var... A growing body of evidence explicitly suggests the significant role of inflammatory processes in the development and progressive deterioration of vascular diseases and cardiomyopathies.1-3 In recent years, a large variety of infections have been reported to be associated with the development of cardiomyopathy; the pathogenic factors include rickets, bacteria, protozoa and other parasites,and also, at least 17 viruses.2。 展开更多
关键词 link Recognition of an additional mechanism leading to myocardial abnormalities DCM HCM HCV
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The ascent of immune checkpoint inhibitors: is the understudy ready for a leading role?
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作者 Amy L. Cummings Edward B. Garon 《Cancer Biology & Medicine》 SCIE CAS CSCD 2017年第4期341-347,共7页
The recent approval of pembrolizumab as second-line treatment for any solid tumor with high-level microsatellite instability or mismatch repair deficiency agnostic of tissue and origin1 has shattered a glass ceiling f... The recent approval of pembrolizumab as second-line treatment for any solid tumor with high-level microsatellite instability or mismatch repair deficiency agnostic of tissue and origin1 has shattered a glass ceiling for immune checkpoint inhibitors.No longer bound to a specific cancer diagnosis but rather a biomarker,pembrolizumab has heightened a burgeoning optimism towards the drug class.Yet how these agents should carve out additional 展开更多
关键词 PD The ascent of immune checkpoint inhibitors:is the understudy ready for a leading role PFS OS ORR IHC
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The Evaluation Indicator System for the Audit of Township Leading Cadres' Economic Responsibility: Based on the Survey of One County in Chongqing
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作者 Yanfen LUO Chaozhou LU 《Asian Agricultural Research》 2014年第10期48-52,共5页
Economic responsibility audit evaluation of township cadres is important and difficult. According to the evaluation content and principles,the paper constructs the evaluation indicator of five subsystems: " econo... Economic responsibility audit evaluation of township cadres is important and difficult. According to the evaluation content and principles,the paper constructs the evaluation indicator of five subsystems: " economic management", " economic decision-making", " implementation of economic policy", " economic development",and " honest and upright administration". Through the field survey of some county in Chongqing,evaluation indicator is screened. According to the expert questionnaire,it uses the Hierarchy Analysis Process method to construct the judgment matrix and calculate the indicator weight and thereby build evaluation indicator system. It focuses on traditional indicators and evaluation indicator of sustainable development to construct a new,more complete evaluation indicator system. 展开更多
关键词 township leading CADRES Economic RESPONSIBILITY au
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Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments
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作者 M. A. Nezami Christopher Duma 《Journal of Cancer Therapy》 2018年第6期522-528,共7页
The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) (since its publication in 2005) and has led to some limited survival improvements. This protocol, consists of radiotherapy and con... The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) (since its publication in 2005) and has led to some limited survival improvements. This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. Temozolomide + radiation, compared to radiation alone had added in average 3 months additional life span, 16 percent improved survival at 2 years. That said since 2005, the standard of care has not changed in regards to the treatment of early diagnosed aggressive or multifocal GBM, and unfortunately the expected survival is still poor with 75 percent of patients dying in less than 2 years and average survival of 15 months. In patients with multifocal tumors (such as the case below) the average survival is even worse with less than 4 months at her age [1]. Here we present a case study of a patient with advanced multifocal, and rapidly progressing Glioblastoma Multiforme treated with STUPP protocol in combination with IV Quercetin. The patient experienced improved quality of life and response, compared to historical data. It is our recommendation to investigate such combinational approach in patients with Glioblastoma, as in our case it proved to be safe and effective with improved quality of life and performance as well as clinical response and survival. 展开更多
关键词 QUERCETIN GLIOBLAStoMA leading Edge GAMMA KNIFE
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China's Booming Machinery Industry——Modern enterprise management leading the Yantai CMC Bearings Co., Ltd. to prosperity
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作者 Li Yalin 《China's Foreign Trade》 1995年第12期27-27,共1页
On July 3, 1994, recognized by the International DNV and the State Quality Appraisal Centre, the Yantai CMC Bearings Co., Ltd. was awarded the ISO9002 (87 version) certificate and gained three firsts—the first enterp... On July 3, 1994, recognized by the International DNV and the State Quality Appraisal Centre, the Yantai CMC Bearings Co., Ltd. was awarded the ISO9002 (87 version) certificate and gained three firsts—the first enterprise to obtain an ISO9002 certificate in the field of bearings production, in foreign trade circles and in Yantai: The ISO9002 (94 version) certificate was conferred on the enterprise after the first DNV reexamination in March 1995. Yearly growth in output and efficiency enables the enterprise to become the best in the bearings production field. It cannot be denied that the China National 展开更多
关键词 CMC Modern enterprise management leading the Yantai CMC Bearings Co ISO DNV LTD to prosperity China’s Booming Machinery Industry
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Microscopic Determination of Leading Terms of the Interaction Hamiltonian Between sd- and g-Parts in the sdg IBM
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作者 Zhang, Zhanjun Liu, Yong Sang, Jianping 《Chinese journal of nuclear physics》 EI 1995年第4期318-321,共4页
Starting from one of the microscopic sdg interacting boson approximations, the lead-ing terms in the interaction Hamiltonian are discussed by using numerical investigations. Com-parisons of both the calculated levels ... Starting from one of the microscopic sdg interacting boson approximations, the lead-ing terms in the interaction Hamiltonian are discussed by using numerical investigations. Com-parisons of both the calculated levels and the overlap of wave functions between the exact re-sults and the approximations are made to find out negligible part in the Hamiltonian. The re-sults show that the leading terms given in this paper may provide a way to simplify the complexcalculations. 展开更多
关键词 The SDG interacting BOSON model DETERMINATION of leading TERMS MICROSCOPIC investigation
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Mechanisms and Processes Leading to Reverse Zoning in the Andong Granitoid Pluton, Andong Batholith, Korea
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作者 Sang Koo HWANG 《Global Geology》 2002年第2期114-127,共14页
The Andong pluton consists of comagmatic granitoid rocks which constitute outstanding examples of reversely zoned granitoids. The pluton has three lithofacies: hornblende biotite tonalite, biotite granodiorite and por... The Andong pluton consists of comagmatic granitoid rocks which constitute outstanding examples of reversely zoned granitoids. The pluton has three lithofacies: hornblende biotite tonalite, biotite granodiorite and porphyritic biotite granite. The zoned pattern forms by locating a tonalite core containing high-temperature mafic assemblages in central part,granodiorite rims in marginal part, and a porphyritic granite cap containing more felsic assemblages in topside of the pluton.Mineral abundances as well as bulk compositions of the granitoids indicate that the interior is enriched in mafic minerals and that it shows higher contents of oxides than the margin and topside. The compositional gradients change gradually with continuity between the lithofacies. The regular compositional variations within the pluton support the argument that the pluton behaved as an individual petrochemical system. Model abundances of the granitoids are in agreement with the bulk compositional gradients, suggesting that no significant interaction with country rocks occurred. Remobilization (resurgence) of deeper parts of the system into the more felsic magmas of the chamber explains the reverse zoning. Fractional crystallization was of importance and probably accounts for the selective removal of the settling phases. The Andong pluton is an example of reversely zoned plutons related by remobilization of more mafic but consanguineous magmas. Large-scale upwelling occurred in the pluton leading to the present arrangement of three lithofacies. It is conceivable that remnants of the reverse zoning become more difficult to discern as the plutonic rocks reach the latest stages of their evolution. In this case, the Andong pluton represents an earlier stage in the evolution of a felsic system that is usually represented by the final stages in normally zoned plutons. 展开更多
关键词 Andong GRANItoID pluton Reverse zoning Mechanisms and processes leading
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Promoting East-West Interaction Exclusive interview with Dr.Cao Yushu,Deputy Director of the Office of the Leading Group for Western Region Development at the State Council
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作者 陈伟 《China Economist》 2008年第1期5-11,共7页
Economic growth and environmental "friendliness" are the dual missions of China's grand western development. In the past eight years,China has seen the gap between eastern and western regions still widen... Economic growth and environmental "friendliness" are the dual missions of China's grand western development. In the past eight years,China has seen the gap between eastern and western regions still widening while also taking on the arduous task of protecting nature,ecology and environment in the western region. How has western development fared in the past eight years? What difficulties and challenges are being encountered? The development of the western region poses the single greatest difficulty facing China's regional economic development,but how can we advance along a "sound and fast" development path? The establishment of economic zones in Chengdu and Chongqing,Guanzhong and North Bay has opened up new possibilities and expectations for western China's economic development. 展开更多
关键词 Promoting East-West Interaction Exclusive interview with Dr.Cao Yushu Deputy Director of the Office of the leading Group for Western Region Development at the State Council OFFICE Bay
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Jiamusi Leading to the Pacific Ocean
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《China Today》 2002年第10期76-77,共2页
SANJIANG Plain in eastern Heilongjiang Province was formed from the alluvium of the winding and rolling Heilong, Songhua, and Wusuli rivers. Located in the hinterland of the fertile Sanjiang Plain, Jiamusi faces Russi... SANJIANG Plain in eastern Heilongjiang Province was formed from the alluvium of the winding and rolling Heilong, Songhua, and Wusuli rivers. Located in the hinterland of the fertile Sanjiang Plain, Jiamusi faces Russia’s far east region on its opposite bank, and a border measuring 438 kilometers. 展开更多
关键词 Jiamusi leading to the Pacific Ocean In
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ZTE Inks Strategic Agreements with Two Leading European Telecom System Integrators
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《ZTE Communications》 2008年第1期61-61,共1页
ZTE Corporation has signed strategic telecommunications software agreement with two leading providers in Europe and Latin America to optimize its offerings for target customers in
关键词 ZTE Inks Strategic Agreements with Two leading European Telecom System Integrators
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Research on Leading Edge Erosion and Aerodynamic Characteristics of Wind Turbine Blade Airfoil
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作者 Xin Guan Yuqi Xie +2 位作者 Shuaijie Wang Mingyang Li Shiwei Wu 《Fluid Dynamics & Materials Processing》 EI 2024年第9期2045-2058,共14页
The effects of the erosion present on the leading edge of a wind turbine airfoil(DU 96-W-180)on its aerodynamic performances have been investigated numerically in the framework of a SST k–ωturbulence model based on ... The effects of the erosion present on the leading edge of a wind turbine airfoil(DU 96-W-180)on its aerodynamic performances have been investigated numerically in the framework of a SST k–ωturbulence model based on the Reynolds Averaged Navier-Stokes equations(RANS).The results indicate that when sand-induced holes and small pits are involved as leading edge wear features,they have a minimal influence on the lift and drag coefficients of the airfoil.However,if delamination occurs in the same airfoil region,it significantly impacts the lift and resistance characteristics of the airfoil.Specifically,as the angle of attack grows,there is a significant decrease in the lift coefficient accompanied by a sharp increase in the drag coefficient.As wear intensifies,these effects gradually increase.Moreover,the leading edge wear can exacerbate flow separation near the trailing edge suction surface of the airfoil and cause forward displacement of the separation point. 展开更多
关键词 Wind energy wind turbine EROSION AIRFOIL leading edge erosion characteristics aerodynamic performance numerical simulation
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Cooperative composites anchored with single atom Pb and carbon confined PbO nanoparticles for superior lead-carbon batteries
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作者 Puqiang He Yi Yang +4 位作者 Hui Huang Jing Huang Hongbiao Wang Yapeng He Zhongcheng Guo 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第10期486-497,I0010,共13页
The mitigation of sulphation and parasitic hydrogen evolution is considered as prominent research emphasis for the development of lead-carbon batteries(LCBs)in large-scale energy storage applications.Here,cooperative ... The mitigation of sulphation and parasitic hydrogen evolution is considered as prominent research emphasis for the development of lead-carbon batteries(LCBs)in large-scale energy storage applications.Here,cooperative Pb-C composites consisting of single atom Pb and carbon-encapsulated PbO nanoparticles were prepared by freeze-drying technique and pyrolytic reduction to address above obstacles.The innovative use of Pb^(2+)to cross-link sodium alginate enabled a uniform distribution of Pb in the composites,generating Pb-C-PbO three-phase heterostructure.Experimental analysis and theoretical calculations revealed the synergistic interactions between single-atom Pb and PbO nanoparticles in suppressing parasitic hydrogen evolution and promoting the adsorption of Pb atoms.The presence of monatomic Pb and PbO enhanced the affinity of the composites for the negative active materials and facilitated the transformation of the active materials from bulk into spherical shapes to enhance the specific surface area,thereby counteracting sulphation.Through the coordinated integration of various functionalities offered by Pb@C-x,the cycle life of the battery at HRPSoC reaches 7025 cycles,which is two times for LCB with pure carbon materials.Additionally,the discharge capacity increased from 3.52 to 3.79 Ah.This study provides substantial insights into the construction of Pb-C composites for LCBs to inhibit negative sulphation and hydrogen evolution. 展开更多
关键词 Lead-carbon battery Negative sulphation Hydrogen evolution SINGLE-AtoM Lead carbon composites
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Multifunctional MOF@COF Nanoparticles Mediated Perovskite Films Management Toward Sustainable Perovskite Solar Cells
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作者 Yayu Dong Jian Zhang +6 位作者 Hongyu Zhang Wei Wang Boyuan Hu Debin Xia Kaifeng Lin Lin Geng Yulin Yang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第9期195-208,共14页
Although covalent organic frameworks(COFs)with highπ-conjugation have recently exhibited great prospects in perovskite solar cells(PSCs),their further application in PSCs is still hindered by face-to-face stacking an... Although covalent organic frameworks(COFs)with highπ-conjugation have recently exhibited great prospects in perovskite solar cells(PSCs),their further application in PSCs is still hindered by face-to-face stacking and aggregation issues.Herein,metal-organic framework(MOF-808)is selected as an ideal platform for the in situ homogeneous growth of a COF to construct a core-shell MOF@COF nanoparticle,which could effectively inhibit COF stacking and aggregation.The synergistic intrinsic mechanisms induced by the MOF@COF nanoparticles for reinforcing intrinsic stability and mitigating lead leakage in PSCs have been explored.The complementary utilization ofπ-conjugated skeletons and nanopores could optimize the crystallization of large-grained perovskite films and eliminate defects.The resulting PSCs achieve an impressive power conversion efficiency of 23.61%with superior open circuit voltage(1.20 V)and maintained approximately 90%of the original power conversion efficiency after 2000 h(30-50%RH and 25-30℃).Benefiting from the synergistic effects of the in situ chemical fixation and adsorption abilities of the MOF@COF nanoparticles,the amount of lead leakage from unpackaged PSCs soaked in water(<5 ppm)satisfies the laboratory assessment required for the Resource Conservation and Recovery Act Regulation. 展开更多
关键词 Perovskite solar cells Covalent organic frameworks Metal-organic frameworks Lead leakage Stability
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MiR-107-3p/Atp6v0e1 contributes to protective effects of two selenium-containing peptides,TSeMMM and SeMDPGQQ on lead-induced neurotoxicity
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作者 Yong Fang Tianhang Huang +5 位作者 Jian Wu Xieqi Luo Fengjiao Fan Peng Li Jian Ding Xinyang Sun 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期2060-2067,共8页
Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced cytotoxicity.However,the crosstalk between mRNA and microRNAs(miRNA)involved in... Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced cytotoxicity.However,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be elucidated.In this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were obtained.It was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and SeMDPGQQ.The protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative PCR.The results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1. 展开更多
关键词 LEAD Se-containing peptides NEUROPROTECTION miRNA
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