This paper describes a series of plugging agents which have been developed these years by the authors. The features of these agents can bestated as: (1) Stopping losses without stopping drilling; (2) High ratio of suc...This paper describes a series of plugging agents which have been developed these years by the authors. The features of these agents can bestated as: (1) Stopping losses without stopping drilling; (2) High ratio of success; (3) Improving fluids properties; (4) Suiting to many types of losses, even large cracks and caves; (5) Perfect efficiency in different conditions of pollution such as calcium, salt pollution and high temperature; (6) Sufficient resources of raw materials, nopoison, noharm, no pollution to the environment; (7) Convenience in use; (8) Lower cost. The properties, mechanisms and applications of these agents are also described in this paper.展开更多
Aiming at the problems of microfracture development in hard brittle shale gas layer in Fuling block, Chongqing, such as collapse of borehole wall and the existence of permeability loss of microfracture during drilling...Aiming at the problems of microfracture development in hard brittle shale gas layer in Fuling block, Chongqing, such as collapse of borehole wall and the existence of permeability loss of microfracture during drilling, and serious pollution of drilling environment with oil-based drilling fluid, a water-based drilling fluid system for anti-collapse and anti-leakage was studied. A water-based drilling fluid system with anti-collapse and anti-leakage was formed by introducing functional treatment agents, such as polypolysaccharide MEG, polymer emulsion film forming wall cementing agent LFGB, polyamine inhibitor LCFA and deformable particle plugging agent BXLZ, into the conventional water-based drilling fluid. After rolling at 130°C for 16 h, the system has good rheological properties, low filtration loss, good inhibition, lubrication and plugging properties. It has good plugging properties for 0.12 mm, 0.24 mm, 0.38 mm micro-cracks and 400 mD and 800 mD sand plates. The system was successfully tested on site in August 2019 in Fuling Reef Block, showing good rheological properties, solid wall plugging, and strong ability to seal and inhibit fracture expansion. There was no block falling in the drilling process, and the tripping, casing running and well cementing operations were all smooth, which provided a new technical idea and scheme for environmental protection and green drilling in Fuling shale gas exploitation.展开更多
Different drillingfluid systems are designed according to mineral composition,lithology and wellbore stability of different strata.In the present study,the conversion of a non-dispersed polymer drillingfluid into a low ...Different drillingfluid systems are designed according to mineral composition,lithology and wellbore stability of different strata.In the present study,the conversion of a non-dispersed polymer drillingfluid into a low potas-sium anti-collapsing drillingfluid is investigated.Since the two drillingfluids belong to completely different types,the key to this conversion is represented by new inhibitors,dispersants and water-loss agents by which a non-dispersed drillingfluid can be turned into a dispersed drillingfluid while ensuring wellbore stability and reason-able rheology(carrying sand—inhibiting cuttings dispersion).In particular,the(QYZ-1)inhibitors and(FSJSS-2)dispersants are used.The former can inhibit the hydration expansion capacity of clay,reduce the dynamic shear force and weaken the viscosity;the latter can improve the sealing effect and reduce thefiltrate loss.The results have shown that after adding a reasonable proportion of these substances(QYZ-1:FSJSS-2)to the non-dispersed polymer drillingfluid,while the apparent viscosity,plastic viscosity,structural viscosity andfluidity index under-went almost negligible changes,the dynamic plastic ratio increased,and thefiltration loss decreased significantly,thereby indicating good compatibility.According to the tests(conducted in the Leijia area),the density was 1.293 g/cm3,and after standing for 24 h,the SF(static settlement factor)was 0.51.Moreover,thefiltration loss was reduced to 4.0 mL,the rolling recovery rate reached 96.92%,with excellent plugging and anti-collapse performances.展开更多
The research progress of deep and ultra-deep drilling fluid technology systematically reviewed,the key problems existing are analyzed,and the future development direction is proposed.In view of the high temperature,hi...The research progress of deep and ultra-deep drilling fluid technology systematically reviewed,the key problems existing are analyzed,and the future development direction is proposed.In view of the high temperature,high pressure and high stress,fracture development,wellbore instability,drilling fluid lost circulation and other problems faced in the process of deep and ultra-deep complex oil and gas drilling,scholars have developed deep and ultra-deep high-temperature and high-salt resistant water-based drilling fluid technology,high-temperature resistant oil-based/synthetic drilling fluid technology,drilling fluid technology for reservoir protection and drilling fluid lost circulation control technology.However,there are still some key problems such as insufficient resistance to high temperature,high pressure and high stress,wellbore instability and serious lost circulation.Therefore,the development direction of deep and ultra-deep drilling fluid technology in the future is proposed:(1)The technology of high-temperature and high-salt resistant water-based drilling fluid should focus on improving high temperature stability,improving rheological properties,strengthening filtration control and improving compatibility with formation.(2)The technology of oil-based/synthetic drilling fluid resistant to high temperature should further study in the aspects of easily degradable environmental protection additives with low toxicity such as high temperature stabilizer,rheological regulator and related supporting technologies.(3)The drilling fluid technology for reservoir protection should be devoted to the development of new high-performance additives and materials,and further improve the real-time monitoring technology by introducing advanced sensor networks and artificial intelligence algorithms.(4)The lost circulation control of drilling fluid should pay more attention to the integration and application of intelligent technology,the research and application of high-performance plugging materials,the exploration of diversified plugging techniques and methods,and the improvement of environmental protection and production safety awareness.展开更多
Aiming at the problems of large load of rotation drive system,low efficiency of torque transmission and high cost for operation and maintenance of liner steering drilling system for the horizontal well,a new method of...Aiming at the problems of large load of rotation drive system,low efficiency of torque transmission and high cost for operation and maintenance of liner steering drilling system for the horizontal well,a new method of liner differential rotary drilling with double tubular strings in the horizontal well is proposed.The technical principle of this method is revealed,supporting tools such as the differential rotation transducer,composite rotary steering system and the hanger are designed,and technological process is optimized.A tool face control technique of steering drilling assembly is proposed and the calculation model of extension limit of liner differential rotary drilling with double tubular strings in horizontal well is established.These results show that the liner differential rotary drilling with double tubular strings is equipped with measurement while drilling(MWD)and positive displacement motor(PDM),and directional drilling of horizontal well is realized by adjusting rotary speed of drill pipe to control the tool face of PDM.Based on the engineering case of deep coalbed methane horizontal well in the eastern margin of Ordos Basin,the extension limit of horizontal drilling with double tubular strings is calculated.Compared with the conventional liner drilling method,the liner differential rotary drilling with double tubular strings increases the extension limit value of horizontal well significantly.The research findings provide useful reference for the integrated design and control of liner completion and drilling of horizontal wells.展开更多
BACKGROUND Application of indocyanine green(ICG)fluorescence has led to new developments in gastrointestinal surgery.However,little is known about the use of ICG for the diagnosis of postoperative gut leakage(GL).In a...BACKGROUND Application of indocyanine green(ICG)fluorescence has led to new developments in gastrointestinal surgery.However,little is known about the use of ICG for the diagnosis of postoperative gut leakage(GL).In addition,there is a lack of rapid and intuitive methods to definitively diagnose postoperative GL.AIM To investigate the effect of ICG in the diagnosis of anastomotic leakage in a surgical rat GL model and evaluate its diagnostic value in colorectal surgery patients.METHODS Sixteen rats were divided into two groups:GL group(n=8)and sham group(n=8).Approximately 0.5 mL of ICG(2.5 mg/mL)was intravenously injected postoperatively.The peritoneal fluid was collected for the fluorescence test at 24 and 48 h.Six patients with rectal cancer who had undergone laparoscopic rectal cancer resection plus enterostomies were injected with 10 mL of ICG(2.5 mg/mL)on postoperative day 1.Their ostomy fluids were collected 24 h after ICG injection to identify the possibility of the ICG excreting from the peripheral veins to the enterostomy stoma.Participants who had undergone colectomy or rectal cancer resection were enrolled in the diagnostic test.The peritoneal fluids from drainage were collected 24 h after ICG injection.The ICG fluorescence test was conducted using OptoMedic endoscopy along with a near-infrared fluorescent imaging system.RESULTS The peritoneal fluids from the GL group showed ICG-dependent green fluorescence in contrast to the sham group.Six samples of ostomy fluids showed green fluorescence,indicating the possibility of ICG excreting from the peripheral veins to the enterostomy stoma in patients.The peritoneal fluid ICG test exhibited a sensitivity of 100%and a specificity of 83.3%for the diagnosis of GL.The positive predictive value was 71.4%,while the negative predictive value was 100%.The likelihood ratios were 6.0 for a positive test result and 0 for a negative result.CONCLUSION The postoperative ICG test in a drainage tube is a valuable and simple technique for the diagnosis of GL.Hence,it should be employed in clinical settings in patients with suspected GL.展开更多
Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in wells.This detachment gives rise to a microannulus,which notably possesses greater permeability than...Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in wells.This detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing efficacy.Conventionally,the permeability of the microannulus is regarded as a uniform value throughout the well.However,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective stress.In this work,we developed a unique experimental apparatus.This equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the cement,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ conditions.The microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage channel.Additionally,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and closure.We observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their relationship.Our findings also indicate a distinct behavior when comparing liquid CO_(2) with water.Specifically,it is easier for liquid CO_(2) to create the microannulus.However,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well leakage.The outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture model.The traditional assumption of a constant aperture significantly underestimates fluid leakage risks.展开更多
The recent interest in the deployment of Generative AI applications that use large language models (LLMs) has brought to the forefront significant privacy concerns, notably the leakage of Personally Identifiable Infor...The recent interest in the deployment of Generative AI applications that use large language models (LLMs) has brought to the forefront significant privacy concerns, notably the leakage of Personally Identifiable Information (PII) and other confidential or protected information that may have been memorized during training, specifically during a fine-tuning or customization process. We describe different black-box attacks from potential adversaries and study their impact on the amount and type of information that may be recovered from commonly used and deployed LLMs. Our research investigates the relationship between PII leakage, memorization, and factors such as model size, architecture, and the nature of attacks employed. The study utilizes two broad categories of attacks: PII leakage-focused attacks (auto-completion and extraction attacks) and memorization-focused attacks (various membership inference attacks). The findings from these investigations are quantified using an array of evaluative metrics, providing a detailed understanding of LLM vulnerabilities and the effectiveness of different attacks.展开更多
The rock mass consists of rock blocks and structural planes,which can reduce its integrity and strength.Therefore,accurately obtaining the characteristics of the rock mass structural plane is a prerequisite for evalua...The rock mass consists of rock blocks and structural planes,which can reduce its integrity and strength.Therefore,accurately obtaining the characteristics of the rock mass structural plane is a prerequisite for evaluating stability and designing supports in underground engineering.Currently,there are no effective testing methods for the characteristic parameters of the rock mass structural plane in underground engineering.The paper presents the digital drilling technology as a new testing method of rock mass structural planes.Flawed rock specimens with cracks of varying widths and angles were used to simulate the rock mass structural planes,and the multifunctional rock mass digital drilling test system was employed to carry out the digital drilling tests.The analysis focuses on the variation laws of drilling parameters,such as drilling pressure and drilling torque,affected by the characteristics of prefabricated cracks,and clarifies the degradation mechanism of rock equivalent compressive strength.Additionally,an identification model for the characteristic parameters of rock mass structural planes during drilling is established.The test results indicate that the average difference of the characteristics of prefabricated cracks identified by the equivalent compressive strength is 2.45°and 0.82 mm,respectively.The identification model while drilling is verified to be correct due to the high identification accuracy.Based on this,a method for testing the characteristic parameters of the surrounding rock structural plane while drilling is proposed.The research offers a theoretical and methodological foundation for precise in situ identification of structural planes of the surrounding rock in underground engineering.展开更多
Rock and geotechnical engineering investigations involve drilling holes in ground with or without retrieving soil and rock samples to construct the subsurface ground profile.On the basis of an actual soil nailing dril...Rock and geotechnical engineering investigations involve drilling holes in ground with or without retrieving soil and rock samples to construct the subsurface ground profile.On the basis of an actual soil nailing drilling for a slope stability project in Hong Kong,this paper further develops the drilling process monitoring(DPM)method for digitally profiling the subsurface geomaterials of weathered granitic rocks using a compressed airflow driven percussive-rotary drilling machine with down-the-hole(DTH)hammer.Seven transducers are installed on the drilling machine and record the chuck displacement,DTH rotational speed,and five pressures from five compressed airflows in real-time series.The mechanism and operations of the drilling machine are elaborated in detail,which is essential for understanding and evaluating the drilling data.A MATLAB program is developed to automatically filter the recorded drilling data in time series and classify them into different drilling processes in sub-time series.These processes include penetration,push-in with or without rod,pull-back with or without rod,rod-tightening and rod-untightening.The drilling data are further reconstructed to plot the curve of drill-bit depth versus the net drilling time along each of the six drillholes.Each curve is found to contain multiple linear segments with a constant penetration rate,which implies a zone of homogenous geomaterial with different weathering grades.The effect from fluctuation of the applied pressures is evaluated quantitatively.Detailed analyses are presented for accurately assess and verify the underground profiling and strength in weathered granitic rock,which provided the basis of using DPM method to confidently assess drilling measurements to interpret the subsurface profile in real time.展开更多
This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system.Combining the basic theory of heat transfer with the environmental requ...This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system.Combining the basic theory of heat transfer with the environmental requirements of polar drilling operations and the characteristics of polar drilling processes,we analyze the factors that affect the insulation effect of the drilling rig system.These factors include the thermal conductivity of the insulation material,the thickness of the insulation layer,ambient temperature,and wind speed.We optimize the thermal insulation material of the polar drilling rig system using a steady-state method to measure solid thermal conductivity.By analyzing the distribution of temperature in space after heating,we optimize the distribution and air outlet angle of the heater using Fluent hydrodynamics software.The results demonstrate that under polar conditions,polyisocyanurate with stable thermodynamic properties is selected as the thermal insulation material.The selection of thermal insulation material and thickness significantly affects the thermal insulation effect of the system but has little effect on its heating effect.Moreover,when the air outlet angle of the heater is set to 32.5°,the heating efficiency of the system can be effectively improved.According to heat transfer equations and heat balance theory,we determine that the heating power required for the system to reach 5°C is close to numerical simulation.展开更多
BiFeO_(3)(BFO)has received considerable attention as a lead-free ferroelectric film due to its large theoretical remnant polariza-tion.However,BFO suffers from a large leakage current,resulting in poor ferroelectric p...BiFeO_(3)(BFO)has received considerable attention as a lead-free ferroelectric film due to its large theoretical remnant polariza-tion.However,BFO suffers from a large leakage current,resulting in poor ferroelectric properties.Herein,the sol-gel method was used to deposit a series of BFO-based thin films on fluorine-doped tin oxide substrates,and the effects of the substitution of the elements Co,Cu,Mn(B-site)and Sm,Eu,La(A-site)on the crystal structure,ferroelectricity,and leakage current of the BFO-based thin films were invest-igated.Results confirmed that lattice distortion by X-ray diffraction can be attributed to the substitution of individual elements in the BFO-based films.Sm and Eu substitutions contribute to the lattice distortion in a pseudo-cubic structure,while La is biased toward pseudo-tet-ragonal.Piezoelectric force microscopy confirmed that reversible switching of ferroelectric domains by nearly 180°can be realized through the prepared films.The ferroelectric hysteresis loops showed that the order for the polarization contribution is as follows:Cu>Co>Mn(B-site),Sm>La>Eu(A-site).The current density voltage curves indicated that the order for leakage contribution is as follows:Mn<Cu<Co(B-site),La<Eu<Sm(A-site).Scanning electron microscopy showed that the introduction of Cu elements facilitates the formation of dense grains,and the grain size distribution statistics proved that La element promotes the reduction of grain size,leading to the increase of grain boundaries and the reduction of leakage.Finally,a Bi_(0.985)Sm_(0.045)La_(0.03)Fe_(0.96)Co_(0.02)Cu_(0.02)O_(3)(SmLa-CoCu)thin film with a qualitative leap in the remnant polarization from 25.5(Bi_(0.985)Sm_(0.075)FeO_(3))to 98.8µC/cm^(2)(SmLa-CoCu)was prepared through the syner-gistic action of Sm,La,Co,and Cu elements.The leakage current is also drastically reduced from 160 to 8.4 mA/cm^(2)at a field strength of 150 kV/cm.Thus,based on the increasing entropy strategy of chemical engineering,this study focuses on enhancing ferroelectricity and decreasing leakage current,providing a promising path for the advancement of ferroelectric devices.展开更多
The study considers gas compression properties,gas slippage,back pressure(BP),phase transition(PT),well depth,and differences in gas-liquid physical properties.A new temperature model for multiphase flow is proposed b...The study considers gas compression properties,gas slippage,back pressure(BP),phase transition(PT),well depth,and differences in gas-liquid physical properties.A new temperature model for multiphase flow is proposed by considering phase transition in the drilling process.The mathematical model of multiphase flow is solved using the finite difference method with annulus mesh division for grid nodes,and a module for multiphase flow calculation and analysis is developed.Numerical results indicate that the temperature varies along the annulus with the variation of gas influx at the bottom of the well.During the process of controlled pressure drilling,as gas slips along the annulus to the wellhead,its volume continuously expands,leading to an increase in the gas content within the annulus,and consequently,an increase in the pressure drop caused by gas slippage.The temperature increases with the increase in BP and decreases in gas influx rate and wellbore diameter.During gas influx,the thermal conductivity coefficient for the gas-drilling mud two phases is significantly weakened,resulting in a considerable change in temperature along the annulus.In the context of MPD,the method of slightly changing the temperature along the annulus by controlling the back pressure is feasible.展开更多
The Inner Product Masking(IPM)scheme has been shown to provide higher theoretical security guarantees than the BooleanMasking(BM).This scheme aims to increase the algebraic complexity of the coding to achieve a higher...The Inner Product Masking(IPM)scheme has been shown to provide higher theoretical security guarantees than the BooleanMasking(BM).This scheme aims to increase the algebraic complexity of the coding to achieve a higher level of security.Some previous work unfolds when certain(adversarial and implementation)conditions are met,and we seek to complement these investigations by understanding what happens when these conditions deviate from their expected behaviour.In this paper,we investigate the security characteristics of IPM under different conditions.In adversarial condition,the security properties of first-order IPMs obtained through parametric characterization are preserved in the face of univariate and bivariate attacks.In implementation condition,we construct two new polynomial leakage functions to observe the nonlinear leakage of the IPM and connect the security order amplification to the nonlinear function.We observe that the security of IPMis affected by the degree and the linear component in the leakage function.In addition,the comparison experiments from the coefficients,signal-to-noise ratio(SNR)and the public parameter show that the security properties of the IPM are highly implementation-dependent.展开更多
Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole point.This paper develops a drilling process detect...Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole point.This paper develops a drilling process detection(DPD)system consisting of a multifunctional sensor and a pilot geophone installed at the top of the drilling rod,geophones at the tunnel face,a laser rangefinder,and an onsite computer.A weighted adjoint-state first arrival travel time tomography method is used to invert the P-wave velocity field of rock mass while borehole drilling.A field experiment in the ongoing construction of a deep buried tunnel in southwestern China demonstrated the DPD system and the tomography method.Time-frequency analysis of typical borehole drilling detection data shows that the impact drilling source is a pulse-like seismic exploration wavelet.A velocity field of the rock mass in a triangular area defined by the borehole trajectory and geophone receiving line can be obtained.Both the borehole core and optical image validate the inverted P-wave velocity field.A numerical simulation of a checkerboard benchmark model is used to test the tomography method.The rapid convergence of the misfits and consistent agreement between the inverted and observed travel times validate the P-wave velocity imaging.展开更多
The environmental hazards and"carbon footprint"of oil and gas drilling can be significantly reduced by replacing traditional petroleum-based chemical additives with natural materials derived from plants and ...The environmental hazards and"carbon footprint"of oil and gas drilling can be significantly reduced by replacing traditional petroleum-based chemical additives with natural materials derived from plants and animals.This paper explored for the first time the interaction mechanism between natural rubber latex(NRL)and bentonite suspensions(BTs)through a series of characterization experiments,as well as the potential applications in water-based drilling fluids(WBDF).The gel viscoelasticity experiments showed that NRL could decrease the consistency coefficient(k)and flow index(n)of BTs,and enhance the shear thinning performance of BTs as pseudo-plastic fluids.In addition,0.5 w/v%NRL not only increased the critical yield stress and strengthened the structural strength between the bentonite particles,but also facilitated the compatibility of pressure loss and flow efficiency.The evaluation of colloidal stability and WBDF performance indicated that NRL particles could promote the hydration and charge stability on the surface of BTs particles,and optimize the particle size distribution and flow resistance of WBDF under the"intercalation-exfoliation-encapsulation"synergistic interaction.Moreover,NRL can improve the rheological properties of WBDF at high temperatures(<150.C),and form a dense blocking layer by bridging and sealing the pores and cracks of the filter cake,which ultimately reduces the permeability of the cake and the filtration loss of WBDF.展开更多
Background: Delayed bile leakage after laparoscopic cholecystectomy, defined as occurring more than 72 hours after surgery, is a rare and serious complication of laparoscopic cholecystectomy, with an incidence rate of...Background: Delayed bile leakage after laparoscopic cholecystectomy, defined as occurring more than 72 hours after surgery, is a rare and serious complication of laparoscopic cholecystectomy, with an incidence rate of 0.060%. Case Declaration: This case report details a patient diagnosed with delayed bile leakage 43 days after laparoscopic cholecystectomy. The patient was discharged from our hospital after undergoing CT-guided puncture treatment, with no obvious complications identified. The patient was monitored for one year following the procedure, during which time no significant discomfort was reported. Objective: This case report is to analyse and review the clinical manifestations, diagnosis, treatment and prevention of delayed bile leakage after cholecystectomy, with reference to the relevant literature. Results: Delayed bile leakage after laparoscopic cholecystectomy can be prevented, although not eliminated. It is recommended that the operator treat the operation with caution, avoid taking risks, and adhere to careful procedures and strict separation according to the requirements. This approach is key to preventing late bile leakage in the postoperative period.展开更多
Multi-gradient drilling is a new offshore drilling method.The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise cont...Multi-gradient drilling is a new offshore drilling method.The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise control of the wellbore pressure.In this study,a new heat transfer model is proposed by which the variable mass flow is properly taken into account.Using this model,the effects of the main factors influencing the wellbore temperature are analyzed.The results indicate that at the position where the separation injection device is installed,the temperature increase of the fluid in the drill pipe is mitigated due to the inflow/outflow of hollow spheres,and the temperature drop of the fluid in the annulus also decreases.In addition,a lower separation efficiency of the device,a shallower installation depth and a smaller circulating displacement tend to increase the temperature near the bottom of the annulus,thereby helping to reduce the hydrate generation area and playing a positive role in the prevention and control of hydrates in deepwater drilling.展开更多
BACKGROUND Anastomotic leakage(AL)is one of the severest complications after laparoscopic surgery for middle/low rectal cancer,significantly impacting patient outcomes.Identifying reliable predictive factors for AL re...BACKGROUND Anastomotic leakage(AL)is one of the severest complications after laparoscopic surgery for middle/low rectal cancer,significantly impacting patient outcomes.Identifying reliable predictive factors for AL remains a clinical challenge.Serum nutritional biomarkers have been implicated in surgical outcomes but are un-derexplored as predictive tools for AL in this setting.Our study hypothesizes that preoperative serum levels of prealbumin(PA),albumin(ALB),and transferrin(TRF),along with surgical factors,can accurately predict AL risk.AIM To determine the predictive value of preoperative serum nutritional biomarkers for rectal cancer AL following laparoscopic surgery.METHODS In the retrospective cohort study carried out at a tertiary cancer center,we examined 560 individuals who underwent laparoscopic procedures for rectal cancer from 2018 to 2022.Preoperative serum levels of PA,ALB,and TRF were measured.We employed multivariate logistic regression to determine the independent risk factors for AL,and a predictive model was constructed and evaluated using receiver operating characteristic curve analysis.RESULTS AL occurred in 11.96%of cases,affecting 67 out of 560 patients.Multivariate analysis identified PA,ALB,and TRF as the independent risk factor,each with an odds ratio of 2.621[95%confidence interval(CI):1.582-3.812,P=0.012],3.982(95%CI:1.927-4.887,P=0.024),and 2.109(95%CI:1.162-2.981,P=0.031),respectively.Tumor location(<7 cm from anal verge)and intraoperative bleeding≥300 mL also increased AL risk.The predictive model demonstrated an excellent accuracy,achieving an area under the receiver operating characteristic curve of 0.942,a sensitivity of 0.844,and a specificity of 0.922,demonstrating an excellent ability to discriminate.CONCLUSION Preoperative serum nutritional biomarkers,combined with surgical factors,reliably predict anastomotic leakage risk after rectal cancer surgery,highlighting their importance in preoperative assessment.展开更多
The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of risers.This approach leads to...The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of risers.This approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex constraints.To accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβmethod.An analysis program is also developed in MATLAB for dynamic simulation.The simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation joint.The bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and application.The platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.展开更多
文摘This paper describes a series of plugging agents which have been developed these years by the authors. The features of these agents can bestated as: (1) Stopping losses without stopping drilling; (2) High ratio of success; (3) Improving fluids properties; (4) Suiting to many types of losses, even large cracks and caves; (5) Perfect efficiency in different conditions of pollution such as calcium, salt pollution and high temperature; (6) Sufficient resources of raw materials, nopoison, noharm, no pollution to the environment; (7) Convenience in use; (8) Lower cost. The properties, mechanisms and applications of these agents are also described in this paper.
文摘Aiming at the problems of microfracture development in hard brittle shale gas layer in Fuling block, Chongqing, such as collapse of borehole wall and the existence of permeability loss of microfracture during drilling, and serious pollution of drilling environment with oil-based drilling fluid, a water-based drilling fluid system for anti-collapse and anti-leakage was studied. A water-based drilling fluid system with anti-collapse and anti-leakage was formed by introducing functional treatment agents, such as polypolysaccharide MEG, polymer emulsion film forming wall cementing agent LFGB, polyamine inhibitor LCFA and deformable particle plugging agent BXLZ, into the conventional water-based drilling fluid. After rolling at 130°C for 16 h, the system has good rheological properties, low filtration loss, good inhibition, lubrication and plugging properties. It has good plugging properties for 0.12 mm, 0.24 mm, 0.38 mm micro-cracks and 400 mD and 800 mD sand plates. The system was successfully tested on site in August 2019 in Fuling Reef Block, showing good rheological properties, solid wall plugging, and strong ability to seal and inhibit fracture expansion. There was no block falling in the drilling process, and the tripping, casing running and well cementing operations were all smooth, which provided a new technical idea and scheme for environmental protection and green drilling in Fuling shale gas exploitation.
文摘Different drillingfluid systems are designed according to mineral composition,lithology and wellbore stability of different strata.In the present study,the conversion of a non-dispersed polymer drillingfluid into a low potas-sium anti-collapsing drillingfluid is investigated.Since the two drillingfluids belong to completely different types,the key to this conversion is represented by new inhibitors,dispersants and water-loss agents by which a non-dispersed drillingfluid can be turned into a dispersed drillingfluid while ensuring wellbore stability and reason-able rheology(carrying sand—inhibiting cuttings dispersion).In particular,the(QYZ-1)inhibitors and(FSJSS-2)dispersants are used.The former can inhibit the hydration expansion capacity of clay,reduce the dynamic shear force and weaken the viscosity;the latter can improve the sealing effect and reduce thefiltrate loss.The results have shown that after adding a reasonable proportion of these substances(QYZ-1:FSJSS-2)to the non-dispersed polymer drillingfluid,while the apparent viscosity,plastic viscosity,structural viscosity andfluidity index under-went almost negligible changes,the dynamic plastic ratio increased,and thefiltration loss decreased significantly,thereby indicating good compatibility.According to the tests(conducted in the Leijia area),the density was 1.293 g/cm3,and after standing for 24 h,the SF(static settlement factor)was 0.51.Moreover,thefiltration loss was reduced to 4.0 mL,the rolling recovery rate reached 96.92%,with excellent plugging and anti-collapse performances.
基金Supported by the Projects of National Natural Science Foundation of China(52288101,52174014,52374023)。
文摘The research progress of deep and ultra-deep drilling fluid technology systematically reviewed,the key problems existing are analyzed,and the future development direction is proposed.In view of the high temperature,high pressure and high stress,fracture development,wellbore instability,drilling fluid lost circulation and other problems faced in the process of deep and ultra-deep complex oil and gas drilling,scholars have developed deep and ultra-deep high-temperature and high-salt resistant water-based drilling fluid technology,high-temperature resistant oil-based/synthetic drilling fluid technology,drilling fluid technology for reservoir protection and drilling fluid lost circulation control technology.However,there are still some key problems such as insufficient resistance to high temperature,high pressure and high stress,wellbore instability and serious lost circulation.Therefore,the development direction of deep and ultra-deep drilling fluid technology in the future is proposed:(1)The technology of high-temperature and high-salt resistant water-based drilling fluid should focus on improving high temperature stability,improving rheological properties,strengthening filtration control and improving compatibility with formation.(2)The technology of oil-based/synthetic drilling fluid resistant to high temperature should further study in the aspects of easily degradable environmental protection additives with low toxicity such as high temperature stabilizer,rheological regulator and related supporting technologies.(3)The drilling fluid technology for reservoir protection should be devoted to the development of new high-performance additives and materials,and further improve the real-time monitoring technology by introducing advanced sensor networks and artificial intelligence algorithms.(4)The lost circulation control of drilling fluid should pay more attention to the integration and application of intelligent technology,the research and application of high-performance plugging materials,the exploration of diversified plugging techniques and methods,and the improvement of environmental protection and production safety awareness.
基金Supported by the Project of National Natural Science Foundation of China(52234002,42230814)。
文摘Aiming at the problems of large load of rotation drive system,low efficiency of torque transmission and high cost for operation and maintenance of liner steering drilling system for the horizontal well,a new method of liner differential rotary drilling with double tubular strings in the horizontal well is proposed.The technical principle of this method is revealed,supporting tools such as the differential rotation transducer,composite rotary steering system and the hanger are designed,and technological process is optimized.A tool face control technique of steering drilling assembly is proposed and the calculation model of extension limit of liner differential rotary drilling with double tubular strings in horizontal well is established.These results show that the liner differential rotary drilling with double tubular strings is equipped with measurement while drilling(MWD)and positive displacement motor(PDM),and directional drilling of horizontal well is realized by adjusting rotary speed of drill pipe to control the tool face of PDM.Based on the engineering case of deep coalbed methane horizontal well in the eastern margin of Ordos Basin,the extension limit of horizontal drilling with double tubular strings is calculated.Compared with the conventional liner drilling method,the liner differential rotary drilling with double tubular strings increases the extension limit value of horizontal well significantly.The research findings provide useful reference for the integrated design and control of liner completion and drilling of horizontal wells.
基金Supported by the Science and Technology Projects in Guangzhou,No.202201010623 and No.2024A03J1016Guangzhou Science and Technology Project of Traditional Chinese Medicine and Combined Chinese and Western Medicine,No.20242A011001Guangdong Medical Science and Research Foundation,No.A2024088.
文摘BACKGROUND Application of indocyanine green(ICG)fluorescence has led to new developments in gastrointestinal surgery.However,little is known about the use of ICG for the diagnosis of postoperative gut leakage(GL).In addition,there is a lack of rapid and intuitive methods to definitively diagnose postoperative GL.AIM To investigate the effect of ICG in the diagnosis of anastomotic leakage in a surgical rat GL model and evaluate its diagnostic value in colorectal surgery patients.METHODS Sixteen rats were divided into two groups:GL group(n=8)and sham group(n=8).Approximately 0.5 mL of ICG(2.5 mg/mL)was intravenously injected postoperatively.The peritoneal fluid was collected for the fluorescence test at 24 and 48 h.Six patients with rectal cancer who had undergone laparoscopic rectal cancer resection plus enterostomies were injected with 10 mL of ICG(2.5 mg/mL)on postoperative day 1.Their ostomy fluids were collected 24 h after ICG injection to identify the possibility of the ICG excreting from the peripheral veins to the enterostomy stoma.Participants who had undergone colectomy or rectal cancer resection were enrolled in the diagnostic test.The peritoneal fluids from drainage were collected 24 h after ICG injection.The ICG fluorescence test was conducted using OptoMedic endoscopy along with a near-infrared fluorescent imaging system.RESULTS The peritoneal fluids from the GL group showed ICG-dependent green fluorescence in contrast to the sham group.Six samples of ostomy fluids showed green fluorescence,indicating the possibility of ICG excreting from the peripheral veins to the enterostomy stoma in patients.The peritoneal fluid ICG test exhibited a sensitivity of 100%and a specificity of 83.3%for the diagnosis of GL.The positive predictive value was 71.4%,while the negative predictive value was 100%.The likelihood ratios were 6.0 for a positive test result and 0 for a negative result.CONCLUSION The postoperative ICG test in a drainage tube is a valuable and simple technique for the diagnosis of GL.Hence,it should be employed in clinical settings in patients with suspected GL.
基金Financial support for this work from the U.S.Department of Energy(DOE)Office of Basic Energy Sciences for“Center for Coupled Chemo-Mechanics of Cementitious Composites for EGS(C4M)”,DOE’s“National Risk Assessment Partnership(NRAP)”programDOE Office of Energy Efficiency&Renewable Energy’s Geothermal Technologies Office for“Advanced Downhole Acoustic Sensing for Wellbore Integrity”is gratefully acknowledged.
文摘Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in wells.This detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing efficacy.Conventionally,the permeability of the microannulus is regarded as a uniform value throughout the well.However,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective stress.In this work,we developed a unique experimental apparatus.This equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the cement,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ conditions.The microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage channel.Additionally,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and closure.We observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their relationship.Our findings also indicate a distinct behavior when comparing liquid CO_(2) with water.Specifically,it is easier for liquid CO_(2) to create the microannulus.However,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well leakage.The outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture model.The traditional assumption of a constant aperture significantly underestimates fluid leakage risks.
文摘The recent interest in the deployment of Generative AI applications that use large language models (LLMs) has brought to the forefront significant privacy concerns, notably the leakage of Personally Identifiable Information (PII) and other confidential or protected information that may have been memorized during training, specifically during a fine-tuning or customization process. We describe different black-box attacks from potential adversaries and study their impact on the amount and type of information that may be recovered from commonly used and deployed LLMs. Our research investigates the relationship between PII leakage, memorization, and factors such as model size, architecture, and the nature of attacks employed. The study utilizes two broad categories of attacks: PII leakage-focused attacks (auto-completion and extraction attacks) and memorization-focused attacks (various membership inference attacks). The findings from these investigations are quantified using an array of evaluative metrics, providing a detailed understanding of LLM vulnerabilities and the effectiveness of different attacks.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFC2907600)the National Natural Science Foundation of China(Grant Nos.42277174 and 52204260).
文摘The rock mass consists of rock blocks and structural planes,which can reduce its integrity and strength.Therefore,accurately obtaining the characteristics of the rock mass structural plane is a prerequisite for evaluating stability and designing supports in underground engineering.Currently,there are no effective testing methods for the characteristic parameters of the rock mass structural plane in underground engineering.The paper presents the digital drilling technology as a new testing method of rock mass structural planes.Flawed rock specimens with cracks of varying widths and angles were used to simulate the rock mass structural planes,and the multifunctional rock mass digital drilling test system was employed to carry out the digital drilling tests.The analysis focuses on the variation laws of drilling parameters,such as drilling pressure and drilling torque,affected by the characteristics of prefabricated cracks,and clarifies the degradation mechanism of rock equivalent compressive strength.Additionally,an identification model for the characteristic parameters of rock mass structural planes during drilling is established.The test results indicate that the average difference of the characteristics of prefabricated cracks identified by the equivalent compressive strength is 2.45°and 0.82 mm,respectively.The identification model while drilling is verified to be correct due to the high identification accuracy.Based on this,a method for testing the characteristic parameters of the surrounding rock structural plane while drilling is proposed.The research offers a theoretical and methodological foundation for precise in situ identification of structural planes of the surrounding rock in underground engineering.
基金supported by grants from the Research Grant Council of the Hong Kong Special Administrative Region,China(Project Nos.HKU 7137/03E and R7005/01E)。
文摘Rock and geotechnical engineering investigations involve drilling holes in ground with or without retrieving soil and rock samples to construct the subsurface ground profile.On the basis of an actual soil nailing drilling for a slope stability project in Hong Kong,this paper further develops the drilling process monitoring(DPM)method for digitally profiling the subsurface geomaterials of weathered granitic rocks using a compressed airflow driven percussive-rotary drilling machine with down-the-hole(DTH)hammer.Seven transducers are installed on the drilling machine and record the chuck displacement,DTH rotational speed,and five pressures from five compressed airflows in real-time series.The mechanism and operations of the drilling machine are elaborated in detail,which is essential for understanding and evaluating the drilling data.A MATLAB program is developed to automatically filter the recorded drilling data in time series and classify them into different drilling processes in sub-time series.These processes include penetration,push-in with or without rod,pull-back with or without rod,rod-tightening and rod-untightening.The drilling data are further reconstructed to plot the curve of drill-bit depth versus the net drilling time along each of the six drillholes.Each curve is found to contain multiple linear segments with a constant penetration rate,which implies a zone of homogenous geomaterial with different weathering grades.The effect from fluctuation of the applied pressures is evaluated quantitatively.Detailed analyses are presented for accurately assess and verify the underground profiling and strength in weathered granitic rock,which provided the basis of using DPM method to confidently assess drilling measurements to interpret the subsurface profile in real time.
基金supported by the Key-Area Research and Development Program of Guangdong Province,Research on the Method of Heat Preservation and Heating for the Drilling System of Polar Offshore Drilling Platform (No.2020B1111010001).
文摘This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system.Combining the basic theory of heat transfer with the environmental requirements of polar drilling operations and the characteristics of polar drilling processes,we analyze the factors that affect the insulation effect of the drilling rig system.These factors include the thermal conductivity of the insulation material,the thickness of the insulation layer,ambient temperature,and wind speed.We optimize the thermal insulation material of the polar drilling rig system using a steady-state method to measure solid thermal conductivity.By analyzing the distribution of temperature in space after heating,we optimize the distribution and air outlet angle of the heater using Fluent hydrodynamics software.The results demonstrate that under polar conditions,polyisocyanurate with stable thermodynamic properties is selected as the thermal insulation material.The selection of thermal insulation material and thickness significantly affects the thermal insulation effect of the system but has little effect on its heating effect.Moreover,when the air outlet angle of the heater is set to 32.5°,the heating efficiency of the system can be effectively improved.According to heat transfer equations and heat balance theory,we determine that the heating power required for the system to reach 5°C is close to numerical simulation.
基金supported by the National Natural Science Foundation of China(No.22371013)the National Key Research and Development Program of China(No.2018YFA0703700)+3 种基金the Fundamental Research Funds for the Central Universities,China(Nos.FRF-IDRY-19-007 and FRF-TP-19-055A2Z)the National Program for Support of Top-notch Young Professionals,Chinathe Young Elite Scientists Sponsorship Program by the China Association for Science and Technology(CAST),China(No.2019-2021 QNRC)the“Xiaomi Young Scholar”Funding Project,China.
文摘BiFeO_(3)(BFO)has received considerable attention as a lead-free ferroelectric film due to its large theoretical remnant polariza-tion.However,BFO suffers from a large leakage current,resulting in poor ferroelectric properties.Herein,the sol-gel method was used to deposit a series of BFO-based thin films on fluorine-doped tin oxide substrates,and the effects of the substitution of the elements Co,Cu,Mn(B-site)and Sm,Eu,La(A-site)on the crystal structure,ferroelectricity,and leakage current of the BFO-based thin films were invest-igated.Results confirmed that lattice distortion by X-ray diffraction can be attributed to the substitution of individual elements in the BFO-based films.Sm and Eu substitutions contribute to the lattice distortion in a pseudo-cubic structure,while La is biased toward pseudo-tet-ragonal.Piezoelectric force microscopy confirmed that reversible switching of ferroelectric domains by nearly 180°can be realized through the prepared films.The ferroelectric hysteresis loops showed that the order for the polarization contribution is as follows:Cu>Co>Mn(B-site),Sm>La>Eu(A-site).The current density voltage curves indicated that the order for leakage contribution is as follows:Mn<Cu<Co(B-site),La<Eu<Sm(A-site).Scanning electron microscopy showed that the introduction of Cu elements facilitates the formation of dense grains,and the grain size distribution statistics proved that La element promotes the reduction of grain size,leading to the increase of grain boundaries and the reduction of leakage.Finally,a Bi_(0.985)Sm_(0.045)La_(0.03)Fe_(0.96)Co_(0.02)Cu_(0.02)O_(3)(SmLa-CoCu)thin film with a qualitative leap in the remnant polarization from 25.5(Bi_(0.985)Sm_(0.075)FeO_(3))to 98.8µC/cm^(2)(SmLa-CoCu)was prepared through the syner-gistic action of Sm,La,Co,and Cu elements.The leakage current is also drastically reduced from 160 to 8.4 mA/cm^(2)at a field strength of 150 kV/cm.Thus,based on the increasing entropy strategy of chemical engineering,this study focuses on enhancing ferroelectricity and decreasing leakage current,providing a promising path for the advancement of ferroelectric devices.
基金support by the financial support of the National Nature Science Foundation of China(No.52274001,No.52074018)China Petrochemical Corporation(No.p21069)The financial support of Fundamental Research Funds for the Central Universities(buctrc202017)。
文摘The study considers gas compression properties,gas slippage,back pressure(BP),phase transition(PT),well depth,and differences in gas-liquid physical properties.A new temperature model for multiphase flow is proposed by considering phase transition in the drilling process.The mathematical model of multiphase flow is solved using the finite difference method with annulus mesh division for grid nodes,and a module for multiphase flow calculation and analysis is developed.Numerical results indicate that the temperature varies along the annulus with the variation of gas influx at the bottom of the well.During the process of controlled pressure drilling,as gas slips along the annulus to the wellhead,its volume continuously expands,leading to an increase in the gas content within the annulus,and consequently,an increase in the pressure drop caused by gas slippage.The temperature increases with the increase in BP and decreases in gas influx rate and wellbore diameter.During gas influx,the thermal conductivity coefficient for the gas-drilling mud two phases is significantly weakened,resulting in a considerable change in temperature along the annulus.In the context of MPD,the method of slightly changing the temperature along the annulus by controlling the back pressure is feasible.
基金the Hunan Provincial Natrual Science Foundation of China(2022JJ30103)“the 14th Five-Year”Key Disciplines and Application Oriented Special Disciplines of Hunan Province(Xiangjiaotong[2022]351)the Science and Technology Innovation Program of Hunan Province(2016TP1020).
文摘The Inner Product Masking(IPM)scheme has been shown to provide higher theoretical security guarantees than the BooleanMasking(BM).This scheme aims to increase the algebraic complexity of the coding to achieve a higher level of security.Some previous work unfolds when certain(adversarial and implementation)conditions are met,and we seek to complement these investigations by understanding what happens when these conditions deviate from their expected behaviour.In this paper,we investigate the security characteristics of IPM under different conditions.In adversarial condition,the security properties of first-order IPMs obtained through parametric characterization are preserved in the face of univariate and bivariate attacks.In implementation condition,we construct two new polynomial leakage functions to observe the nonlinear leakage of the IPM and connect the security order amplification to the nonlinear function.We observe that the security of IPMis affected by the degree and the linear component in the leakage function.In addition,the comparison experiments from the coefficients,signal-to-noise ratio(SNR)and the public parameter show that the security properties of the IPM are highly implementation-dependent.
基金the support of the National Natural Science Foundation of China(Nos.42207211,42202320 and 42172296)Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education,Tongji University(No.KLE-TJGE-G2304).
文摘Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole point.This paper develops a drilling process detection(DPD)system consisting of a multifunctional sensor and a pilot geophone installed at the top of the drilling rod,geophones at the tunnel face,a laser rangefinder,and an onsite computer.A weighted adjoint-state first arrival travel time tomography method is used to invert the P-wave velocity field of rock mass while borehole drilling.A field experiment in the ongoing construction of a deep buried tunnel in southwestern China demonstrated the DPD system and the tomography method.Time-frequency analysis of typical borehole drilling detection data shows that the impact drilling source is a pulse-like seismic exploration wavelet.A velocity field of the rock mass in a triangular area defined by the borehole trajectory and geophone receiving line can be obtained.Both the borehole core and optical image validate the inverted P-wave velocity field.A numerical simulation of a checkerboard benchmark model is used to test the tomography method.The rapid convergence of the misfits and consistent agreement between the inverted and observed travel times validate the P-wave velocity imaging.
基金supported by the National Natural Science Foundation of China (Grant No.51991361 and Grant No.51874329)。
文摘The environmental hazards and"carbon footprint"of oil and gas drilling can be significantly reduced by replacing traditional petroleum-based chemical additives with natural materials derived from plants and animals.This paper explored for the first time the interaction mechanism between natural rubber latex(NRL)and bentonite suspensions(BTs)through a series of characterization experiments,as well as the potential applications in water-based drilling fluids(WBDF).The gel viscoelasticity experiments showed that NRL could decrease the consistency coefficient(k)and flow index(n)of BTs,and enhance the shear thinning performance of BTs as pseudo-plastic fluids.In addition,0.5 w/v%NRL not only increased the critical yield stress and strengthened the structural strength between the bentonite particles,but also facilitated the compatibility of pressure loss and flow efficiency.The evaluation of colloidal stability and WBDF performance indicated that NRL particles could promote the hydration and charge stability on the surface of BTs particles,and optimize the particle size distribution and flow resistance of WBDF under the"intercalation-exfoliation-encapsulation"synergistic interaction.Moreover,NRL can improve the rheological properties of WBDF at high temperatures(<150.C),and form a dense blocking layer by bridging and sealing the pores and cracks of the filter cake,which ultimately reduces the permeability of the cake and the filtration loss of WBDF.
文摘Background: Delayed bile leakage after laparoscopic cholecystectomy, defined as occurring more than 72 hours after surgery, is a rare and serious complication of laparoscopic cholecystectomy, with an incidence rate of 0.060%. Case Declaration: This case report details a patient diagnosed with delayed bile leakage 43 days after laparoscopic cholecystectomy. The patient was discharged from our hospital after undergoing CT-guided puncture treatment, with no obvious complications identified. The patient was monitored for one year following the procedure, during which time no significant discomfort was reported. Objective: This case report is to analyse and review the clinical manifestations, diagnosis, treatment and prevention of delayed bile leakage after cholecystectomy, with reference to the relevant literature. Results: Delayed bile leakage after laparoscopic cholecystectomy can be prevented, although not eliminated. It is recommended that the operator treat the operation with caution, avoid taking risks, and adhere to careful procedures and strict separation according to the requirements. This approach is key to preventing late bile leakage in the postoperative period.
基金funded by the Key Program of National Natural Science Foundation of China (Grant No.51734010)the Startup Fund of Changzhou University Science Research (Grant No.ZMF22020060).
文摘Multi-gradient drilling is a new offshore drilling method.The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise control of the wellbore pressure.In this study,a new heat transfer model is proposed by which the variable mass flow is properly taken into account.Using this model,the effects of the main factors influencing the wellbore temperature are analyzed.The results indicate that at the position where the separation injection device is installed,the temperature increase of the fluid in the drill pipe is mitigated due to the inflow/outflow of hollow spheres,and the temperature drop of the fluid in the annulus also decreases.In addition,a lower separation efficiency of the device,a shallower installation depth and a smaller circulating displacement tend to increase the temperature near the bottom of the annulus,thereby helping to reduce the hydrate generation area and playing a positive role in the prevention and control of hydrates in deepwater drilling.
基金Supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region,No.2019D01C261.
文摘BACKGROUND Anastomotic leakage(AL)is one of the severest complications after laparoscopic surgery for middle/low rectal cancer,significantly impacting patient outcomes.Identifying reliable predictive factors for AL remains a clinical challenge.Serum nutritional biomarkers have been implicated in surgical outcomes but are un-derexplored as predictive tools for AL in this setting.Our study hypothesizes that preoperative serum levels of prealbumin(PA),albumin(ALB),and transferrin(TRF),along with surgical factors,can accurately predict AL risk.AIM To determine the predictive value of preoperative serum nutritional biomarkers for rectal cancer AL following laparoscopic surgery.METHODS In the retrospective cohort study carried out at a tertiary cancer center,we examined 560 individuals who underwent laparoscopic procedures for rectal cancer from 2018 to 2022.Preoperative serum levels of PA,ALB,and TRF were measured.We employed multivariate logistic regression to determine the independent risk factors for AL,and a predictive model was constructed and evaluated using receiver operating characteristic curve analysis.RESULTS AL occurred in 11.96%of cases,affecting 67 out of 560 patients.Multivariate analysis identified PA,ALB,and TRF as the independent risk factor,each with an odds ratio of 2.621[95%confidence interval(CI):1.582-3.812,P=0.012],3.982(95%CI:1.927-4.887,P=0.024),and 2.109(95%CI:1.162-2.981,P=0.031),respectively.Tumor location(<7 cm from anal verge)and intraoperative bleeding≥300 mL also increased AL risk.The predictive model demonstrated an excellent accuracy,achieving an area under the receiver operating characteristic curve of 0.942,a sensitivity of 0.844,and a specificity of 0.922,demonstrating an excellent ability to discriminate.CONCLUSION Preoperative serum nutritional biomarkers,combined with surgical factors,reliably predict anastomotic leakage risk after rectal cancer surgery,highlighting their importance in preoperative assessment.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52271300,52071337,and 51809279)the National Key Research and Development Program of China(Grant No.2022YFC2806501)the High-tech Ship Research Projects Sponsored by MIIT(Grant No.CBG2N21-4-2-5).
文摘The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of risers.This approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex constraints.To accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβmethod.An analysis program is also developed in MATLAB for dynamic simulation.The simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation joint.The bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and application.The platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.