Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairmen...Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain axis.Thus,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in mice.It was found that AA-2βG prevented HFr D-induced cognitive deficits.AA-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory response.These beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed mice.Additionally,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal bacteria.The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut.As a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.展开更多
BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a candidate.AIM To eva...BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a candidate.AIM To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious infection.METHODS This study included 48 patients with Child–Pugh cirrhosis classes B and C and 15 healthy controls.The fecal microbiome was assessed using 16S rRNA gene sequencing.Plasma levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 months.RESULTS Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included patients.They had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh scale.Patients with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely Bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier function.The presepsin level directly correlated with the relative abundance of Bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and Propionibacteriaceae.After 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin before the prescription of the probiotic was an independent predictor of a greater decrease in Child–Pugh scores(P=0.046),as well as a higher level of the Child–Pugh scale(P=0.042),but not the C-reactive protein level(P=0.679)according to multivariate linear regression analysis.CONCLUSION The level of presepsin directly correlates with the abundance in the gut microbiota of the main taxa that are substrates of bacterial translocation in cirrhosis.This biomarker,in the absence of obvious infection,seems important for assessing the state of the gut–liver axis in cirrhosis and deciding on therapy targeted at the gut microbiota in this disease.展开更多
The communication system of high-speed trains in railway tunnels needs to be built with leaky cables fixed on the tunnel wall with special fixtures.To ensure safety,checking the regular leaky cable fixture is necessar...The communication system of high-speed trains in railway tunnels needs to be built with leaky cables fixed on the tunnel wall with special fixtures.To ensure safety,checking the regular leaky cable fixture is necessary to elimi-nate the potential danger.At present,the existing fixture detection algorithms are difficult to take into account detection accuracy and speed at the same time.The faulty fixture is also insufficient and difficult to obtain,seriously affecting the model detection effect.To solve these problems,an innovative detection method is proposed in this paper.Firstly,we presented the Res-Net and Wasserstein-Deep Convolution GAN(RW-DCGAN)to implement data augmentation,which can enable the faulty fixture to export more high-quality and irregular images.Secondly,we proposed the Ghost SENet-YOLOv5(GS-YOLOv5)to enhance the expression of fixture feature,and further improve the detection accuracy and speed.Finally,we adopted the model compression strategy to prune redundant channels,and visualized training details with Grad-CAM to verify the reliability of our model.Experimental results show that the algorithm model is 69.06%smaller than the original YOLOv5 model,with 70.07%fewer parameters,2.1%higher accuracy and 14.82 fps faster speed,meeting the needs of tunnel fixture detection.展开更多
The high reliability of the communication system is critical in metro and mining applications for personal safety,channel optimization,and improving operational performance.This paper surveys the progress of wireless ...The high reliability of the communication system is critical in metro and mining applications for personal safety,channel optimization,and improving operational performance.This paper surveys the progress of wireless communication systems in underground environments such as tunnels and mines from 1920 to 2022,including the evolution of primitive technology,advancements in channel modelling,and realization of various wireless propagation channels.In addition,the existing and advanced channel modeling strategies,which include the evolution of different technologies and their applications;mathematical,analytical,and experimental techniques for radio propagation;and significance of the radiation characteristics,antenna placement,and physical environment of multiple-input multiple-output(MIMO)communication systems,are analyzed.The given study introduces leaky coaxial cable(LCX)and distributed antenna system(DAS)designs for improving narrowband and wideband channel capacity.The paper concludes by figuring out open research areas for the future technologies.展开更多
为了提高表情识别率并降低表情识别的功耗,提出一种基于改进深度残差网络的表情识别方法。残差学习在解决深度卷积神经网络退化问题、使网络层次大幅加深的同时,进一步增加了网络的功耗。为此,引入具有生物真实性的激活函数来代替已有...为了提高表情识别率并降低表情识别的功耗,提出一种基于改进深度残差网络的表情识别方法。残差学习在解决深度卷积神经网络退化问题、使网络层次大幅加深的同时,进一步增加了网络的功耗。为此,引入具有生物真实性的激活函数来代替已有的整流线性单元(Rectified Linear Units,ReLU)函数,并将其作为卷积层激活函数对深度残差网络进行改进。该方法不仅提高了残差网络的精度,而且训练出的网络权重可直接作为与该深度残差网络具有相同结构的深度脉冲神经网络的权重。将该深度脉冲神经网络部署在类脑硬件上时,其能够以较高的识别率和较低的能耗进行表情识别。展开更多
基金the financial support from the Key Research and Development Program of Ningxia Hui Autonomous Region of China(2021BEF02008)the National Natural Science Foundation of China(32272330)the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain axis.Thus,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in mice.It was found that AA-2βG prevented HFr D-induced cognitive deficits.AA-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory response.These beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed mice.Additionally,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal bacteria.The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut.As a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.
基金approved by the Ethics Committee of Sechenov University and performed in accordance with the Declaration of Helsinki.
文摘BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a candidate.AIM To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious infection.METHODS This study included 48 patients with Child–Pugh cirrhosis classes B and C and 15 healthy controls.The fecal microbiome was assessed using 16S rRNA gene sequencing.Plasma levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 months.RESULTS Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included patients.They had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh scale.Patients with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely Bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier function.The presepsin level directly correlated with the relative abundance of Bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and Propionibacteriaceae.After 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin before the prescription of the probiotic was an independent predictor of a greater decrease in Child–Pugh scores(P=0.046),as well as a higher level of the Child–Pugh scale(P=0.042),but not the C-reactive protein level(P=0.679)according to multivariate linear regression analysis.CONCLUSION The level of presepsin directly correlates with the abundance in the gut microbiota of the main taxa that are substrates of bacterial translocation in cirrhosis.This biomarker,in the absence of obvious infection,seems important for assessing the state of the gut–liver axis in cirrhosis and deciding on therapy targeted at the gut microbiota in this disease.
基金supported by the National Natural Science Foundation of China(No.61702347,No.62027801)Natural Science Foundation of Hebei Province(No.F2022210007,No.F2017210161)+2 种基金Science and Technology Project of Hebei Education Department(No.ZD2022100,No.QN2017132)Central Guidance on Local Science and Technology Development Fund(No.226Z0501G)National innovation and Entrepreneurship training program for college students(No.202110107024).
文摘The communication system of high-speed trains in railway tunnels needs to be built with leaky cables fixed on the tunnel wall with special fixtures.To ensure safety,checking the regular leaky cable fixture is necessary to elimi-nate the potential danger.At present,the existing fixture detection algorithms are difficult to take into account detection accuracy and speed at the same time.The faulty fixture is also insufficient and difficult to obtain,seriously affecting the model detection effect.To solve these problems,an innovative detection method is proposed in this paper.Firstly,we presented the Res-Net and Wasserstein-Deep Convolution GAN(RW-DCGAN)to implement data augmentation,which can enable the faulty fixture to export more high-quality and irregular images.Secondly,we proposed the Ghost SENet-YOLOv5(GS-YOLOv5)to enhance the expression of fixture feature,and further improve the detection accuracy and speed.Finally,we adopted the model compression strategy to prune redundant channels,and visualized training details with Grad-CAM to verify the reliability of our model.Experimental results show that the algorithm model is 69.06%smaller than the original YOLOv5 model,with 70.07%fewer parameters,2.1%higher accuracy and 14.82 fps faster speed,meeting the needs of tunnel fixture detection.
文摘The high reliability of the communication system is critical in metro and mining applications for personal safety,channel optimization,and improving operational performance.This paper surveys the progress of wireless communication systems in underground environments such as tunnels and mines from 1920 to 2022,including the evolution of primitive technology,advancements in channel modelling,and realization of various wireless propagation channels.In addition,the existing and advanced channel modeling strategies,which include the evolution of different technologies and their applications;mathematical,analytical,and experimental techniques for radio propagation;and significance of the radiation characteristics,antenna placement,and physical environment of multiple-input multiple-output(MIMO)communication systems,are analyzed.The given study introduces leaky coaxial cable(LCX)and distributed antenna system(DAS)designs for improving narrowband and wideband channel capacity.The paper concludes by figuring out open research areas for the future technologies.
文摘为了提高表情识别率并降低表情识别的功耗,提出一种基于改进深度残差网络的表情识别方法。残差学习在解决深度卷积神经网络退化问题、使网络层次大幅加深的同时,进一步增加了网络的功耗。为此,引入具有生物真实性的激活函数来代替已有的整流线性单元(Rectified Linear Units,ReLU)函数,并将其作为卷积层激活函数对深度残差网络进行改进。该方法不仅提高了残差网络的精度,而且训练出的网络权重可直接作为与该深度残差网络具有相同结构的深度脉冲神经网络的权重。将该深度脉冲神经网络部署在类脑硬件上时,其能够以较高的识别率和较低的能耗进行表情识别。