The DUF579 proteins GhIRX15s regulate cotton fiber development by interacting with proteins involved in xylan synthesis

Cotton provides the most abundant natural fiber for the textile industry.The mature cotton fiber largely consists of secondary cell walls with the highest proportion of cellulose and a small amount of hemicellulose and lignin.To dissect the roles of hemicellulosic polysaccharides during fiber development,four IRREGULAR XYLEM 15(IRX15)genes,GhIRX15-1/-2/-3/-4,were functionally characterized in cotton.These genes encode DUF579 domain-containing proteins,which are homologs of AtIRX15 involved in xylan biosynthesis.The four GhIRX15 genes were predominantly expressed during fiber secondary wall thickening,and the encoded proteins were localized to the Golgi apparatus.Each GhIRX15 gene could restore the xylan deficient phenotype in the Arabidopsis irx15irx15l double mutant.Silencing of GhIRX15s in cotton resulted in shorter mature fibers with a thinner cell wall and reduced cellulose content as compared to the wild type.Intriguingly,GhIRX15-2 and GhIRX15-4 formed homodimers and heterodimers.In addition,the GhIRX15s showed physical interaction with glycosyltransferases GhGT43C,GhGT47A and GhGT47B,which are responsible for synthesis of the xylan backbone and reducing end sequence.Moreover,the GhIRX15s can form heterocomplexes with enzymes involved in xylan modification and side chain synthesis,such as GhGUX1/2,GhGXM1/2 and GhTBL1.These findings suggest that GhIRX15s participate in fiber xylan biosynthesis and modulate fiber development via forming large multiprotein complexes.

Dietary polyphenols reduced the allergenicity ofβ-lactoglobulin via non-covalent interactions:a study on the structure-allergenicity relationship

Studies showed that complexation of polyphenols with milk allergens reduced their immunogenic potential.However,the relationship between structures of polyphenols and their hypoallergenic effects on milk allergens in association with physiological and conformational changes of the complexes remain unclear.In this study,polyphenols from eight botanical sources were extracted to prepare non-covalent complexes withβ-lactoglobulin(β-LG),a major allergen in milk.The dominant phenolic compounds bound toβ-LG with a diminished allergenicity were identified to investigate their respective role on the structural and allergenic properties ofβ-LG.Extracts from Vaccinium fruits and black soybeans were found to have great inhibitory effects on the IgE-and IgG-binding abilities ofβ-LG.Among the fourteen structure-related phenolic compounds,flavonoids and tannins with larger MWs and multi-hydroxyl substituents,notably rutin,EGCG,and ellagitannins were more potent to elicit changes on the conformational structures ofβ-LG to decrease the allergenicity of complexedβ-LG.Correlation analysis further demonstrated that a destabilized secondary structure and protein depolymerization caused by polyphenol-binding were closely related to the allergenicity property of formed complexes.This study provides insights into the understanding of structure-allergenicity relationship ofβ-LG-polyphenol interactions and would benefit the development of polyphenol-fortified matrices with hypoallergenic potential.

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s disease.We used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse brain.CHIP overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated tau.CHIP also alleviated the concentration of microglia and astrocytes around plaques.In APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin expression.Levels of HSP70 and HSP40,which have functional relevance to CHIP,were also increased.Single nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of CHIP.Our research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 mice.Indeed,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

Tuning interface mechanism of FeCo alloy embedded N,S-codoped carbon substrate for rechargeable Zn-air battery

The interface mechanism between catalyst and carbon substrate has been the focus of research.In this paper,the FeCo alloy embedded N,S co-doped carbon substrate bifunctional catalyst(FeCo/S-NC)is obtained by a simple one-step pyrolysis strategy.The experimental results and density functional theory(DFT)calculation show that the formation of FeCo alloy is conducive to promoting electron transfer,and the introduction of S atom can enhance the interaction between FeCo alloy and carbon substrate,thus inhibiting the migration and agglomeration of particles on the surface of carbon material.The FeCo/SNC catalysts show outstanding performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).FeCo/S-NC shows a high half-wave potential(E_(1/2)=0.8823 V)for ORR and a low overpotential at 10 mA cm^(-2)(E_(j=10)=299 mV)for OER.In addition,compared with Pt/C+RuO_(2) assembled Zn-air battery(ZAB),the FeCo/S-NC assembled ZAB exhibits a larger power density(198.8 mW cm^(-2)),a higher specific capacity(786.1 mA h g_(zn)~(-1)),and ultra-stable cycle performance.These results confirm that the optimized composition and the interfacial interaction between catalyst and carbon substrate synergistically enhance the electrochemical performance.

Numerical Study on the Duct Acoustic Mode Control of Turbine Interaction Noise with Serrated Configurations

Turbine noise would be one of the dominant noise sources especially in future UHBR (Ultra High Bypass-Ratio) aeroengine, but its currently far from being studied enough. Acoustic mode is crucial for duct propagation but little study about the relation between serration and mode. Thus, taking axial single-turbine test bench NPU-Turb as object, the effect of Stator with Serrated Trailing-edge (Bionic S) and Rotor with Serrated Leading-edge (Bionic R) on duct acoustic modes of turbine turbulence interac-tion noise were studied in detail using DDES/AA hybrid model validated by acoustic experiment of NPU-Turb. Serval conclusions can be made here. First, for broadband noise, the effect of serrations on duct modes (increased or reduced of PWLmn) with the increasing frequency is more prominent. Second, the changing trend of ?PWLmn is something like Chinese character “人” with circumferential mode m and alternating with radial mode. Such distribution is more obvious at higher frequency. More theoretical and mechanistic research work needs to be carried out in depth in the future. .

宿主因子NPSR调节伪狂犬病病毒感染能力的研究

[目的]伪狂犬病病毒(Pseudorabies virus,PRV)属甲型疱疹病毒科,是一种嗜神经性病毒,通过接触传播感染造成神经和呼吸系统疾病。猪是PRV的自然宿主,PRV的感染和流行对养猪业造成巨大经济损失。PRV侵染宿主中枢神经系统后,引发神经肽S(Neuropeptide S,NPS)系统表达水平的改变。NPS是一种神经肽物质,作为神经内分泌系统的关键成员在中枢神经系统中广泛分布,与慢性疾病相关联,NPS通过神经肽S受体(Neuropeptide S receptor,NPSR)介导多样化的生理功能,在机体内以NPS/NPSR系统形式共同参与神经内分泌-免疫网络调节。本研究探讨了NPS/NPSR系统在PRV感染宿主细胞中的作用,以期待开发新的抗PRV靶点。[方法]通过CRISPR/Cas9构建NPS和NPSR敲除的PK15细胞系,利用qPCR、免疫荧光、Western blot、免疫共沉淀(CO-IP)等方法检测感染PRV病毒后细胞系的抗病毒能力及NPSR与病毒表面糖蛋白的结合能力。[结果]NPSR敲除能减弱PRV对PK15细胞的感染能力,而NPS基因敲除增强了PRV对PK15细胞的感染能力。NPSR敲除细胞在PRV吸附过程中能减少病毒的侵入量,因此NPSR是潜在的PRV入侵受体。CO-IP试验证明,NPSR与病毒包膜蛋白gB和gD存在相互作用。[结论]NPSR通过与病毒表面糖蛋白结合促进PRV感染,NPSR可能是PRV感染神经系统的受体因子之一。NPSR敲除能显著抑制PRV对PK15细胞的感染。NPSR可为开发PRV防控药物和治疗策略提供新的研究靶点。

“U-S”合作中高校教师与中小学教师的跨界知识互动探究

对于“U-S”合作情境中高校教师与中小学教师如何进行知识互动这一重要问题,鲜有实证研究涉及。通过对高校与中小学合作的多个案例进行质性研究,发现高校教师与中小学教师的知识互动存在三种不同的模式:一是高校教师主导下的知识迁移模式,二是内化与重构后的知识转化模式,三是基于研究伙伴关系的知识生产模式。基于此,自我定位与地位关系、知识互动的聚焦性和持续性、卷入程度及跨界互动能力,是影响高校教师与中小学教师知识互动效果的重要因素。

Evaluation of Technical Education by Using a Modern Structured MOODLE Laboratory Course, in Relation to Recent Data

E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a modern structured MOODLE interactive course, designed for the needs of the laboratory course “Automotive Systems”. The study concerns Greek secondary vocational education pupils aged 18 and vocational training adult students aged 20 to 50 years. The multistage, equal size simple random cluster sample was used as a sampling method. Pupils and adult students of each cluster completed structured 10-question questionnaires both before and after attending the course. A total of 120 questionnaires were collected. In general, our findings disclosed that the majority of pupils and adult students had significantly improved their knowledge and skills from using MOODLE. They reported strengthening conventional teaching, using the new MOODLE technology. The satisfaction indices improved quite, with the differences in their mean values being statistically significant.

黑龙江争光大型金矿成矿流体He-Ar-S同位素组成及成矿流体来源的示踪

【研究目的】黑龙江争光金矿床位于兴安地块东缘嫩江—黑河北东向断裂带西北侧的奥陶纪多宝山岛弧带上。本文通过对主成矿期的矿石样品研究,探讨了成矿流体的来源。【研究方法】选择9件主成矿期的黄铁矿和方铅矿进行了系统研究,测定了He、Ar和S同位素组成。【研究结果】其含金石英脉中黄铁矿和方铅矿的流体包裹体3He/4He=1.95×10^(-6)~5.03×10^(-6),^(40)Ar/^(36)Ar=349.1~453.9。幔源He占13.17%~44.67%,平均27.58%,显示了成矿流体以大气降水为主,但同时有地幔流体成分,表明金矿床成矿作用与地幔活动有着密切的关系。矿物δ^(34)S=-1.2‰~-3.9‰,平均-2.33‰,可能来自深源地幔流体,但其中有地壳流体的加入。【结论】洋壳向兴安地块俯冲,俯冲流体交代地幔楔发生部分熔融,流体上升至地表浅部与下渗的大气降水混合形成成矿流体,由于温度和压力的下降和流体沸腾作用导致成矿流体物理化学条件的改变,从而使成矿物质沉淀。

Interactions of Sn and S and their effects on the magnetic properties of non-oriented silicon steel sheets

The interactions of Sn and S and their effects on the magnetic properties of non-oriented silicon steel sheets were discussed in reference to industrial production. Results show that minor amounts of Sn can improve magnetic induction sharply but have little effect on core loss when the S content is below 10 × 10 ^-4%. The precipitation of AlN can be restrained effectively by Sn. Sn, as the nucleus, can remove some of the inclusions with a size of 0.5μm or larger, but has little effect on inclusions smaller than 0.5 μm,which is the key factor affecting core loss. Sn improves the magnetic induction of finished steel sheets mainly through the change of the steel texture. The relationship between the magnetic induction and Sn and S content can be regressed as B50 = 1.69 -4.37 ws ＋0.30 Ws,. From the regression formulation,the magnetic induction can be improved by 0.03 T when 0.01% Sn is added under relatively low S content conditions.

Groundwater monitoring of an open-pit limestone quarry:Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses

Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately watersoluble minerals like calcite. In this study, the hydrogeological and geochemical evolutions of groundwater in a limestone quarry composed of three strata: limestone layer(covering), interbedded layer under the covering layer, and slaty greenstone layer(basement) were investigated. Water-rock interaction in the open-pit limestone quarry was evaluated using PHREEQC, while hierarchical cluster analysis(HCA)and principal component analysis(PCA) were used to classify and identify water sources responsible for possible groundwater mixing within rock layers. In addition, Geochemist's Workbench was applied to estimate the mixing fractions to clarify sensitive zones that may affect rock slope stability. The results showed that the changes in Ca2+and HCO3àconcentrations of several groundwater samples along the interbedded layer could be attributed to mixing groundwater from the limestone layer and that from slaty greenstone layer. Based on the HCA and PCA results, groundwaters were classified into several types depending on their origin:(1) groundwater from the limestone layer(LO),(2) mixed groundwater flowing along the interbedded layer(e.g., groundwater samples L-7, L-11, S-3 and S-4), and(3) groundwater originating from the slaty greenstone layer(SO). The mixing fractions of 41% LO: 59% SO, 64% LO: 36% SO, 43%LO: 57% SOand 25% LO: 75% SOon the normal days corresponded to groundwaters L-7, L-11, S-3 and S-4,respectively, while the mixing fractions of groundwaters L-7 and L-11(61% LO: 39% SOand 93% LO: 7% SO,respectively) on rainy days became the majority of groundwater originating from the limestone layer.These indicate that groundwater along the interbedded layer significantly affected the stability of rock slopes by enlarging multi-breaking zones in the layer through calcite dissolution and inducing high water pressure, tension cracks and potential sliding plane along this layer particularly during intense rainfall episodes.

Parallel Sensing in Metaverses: Virtual-Real Interactive Smart Systems for “6S” Sensing

In the construction of Metaverses,sensors that are referred to as the“bridge of information transmission”,play a key role.The functionality and efficiency of today’s sensors,which operate in a manner similar to physical sensing,are frequently constrained by their hardware and software.In this research,we proposed the Parallel Sensing framework,which includes background,concept,basic methods and typical application of parallel sensing.In our formulation,sensors are redefined as the integration of real physical sensors and virtual software-defined sensors based on parallel intelligence,in order to boost the performance of the sensors.Each sensor will have a parallel counterpart in the virtual world within the framework of parallel sensing.Digital sensors serve as the brain of sensors and maintain the same properties as physical sensors.Parallel sensing allows physical sensors to operate in discrete time periods to conserve energy,while cloud-based descriptive,predictive,and prescriptive sensors operate continuously to offer compensation data and serve as guardians.To better illustrate parallel sensing concept,we show some example applications of parallel sensing such as parallel vision,parallel point cloud and parallel light fields,both of which are designed by construct virtual sensors to extend small real data to virtual big data and then boost the performance of perception models.Experimental results demonstrate the effective of parallel sensing framework.The interaction between the real and virtual worlds enables sensors to operate actively,allowing them to intelligently adapt to various scenarios and ultimately attain the goal of“Cognitive,Parallel,Crypto,Federated,Social and Ecologic”6S sensing.

Soliton solution and interaction property for a coupled modified Korteweg-de Vries (mKdV) system

Hirota＇s bilinear direct method is applied to constructing soliton solutions to a special coupled modified Korteweg- de Vries （mKdV） system. Some physical properties such as the spatiotemporal evolution, waveform structure, interactive phenomena of solitons are discussed, especially in the two-soliton case. It is found that different interactive behaviours of solitary waves take place under different parameter conditions of overtaking collision in this system. It is verified that the elastic interaction phenomena exist in this （1＋1）-dimensional integrable coupled model.

Study on soil-pile-structure-TMD interaction system by shaking table model test

The success of the tuned mass damper (TMD) in reducing wind-induced structural vibrations has been well established. However, from most of the recent numerical studies, it appears that for a structure situated on very soft soil, soil-structure interaction (SSI) could render a damper on the structure totally ineffective. In order to experimentally verify the SSI effect on the seismic performance of TMD, a series of shaking table model tests have been conducted and the results are presented in this paper. It has been shown that the TMD is not as effective in controlling the seismic responses of structures built on soft soil sites due to the SSI effect. Some test results also show that a TMD device might have a negative impact if the SSI effect is neglected and the structure is built on a soft soil site. For structures constructed on a soil foundation, this research verifies that the SSI effect must be carefully understood before a TMD control system is designed to determine if the control is necessary and if the SSI effect must be considered when choosing the optimal parameters of the TMD device.

An Analysis of Michael Long’s Interaction Hypothesis in Second Language Acquisition

The Interaction Hypothesis,which was first advanced by Michael Long,is considered as a further supplement or extension of the Input Hypothesis in the field of second language acquisition. This paper explains the main claims of Michael Long's Interaction Hypothesis,the three steps to study how input and interaction affect the acquisition of a second language,and the importance of the interactional modifications applied by both participants of the interaction. Emphasis is placed on the evaluation of the theory as well as its relation to second language teaching,with many researchers' findings and arguments discussed as supporting evidence. It aims to help the effective application of this theory in second language teaching.

Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients

AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci.

Vaccine by Chicken Line Interaction Alters the Protective Efficacy against Challenge with a Very Virulent plus Strain of Marek’s Disease Virus in White Leghorn Chickens

Marek’s disease (MD) is a lymphoproliferative disease of domestic chickens caused by Marek’s disease virus (MDV), an oncogenic and highly contagious α-herpesvirus. MD has been controlled by vaccination but sporadic outbreaks of MD still occur in some parts of the world. Efforts to improve vaccine efficacy have continued in both research communities and vaccine industries. We reported the host genetic variation affecting Marek’s disease vaccine-induced immunity in chickens earlier. In this study, we evaluated chicken lines, vaccines, and line by vaccine interaction on the protective efficacy of vaccination against MD. Specific pathogen free chickens from the relatively resistant line 63 and the highly susceptible line 72 were primarily used to evaluate the protection by three kinds of vaccines (rMd5ΔMeq, CVI988/Rispens, and HVT) upon challenge with a very virulent plus strain of MDV, vv+648A. Our data confirmed that both the chicken line and the vaccine significantly affected the protective efficacy of vaccination and showed that a chicken line by vaccine interaction, in most of the trials, also altered vaccine protective efficacy. More interestingly, although the protective index of all vaccine strains was higher in resistant than in susceptible line of chickens, the difference for HVT protection was striking and warrants further study. The findings may have important implications for vaccine development as well as for selective use of particular vaccines in specific lines of chickens to achieve maximum protection at minimized costs.

An overview of a unified theory of dynamics of vehicle–pavement interaction under moving and stochastic load

This article lays out a unified theory for dynamics of vehicle-pavement interaction under moving and stochastic loads. It covers three major aspects of the subject： pavement surface, tire-pavement contact forces, and response of continuum media under moving and stochastic vehicular loads. Under the subject of pavement surface, the spectrum of thermal joints is analyzed using Fourier analysis of periodic function. One-dimensional and two-dimensional random field models of pavement surface are discussed given three different assumptions. Under the subject of tire-pavement contact forces, a vehicle is modeled as a linear system. At a constant speed of travel, random field of pavement surface serves as a stationary stochastic process exciting vehicle vibration, which, in turn, generates contact force at the interface of tire and pavement. The contact forces are analyzed in the time domain and the frequency domains using random vibration theory. It is shown that the contact force can be treated as a nonzero mean stationary process with a normal distribution. Power spectral density of the contact force of a vehicle with walking-beam suspension is simulated as an illustration. Under the subject of response of continuum media under moving and stochastic vehicular loads, both time-domain and frequency-domain analyses are presented for analytic treatment of moving load problem. It is shown that stochastic response of linear continuum media subject to a moving stationary load is a nonstationary process. Such a nonstationary stochastic process can be converted to a stationary stochastic process in a follow-up moving coordinate.

Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer's disease

Blood-brain barrier disruption occurs in the early stages of Alzheimer’s disease.Recent studies indicate a link between blood-brain barrier dysfunction and cognitive decline and might accelerate Alzheimer’s disease progression.Astrocytes are the most abundant glial cells in the central nervous system with important roles in the structural and functional maintenance of the blood-brain barrier.For example,astrocytic cove rage around endothelial cells with perivascular endfeet and secretion of homeostatic soluble factors are two major underlying mechanisms of astrocytic physiological functions.Astrocyte activation is often observed in Alzheimer’s disease patients,with astrocytes expressing a high level of glial fibrillary acid protein detected around amyloid-beta plaque with the elevated phagocytic ability for amyloid-beta.Structural alte rations in Alzheimer’s disease astrocytes including swollen endfeet,somata shrinkage and possess loss contribute to disruption in vascular integrity at capillary and arte rioles levels.In addition,Alzheimer’s disease astrocytes are skewed into proinflammatory and oxidative profiles with increased secretions of vasoactive mediators inducing endothelial junction disruption and immune cell infiltration.In this review,we summarize the findings of existing literature on the relevance of astrocyte alte ration in response to amyloid pathology in the context of blood-brain barrier dysfunction.First,we briefly describe the physiological roles of astrocytes in blood-brain barrier maintenance.Then,we review the clinical evidence of astrocyte pathology in Alzheimer’s disease patients and the preclinical evidence in animal and cellular models.We further discuss the structural changes of blood-brain barrier that correlates with Alzheimer’s disease astrocyte.Finally,we evaluate the roles of soluble factors secreted by Alzheimer’s disease astrocytes,providing potential molecular mechanisms underlying blood-brain barrier modulation.We conclude with a perspective on investigating the therapeutic potential of targeting astrocytes for blood-brain barrier protection in Alzheimer’s disease.

Snyder希望理论指导的健康行为互动模式干预对肝硬化患者心理弹性及自理能力的影响

目的探讨Snyder希望理论指导的健康行为互动模式干预对肝硬化患者心理弹性以及自理能力的影响。方法选择2021年2月至2022年10月在我院接受治疗的78例肝硬化患者,按照随机数字表法分成常规组与研究组各39例,常规组给予基础护理,研究组在常规组的基础上给予Snyder希望理论指导的健康行为互动模式干预,比较两组的Herth希望量表(HHI)、Frank依从量表(FCS)、心理弹性量表(CD-RISC10)及自理能力(肝硬化自我管理行为量表)评分。结果护理后,两组患者HHI、FCS、CD-RISC10评分均升高,研究组各评分高于对照组(P<0.05);日常生活管理、病情监测管理、用药管理及饮食管理评分均较护理前升高,且研究组自理能力各评分高于对照组(P<0.05)。结论Snyder希望理论指导的健康行为互动模式干预能提高患者的希望水平和治疗依从性,改善其心理弹性,提升自理能力。