Effects of hypoxia on learning-memory function and swimming capability of rat were studied and the ergonomics under hypoxic condition was also evaluated from the biological point of view.Three modes of hypoxia were de...Effects of hypoxia on learning-memory function and swimming capability of rat were studied and the ergonomics under hypoxic condition was also evaluated from the biological point of view.Three modes of hypoxia were designed and plots of oxygen concentration versus time for each group in hypoxic environment were produced.Results showed that the effects of hypoxia on learning-memory function and swimming capability were related with the time and strength of hypoxia.It had nothing to do with the individual difference of rat models.10% O2 long-term intermittent anamorphosis hypoxia could improve the swimming capability of rat model significantly.Stimulating with proper level of hypoxia,carbon dioxide could improve ergonomics in airtight hypoxia environment.Under hypoxia condition,from the ergonomic point of view,6% O2 is the important threshold and might belong in critical region.展开更多
Objective To explore the possible neurophysiologic mechanisms of propofol and N-methyl-Daspartate(NMDA) receptor antagonist against learning-memory impairment of depressed rats without olfactory bulbs. Methods Models ...Objective To explore the possible neurophysiologic mechanisms of propofol and N-methyl-Daspartate(NMDA) receptor antagonist against learning-memory impairment of depressed rats without olfactory bulbs. Methods Models of depressed rats without olfactory bulbs were established. For the factorial design in analysis of variance, two intervention factors were included: electroconvulsive shock groups(with and without a course of electroconvulsive shock) and drug intervention groups [intraperotoneal(ip) injection of saline, NMDA receptor antagonist MK-801 and propofol. A total of 60 adult depressed rats without olfactory bulbs were randomly divided into 6 experimental groups(n=10 per group): ip injection of 5 ml saline; ip injection of 5 ml of 10 mg/kg MK-801; ip injection of 5 ml of 10 mg/kg MK-801 and a course of electroconvulsive shock; ip injection of 5 ml of 200 mg/kg propofol; ip injection of 5 ml of 200 mg/kg propofol and a course of electroconvulsive shock; and ip injection of 5 ml saline and a course of electroconvulsive shock. The learning-memory abilities of the rats was evaluated by the Morris water maze test. The content of glutamic acid in the hippocampus was detected by high-performance liquid chromatography. The expressions of p-AT8Ser202 in the hippocampus were determined by Western blot analysis. Results Propofol, MK-801 or electroconvulsive shock alone induced learning-memory impairment in depressed rats, as proven by extended evasive latency time and shortened space probe time. Glutamic acid content in the hippocampus of depressed rats was significantly up-regulated by electroconvulsive shock and down-regulated by propofol, but MK-801 had no significant effect on glutamic acid content. Levels ofphosphorylated Tau protein p-AT8Ser202 in the hippocampus was up-regulated by electroconvulsive shock but was reduced by propofol and MK-801 alone. Propofol prevented learning-memory impairment and reduced glutamic acid content and p-AT8Ser202 levels induced by electroconvulsive shock. Conclusion Electroconvulsive shock might reduce learning-memory impairment caused by protein Tau hyperphosphorylation in depressed rats by down-regulating glutamate content.展开更多
在用户的印象中,Abit有两项最深入民心的发明,第一是SoftMenu,这是无可否定的。自从HX晶片组主板开始,至今Softmenu Ⅲ,早已成为Abit的身份象征。第二相信是其BX6 ver 2.0主板,还记得它在全球推出时,所获的奖项简直不计其数。那么大家...在用户的印象中,Abit有两项最深入民心的发明,第一是SoftMenu,这是无可否定的。自从HX晶片组主板开始,至今Softmenu Ⅲ,早已成为Abit的身份象征。第二相信是其BX6 ver 2.0主板,还记得它在全球推出时,所获的奖项简直不计其数。那么大家又可曾想过,BX6、Softmenu Ⅲ、AMD Athlon,可以做出多么强大的化学作用?展开更多
虽然采用800MHz处理器外频的P4芯片组即将推出,但由于i845PE芯片组的售价会较低,因而还会有其市场价值。Abit日前推出的采用i845PE芯片组的Max2 Pro 2.0主板,便是反映了这一情况。从板上的设计可见,它并不是主攻主流主板市场,因主板上...虽然采用800MHz处理器外频的P4芯片组即将推出,但由于i845PE芯片组的售价会较低,因而还会有其市场价值。Abit日前推出的采用i845PE芯片组的Max2 Pro 2.0主板,便是反映了这一情况。从板上的设计可见,它并不是主攻主流主板市场,因主板上拥有多项配备,较适合高端用户使用。不过亦因于板上有太多配备,所以使主板本身的扩充能力较低,由于板上只提供了1条AGP与4条PCI插槽,但其实已经够用,看了以下的主板装备介绍就会明白。展开更多
基金Sponsored by the National Natural Science Foundation of China(20705005)Commission of Science Technology and Industry for National Defence(A2220060042)
文摘Effects of hypoxia on learning-memory function and swimming capability of rat were studied and the ergonomics under hypoxic condition was also evaluated from the biological point of view.Three modes of hypoxia were designed and plots of oxygen concentration versus time for each group in hypoxic environment were produced.Results showed that the effects of hypoxia on learning-memory function and swimming capability were related with the time and strength of hypoxia.It had nothing to do with the individual difference of rat models.10% O2 long-term intermittent anamorphosis hypoxia could improve the swimming capability of rat model significantly.Stimulating with proper level of hypoxia,carbon dioxide could improve ergonomics in airtight hypoxia environment.Under hypoxia condition,from the ergonomic point of view,6% O2 is the important threshold and might belong in critical region.
基金Supported by the National Natural Science Foundation(30972831)the China Postdoctoral Science Foundation(2013M530880)
文摘Objective To explore the possible neurophysiologic mechanisms of propofol and N-methyl-Daspartate(NMDA) receptor antagonist against learning-memory impairment of depressed rats without olfactory bulbs. Methods Models of depressed rats without olfactory bulbs were established. For the factorial design in analysis of variance, two intervention factors were included: electroconvulsive shock groups(with and without a course of electroconvulsive shock) and drug intervention groups [intraperotoneal(ip) injection of saline, NMDA receptor antagonist MK-801 and propofol. A total of 60 adult depressed rats without olfactory bulbs were randomly divided into 6 experimental groups(n=10 per group): ip injection of 5 ml saline; ip injection of 5 ml of 10 mg/kg MK-801; ip injection of 5 ml of 10 mg/kg MK-801 and a course of electroconvulsive shock; ip injection of 5 ml of 200 mg/kg propofol; ip injection of 5 ml of 200 mg/kg propofol and a course of electroconvulsive shock; and ip injection of 5 ml saline and a course of electroconvulsive shock. The learning-memory abilities of the rats was evaluated by the Morris water maze test. The content of glutamic acid in the hippocampus was detected by high-performance liquid chromatography. The expressions of p-AT8Ser202 in the hippocampus were determined by Western blot analysis. Results Propofol, MK-801 or electroconvulsive shock alone induced learning-memory impairment in depressed rats, as proven by extended evasive latency time and shortened space probe time. Glutamic acid content in the hippocampus of depressed rats was significantly up-regulated by electroconvulsive shock and down-regulated by propofol, but MK-801 had no significant effect on glutamic acid content. Levels ofphosphorylated Tau protein p-AT8Ser202 in the hippocampus was up-regulated by electroconvulsive shock but was reduced by propofol and MK-801 alone. Propofol prevented learning-memory impairment and reduced glutamic acid content and p-AT8Ser202 levels induced by electroconvulsive shock. Conclusion Electroconvulsive shock might reduce learning-memory impairment caused by protein Tau hyperphosphorylation in depressed rats by down-regulating glutamate content.
文摘虽然采用800MHz处理器外频的P4芯片组即将推出,但由于i845PE芯片组的售价会较低,因而还会有其市场价值。Abit日前推出的采用i845PE芯片组的Max2 Pro 2.0主板,便是反映了这一情况。从板上的设计可见,它并不是主攻主流主板市场,因主板上拥有多项配备,较适合高端用户使用。不过亦因于板上有太多配备,所以使主板本身的扩充能力较低,由于板上只提供了1条AGP与4条PCI插槽,但其实已经够用,看了以下的主板装备介绍就会明白。