Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation infrastructure. Despite government efforts, many still prefer motorized transport, citing mobility and safety concerns, exacerbated by insufficient pedestrian infrastructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. Findings reveal safety and convenience as primary factors driving motorized transport use, especially for accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of addressing economic factors and improving access infrastructure to manage motorized vehicle reliance and foster sustainable urban mobility in Hanoi.

Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Objective: In the manuscript titled Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinsons Disease: A Systematic Review and Meta-Analysis, the objective was to conduct a systematic review with meta-analysis to investigate the effects that Rasagiline has on motor and non-motor symptoms in individuals with PD. Introduction: Rasagiline is a second-generation monoamine oxidase-B (MAO-B) inhibitor used both as monotherapy and adjunctive therapy for Parkinsons Disease (PD). Methods: A systematic literature search and meta-analysis were performed with randomized control trials that investigated the effects of Rasagiline on motor and non-motor symptoms in individuals with PD. The systematic search was conducted in PubMed, Cochrane, and EBSCO databases. Methodological quality was assessed using the Cochrane Grading Recommendations Assessment, Development and Evaluation approach. Results: Fourteen studies were included in our review. There were trivial to small and statistically significant improvements in motor symptoms for individuals with PD treated with Rasagiline compared to placebo. Non-motor symptoms showed no significant improvement with Rasagiline compared to placebo in five of six meta-analyses. Results were based on very low to moderate certainty of evidence. Conclusion: 1 mg/day Rasagiline significantly improved Parkinsonian motor symptoms in individuals with PD compared with placebo. For all outcomes, the 1 mg/day Rasagiline group was favored over the placebo group.

Effects of a Cocktail Supplement of Ginkgo Biloba and Acai Extract on Cognitive Symptoms of Parkinson’s Disease

Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767).

Set methods of left-turn waiting zone at signalized intersection

To maximize the number of vehicles passing by the stop-line in a cycle and improve the operation efficiency of intersection in China, the settlement of left-turn lane waiting-zone is becoming prevailing. Based on conflicting-point method, the internal mechanism of left-turn flow after stopping line was analyzed through taking postposition left-turn lane waiting-zone intersection for instance. The relationship between the first left-turn vehicle and the last vehicle of previous phase passing the conflicting point was expounded. According to the time of successive arriving of two vehicle flows at conflicting-point, the reasonable layout for waiting area of left-turn vehicles was researched when the clearance index was less than O. The results suggest that the appropriate layout for waiting area of left-turning vehicles can improve the operation efficiency of intersections.

Analysis of opposing left-turn conflicts based on traffic conflict technology

The relationship between the opposing left-turn conflict and the traffic participants was analyzed in this study. Based on the traffic conflict technology, the image data were collected in a real traffic situation. The relationship was investigated under two different conditions. The number of opposing left-turn conflicts was positively correlated with the number of left-turn vehicles while the ratio of left-turn vehicles to opposing vehicles was less than 1, and showed a positive correlation with the number of opposing-through vehicles when the ratio of left-turn vehicles to opposing vehi- cles was more than 1. In other words, the opposing left-turn risk was positively correlated with the number of the minor traffic participants, which had a negative effect on the whole traffic system op- eration.

Modeling Bicycle Conflict on Non-Motorized Paths on Suburban College Campuses

Bicycling is an important way for college students and employees to get around campuses. With a rise in bicycling on campuses there comes a rise in bicycle collisions with pedestrians walking to and from classes and work. The literature review showed many papers involving bicycle conflict modeling but on roads with motor vehicles. While some aspects of this research can be applied to non-motorized paths, there is a lack of research strictly focusing on only bicycles and pedestrians. This study aims to fill this knowledge gap by developing a model to identify locations on roads and paths (hotspots) on college campuses that are likely to have a bicycle collision and predict the likelihood of a serious bicycle crash on a non-motorized path based on the characteristics of the path. This study identifies those interactions between bicyclists and pedestrians on non-motorized paths on a suburban college campus in Newark, USA. Findings suggest that pedestrian density of a path is a major factor in the maximum speed bicyclists can achieve. The wider the path is, the higher the maximum speed is that a bicyclist can obtain. This is because a wider path width decreases the pedestrian density. The grade of the path has little effect on bicycle speeds. The results of the models were displayed on a GIS map that is visually appealing to a viewer. The paths were color coded based on their level of safety, so it is easy to observe problematic areas of the network. This technique can be applied to the entire campus network of non-motorized paths to study the whole system. This can then be used by planners and designers to identify areas that need upgrading and improve the overall safety of the non-motorized path system.

Temporal Stability and Transferability of Non-Motorized and Total Trip Generation Models

Transportation systems provide a means for moving people and the goods from which they are spatially separated. Of the two means of surface transportation, the motorized mode is used extensively for utilitarian travel in developed countries. The increasing reliance on motorized travel has contributed to increased traffic congestion, air pollution, and greenhouse emissions. Non-motorized travel has recently received significant attention as a means to reduce congestion and environmental problems and improve human health. However, non-motorized modeling is generally underdeveloped. This study investigated some changes in non-motorized and total travel and the characteristics of the traveling public in 1990, 1995, 2001, and 2009 using a national travel survey. The study also investigated the temporal transferability of linear-regression trip generation models for non-motorized and total travel under such changes. High-income households made fewer non-motorized trips in 1990 and 1995 compared to 2001 and 2009. Persons aged 50 and over showed an increased demand for non-motorized travel, whereas children aged 0 - 15 showed a decreasing preference for non-motorized travel over time. Regarding temporal stability, only the coefficient for single-adult households with no children was stable across all of the analysis years. For both non-motorized and total travel, most model parameter estimates were stable short term but not long term. In general, the total travel models transferred better than non-motorized models, both short term and long term. Despite not finding universal stability in model parameter estimates, the models were marginally able to replicate travel in 2009 relative to the locally estimated 2009 model.

Influence of bus stop with left-turn lines between two adjacent signalized intersections

Based on the symmetric two-lane Nagel–Schreckenberg（STNS） model, a three-lane cellular automaton model between two intersections containing a bus stop with left-turning buses is established in which model the occurrences of vehicle accidents are taken into account. The characteristics of traffic flows with different ratios of left-turn lines are discussed via the simulation experiments. The results indicate that the left-turn lines have more negative effects on capacity,accident rate as well as delay if the stop is located close to the intersections, where the negative effect in a near-side stop is more severe than that in a far-side one. The range of appropriate position for a bus stop without the bottleneck effect becomes more and more narrow with the increase of the ratio of left-turn bus lines. When the inflow is small, a short signal cycle and a reasonable offset are beneficial. When the inflow reaches or exceeds the capacity, a longer signal cycle is helpful. But if the stop position is inappropriate, the increase of cycle fails in reducing the negative effect of left-turning buses and the effectiveness of offset is weakened.

Investigation and Optimization of Priority for Non-motor Vehicles in the Old Urban Area of Nanchang

Under the background of"people-oriented"thought and"green transportation",the idea of"priority for non-motor vehicles"came into being,which can improve the riding environment of non-motor vehicle riders to a certain extent.According to the current situation of priority for non-motor vehicles in the old urban area of Nanchang,through field investigation,questionnaire investigation and interview,this study summarized the existing problems,and put forward optimization suggestions for these problems,in order to provide reference for areas with similar conditions.

Bandwidth Maximization Approach for Displaced Left-Turn Crossovers Coordination under Heterogeneous Traffic Conditions

As one of the UAIDs(unconventional alternative intersection designs),DLTs(displaced left-turn crossovers)have been presented to mitigate traffic congestion.Although,qualitatively and quantitatively isolated UAIDs outperform their conventional counterparts,there is no simplified procedure to consider the DLTs coordination.Hence,this research investigates the coordination of consecutive DLTs under heterogeneous traffic conditions.To achieve the optimal coordination and provide an efficient coordination control,a bandwidth maximization progression approach was used.Seeking the optimal offset for each pair of consecutive intersections to guarantee the green bandwidth waves along the coordinated corridor,a mixed-integer linear program was adopted.The optimization problem was formulated and solved based on the standard branch-and-bound technique.As a real-world study case,data of three typical intersections located in an arterial corridor in Cairo,Egypt was used.PTV-VISSIM as a microsimulation platform was employed to simulate and evaluate the different signal timing plans.However,to represent the heterogeneous traffic characteristics as close as possible to the reality,different simulation parameters were tuned and validated carefully.The results emphasized the undoubted improvement of coordinated DLTs by different operational performance indices.The total travel time,average delay,the number of stops per vehicle were obviously improved.

Non-Motor Symptoms in Parkinson’s Disease Patients—An Observational Study

Background: Parkinson’s disease (PD) remains a challenge for neurologists, particularly in its advanced stages when non-motor symptoms become a burden for the patient. While motor symptoms may be satisfactorily controlled with levodopa therapy or continuous levodopa/carbidopa intestinal gel (LCIG) administration, autonomic, sleep and mental disorders are hard to treat. During the last years, researchers have shifted their interest more to non-motor symptoms, PD being now considered a complex multiorgan impairment. Objective: The aim of this study was to describe non-motor symptoms in 40 Romanian patients diagnosed with PD, under conventional and LCIG administration treatment. Methods: A cross-sectional observational study was conducted, consisting of two groups of 20 patients each: the first group comprised PD patients who received conventional Levodopa treatment, while the second group was formed of patients receiving LCIG therapy. Various data concerning patient’s age, gender, duration of illness, comorbidities, motor and non-motor symptoms were recorded. The data were processed in SPSS v.20. Results: Subjects under continuous LCIG administration, although showing amelioration of motor symptoms, complained more frequently of constipation, mental, and sleeping disorders (statistically significant). Regarding anosmia, orthostatic hypotension, hypersalivation, urinary incontinence and restless legs syndrome, no statistical significant difference was observed between the two groups (p > 0.05). Conclusion: Nowadays, more research is conducted on non-motor symptoms in PD patients, as therapeutic measures try to limit these burdens, in order to improve patient’s quality of life.

Non-motor signs and symptoms in Parkinson’s disease

Motor symptoms are cardinal clinical features of Parkinson’s disease (PD). Progress in drug therapy and rehabilitation has been presenting beneficial effect for motor symptoms. However, non-motor symptoms and signs in PD have been accumulated growing attentions and its amelioration may also give beneficial effect for PD patients’ and their care givers’ quality of life. In this mini-review, I overviewed non-motor symptoms and signs in PD.

Genetic factors associated with non-motor symptoms in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is a complex syndrome with heterogeneous aetiologies, pathogenesis and manifestations. Patients with PD may present with motor symptoms and various non-motor symptoms (NMSs). NMSs have been reported in almost every diagnosed case of PD and usually precede motor symptoms. Multiple factors have been proved to be associated with the occurrence of NMSs in PD, among which genetic differentiation is a featured one. With the development of sequencing techniques, an increasing number of NMS-related genetic factors have been identified. This article reviews some of the latest discoveries in this regard.

Impact of Pedestrian Traffic on Saturation Rate of Protected Left-Turn at Urban Intersections

Heavily congested intersections in metropolitan areas in China are facing unique problems due to high travel demand and a high degree of traffic law violations. Based on a study conducted by the authors of this paper, 93% of left-turn vehicles turning left in these areas were slowed in order to avoid conflict with pedestrians. Intertwined pedestrian and vehicular flows can significantly reduce the capacity of exclusive left-turn lane group through reducing saturation flow rate, which increases the congestion at intersections. This paper investigates how the saturation flow rate of exclusive left-turn lane group is affected by the characteristics of pedestrian flow. By analyzing the imagery data collected by video cameras installed at intersections, the research team is able to obtain the characteristics of both vehicular and pedestrian flows, such as speed and spatial locations. The average operating speed at the saturation flow rate with and without pedestrian traffic is used as a direct measurement to evaluate the effect of pedestrians. Based on the statistical analysis, the paper concludes that saturation flow rate is mainly affected by the position of pedestrian in the crosswalk (inside or outside of left-turn vehicle’s trajectory), and the distance between the vehicle and pedestrians. In general, when the distance is less than four meters, the smaller the distance between vehicle and pedestrians, the larger the impact. However, there is no significant impact when the distance is larger than four meters. To accurately quantify the effect, the degree of pedestrian-vehicle impact is defined in four levels. The results show that the difference in the saturation flow rate between the best and the worst level could be 15.7%, which clearly indicates how important it is to enforce pedestrian crossing behavior.

Developing Framework to Test Driving Performance at Left-Turn Movement with In-Vehicle Advance Collision Warning Message

Left-turning traffic without a protected left-turn signal is one of the major safety concerns at urban intersections. Though an average of only l0% - 15% of all approaching traffic turns left, significantly a large proportion of left-turn crashes occur involving 21% of all intersection fatal crashes. Where traditional safety countermeasures of signal timing-phasing and use of flashing yellow light have reportedly failed to significantly reduce the rate of crashes, an in-vehicle advance collision warning message can be helpful to reduce left-turn collisions at intersections. In this study, an in-vehicle audio warning application has been designed by providing two safety warning messages (Advance Warning Message and Safe Left-turn Maneuver Message) under the vehicle to vehicle (V2V) communication system, which is triggered based on the acceptable gaps of oncoming opposing vehicles for a safe left-turn. A driving simulator test has been conducted with 30 participants to investigate the impacts of warning messages on performance measures such as speed and acceleration profiles, collision records, brake reaction distance, and intersection clearance time. Statistical results showed that with the help of these messages, all participants were able to reduce speeds and accelerations and chose suitable gaps without potential conflicts. Moreover, the results of questionnaire analysis provide a positive acceptability especially for the Safe Left-turn Maneuver Message. Based on the performance measurements, this type of safety warning messages can be recommended for possible real-road tests for practical applications.

Connected and Autonomous Vehicles (CAVs) Challenges with Non-motorized Amenities Environments

With the deployment of Connected and Automated Vehicles in the coming decades,road transportation will experience a significant upheaval.CAVs(Connected and Autonomous Vehicles)have been a main emphasis of Transportation and the automotive sector,and the future of transportation system analysis is widely anticipated.The examination and future devel­opment of CAVs technology has been the subject of numerous researches.However,as three essential kinds of road users,pedestrians,bicyclists,and motorcyclists have experienced little to no handling.We explored the influ­ence of CAVs on non-motorized mobility in this article and seven various issues that CAVs face in the environment.

Redesign of Motorized and Non-motorized Transport in Cities and Sustainable Mobility

Redesign of motorized and non-motorized transport in cities and sustainable mobility possibilities and utilization of already occupied areas for motorized and non-motorized transport in cities. Reserved area for public transport may be the redesign much more to take advantage of without taking up new space in cities. Redesigned solutions shown in the work of public mass transport and the redesign of non-motorized transport, bicycle and pedestrian paths point to the improved use and safety of movement of passengers, cyclists and pedestrians. This paper presents five redesigned concept designs as improving existing forms of transport and movement of cyclists and pedestrians in cities. Redesigned conceptual designs of motorized and non-motorized transport in cities should serve as ideas for the growing problems of urban development in the segment of insufficient surface for pedestrians and cyclists, as well as sustainable mobility transport people in the city.

平行流交叉口左转非机动车钩形转弯优化设计

为提升平行流交叉口的运行效率,消除左转非机动车和直行机动车冲突,将钩形转弯的概念引入到平行流交叉口设计中,给出非机动车过街控制策略,并结合机动车通行和行人过街,将其整合到一个统一的优化模型中。考虑信号相位相序、绿灯时长、周期时长、左转非机动车待行区容量、非机动车清空时长、车道平衡等约束条件,以机动车通过量最大为优化目标,建立线性规划优化模型。研究结果表明:两步过街和优化设计解决了左转非机动车安全过街问题,是平行流交叉口非机动车过街设置的有效替代设计方案;在低高两种流量场景下,相对于常规设计,两步过街分别降低了35.02%、55.52%的机动车延误,优化设计分别降低了42.71%、65.60%的机动车延误;两步过街会造成左转非机动车延误大幅增加,不适用于左转非机动车流量较高的场景;常规设计机动车最大通过量受直行机动车流量和左转非机动车流量的影响最为严重,说明消除左转非机动车和直行机动车冲突,对提升交叉口通行能力作用显著,有助于推动绿色出行发展。

Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease

There are many documented sex differences in the clinical course,symptom expression profile,and treatment response of Parkinson’s disease,creating additional challenges for patient management.Although subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease,the effects of sex on treatment outcome are still unclear.The aim of this retrospective observational study,was to examine sex differences in motor symptoms,nonmotor symptoms,and quality of life after subthalamic nucleus deep brain stimulation.Outcome measures were evaluated at 1 and 12 months post-operation in 90 patients with Parkinson’s disease undergoing subthalamic nucleus deep brain stimulation aged 63.00±8.01 years(55 men and 35 women).Outcomes of clinical evaluations were compared between sexes via a Student’s t-test and within sex via a paired-sample t-test,and generalized linear models were established to identify factors associated with treatment efficacy and intensity for each sex.We found that subthalamic nucleus deep brain stimulation could improve motor symptoms in men but not women in the on-medication condition at 1 and 12 months post-operation.Restless legs syndrome was alleviated to a greater extent in men than in women.Women demonstrated poorer quality of life at baseline and achieved less improvement of quality of life than men after subthalamic nucleus deep brain stimulation.Furthermore,Hoehn-Yahr stage was positively correlated with the treatment response in men,while levodopa equivalent dose at 12 months post-operation was negatively correlated with motor improvement in women.In conclusion,women received less benefit from subthalamic nucleus deep brain stimulation than men in terms of motor symptoms,non-motor symptoms,and quality of life.We found sex-specific factors,i.e.,Hoehn-Yahr stage and levodopa equivalent dose,that were related to motor improvements.These findings may help to guide subthalamic nucleus deep brain stimulation patient selection,prognosis,and stimulation programming for optimal therapeutic efficacy in Parkinson’s disease.

考虑非机动车过街的移位左转交叉口延误建模

为了评价非常规交叉口非机动车过街的通行效率,以移位左转交叉口为研究对象,对多种非机动车过街方式进行分析。从人均延误的角度考虑,基于非机动车到达离散曲线特征,建立了传统过街、二次连续过街和混行相位一体化过街3种延误评价模型;应用VISSIM仿真验证了模型的有效性,并进行适用性分析,探究了机动车交通量、非机动车交通量与非机动车左转比例的参数敏感影响。结果表明:所建模型的人均延误计算值与延误仿真结果值的偏差为3%,在非机动车交通量和左转比例均较低条件下适用于传统过街,机非混行相位过街方式在高车流密度情境下改善效果更佳,而二次过街的非机动车延误整体偏大。