AIM To investigate the pathophysiologic basis of syndrome of Liver Qi stagnation and parameters for clinical differentiation. METHODS Plasma L ENK, AVP, ANP and serum gastrin were determined by RIA in 84 patients...AIM To investigate the pathophysiologic basis of syndrome of Liver Qi stagnation and parameters for clinical differentiation. METHODS Plasma L ENK, AVP, ANP and serum gastrin were determined by RIA in 84 patients with neurasthenia, mastodynia, chronic gastritis, and chronic cholecystitis presenting the same syndrome of Liver Qi stagnation in traditional Chinese medicine (TCM). Healthy subjects served as controls in comparison with patients having the same syndrome but with different diseases. RESULTS Among the patients with Liver Qi stagnation, the plasma L ENK, ANP and gastrin levels were 38 83ng/L ± 6 32ng/L , 104 11ng/L ± 29 01ng/L and 32 20ng/L ± 6 68ng/L , being significantly lower than those in the healthy controls ( t =3 34, 6 17, 4 48; P <0 01). The plasma AVP of the patient group ( 52 82ng/L ± 19 09ng/L ) was significantly higher than that of the healthy controls ( t =5 79, P <0 01). The above changes in patients having the same symptom complex but different diseases entities showed no significant differences, P >0 05. CONCLUSION The syndrome of Liver Qi stagnation is closely related to the emotional modulatory abnormality of the brain, with decrease of plasma L ENK, ANP and gastrin, and increase of plasma AVP as the important pathophysiologic basis.展开更多
文摘AIM To investigate the pathophysiologic basis of syndrome of Liver Qi stagnation and parameters for clinical differentiation. METHODS Plasma L ENK, AVP, ANP and serum gastrin were determined by RIA in 84 patients with neurasthenia, mastodynia, chronic gastritis, and chronic cholecystitis presenting the same syndrome of Liver Qi stagnation in traditional Chinese medicine (TCM). Healthy subjects served as controls in comparison with patients having the same syndrome but with different diseases. RESULTS Among the patients with Liver Qi stagnation, the plasma L ENK, ANP and gastrin levels were 38 83ng/L ± 6 32ng/L , 104 11ng/L ± 29 01ng/L and 32 20ng/L ± 6 68ng/L , being significantly lower than those in the healthy controls ( t =3 34, 6 17, 4 48; P <0 01). The plasma AVP of the patient group ( 52 82ng/L ± 19 09ng/L ) was significantly higher than that of the healthy controls ( t =5 79, P <0 01). The above changes in patients having the same symptom complex but different diseases entities showed no significant differences, P >0 05. CONCLUSION The syndrome of Liver Qi stagnation is closely related to the emotional modulatory abnormality of the brain, with decrease of plasma L ENK, ANP and gastrin, and increase of plasma AVP as the important pathophysiologic basis.
