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Quick System-Level DDR3 Signal Integrity Simulation Research 被引量:2
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作者 Run-Jing Zhou Yuan-Yuan Hao Jin-Song Hu 《Journal of Electronic Science and Technology》 CAS 2013年第3期286-290,共5页
---Double data rate synchronous dynamic random access memory (DDR3) has become one of the most mainstream applications in current server and computer systems. In order to quickly set up a system-level signal integri... ---Double data rate synchronous dynamic random access memory (DDR3) has become one of the most mainstream applications in current server and computer systems. In order to quickly set up a system-level signal integrity (SI) simulation flow for the DDR3 interface, two system-level SI simulation methodologies, which are board-level S-parameter extraction in the frequency-domain and system-level simulation assumptions in the time domain, are introduced in this paper. By comparing the flow of Speed2000 and PowerSI/Hspice, PowerSI is chosen for the printed circuit board (PCB) board-level S-parameter extraction, while Tektronix oscilloscope (TDS7404) is used for the DDR3 waveform measurement. The lab measurement shows good agreement between simulation and measurement. The study shows that the combination of PowerSI and Hspice is recommended for quick system-level DDR3 SI simulation. 展开更多
关键词 Index Terms--Double data rate synchronousdynamic random access memory HSPICE PowerSI signal integrity system-level signal integrity simulation.
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New Method to Measure the Fill Level of the Ball Mill Ⅱ-Analysis of the Vibration Signals 被引量:1
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作者 HUANG Peng JIA Minping ZHONG Binglin 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第4期553-560,共8页
The exact measurement of the fill level is the key and basic problem for automatic control and optimized operation of the coal pulverizing system. Because the ball mill pulverizing system is non-linearity, long time d... The exact measurement of the fill level is the key and basic problem for automatic control and optimized operation of the coal pulverizing system. Because the ball mill pulverizing system is non-linearity, long time delay and time-varying, the reliable and effective method for measuring the fill level was lacked at present. In order to reduce the influence by various factors on measuring the fill level and improve the measuring accuracy of the fill level, a novel characteristic variable is proposed. A set of wireless transmission device was designed to record vibration signals, and an accelerometer with high accuracy and large measuring range was mounted directly on the mill shell to pick up the vibration signals from the mill shell. A series of data acquisition experiments under various ball load and water content of coal conditions were conducted in an industrial mill to investigate the relationship between the fill level and the angular position of the maximum vibration point of the mill shell through the analysis of the vibration signals. The analytical result of test data clearly show that the angular position of the maximum vibration point on the mill shell decreases as the fill level increases. At the same time, comparing with the traditional characteristic variable, the feature variable of the fill level proposed in this paper is not subject to the effect of the ball load and water content of coal, which provides a new solution and reliable basis for the accurate measurement of the fill level. 展开更多
关键词 ball mill fill level vibration signal signal processing
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Pedestrian perception-based level-of-service model at signalized intersection crosswalks 被引量:1
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作者 S.Marisamynathan P.Vedagiri 《Journal of Modern Transportation》 2019年第4期266-281,共16页
Pedestrian level of service(PLOS)is an important measure of performance in the analysis of existing pedestrian crosswalk conditions.Many researchers have developed PLOS models based on pedestrian delay,turning vehicle... Pedestrian level of service(PLOS)is an important measure of performance in the analysis of existing pedestrian crosswalk conditions.Many researchers have developed PLOS models based on pedestrian delay,turning vehicle effect,etc.,using the conventional regression method.However,these factors may not effectively reflect the pedestrians'perception of safety while crossing the crosswalk.The conventional regression method has failed to estimate accurate PLOS because of the primary assumption of an arbitrary probability distribution and vagueness in the input data.Moreover,PLOS categories in existing studies are based on rigid threshold values and the boundaries that are not well defined.Therefore,it is an important attempt to develop a PLOS model with respect to pedestrian safety,convenience,and efficiency at signalized intersections.For this purpose,a video-graphic and user perception surveys were conducted at selected nine signalized intersections in Mumbai,India.The data such as pedestrian,traffic,and geometric characteristics were extracted,and significant variables were identified using Pearson correlation analysis.A consistent and statistically calibrated PLOS model was developed using fuzzy linear regression analysis.PLOS was categorized into six levels(A–F)based on the predicted user perception score,and threshold values for each level were estimated using the fuzzy c-means clustering technique.The developed PLOS model and threshold values were validated with the fieldobserved data.Statistical performance tests were conducted and the results provided more accurate and reliable solutions.In conclusion,this study provides a feasible alternative to measure pedestrian perception-based level of service at signalized intersections.The developed PLOS model and threshold values would be useful for planning and designing pedestrian facilities and also in evaluating and improving the existing conditions of pedestrian facilities at signalized intersections. 展开更多
关键词 PEDESTRIAN signalized INTERSECTION level of service FUZZY regression FUZZY C-MEANS
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Weighted Multi-sensor Data Level Fusion Method of Vibration Signal Based on Correlation Function 被引量:7
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作者 BIN Guangfu JIANG Zhinong +1 位作者 LI Xuejun DHILLON B S 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第5期899-904,共6页
As the differences of sensor's precision and some random factors are difficult to control,the actual measurement signals are far from the target signals that affect the reliability and precision of rotating machinery... As the differences of sensor's precision and some random factors are difficult to control,the actual measurement signals are far from the target signals that affect the reliability and precision of rotating machinery fault diagnosis.The traditional signal processing methods,such as classical inference and weighted averaging algorithm usually lack dynamic adaptability that is easy for trends to cause the faults to be misjudged or left out.To enhance the measuring veracity and precision of vibration signal in rotary machine multi-sensor vibration signal fault diagnosis,a novel data level fusion approach is presented on the basis of correlation function analysis to fast determine the weighted value of multi-sensor vibration signals.The approach doesn't require knowing the prior information about sensors,and the weighted value of sensors can be confirmed depending on the correlation measure of real-time data tested in the data level fusion process.It gives greater weighted value to the greater correlation measure of sensor signals,and vice versa.The approach can effectively suppress large errors and even can still fuse data in the case of sensor failures because it takes full advantage of sensor's own-information to determine the weighted value.Moreover,it has good performance of anti-jamming due to the correlation measures between noise and effective signals are usually small.Through the simulation of typical signal collected from multi-sensors,the comparative analysis of dynamic adaptability and fault tolerance between the proposed approach and traditional weighted averaging approach is taken.Finally,the rotor dynamics and integrated fault simulator is taken as an example to verify the feasibility and advantages of the proposed approach,it is shown that the multi-sensor data level fusion based on correlation function weighted approach is better than the traditional weighted average approach with respect to fusion precision and dynamic adaptability.Meantime,the approach is adaptable and easy to use,can be applied to other areas of vibration measurement. 展开更多
关键词 vibration signal MULTI-SENSOR data level fusion correlation function weighted value
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Read channel for signal waveform modulation multi-level disc
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作者 王鹤群 徐海峥 +1 位作者 潘龙法 刘海龙 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第12期334-338,共5页
A novel read channel for signal waveform modulation multi-level disc is presented in this paper. This read channel employs timing recovery system and partial response maximum likelihood detector. Compared to the previ... A novel read channel for signal waveform modulation multi-level disc is presented in this paper. This read channel employs timing recovery system and partial response maximum likelihood detector. Compared to the previous read channel composed of level detection and run-length detection, the present read channel shows superiority in capacity increase and robust performance. Especially, relying on the partial response maximum likelihood detection, lower bit error rate can be obtained. 展开更多
关键词 multi-level disc signal waveform modulation read channel partial response maximum likelihood
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Improved partial response maximum likelihood method combining modulation code for signal waveform modulation multi-level disc
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作者 王鹤群 裴京 潘龙法 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第10期213-219,共7页
In this paper, we describe an improved adaptive partial response maximum likelihood (PRML) method combining modulation code tbr signal waveform modulation multi-level disc. This improved adaptive PRML method employs... In this paper, we describe an improved adaptive partial response maximum likelihood (PRML) method combining modulation code tbr signal waveform modulation multi-level disc. This improved adaptive PRML method employs partial response equalizer and adaptive viterbi detector combining modulation code. Compared with the traditional adaptive PRML detector, the improved PRML detector additionally employs illogical sequence detector and corrector. Illogical sequence detector and corrector can aw)id the appearance of illogical sequences effectively, which do not follow the law of modulation code for signal waveform modulation multi-level disc, and obtain the correct sequences. We implement the improved PRML detector using a DSP and an FPGA chip. The experimental results show good performance. The higher efficient and lower complexity can be obtained by using the improved PRML method than by using the previous PRML method. Meanwhile, resource utilization of the improved PRML detector is not changed, but the bit error rate (BER) is reduced by more than 20%. 展开更多
关键词 multi-level disc signal waveform modulation viterbi detector partial response maximum likeli-hood
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A new tracking error detection method using amplitude difference detection for signal waveform modulation multi-level discs 被引量:1
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作者 严明铭 裴京 潘龙法 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第10期319-323,共5页
The sub-land/sub-pit affects the characteristic of the tracking error signal which is generated by the conventional differential phase detection (DPD) method in the signal waveform modulation multi-level (SWML) re... The sub-land/sub-pit affects the characteristic of the tracking error signal which is generated by the conventional differential phase detection (DPD) method in the signal waveform modulation multi-level (SWML) read-only disc. To solve this problem, this paper proposes a new tracking error detection method using amplitude difference. Based on the diffraction theory, the amplitude difference is proportional to the tracking error and is feasible to be used for obtaining the off-track information. The experimental system of the amplitude difference detection method is developed. The experimental results show that the tracking error signal derived from the new method has better performance in uniformity and signal-to-noise ratio than that derived from the conventional DPD method in the SWML read-only disc. 展开更多
关键词 signal waveform modulation multi-level technology tracking error amplitude difference
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Radio Frequency Environment Effect Algorithms and Implementation in Signal-level Radar System Simulation
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作者 WANG Quanmin WANG Chuncai GUO Gang HUANG Kedi 《系统仿真技术》 2009年第1期45-54,共10页
In radar system simulation,the reliability of simulation results depends not only on radar and target models,but also on radio frequency (RF) environment models,including clutter,multipath,diffraction,atmosphere refra... In radar system simulation,the reliability of simulation results depends not only on radar and target models,but also on radio frequency (RF) environment models,including clutter,multipath,diffraction,atmosphere refraction and attenuation.In traditional radar function simulation,all of these factors are grouped into a single pattern-propagation factor and can only give limited information for radar models.In signal-level simulation,radar models require simulated echoes should include information such as delay,doppler frequency,polarization,etc.By discussing and analyzing the principles and algorithms of RF environment effects (clutter,multipath,diffraction,atmosphere refraction and attenuation),this paper is supposed to provide a general RF environment model in signal-level.Algorithms for the Weibull clutter with Gaussian power spectral density (PSD) is discussed;A standard multipath and diffraction algorithm is analyzed,and the spherical earth and knife edge(SEKE)diffraction algorithm is introduced;The ray-tracing algorithm and the effective earth model are discussed;Algorithms for the absorption of oxygen and vapor are introduced;For certain algorithms,some practical advice is given.Finally,an object-oriented RF environment effects model is implemented,which has been dedicatedly designed for signal-level simulations and can provide relatively authentic simulated RF environment for the signal-level simulation of radar systems.Two simulation examples including clutter model and multipath and diffraction model are carried out and analyzed. 展开更多
关键词 雷达 系统仿真技术 偏振 射线追踪算法 计算方法
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连续振动载荷在线复现控制技术研究
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作者 严侠 王军评 +1 位作者 毛勇建 邓婷 《振动工程学报》 EI CSCD 北大核心 2024年第10期1679-1687,共9页
提出一种主从分布式振动试验方法,建立了连续振动载荷在线复现控制技术,研制了系统样机。其中,提出一种信号分帧处理与重构技术,解决了长时连续振动载荷的在线波形复现难题;提出一种基于多量级样本库构建与加权平均的传递函数动态估计方... 提出一种主从分布式振动试验方法,建立了连续振动载荷在线复现控制技术,研制了系统样机。其中,提出一种信号分帧处理与重构技术,解决了长时连续振动载荷的在线波形复现难题;提出一种基于多量级样本库构建与加权平均的传递函数动态估计方法,抑制了系统非线性对控制精度的影响;采用谱误差反馈修正方法,改善了系统的频域控制精度。开展了“1主2从”联台试验,结果表明:时域和频域控制精度良好,整体延迟时间在亚秒量级,全程总均方根值误差在1%以内,为主从分布式振动试验提供了关键技术支撑。 展开更多
关键词 主从分布式振动试验 振动控制 在线波形复现 传递函数 分帧与重构 多量级随机信号驱动
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一种基于可编程逻辑器件的多功能信号源设计
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作者 林智慧 何颖 《计算技术与自动化》 2024年第3期50-54,共5页
为适应不同应用场景下对多种信号类型和特性的需求改变,设计一种基于可编程逻辑器件的多功能信号源,以解决通信信号输出过程存在偏差问题。基于可编程逻辑器件进行多功能信号源的电路排布,采用巴特沃斯低通滤波器对信号噪声进行处理,确... 为适应不同应用场景下对多种信号类型和特性的需求改变,设计一种基于可编程逻辑器件的多功能信号源,以解决通信信号输出过程存在偏差问题。基于可编程逻辑器件进行多功能信号源的电路排布,采用巴特沃斯低通滤波器对信号噪声进行处理,确定波形优化指标,利用数字频率合成技术进行信号波形优化,设计顶层逻辑模块布局。对设计的多功能信号源进行性能测试,结果表明:在改变载波频率和调制度的情况下,设计的多功能信号源在传输过程中输出的信号频谱和解调波形的偏置精度,均优于传统的信号源。 展开更多
关键词 可编程逻辑器件 多功能信号源 顶层逻辑 波形优化
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基于经验小波变换的多通道微弱电流信号噪声控制
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作者 于双江 倪建军 富帅 《计算机测量与控制》 2024年第2期122-128,共7页
多通道微弱电流信号受很多噪声因素的干扰,导致输出的微弱电流信号与原始信号之间的相对误差增加,控制效果变差,为此提出基于经验小波变换的多通道微弱电流信号噪声控制方法;采集多通道微弱电流信号,利用经验小波变换技术分解采集到的... 多通道微弱电流信号受很多噪声因素的干扰,导致输出的微弱电流信号与原始信号之间的相对误差增加,控制效果变差,为此提出基于经验小波变换的多通道微弱电流信号噪声控制方法;采集多通道微弱电流信号,利用经验小波变换技术分解采集到的微弱电流信号,判断电流信号中是否存在噪声并确定噪声类型;设计微弱电流信号噪声控制器,根据电流信号中的噪声量与噪声类型生成控制指令,对不同通道微弱电流信号噪声进行控制;在两种不同噪声强度的实验环境下,该方法控制下的多通道微弱电流信号信噪比较高,输出信号与原始信号间的相对误差较低,控制任务完成时间更短;以此证明该方法的多通道微弱电流信号噪声控制效果更好,可以广泛应用至电流信号噪声控制领域。 展开更多
关键词 经验小波变换 多通道 微弱电流信号 噪声控制 信号分解 噪声量 噪声类型
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基于选频电平表设计的信号与系统综合实验
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作者 王虹 庞姣 梁晓琳 《实验室科学》 2024年第2期57-62,共6页
针对学生的工程实践能力培养,为信号与系统实验课程设计了项目驱动式综合实验“选频电平表设计”。基于CDIO工程教育模式设计了实验内容,指导学生通过团队协作完成电子产品从研发到运行的完整周期。实验项目涉及傅里叶变换、频谱搬移、... 针对学生的工程实践能力培养,为信号与系统实验课程设计了项目驱动式综合实验“选频电平表设计”。基于CDIO工程教育模式设计了实验内容,指导学生通过团队协作完成电子产品从研发到运行的完整周期。实验项目涉及傅里叶变换、频谱搬移、滤波等信号的频域分析和处理方法,同时结合了模拟电路设计、单片机技术、 EDA技术、电路焊接与调试等内容,综合性强,紧贴工程实际。教学实践表明,该实验能帮助学生加深对理论知识的理解,积累实践经验,提高学习兴趣和实践能力。 展开更多
关键词 信号与系统 综合实验 选频电平表 实践能力
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基于A3C的认知物联网通信干扰消除算法
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作者 刘新梦 谢健骊 +1 位作者 李翠然 王亦鸣 《计算机工程》 CAS CSCD 北大核心 2024年第10期281-290,共10页
针对频谱资源干扰管理的智能化需求,提出一种基于异步优势行动者-评论家(A3C)的干扰消除算法,旨在应对认知物联网(CIoT)通信系统中由频谱资源共享引起的干扰问题。通过智能体的学习和优化,帮助次级用户(SU)在受到干扰影响时做出最优的决... 针对频谱资源干扰管理的智能化需求,提出一种基于异步优势行动者-评论家(A3C)的干扰消除算法,旨在应对认知物联网(CIoT)通信系统中由频谱资源共享引起的干扰问题。通过智能体的学习和优化,帮助次级用户(SU)在受到干扰影响时做出最优的决策,从而改善通信质量和系统性能。在该算法中,当SU遭受干扰影响通信质量时,智能体通过学习和优化,使SU能够根据当前的位置信息、发射功率、接收功率以及干扰程度选择最低干扰程度的行动,并执行该行动后获得的奖励。智能体通过尝试不同减少干扰的行动,并根据奖励的反馈调整策略,达到最大化定义干扰程度指标和信号质量指标的奖励函数的目的,从而最大程度地减少干扰对通信质量的影响。实验结果表明,与传统k-means算法以及深度递归Q网络(DRQN)和深度Q网络(DQN)优化算法相比,基于A3C的干扰消除算法具有更短的收敛时间、更高的执行效率以及更高的系统吞吐量,较3种基准方法在吞吐量性能上至少提高7%,能够有效地减少干扰对通信质量的不利影响。 展开更多
关键词 认知物联网 干扰消除 异步优势行动者-评论家算法 干扰程度 信号质量 吞吐量
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面向射电天文的微秒量级射频信号检测系统
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作者 马凌 刘奇 +3 位作者 蔡明辉 董晓玉 王娜 苏晓明 《电波科学学报》 CSCD 北大核心 2024年第4期650-657,共8页
瞬态信号对射电天文观测的影响越来越大,开发射频信号检测系统,可提升瞬态干扰检测能力,为进一步的瞬态信号特征分析提供重要技术支撑。本文基于USRP X310和GNU Radio平台,采用多相滤波、快速傅里叶变换、积分处理等,开发了微秒量级射... 瞬态信号对射电天文观测的影响越来越大,开发射频信号检测系统,可提升瞬态干扰检测能力,为进一步的瞬态信号特征分析提供重要技术支撑。本文基于USRP X310和GNU Radio平台,采用多相滤波、快速傅里叶变换、积分处理等,开发了微秒量级射频信号检测系统,实现了140 MHz实时带宽、30 MHz~6 GHz工作带宽、0.5μs时间分辨率的信号检测,并通过实测给出了检测系统的幅度测量精度、动态范围。实例应用表明,本文系统可应用于电子设备的辐射发射测量和电磁环境瞬态信号测量,为射电望远镜电磁兼容设计和干扰缓减提供技术支持。 展开更多
关键词 射电天文 软件无线电 射频信号检测 微秒级瞬态信号
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膀胱癌100例血清Zeste基因增强子同源物2和信号传导蛋白3表达水平及诊断价值分析
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作者 吴娟 王丹 +1 位作者 张前进 裴兵 《安徽医药》 CAS 2024年第10期2035-2038,共4页
目的探讨膀胱癌病人血清Zeste基因增强子同源物2(EZH2)和信号传导蛋白3(SMAD3)表达水平及临床意义。方法纳入江苏省人民医院宿迁医院于2021年1月至2022年12月收治的膀胱癌病人进行研究(100例),另选取同期于该院就诊的泌尿系统良性疾病... 目的探讨膀胱癌病人血清Zeste基因增强子同源物2(EZH2)和信号传导蛋白3(SMAD3)表达水平及临床意义。方法纳入江苏省人民医院宿迁医院于2021年1月至2022年12月收治的膀胱癌病人进行研究(100例),另选取同期于该院就诊的泌尿系统良性疾病病人作为良性疾病组(93例)以及健康体检者作为对照(100例)。采用Pearson相关性分析法分析膀胱癌病人血清中EZH2和SMAD3表达水平的相关性;采用logistic多因素回归分析法分析膀胱癌发生的影响因素;采用ROC曲线分析EZH2和SMAD3对膀胱癌的诊断效能。结果膀胱癌病人血清中EZH2(101.34±15.09)ng/L和SMAD3(226.53±25.94)ng/L表达水平均高于良性疾病组(85.96±11.23)ng/L、(203.11±22.18)ng/L和对照组(83.91±9.14)ng/L、(198.03±20.30)ng/L(均P<0.001);膀胱癌病人血清EZH2和SMAD3表达水平呈正相关(r=0.72,P<0.001);膀胱癌组年龄≥60岁(74/187)、有吸烟史的病人(76/166)所占比例均高于良性疾病组(65/187、55/166)及对照组(48/187、35/166)(均P<0.05);年龄、吸烟史、EZH2、SMAD3为发生膀胱癌的危险因素(P<0.05);以良性疾病组为对照,血清EZH2和SMAD3单独检测诊断膀胱癌的曲线下面积(AUC)分别为0.78、0.78,二者联合检测的AUC为0.85,优于各自单独检测(Z_(二者联合-EZH2)=2.81、Z_(二者联合-SMAD3)=2.68,P=0.009、0.007)。结论血清EZH2和SMAD3与膀胱癌的发生有关,二者联合对膀胱癌具有一定的诊断价值。 展开更多
关键词 膀胱肿瘤 Zeste基因增强子同源物2 信号传导蛋白3 诊断价值 表达水平
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制导雷达对抗信号级仿真环境构建方法探讨
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作者 王振兴 张德锋 +1 位作者 刘敏 郭金良 《航天电子对抗》 2024年第4期15-19,共5页
信号级全数字仿真是开展制导雷达干扰对抗效能检验的重要方法,针对制导雷达对抗信号级背靠背全数字仿真试验环境构建问题,从全数字仿真平台架构和试验方法入手,探讨了制导雷达对抗仿真模型体系和仿真模型框架,并对信号级仿真时序和仿真... 信号级全数字仿真是开展制导雷达干扰对抗效能检验的重要方法,针对制导雷达对抗信号级背靠背全数字仿真试验环境构建问题,从全数字仿真平台架构和试验方法入手,探讨了制导雷达对抗仿真模型体系和仿真模型框架,并对信号级仿真时序和仿真模型交互接口进行了初步的研究。 展开更多
关键词 制导雷达 信号级 背靠背 全数字仿真
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政策信号的多层级传递与市级政府行为合规:基于环境信息公开案例的实证研究 被引量:1
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作者 李珒 《中国软科学》 CSCD 北大核心 2024年第5期188-196,共9页
政策信号是传递上级政府治理意向、激励下级政府行为合规的重要手段。分析政策信号多层级作用机制下市级政府2008-2018年环境信息公开行为发现,政府组织中的上层与中层信号均会显著影响下层政府合规行为;在多层级传递过程中,政策信号的... 政策信号是传递上级政府治理意向、激励下级政府行为合规的重要手段。分析政策信号多层级作用机制下市级政府2008-2018年环境信息公开行为发现,政府组织中的上层与中层信号均会显著影响下层政府合规行为;在多层级传递过程中,政策信号的影响随行政级别差异的增加而减弱;中间环节传递的不一致信号会削弱上层政府信号效果;在交互作用中,上层政府的“强信号”将翻转中层政府的“不一致”信号,而“弱信号”则可能被后者抵消。在此基础上,提出研究结论与政策建议。 展开更多
关键词 政策执行 政策信号 市级政府 行为合规
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白藜芦醇对膝骨关节炎模型大鼠关节液中氧化应激和炎症因子的调控作用 被引量:4
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作者 任伟亮 焦永伟 +2 位作者 张健 杨立英 杨琦 《中国组织工程研究》 CAS 北大核心 2024年第32期5154-5158,共5页
背景:膝骨关节炎是临床常见退行性关节疾病,主要表现为慢性炎症和氧化应激反应。白藜芦醇具有抗炎和抗氧化应激的生物作用,因此可对症进行治疗,有望为膝骨关节炎治疗提供新的策略。目的:探讨白藜芦醇通过沉默信息调节因子1(silence info... 背景:膝骨关节炎是临床常见退行性关节疾病,主要表现为慢性炎症和氧化应激反应。白藜芦醇具有抗炎和抗氧化应激的生物作用,因此可对症进行治疗,有望为膝骨关节炎治疗提供新的策略。目的:探讨白藜芦醇通过沉默信息调节因子1(silence information regulator 1,SIRT1)/叉头框转录因子O1(forkhead transcription factor O1,FOXO1)通路对大鼠膝骨关节炎的作用机制。方法:40只SD大鼠随机分为对照组、模型组、白藜芦醇低剂量组和白藜芦醇高剂量组,每组10只,除对照组外均建立膝骨关节炎模型,分别在造模的第1,4,7天注射4%木瓜蛋白酶溶液与0.3 mol/L半胱氨酸溶液(1∶1混置0.5 h)的混合液20μL。造模成功后1 d开始给药,白藜芦醇低剂量组和白藜芦醇高剂量组大鼠经关节腔注射白藜芦醇25 mg/kg或100 mg/kg,对照组和模型组经关节腔注射等体积生理盐水。治疗28 d后,测定4组大鼠膝关节最大活动度;应用放射免疫法和ELISA法检测膝关节液中氧化应激指标和炎症因子水平;番红O-固绿染色分析膝关节中胶原纤维含量;采用Mankin组织学评分分析关节炎病变程度;蛋白质免疫印迹法检测膝关节SIRT1和FOXO1水平。结果与结论:①与模型组比较,白藜芦醇低剂量组和高剂量组大鼠膝关节最大屈伸角度明显增加,且高剂量组明显高于低剂量组(P<0.05);②与模型组比较,白藜芦醇低剂量组和高剂量组大鼠膝关节液中超氧化物歧化酶和谷胱甘肽过氧化物酶水平显著增加;而丙二醛水平显著下降,且高剂量组明显优于低剂量组(P<0.05);③与模型组比较,白藜芦醇低剂量组和高剂量组大鼠膝关节液炎症因子白细胞介素1β、白细胞介素6和肿瘤坏死因子α水平明显下降,且高剂量组明显低于低剂量组(P<0.05);④与模型组比较,白藜芦醇低剂量组和高剂量组大鼠膝关节胶原纤维含量增加,且高剂量组明显高于低剂量组(P<0.05);⑤与模型组比较,白藜芦醇低剂量组和高剂量组大鼠膝关节SIRT1表达水平显著增加,乙酰化FOXO1水平显著下调,且高剂量组变化幅度明显优于低剂量组(P<0.05);⑥提示白藜芦醇可显著改善膝骨关节炎大鼠关节液中的氧化应激和炎症因子水平,缓解关节炎症状,且呈剂量依赖性,可能是通过SIRT1/FOXO1通路实现的。 展开更多
关键词 膝骨关节炎 白藜芦醇 SIRT1/FOXO1通路 炎症水平 氧化应激
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丽江黑龙潭泉群修复中地下水位作为补水控制信号的研究与应用
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作者 韩啸 王森林 +1 位作者 贺睿 郑克勋 《中国岩溶》 CAS CSCD 北大核心 2024年第2期302-313,共12页
文章以丽江黑龙潭为例,研究岩溶地区泉水修复补水控制过程。基于九子海洼地为黑龙潭泉群主要补给来源这一基本判断,从宏观的地形地貌、地层岩性、地质构造、岩溶现象和地下水位动态变化规律入手,首先明确拟采用作为补水控制信号的水文... 文章以丽江黑龙潭为例,研究岩溶地区泉水修复补水控制过程。基于九子海洼地为黑龙潭泉群主要补给来源这一基本判断,从宏观的地形地貌、地层岩性、地质构造、岩溶现象和地下水位动态变化规律入手,首先明确拟采用作为补水控制信号的水文观测井与目标泉群属于同一地下水系统,而后分析观测井地下水位变化规律与目标泉群流量变化规律具有良好的相关性,可作为补水控制井。通过泉群目标状态的拟定−对应补水控制井水位−考虑补水过程提前量时间−修正补水控制井水位这一过程,确定考虑补水时间过程的补水控制井信号水位为2409.41 m,最终实现对观测井水位数据为控制信号的补水过程的实时精准控制。 展开更多
关键词 岩溶大泉 补水 地下水系统 地下水位 信号 过程控制
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一种稳健的频率步进SAR距离向栅瓣抑制方法
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作者 高文斌 《计算机科学》 CSCD 北大核心 2024年第8期209-216,共8页
频率步进合成孔径雷达(Synthetic Aperture Radar,SAR)的系统传递函数中存在幅度和相位误差(Magnitude Error and Phase Error,MEPE),通过宽带合成操作在距离宽带信号中引入了周期性MEPE,从而导致宽带合成后的高分辨率距离像(HRRP)中出... 频率步进合成孔径雷达(Synthetic Aperture Radar,SAR)的系统传递函数中存在幅度和相位误差(Magnitude Error and Phase Error,MEPE),通过宽带合成操作在距离宽带信号中引入了周期性MEPE,从而导致宽带合成后的高分辨率距离像(HRRP)中出现周期性栅瓣。经过后续SAR成像处理,这些周期性栅瓣在图像中表现为虚假目标,严重影响SAR图像目标的检测与识别。为此,基于SAR图像的栅瓣抑制(Grating Lobe Suppression,GLS)算法被提出,其基于点状目标假设,利用SAR图像中的强点目标实现图像栅瓣的有效抑制。然而,对于非点状目标场景,已有基于SAR图像的GLS算法的性能显著下降,而且会引起图像散焦。因此,文中提出了一种基于目标信息差异的GLS算法,取名为目标信息差异法。该算法不基于点状目标假设,通过估计宽带合成后的理想HRRP与实际HRRP之间的信息差异,稳健地估计出合成宽带信号中的周期性MEPE。通过补偿该周期性MEPE,该算法可以将频率步进SAR距离向栅瓣抑制到图像的背景水平。通过对不同GLS算法进行性能对比发现,所提GLS算法受图像信杂比影响小,且同时适用于非点状目标和点状目标场景,相比已有GLS算法具有明显的优势。实测数据处理结果证明了所提方法的有效性和相对已有GLS算法的优越性。 展开更多
关键词 栅瓣图像 频率步进合成孔径雷达 背景水平 宽带信号 图像散焦
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