Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are ...Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are the analysis of amikacin dose, serum level and the examination of the effectiveness of the clinical pharmacologist (CP) therapeutic drug monitoring (TDM) intervention to guarantee the safety of amikacin use. Methods: This is a one-year retrospective observational chart review study, which evaluates amikacin dose, serum drug level, development of adverse effects in patients on amikacin with or without CP TDM consultation. Results: Amikacin was prescribed for 393 complex patients, with median age 83. Amikacin group (AG) included 140 (32%) courses with CP consultation (AG1) and 292 (68%) courses without CP consultation (AG2). The distribution of most study characteristics in both groups was similar including amikacin dose (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP consultation was in 46% of amikacin courses and dose changes were done in 63% after CP intervention. Prolonged antibiotic course (4.6 ± 1.5 vs 3.8 ± 1.6 days, p < 0.0001) and the patient’s hemodynamic instability (15% vs 7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was a strong association between CP consultation and prolonged hospitalization (p = 0.005), while no association between it and amikacin adverse effects, renal failure or mortality. Conclusions: There was no trend to reducing amikacin toxicity, days of hospitaliza tion or mortality in patients with CP consultation. CP TDM intervention was more in the management of complicated clinical situations. However, it is necessary to optimize it.展开更多
Medical English,as a specialized form of English,has attracted considerable attention due to its unique linguistic features.Grammaticalization and lexicalization represent critical mechanisms in the evolution of langu...Medical English,as a specialized form of English,has attracted considerable attention due to its unique linguistic features.Grammaticalization and lexicalization represent critical mechanisms in the evolution of language and are essential for understanding and mastering medical English.This study,drawing on the MEDLINE corpus,investigates the characteristics of grammaticalization and lexicalization in medical English from the perspective of cognitive linguistics,aiming to unveil its underlying cognitive foundations.The findings suggest that the processes of grammaticalization and lexicalization in medical English reflect cognitive mechanisms such as categorization,inferential processing,and pragmatic strategies.These insights provide novel approaches and methodologies for the teaching of medical English.展开更多
Purpose: This study aimed to develop teaching materials to prevent the dangers of ablution and bathing infants, based on the dangerous experiences of mothers and family members, and examine their appropriateness. Meth...Purpose: This study aimed to develop teaching materials to prevent the dangers of ablution and bathing infants, based on the dangerous experiences of mothers and family members, and examine their appropriateness. Methods: A total of 20 midwives and public health nurses were selected as participants. Teaching materials and anonymous self-administered questionnaires were distributed, and the participants were asked to view the teaching materials and fill in the questionnaires. Retrieval was done by mail. The teaching materials included digital content, such as videos, sounds, and characters, which incorporated dangerous situations, preventions, and innovations in ablution and bathing procedures. The analysis was conducted by simple tabulation for each survey item. The free description was coded to preserve anonymity. This study was conducted with the approval of the Research Ethics Review Board of the authors’ affiliated university. Results: The teaching materials were found to be appropriate in terms of suitability to purpose, degree of difficulty of content, ease of viewing the videos, validity of time, appropriateness of expression, and usability. Conclusions: Ablution teaching materials that are used at the present time do not focus on dangers, and to date, no resources on bathing have been used as teaching materials. The created teaching materials in this study can be viewed multiple times, and mothers and family members who are unfamiliar with ablution and bathing can acquire knowledge regarding dangers and danger prevention. The addition of specific preventive measures and countermeasures for the occurrence of danger, along with practice, would result in the development of further appropriate teaching materials to reduce danger and alleviate anxiety.展开更多
Listening is an important input way of language learning,and is closely related to language learning.Now,listening is still a weakness for English learners in colleges.In recent years,many experts and scholars have ex...Listening is an important input way of language learning,and is closely related to language learning.Now,listening is still a weakness for English learners in colleges.In recent years,many experts and scholars have explored the application of lexical chunks in teaching,trying to solve the problem of students’vocabulary acquisition.However,there are relatively few researches between lexical chunks and listening achievement.Based on the lexical chunks theory,the research finds that lexical chunks teaching can relieve students’anxiety in English listening,improve their English listening scores,and stimulate students’chunk consciousness.展开更多
文摘Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are the analysis of amikacin dose, serum level and the examination of the effectiveness of the clinical pharmacologist (CP) therapeutic drug monitoring (TDM) intervention to guarantee the safety of amikacin use. Methods: This is a one-year retrospective observational chart review study, which evaluates amikacin dose, serum drug level, development of adverse effects in patients on amikacin with or without CP TDM consultation. Results: Amikacin was prescribed for 393 complex patients, with median age 83. Amikacin group (AG) included 140 (32%) courses with CP consultation (AG1) and 292 (68%) courses without CP consultation (AG2). The distribution of most study characteristics in both groups was similar including amikacin dose (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP consultation was in 46% of amikacin courses and dose changes were done in 63% after CP intervention. Prolonged antibiotic course (4.6 ± 1.5 vs 3.8 ± 1.6 days, p < 0.0001) and the patient’s hemodynamic instability (15% vs 7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was a strong association between CP consultation and prolonged hospitalization (p = 0.005), while no association between it and amikacin adverse effects, renal failure or mortality. Conclusions: There was no trend to reducing amikacin toxicity, days of hospitaliza tion or mortality in patients with CP consultation. CP TDM intervention was more in the management of complicated clinical situations. However, it is necessary to optimize it.
基金Project of Social Science Achievement Evaluation Committee of Hunan Province of China(XSP2023WXC037)Project of Teaching Reform Research of Hunan Province of China(202401001822)。
文摘Medical English,as a specialized form of English,has attracted considerable attention due to its unique linguistic features.Grammaticalization and lexicalization represent critical mechanisms in the evolution of language and are essential for understanding and mastering medical English.This study,drawing on the MEDLINE corpus,investigates the characteristics of grammaticalization and lexicalization in medical English from the perspective of cognitive linguistics,aiming to unveil its underlying cognitive foundations.The findings suggest that the processes of grammaticalization and lexicalization in medical English reflect cognitive mechanisms such as categorization,inferential processing,and pragmatic strategies.These insights provide novel approaches and methodologies for the teaching of medical English.
文摘Purpose: This study aimed to develop teaching materials to prevent the dangers of ablution and bathing infants, based on the dangerous experiences of mothers and family members, and examine their appropriateness. Methods: A total of 20 midwives and public health nurses were selected as participants. Teaching materials and anonymous self-administered questionnaires were distributed, and the participants were asked to view the teaching materials and fill in the questionnaires. Retrieval was done by mail. The teaching materials included digital content, such as videos, sounds, and characters, which incorporated dangerous situations, preventions, and innovations in ablution and bathing procedures. The analysis was conducted by simple tabulation for each survey item. The free description was coded to preserve anonymity. This study was conducted with the approval of the Research Ethics Review Board of the authors’ affiliated university. Results: The teaching materials were found to be appropriate in terms of suitability to purpose, degree of difficulty of content, ease of viewing the videos, validity of time, appropriateness of expression, and usability. Conclusions: Ablution teaching materials that are used at the present time do not focus on dangers, and to date, no resources on bathing have been used as teaching materials. The created teaching materials in this study can be viewed multiple times, and mothers and family members who are unfamiliar with ablution and bathing can acquire knowledge regarding dangers and danger prevention. The addition of specific preventive measures and countermeasures for the occurrence of danger, along with practice, would result in the development of further appropriate teaching materials to reduce danger and alleviate anxiety.
文摘Listening is an important input way of language learning,and is closely related to language learning.Now,listening is still a weakness for English learners in colleges.In recent years,many experts and scholars have explored the application of lexical chunks in teaching,trying to solve the problem of students’vocabulary acquisition.However,there are relatively few researches between lexical chunks and listening achievement.Based on the lexical chunks theory,the research finds that lexical chunks teaching can relieve students’anxiety in English listening,improve their English listening scores,and stimulate students’chunk consciousness.
