Government's Responsibility for Control of Agricultural Environmental Pollution in China

In this paper,the current situation of agricultural environmental pollution caused by the increase of chemicals input in agriculture in China was analyzed,and it is found that agricultural pollution is related to agricultural industrial policies,urban-rural economic structure,funds input in pollution control,comprehensive environmental management,laws of pollution control,and so forth. To control agricultural pollution effectively,it is needed to implement integration of agricultural and environmental policies,establish environmentally friendly agricultural technology popularizing system,implement integrated planning and management of a basin,and set up and improve legislation to protect agricultural environment.

On the Government's Responsibility in China's Rural Land Transfer

There is an urgent need for China's rural land transfer in order to develop modern agriculture,ensure food security,transfer rural population,and accelerate industrialization and urbanization.At present,there is still disordered transfer of rural land in China,making the interests of the transferors and transferees difficult to be effectively guaranteed;there is inefficient transfer,leading to decline in actual agricultural production level after transfer;there is jobless transfer,leading to difficult placement for rural surplus labor after transfer,seriously restricting rural land transfer.Therefore,the Chinese government's legal responsibility,economic responsibility and social responsibility in rural land transfer should be further strengthened.

Estimating peak response frequencies in a tidal band in the seas adjacent to China with a numerical model

A numerical method is designed to examine the response properties of real sea areas to open ocean forcing. The application of this method to modeling the China＇s adjacent seas shows that the Bohai Sea has a highest peak response frequency （PRF） of 1.52 d^-1; the northern Yellow Sea has a PRF of 1.69 d^-1; the Gyeonggi Bay has a high amplitude gain plateau in the frequency band roughly from 1.7 to 2.7 d^-1; the Yellow Sea （includ- ing the Gyeonggi Bay）, the East China Sea shelf and the Taiwan Strait have a common high amplitude gain band with frequencies around 1.76 to 1.78 d^-1 and are shown to be a system that responds to the open ocean forcing in favor of amplifying the waves with frequencies in this band; the Beibu Gulf, the Gulf of Thailand and the South China Sea deep basin have PRFs of 0.91, 1.01 and 0.98 d^-1 respectively. In addition, the East China Sea has a Poincare mode PRF of 3.91 d^-1. The PRFs of the Bohal Sea, the northern Yellow Sea, the Bei- bu Gulf and the South China Sea can be explained by a classical quarter （half for the Bohai Sea） wavelength resonance theory. The results show that further investigations are needed for the response dynamics of the Yellow Sea-East China Sea-Taiwan Strait system, the East China Sea Poincare mode, the Talwan Strait, and the Gulf of Thailand.

Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence-accelerated mouse

At 8 weeks after intragastric administration of icariin to senescence-accelerated mice （P8 strain）, Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.

3-D DYNAMIC RESPONSE OF TRANSVERSELY ISOTROPIC SATURATED SOILS

A study on dynamic response of transversely isotropic saturated poroelastic media under a circular non-axisymmetrical harmonic source has been presented by Huang Yi et al. using the technique of Fourier expansion and Hankel transform. However, the method may not always be valid. The work is extended to the general case being in the rectangular coordinate. The purpose is to study the 3-d dynamic response of transversely isotropic saturated soils under a general source distributing in arbitrary rectangular zoon on the medium surface. Based on Biot＇s theory for fluid- saturated porous media, the 3-d wave motion equations in rectangular coordinate for transversely isotropic saturated poroelastic media were transformed into the two uncoupling governing differential equations of 6-order and 2-order respectively by means of the displacement functions. Then, using the technique of double Fourier transform, the governing differential equations were easily solved. Integral solutions of soil skeleton displacements and pore pressure as well as the total stresses for poroelastic media were obtained. Furthermore, a systematic study on half-space problem in saturated soils was performed. Integral solutions for surface displacements under the general harmonic source distributing on arbitrary surface zone, considering both case of drained surface and undrained surface, were presented.

Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10

Immunotherapy for Alzheimer＇s disease （AD） is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid （Aβ） 1-42] vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a nove） vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ-10 is a promising vaccine for AD.

Hydroelastic Response of VLFS with An Attached Submerged Horizontal Solid/Porous Plate Under Wave Action

The hydroelastic responses of a submerged horizontal solid/porous plate attached at the front of a very large rectangular floating structure(VLFS)under wave action has been investigated in the context of linear water wave theory.Darcy’s law is adopted to represent energy dissipation in pores.It is assumed that the porous plates are made of material with very fine pores so that the normal velocity across the perforated porous is linearly associated with the pressure drop.In the analytic method,the eigenfunction expansion-matching method(EEMM)for multiple domains is applied to solve the hydrodynamic problem and the elastic equation of motion is solved by the modal expansion method.The performance of the proposed submerged horizontal solid/porous plate can be significantly enhanced by selecting optimal design parameters,such as plate length,horizontal position,submerged depth and porosity.It is concluded that good damping effect can be achieved through installation of solid and porous plate.Porous plate has better damping effect at low frequencies,while solid plate has better damping effect at high frequencies.The optimal ratio of plate length to water depth is 0.25-0.375,and the optimal ratio of submerged depth to water depth is 0.09-0.181.

Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease

To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood, and 7 single nucleotide polymorphisms (SNPs) were assessed. The main outcome measure (following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age, gender, race, and socioeconomic status disease, as well as disease characteristics (such as Montreal criteria). RESULTS121 patients were included. Twenty-one were non-responders, and 100 were ever-responders. Fas ligand SNP (rs763110) genotype frequencies, TNF gene -308 SNP (rs1800629) genotype frequencies, and their combination, were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype (P = 0.009, OR = 4.30, 95%CI: 1.45-12.80). The presence of the A (minor) TNF gene -308 allele correlated with three-fold higher odds of being a non-responder (P = 0.049, OR = 2.88, 95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF -308 A allele had nearly five-fold higher odds of being a non-responder (P = 0.015, OR = 4.76, 95%CI: 1.35-16.77). No difference was seen for the remaining SNPs. CONCLUSIONThe Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment response in CD and may help select patients likely to benefit from therapy.

Determination of the Response Amplitude Operator(s) of an FPSO

The driving necessities of cost reduction and the need to develop fields at ever increasing water depths have led to the use of floating structures. Among these structures are the Floating Production Storage and Offloading (FPSO) units whose motion analysis is considered in this paper. In actual environmental condition, it is required to accurately determine or predict large amplitude motion of the FPSO before any offshore operation. This paper seeks to present a detailed method of computing the Response Amplitude Operator(s) (RAOs) for the six (6) degrees of freedom using ANSYS AQWA. The results indicate for Heave motion a tendency for the heave peak value to move slightly higher dimensionless encounter-frequency as the wave moves from Head sea to Beam sea direction. A MATLAB source code was developed to validate the result for heave motion at head sea. Although a small difference in predicted heave motion occurred, it is pertinent to note that the comparisons between results generated in the MATLAB program and ANSYS AQWA demonstrate generally good agreement, and the roll response of the FPSO is noted to be critical.

Approximate analytical solutions and experimental analysis for transient response of constrained damping cantilever beam

Vibration mode of the constrained damping cantilever is built up according to the mode superposition of the elastic cantilever beam. The control equation of the constrained damping cantilever beam is then derived using Lagrange＇s equation. Dynamic response of the constrained damping cantilever beam is obtained according to the principle of virtual work, when the concentrated force is suddenly unloaded. Frequencies and transient response of a series of constrained damping cantilever beams are calculated and tested. Influence of parameters of the damping layer on the response time is analyzed. Analyitcal and experimental approaches are used for verification. The results show that the method is reliable.

2022年四川泸定 M_(s)6.8地震强震动特性研究

北京时间2022年9月5日12时52分,四川省甘孜州泸定县发生M_(s)6.8级地震。国家强震动台网获得了133组三分量加速度记录,在对记录进行初步筛选和滤波后,研究了PGA和PGV衰减关系、竖向地震动特点、地震动速度脉冲,对比分析了反应谱和设计谱,着重对石棉挖角台站附近震害与地震动的相关性进行了分析,结论如下:1)三种台站强震动记录的PGA和PGV拟合曲线都比较相近,PGA、PGV拟合曲线与霍俊荣的预测模型较为接近;2)竖向地震动偏大,约38.2%的强震动记录V/H大于2/3,可能是屋顶塌落、柱子扭转和天花板坠落等震害现象出现的主要原因;3)识别出具有速度脉冲特性的记录11条,该类记录对长周期结构影响较大;4)所选记录反应谱大多超过了罕遇地震设计谱水平段,具有速度脉冲特性的051SMW台站周围房屋破坏较严重,人员伤亡较重。

The Planet’s Response to Human Activity. Thermodynamic Approach

The applicability of the laws of thermodynamics to processes on Earth is discussed and it is shown that the chemical thermodynamics provides the reasonable basis for predicting probable changes. The historical evolution of the planet is considered in the framework of the Harari approach;a civilization’s level is estimated by the Kardashev scale based on the amount of energy it is able to use. During a short historical interval (≈500 years), when the effect of biological evolution is imperceptible and the main changes on the planet are caused by human activity, two systems are considered: 1) a nonequilibrium inhabited planet and 2) a quasi-equilibrium hypothetical planet without people, which is accepted as a comparison system. It is shown that in response to the energy impact, the equilibrium of the hypothetical system with the primordial nature is disturbed and processes are initiated aimed to prevent further growth of energy production. In the case of a real planet, this implements changes preventing the uncontrolled activities of humans—the energy producers. Climate change, an increase in the number of natural disasters and epidemics can be recognized as a direct response of the planet, while changes in socio-economic relations, morality, demographic situation, new threats etc. can be considered as an indirect reaction to changing conditions of human beings. The latter results from the mutual correlation between the progress of society, on the one hand, and humanitarian and political processes, on the other. The role of renewable and non-renewable energy sources in evolution is taken into account. Obviously, it is better to take meaningful measures to achieve an acceptable balance now than to wait for the blind and extremely painful action of the laws of nature, which would lead to a reduction in the population.

Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response

In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle's invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if the immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result.

INFLUENCE OF UNCERTAINTY OF ROCK PROPERTIES ON SEISMIC RESPONSES OF REACTOR BUILDINGS

The influence of the dispersion and uncertainty of the dynamic shear wave velocity and Poisson＇s ratio of soil in a hard rock site was investigated on the seismic response of reactor building structure. The analysis is performed by considering the soil-structure interaction effects and based on the model of the reactor building in a typical pressurized water reactor nuclear power plant （NPP）. The numerical results show that for the typical floor selected, while the relative increment ratio of the dynamic shear wave velocity varies from -30% to 30% compared to the basis of 1 930 m/s, the relative variation of the horizontal response spectra peak value lies in the scope of ±10% for the internal structure, and the relative variation of the frequency corresponding to the spectra peak is 0.0% in most cases. The relative variation of the vertical response spectra peak value lies in the scope of - 10% to 22%, and the relative variation of the frequency corresponding to the Spectra peak lies in the scope of - 22% to 4%. The analysis indicates that the dynamic shear wave velocity and the Poisson＇s ratio of the rock would affect the seismic response of structure and the soil-structure interaction effects should be considered in seismic analysis and design of NPP even for a hard rock site.

Biochemical responses of freshwater fish Carassius auratus to polycyclic aromatic hydrocarbons and pesticides

The freshwater fish Carassius auratus was chosen as an experimental subject, and their hepatic biochemical responses to the medium-term exposure of Benzo（k）fluoranthene （BkF） alone and in combination with PCB 118 and dichlorodiphenyltrichloroethane （DDT） were investigated by measuring the reduced glutathione （GSH）, glutathione S-transferase （GST）, and thiobarbituric acid reactive substances （TBARS）, to assess sublethal effects. The hepatic GSH content was significantly inhibited by organic pollutants, alone and in mixtures, while the TBARS content was significantly induced after three days of exposure. Bell-shaped concentration-response charts of GST activities were obtained. Significant dose-response relationships were found for hepatic GSH and TBARS contents of all concentrations and for the GST activity, except at the highest concentration. The GSH content, GST activity, and TBARS content in Carassius auratus were confirmed as useful biomarkers of exposure to organic pollutions.

Inactivated Pseudomonas PE(△Ⅲ)exotoxin fused to neutralizing epitopes of PEDV S proteins produces a specific immune response in mice

Porcine epidemic diarrhea(PED)caused by the porcine epidemic diarrhea virus(PEDV),is a severe infectious and devastating swine disease that leads to serious economic losses in the swine industry worldwide.An increased number of PED cases caused by variant PEDV have been reported in many countries since 2010.S protein is the main immunogenic protein containing some B-cell epitopes that can induce neutralizing antibodies of PEDV.In this study,the construction,expression and purification of Pseudomonas aeruginosa exotoxin A(PE)without domain Ⅲ(PE△Ⅲ)as a vector was performed for the delivery of PEDV S-A or S-B.PE(△Ⅲ)PEDV S-A and PE(△Ⅲ)PEDV S-B recombinant proteins were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis.The immunogenicity of PEDV S-A and PEDV S-B subunit vaccines were evaluated in mice.The results showed that PEDV-S-B vaccine could not only induce specific humoral and Th1 type-dominant cellular immune responses,but also stimulate PEDV-specific mucosal immune responses in mice.PEDV-S-B subunit vaccine is a novel candidate mucosal vaccine against PEDV infection.

CHINA'S VEGETATION/ECOSYSTEM RESPONSE TO GLOBAL CHANGE: RESEARCH PROGRESS & PROSPECTS

This paper presents the latest developments in the re search progress on mechanisms by which natural plants and crops respond to the doubled concentration of CO2 in the atmosphere, resultant climatic change and the modeling of vegetation and eco-systems in China. In addition, it points out that the future study on global change and terrestrial ecosystems should stress m(?)iti-disciplinary teamwork and inter-discipline penetration. Finally, the paper emphasizes 10 research realms in the field to be enhanced in the future.

Treat to target in Crohn’s disease:A practical guide for clinicians

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these timepoints.Scheduled appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or modified.Consensus treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic healing.Although the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all patients.This underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment targets.The use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural healing.Two randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s disease.Findings from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be clarified.Moreover,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world studies.Despite the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its uptake.This highlights the need to describe strategies,processes,and models of care capable of supporting the integration and execution of a T2T approach in real-world clinical practice.Hence,this review seeks to examine the current and emerging literature to provide clinicians with practical guidance on how to incorporate the principles of T2T into routine clinical practice for the management of Crohn’s disease.

Role of CuO-ZnO Heterojunctions in Gas Sensing Response of CuO-ZnO Thick Films

The CuO-doped ZnO thick films were prepared by the screen printing technique. The CuO doped ZnO composite materials were obtained by mixing AR grade （99.9% pure） Zinc Oxide powder mechanochemically in acetone medium with various weight percentages of Copper Chloride （CulCI2.2H20） powder （1, 3, 5, 7 and 9wt.%）. The prepared materials were sintered at 1,000 ℃ for 12 h in air ambience and ball milled to ensure sufficiently fine particle size. The films were characterized by different techniques with respect to their surface morphology and compositional property by means of SEM （scanning electron microscope） and EDXA （energy dispersive x-ray analysis）. The surface morphology of the films was studied by SEM and it shows the films are porous in nature and petal-shaped grains of sizes varies from 220 nm to 250 nm were observed. The final composition of each film was determined by the EDXA analysis. The gas response of undoped ZnO and CuO doped ZnO films was studied for different gases such as CO, C12, NH3, Ethanol, H2S and LPG at operating temperature ranging from 50 ℃ to 400 ℃. The 7wt.% CuO-doped ZnO film shows good response to H2S gas （100 ppm） at 250 ℃.

Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn's disease

AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD).