Integrated Project Library Exploration in Landscape Design Teaching for Environmental Design Majors

To enhance our talent cultivation model through“school-enterprise cooperation and industry-teaching fusion”,we aim to improve the“4321”Industry-Education Integration System.This includes actively promoting the use of case banks and project banks in teaching to develop students’practical engineering skills through hands-on application of professional knowledge.Additionally,landscape design courses emphasize practical learning experiences to implement the fundamental goal of“cultivating morality”.Guided by enhancing students’practical skills,we ensure alignment with course objectives and professional training requirements,emphasizing the seamless integration of theory and practice.

RockSL:an integrated rock spectral library for better global shared services

Spectral data of different rocks and minerals usually show different waveforms and absorption characteristics in visible and infrared wavelengths,which allow identification of mineral species and composition.However,massive spectra of rock/mineral on earth surface were scattered across a variety of spectral libraries world-wide,exhibiting inconsistent data structures and measurement conditions.To advance the data interoperability and the data usability,we collected data and information from six shared libraries with different format and measured field specimen in laboratory to establish an integrated rock spectral library(RockSL).Both the data quality of spectral curves and the integrity of descrip-tive metadata are considered in the integrated RockSL to be pub-lished in GitHub open-source repository.RockSL contains not only the big spectral dataset of rocks and minerals for data service(i.e.data sharing and retrieval)and geological discrimination,but also the characteristics dataset of key parameters/metadata(e.g.particle size,mineral composition and full-band signature,etc.)for explora-tion of data mining and knowledge discovery.We hope that more researchers will join to improve the availability and practical value of RockSL for remote sensing community.This article introduces the database structure and data processing workflow,and demon-strates a matching service and several examples of characteristic datasets of RockSL.

Current status and future development of Chinese Government Public Information Online

Since its launch last year, the Chinese Government Public Information Online(CGPIO) platform's basic construction has developed rapidly. This paper describes the technology and service status of the platform, analyzes its problems, and details the future development of the alliance platform in the future.

Repurposable drugs for SARS-CoV-2 and influenza sepsis with scRNA-seq data targeting post-transcription modifications

Coronavirus disease 2019(COVID-19)has impacted almost every part of human lifeworldwide,posing amassive threat to human health.The lack of time for new drug discovery and the urgent need for rapid disease control to reduce mortality have led to a search for quick and effective alternatives to novel therapeutics,for example drug repurposing.To identify potentially repurposable drugs,we employed a systematic approach to mine candidates from U.S.FDA-approved drugs and preclinical small-molecule compounds by integrating gene expression perturbation data for chemicals from the Library of Integrated Network-Based Cellular Signatures project with a publicly available single-cell RNA sequencing dataset from patients withmild and severe COVID-19(GEO:GSE145926,public data available and accessed on 22 April 2020).We identified 281 FDA-approved drugs that have the potential to be effective against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,16 of which are currently undergoing clinical trials to evaluate their efficacy against COVID-19.We experimentally tested and demonstrated the inhibitory effects of tyrphostin-AG-1478 and brefeldin-a,two chemical inhibitors of glycosylation(a post-translational modification)on the replication of the single-stranded ribonucleic acid(ssRNA)virus influenza A virus as well as on the transcription and translation of host cell cytokines and their regulators(IFNs and ISGs).In conclusion,we have identified and experimentally validated repurposable anti-SARS-CoV-2 and IAV drugs using a systems biology approach,which may have the potential for treating these viral infections and their complications(sepsis).