Combinatorial Synthesis and High-Throughput Characterization of Microstructure and Phase Transformation in Ni-Ti-Cu-V Quaternary Thin-Film Library

Ni-Ti-based shape memory alloys(SMAs)have found widespread use in the last 70 years,but improving their functional stability remains a key quest for more robust and advanced applications.Named for their ability to retain their processed shape as a result of a reversible martensitic transformation,SMAs are highly sensitive to compositional variations.Alloying with ternary and quaternary elements to finetune the lattice parameters and the thermal hysteresis of an SMA,therefore,becomes a challenge in materials exploration.Combinatorial materials science allows streamlining of the synthesis process and data management from multiple characterization techniques.In this study,a composition spread of Ni-Ti-Cu-V thin-film library was synthesized by magnetron co-sputtering on a thermally oxidized Si wafer.Composition-dependent phase transformation temperature and microstructure were investigated and determined using high-throughput wavelength dispersive spectroscopy,synchrotron X-ray diffraction,and temperature-dependent resistance measurements.Of the 177 compositions in the materials library,32 were observed to have shape memory effect,of which five had zero or near-zero thermal hysteresis.These compositions provide flexibility in the operating temperature regimes that they can be used in.A phase map for the quaternary system and correlations of functional properties are discussed w让h respect to the local microstructure and composition of the thin-film library.

Rapid characterization of the binding property of HtrA2/Omi PDZ domain by validation screening of PDZ ligand library

HtrA2/Omi is a mammalian mitochondrial serine protease, and was found to have dual roles in mam- malian cells, not only acting as an apoptosis-inducing protein but also maintaining mitochondrial ho- meostasis. PDZ domain is one of the most important protein-protein interaction modules and is in- volved in a variety of important cellular functions, such as signal transduction, degradation of proteins, and formation of cytoskeleton. Recently, it was reported that the PDZ domain of HtrA2/Omi might regulate proteolytic activity through its interactions with ligand proteins. In this study, we rapidly characterized the binding properties of HtrA2/Omi PDZ domain by validation screening of the PDZ ligand library with yeast two-hybrid approach. Then, we predicted its novel ligand proteins in human proteome and reconfirmed them in the yeast two-hybrid system. Finally, we analyzed the smallest networks bordered by the shortest path length between the protein pairs of novel interactions to evaluate the confidence of the identified interactions. The results revealed some novel binding proper- ties of HtrA2/Omi PDZ domain. Besides the reported Class II PDZ motif, it also binds to Class I and Class III motifs, and exhibits restricted variability at P?3, which means that the P?3 residue is selected according to the composition of the last three residues. Seven novel ligand proteins of HtrA2/Omi PDZ domain were discovered, providing significant clues for further clarifying the roles of HtrA2/Omi. Moreover, this study proves the high efficiency and practicability of the newly developed validation screening of candidate ligand library method for binding property characterization of peptide-binding domains.

Chlorination pattern effect on thermodynamic parameters and environmental degradability for C_(10)-SCCPs: Quantum chemical calculation based on virtual combinational library

Short-chain chlorinated paraffins（SCCPs） are still controversial candidates for inclusion in the Stockholm Convention.The inherent mixture nature of SCCPs makes it rather difficult to explore their environmental behaviors.A virtual molecule library of 42,720 C10-SCCP congeners covering the full structure spectrum was constructed.We explored the structural effects on the thermodynamic parameters and environmental degradability of C10-SCCPs through semi-empirical quantum chemical calculations.The thermodynamic properties were acquired using the AM1 method,and frontier molecular orbital analysis was carried out to obtain the EHOMO,ELUMO and ELUMO-EHOMO for degradability exploration at the same level.The influence of the chlorination degree（NCl on the relative stability and environmental degradation was elucidated.A novel structural descriptor,μ,was proposed to measure the dispersion of the chlorine atoms within a molecule.There were significant correlations between thermodynamic values and NCl,while the reported NCl-dependent pollution profile of C10-SCCPs in environmental samples was basically consistent with the predicted order of formation stability of C10-SCCP congeners.In addition,isomers with largeμ showed higher relative stability than those with small μ.This could be further verified by the relationship between μ and the reactivity of nucleophilic substitution and · OH attack respectively.The C10-SCCP congeners with less Cl substitution and lower dispersion degree are susceptible to environmental degradation via nucleophilic substitution and hydroxyl radical attack,while direct photolysis of C10-SCCP congeners cannot readily occur due to the large ELUMO-EHOMO values.The chlorination effect and the conclusions were further checked with appropriate density functional theory（DFT） calculations.

Protection of Geographical Indication and Intangible Cultural Heritage of the Chinese Food Product Resources

The geographical Indications intellectual property and intangible cultural heritage are the general focus of attention of the world today. In the Chinese food product resources, there are 44 kinds of national geographical indication products, 41 national geographical indication trademarks, 9 kinds of national and 212 kinds of provincial-level intangible cultural heritage. This article introduces the geographical indication protection and geographical indication trademark registration of the Chinese food products, the protection of intangible cultural heritage of traditional craftsmanship; discusses the countermeasures for the protection of geographical indication intellectual property and intangible cultural heritage; finally puts forth several recommendations.

Justification and System Arrangement of Virtual Property Rights——Comments on Article No. 127 of General Provisions of the Civil Law

In the process of formulating the General Provisions of the Civil Law of P. R. China, the attribute of virtual property rights has changed from real rights to non-real rights. Article No. 127 thereof does not clarify the nature of virtual property rights after all, and the place where virtual property is put in the "Civil Rights" chapter of General Provisions of the Civil Law makes the concept even more complex and confusing. The "relationships paradigm" protection of virtual property does not have a definite classification criterion, nor stands opposite to the "rights paradigm." There are two different ways to justify the "theory of virtual property as a real right" under the "rights paradigm" protection, namely, essentialism and consequentialism. The former resulted from utilizing features in a demonstration and identifying disposal rights with real rights, while the latter resulted from adherence to the dichotomy system of property rights comprising real rights and creditor's rights. From the perspective of larceny in Criminal Law and virtual property insurance in The Social Insurance Law, the attribute of virtual property rights is irrelevant to creditor's rights. The attribute of virtual property rights shall be defined as virtual property rights so that it can be included in the system of civil rights. The uniqueness of virtual property is enough to become an object of emerging civil rights; intangible property rights as a superordinate theoretical concept cannot reflect the essence of virtual property rights. The legislative frame of virtual property rights shall be comprised of the subject, object, exercise, publication and change of the rights.

Paying Close Attention to the Research on Property Right of Market

The property fight of market is a foundation, on which various kinds of micro tangible property rights and intangible property rights exist and realize, and as an economic category, the property right of market appears after the class, the state and the equity title. The contents that are involved in the research on the theory and the practice of property fight of market are extensive, including a lot of aspects such as its key theory, the relation between market economy and international competitiveness, etc. Therefore, the research on the property right of market has very important theoretic and practical significance.

数字化时代非物质文化遗产的知识产权保护:基础、困境及应对

步入数字时代,随着技术与经济的进步,非物质文化遗产的良性传承与发展对知识产权保护提出了更高的要求。加强非物质文化遗产数字化知识产权保护,既回应了非物质文化遗产数字化创新发展的现实需要,又与非物质文化遗产数字化保护与传承的利益平衡需求相契合。现阶段我国非物质文化遗产数字化知识产权保护存在权利主体模糊、权利客体形态复杂、权利内容不清及权利交易不畅的现实困境。对此,为促进非物质文化遗产数字化传承与发展,可以从明晰相关权利主体、构建分层保护体系、廓清相关权利主体的利益边界及建设非物质文化遗产知识产权交易平台入手,破解当前的保护困境。

类型化视角下非遗知识产权保护体系研究

非遗知识产权保护的类型化梳理是非遗知识产权保护体系构建的前提,类型化思维和传统概念化思维的有效互补可以化解非遗知识产权保护的规则冲突。以促进文化传承和推动区域经济发展为价值标准规划出非遗知识产权保护的具体路径,通过利益平衡原则指导下的非遗“权利主体”和惠益原则指导下的非遗“保护客体”类型化分析,解构非遗的传统类型,厘清非遗知识产权保护的内容和样态,合理重构非遗知识产权保护类型,为非遗知识产权保护提出有效配置方案,实现非遗知识产权保护的良性循环。

面向区域创新的高校知识产权信息公共服务营销策略研究

优质的知识产权信息公共服务供给将有效发挥知识产权对区域经济社会发展的支撑作用。作为区域网点机构,高校知识产权信息公共服务营销策略对于知识产权信息公共服务推广与实践,满足社会公众信息服务的可及性、便利性需求,具有理论价值和现实意义。本文对30家高校国家知识产权信息服务中心营销效果现状展开调研,结合实践经验进行问题分析,并从区域创新需求视角出发构建面向区域创新的高校知识产权信息公共服务营销框架,从而提出相应策略。研究策略为高校知识产权信息公共服务提供了针对性较强的参考。

权利束对财产权范式的贡献及不足——以资源配置效率为视角

随着科技的进步,越来越多的新型资源被纳入财产的范畴。受制于“物债二分”与“物权法定”思维,传统财产权范式的弊端逐渐显露。区别于传统财产权范式,权利束在整合霍菲尔德权利概念与科斯产权理论的基础上,将财产拟制为法律关系的集合,且允许有关主体根据案件情况重新排列每束权利的顺位。通过个案决策,权利束能够更灵活地分配财产权益,但权利束也存在“增加交易成本”“打击劳动者生产积极性”等弊端。借助类型化的分析,权利束与传统财产权范式在不同类型财产的资源配置中呈现出差异化的优势与不足。

高校知识产权信息服务体系的探索与实践——以北京邮电大学为例

文章聚焦高校知识产权信息服务体系建设,通过明确高校知识产权信息服务工作目标,提出高校知识产权信息服务高质量发展策略,即以服务体系建设目标为导向,加强知识产权信息基础服务内容规划、形成区域联盟、优化知识产权信息服务团队结构、夯实高校知识产权意识、统一高校知识产权职能机构等。并以北京邮电大学推进服务内容纵深发展、协同校内外多元主体、注重知识产权信息服务团队建设、提高知识产权意识与服务能力、构建三位一体服务格局的实践为例,探讨高校知识产权信息服务体系建设成效。

公共图书馆参与公众知识产权素养培育:角色与路径

公共图书馆是知识产权信息公共服务体系的组成部分,是开展知识产权信息公共服务的社会化服务机构。在国家政策支持、机构职能保障、馆藏资源满足等优势下,加之受“行业转型发展的内在需求”“提高公众素养的有效举措”“创新服务内容的重要手段”的综合影响,公共图书馆参与知识产权素养培育具有一定的可行性,可扮演担当者、新阵地、协作者等角色。未来,公共图书馆应通过以下路径来提升知识产权素养培育的影响力:以提高认识为前提,彰显行业属性;以馆藏资源为依托,重视团队建设;以公众需求为导向,完善培育体系;以多方协作为契机,完善相关机制。

我国非物质文化遗产传承人法律保护制度运行检视与本土化构建

非物质文化遗产传承人保护是中华优秀传统文化传承保护的关键举措之一。在实践中,部分非物质文化遗产传承“无人”,并呈现传承人的断层危机、传承人欠缺自主品牌的保护意识、传承人对非物质文化遗产二次创造的能力较弱和特色保护机制缺失等现象,亟须予以解决。现行代表性传承人认定制度欠缺理性构建、传承人难以获得知识产权保护、传承人获得利益分享的空间受限和现行法对传承人的保护不完备等问题凸显出传承人保护法律制度的不足。结合我国非物质文化遗产传承人法律保护制度运行实践,可以通过厘清代表性传承人的认定标准、突破现行知识产权制度的保护范围、探索本土化的利益分享制度和完善传承人保护制度的本土化设计等举措,构建符合我国国情的非物质文化遗产传承人保护法律制度体系。

基于创新人才培养的高校图书馆知识产权素养教育研究

[目的/意义]高校是国家创新人才培养的重要阵地,在中国实施人才强国和创新型国家战略背景下,知识产权素养已成为高校学生适应社会需求必备的基本素质。研究基于创新人才培养的知识产权素养教育,以期共同探讨高校图书馆在创新人才培养中知识产权素养教育模式。[方法/过程]将大学生创新人才培养的知识产权素养教育分为4个阶段:创新创业认知阶段、综合素养教育阶段、创新能力提升阶段和专业技能应用阶段,根据不同教育阶段对知识产权素养需求特点,制定了知识产权素养教育目标。[结果/结论]高校创新人才知识产权素养教育是一项系统工程,需要图书馆不断地实践与改革,才能为创新人才培养注入活力。

知识产权情报:背景、理论发展及应用研究

知识产权情报是创新发展的重要助推器,已引起图书情报领域的关注,但尚未形成相应的学科系统认知。通过对国家战略、知识产权发展和社会实践需求的背景考察,明确建立和发展知识产权情报体系的重要性。通过对知识产权情报研究发展阶段的回顾,界定知识产权情报的核心概念,提出知识产权情报的特征、研究内容和研究对象,进而形成知识产权情报框架;以实践情境为例,充分展示知识产权情报与创新实践的密切关系。知识产权情报与图书情报学科发展紧密同行,是图书情报学科的重要分支,同时能为科技创新、国家发展提供强有力的支撑。

传播学视域下的高校图书馆非遗传承与传播策略探究

为弘扬中华优秀传统文化,促进非物质文化遗产在高校中的传承和传播,提升大学生的文化体验和文化自信,该文基于高校图书馆开展非物质文化遗产传承与传播的政策指导意见,调研了高校图书馆开展非遗传承与传播活动的现状。为丰富高校图书馆非遗传承和传播的理论和实践,依据传播学原理,提出高校图书馆参与非遗传承和传播的具体策略,如建立可靠的非遗信息源,加强与高校非遗传播其他主体的合作,结合大学生受众特点策划内容丰富、形式多样的非遗活动,提升活动的系统性、互动性、体验性,灵活运用多种媒介和信息技术进行传播,制定定性定量的评价标准等,为参与非遗传承的高校图书馆提供经验借鉴。

山西省非物质文化遗产本体构建和可视化计算

非物质文化遗产是一个国家或地区的历史文化资产的重要组成部分,山西省在国家级非遗项目申报认证中居于全国前列,但是中国非物质文化遗产官网主页指向的省级非物质文化遗产子网中没有提供山西省非遗的本体知识以支持多角度的非物质文化遗产知识展示。基于此,文章采用语义网和本体技术,从中国非物质文化遗产官网和相关网站收集山西省知识,采用Protégé5.5.0软件构建山西省非遗本体。具体而言,采用查询工具SPARQL,查询计算非物质文化遗产项目的类别、类型、认证批次等属性以及非物质文化遗产项目和传承人的相关关系,将结果利用Python3.7图形软件包进行可视化呈现,分析各类别的非物质文化遗产项目传承面临的具体困境,并提出针对性建议。

基于SWOT分析的高校图书馆知识产权信息服务策略研究——以华南师范大学图书馆为例

在国际竞争中,知识产权拥有重要的地位,高校图书馆作为重要的知识产权信息公共服务体系,有效开展知识产权信息服务是非常具有研究价值的课题。本文以华南师范大学图书馆知识产权信息服务为例,通过调研高校图书馆服务现状,运用SWOT分析法分析高校图书馆知识产权信息服务的内部优势和劣势、外部机会和威胁,提出了:抓住机遇,服务科研;深化基础服务,拓展高级服务;加强合作,优化服务;提升能力,保证质量等图书馆知识产权信息服务策略。

从“述古”到“开新”:长沙市图书馆地域文化IP的开发与应用

文章基于泛IP时代特点,从创意来源、品牌塑造、呈现形式以及发展瓶颈四方面,总结分析公共图书馆地域文化IP发展现状,结合长沙市图书馆地域文化IP的建设与应用实践,介绍长沙市图书馆如何从“述古”到“开新”,实现优秀传统文化和馆藏特色资源的创造性转化与创新性发展。提出公共图书馆地域文化IP建设路径:通过个性化、感性化、人本化、数字化、体系化层层递进,构建以IP为核心的全新文化资源生产方式,实现图书馆文化创意的传统继承与未来发展,助力文化价值和产业价值良性循环。

高校知识产权信息服务助力地方经济发展研究——以井冈山大学知识产权信息服务中心为例

【目的】探索新时代地方高校知识产权信息服务助力地方经济发展的现状及建议,以期对相关领域工作提供一些借鉴。【方法】以井冈山大学知识产权信息服务中心为例,通过图书馆知识产权信息服务实施情况,从内容概要、区域分布、服务模式、定位分析4个维度,明晰图书馆知识产权信息服务内容建设的关键所在。【结果】提出夯实基础,持续发力;提前谋划,强化队伍;依托学科,转型拓展;合作共享,协调发展等加强高校图书馆知识产权信息服务的建议。【结论】在知识产权信息服务能力薄弱的中西部地方高校,应该走一条兼顾高校科研、国家战略和区域经济发展的创新之路:梳理高校知识产权信息服务体系,突出知识产权信息服务高校科技创新和成果转化的目标,发挥知识产权信息服务在知识产权全链条中的作用和效能。