Impaired pericyte-Müller glia interaction via PDGFRβ suppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury

AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retinal pericytes on photoreceptor loss and Müller glial response.METHODS:Sprague-Dawley rats were exposed to intense light to induce retinal injury.Neutralizing antibody against PDGFRβwere deployed to block the signaling pathway in retinal pericytes through intravitreal injection.Retinal histology and Müller glial reaction were assessed following light injury.In vitro,normal and PDGFRβ-blocked retinal pericytes were cocultured with Müller cell line(rMC-1)to examine morphological and protein expression changes upon supplementation with light-injured supernatants of homogenized retinas(SHRs).RESULTS:PDGFRβblockage 24h prior to intense light exposure resulted in a significant exacerbation of photoreceptor loss.The upregulation of GFAP and p-STAT3,observed after intense light exposure,was significantly inhibited in the PDGFRβblockage group.Fur ther upregulation of cytokines monocyte chemoattractant protein 1(MCP-1)and interleukin-1β(IL-1β)was also observed following PDGFRβinhibition.In the in vitro coculture system,the addition of light-injured SHRs induced pericyte deformation and upregulation of proliferating cell nuclear antigen(PCNA)expression,while Müller cells exhibited neuron-like morphology and expressed Nestin.However,PDGFRβblockage in retinal pericytes abolished these cellular responses to light-induced damage,consistent with the in vivo PDGFRβblockage findings.CONCLUSION:Pericyte-Müller glia interaction plays a potential role in the endogenous repair process of retinal injury.Impairment of this interaction exacerbates photoreceptor degeneration in light-induced retinal injury.

Light-Induced Changes in a-Si∶H Films Studied by Transient Photoconductivity

Light induced changes in a-Si∶H films are investigated by transient photoconductivity.The transient photoconductivity decay data can neither be fit well by common power-law for transient photocurrent in amorphous semiconductors,nor by stretched exponential rule for transient decay from the steady state in photoconductivity.Instead,the data are fit fairly well with a sum of two exponential functions.The results show that the long time decay is governed by deep traps rather than band tail states,and two different traps locating separately at 0.52 and 0.59eV below E _c are responsible for the two exponential functions.They are designated as negatively charged dangling bond D - centers.The light-induced changes in photoconductivity are attributed mainly to the decrease in electron lifetime caused by the increase of recombination centers after light soaking.

Light-Induced Reaction of Benzene with Carbonates

We found an ultraviolet （UV）-light induced formation of biphenyl and sodium benzoate from benzene and sodium carbonate. The reaction happens in the interface of benzene and aqueous solution at the room temperature. After 5 h of UV-light exposure, 11.4% of initial amount of 4.4 g （5.0 mL） benzene are converted to biphenyl and sodium benzoate, which are distributed in benzene and aqueous solution, respectively. Using density function theory （DFT） and time dependent DFT, we have investigated the mechanism of this light-induced reaction, and found that the sodium carbonate is not only a reactant for the formation of sodium benzoate, but also a catalyst for the formation of biphenyl.

Path planning for light-induced dielectrophoretic manipulation of micro-particles

To realize automatic manipulation of micro-particles by light-induced dielectrophoresis （LDEP）, a path-planning scheme based on the improved artificial potential field （APF） for micro light pattern movements is proposed. An algorithm combining guided target and point obstacle based on a new local minimum judging criterion is specially designed, which can solve the local minimum problems encountered by the traditional APF. Experiments of real-time particle manipulation based on this algorithm are implemented and the experimental results show that the proposed approach can overcome the local minimum problems of the traditional APF method, and it is validated to be highly stable for intensive particle obstacles during LDEP manipulation. Consequently, this method can realize real-time manipulation of micro-nano particles with safety, decrease the difficulty of manual manipulation, and thus improve the efficiency of manipulation of micro-particles.

Dark Oscillation of Light-induced Absorption in Heavy Reduced Co: KNSBN Crystal

This paper presents dark oscillations of light-indhced absorption in heavy reduced Co: KNSBN crystal, points out there are double carriers and multiple traps in the crystal and explains the experimental results with the newly established model of double carriers and multiple traps.

Light-Induced Charge Transfer at Interface Between Lipid-Free RhTSPc Film and p-Si(111)

The present paper covers the lipid-free rhodium tetrasulfonato-phthalocyanine (RhTSPc) films prepared on p-Si(111) by using Langmuir-Blodgett technique. Their surface photovoltage spectra were measured. It was found that there is a strong interaction at the interface between the RhTSPc film and p-Si (111) and that the surface photovoltaic effect of the film system is maximum when only one monolayer of RhTSPc molecules coats p-Si(111), which is similar to that of CuTSPc films on p-Si(111) reported previously. These results confirm that only the monolayer of dye molecules being adjacent to the semiconductor surface plays a key role in the light-induced interfacial charge transfer process.

Oscillation of the spin-currents of cold atoms on a ring due to light-induced spin–orbit coupling

The evolution of two-component cold atoms on a ring with spin-orbit coupling has been studied analytically for the case with N noninteracting particles. Then, the effect of interaction is evaluated numerically via a two-body system. Two cases are considered： （i） Starting from a ground state the evolution is induced by a sudden change of the laser field, and （ii） the evolution starting from a superposition state. Oscillating persistent spin-currents have been found. A set of formulae have been derived to describe the period and amplitude of the oscillation. Based on these formulae the oscillation can be well controlled via adjusting the parameters of the laser beams. In particular, it is predicted that movable stripes might emerge on the ring.

Advantage of Introducing Quantitative Light-Induced Fluorescence in School Dental Checkups

Background: Caries detection in school oral examinations insufficient accuracy. Objective: To evaluate advantages of introducing quantitative light-induced fluorescence-digital (QLF-D) in school oral examinations. Methods: Experiment No. 1. Early demineralized lesions in the upper and lower incisors and canines were visually inspected by three dentists and by QLF-D. The numbers of tooth planes with early demineralized lesions were compared between the methods. Experiment No. 2. Approximal demineralized lesions in molars were assessed by visual inspection, x-ray imaging, and QLF-D. The numbers of tooth planes with demineralized lesions were compared among the methods. Experiment No. 3. Plaque distribution was evaluated by QLF-D and a traditional staining method. The ratio of the diameter of plaque to tooth crown in the tooth axis direction in each method was calculated. The results were evaluated by Pearson’s correlation coefficient analysis and Bland-Altman plot. Results: Experiment No. 1. The three dentists found 0.67 tooth planes on average. QLF-D found 22 tooth planes with early demineralized lesions in the same samples. Experiment No. 2. Fourteen approximal tooth planes of molars were found to have demineralized lesions by x-ray imaging. QLF-D detected 71.4% of the tooth planes out of the 14, whereas visual inspection found 7.1%. Experiment No. 3. The Pearson’s correlation coefficient for the evaluations of plaque distribution between the QLF-D and traditional staining methods was 0.77 (P Conclusion: The results support introduction of QLF-D for use in school dental examinations.

Evaluating Acid Resistance Effect of Fluoride-Releasing Dental Materials Using Quantitative Light-Induced Fluorescence-Digital in Vitro

As erosion has become one of the serious oral health problems, some fluoride-releasing dental materials have been developed to protect enamel from demineralization. The purpose of this study was to evaluate the antidemineralization effect of PRG Barrier Coat® and FujiVII® (fluoride-releasing dental materials). Four square windows measuring 1 mm2 were prepared on the labial enamel surface of each bovine tooth using masking tape and nail varnish. The first and second windows were half covered by fluoride-releasing material and control material, respectively, whereas the third and fourth windows were left untreated. All windows were immersed into 0.1 M lactic acid and 6wt% CM-cellulose (pH 4.5) at 38℃ for 21 days. Subsequently, the first and second windows were covered with nail varnish after removal of the materials, and the third and fourth windows were immersed into ultrapure water at 38℃ for 28 days after being half covered with fluoride-releasing and control materials, respectively. The following procedure was performed separately during evaluations of the fluoride-releasing materials, PRG Barrier Coat, and FujiVII®, using eight and six bovine teeth, respectively. The first, second, third, and fourth windows were classified into DM-PRG;Demineralized-PRG or DM-FujiVII;Demineralized-FujiVII, DM-TCM;Demineralized-traditional cement or DM-TGIC;De-mineralized-traditional glass ionomer cement, RM-PRG;Remineralized-PRG or RM-FujiVII;Re-mineralized-FujiVII, and RM-TCM;Remineralized- traditional cement or RM-TGIC;Remineral-ized-traditional glass ionomer cement, respectively. After nail varnish was removed, △Q values (mean ± SD) of the windows were measured using QLF-D and were compared between DM-PRG and DM-TCM, RM-PRG and RM-TCM, DM-FujiVII and DM-TGIC, and RM-FujiVII and RM-TGIC groups. △Q values of RM-PRG (-60 ± 44) and RM-FujiVII (-5.0 ± 10) were significantly higher than that of RM-TCM (-315 ± 193) and RM-TGIC (-56 ± 43), respectively. The fluoride releasing materials provided remineralization effects to bovine enamel.

Light-Induced Mid-Infrared Emission of Liquid Carbon Tetrachloride and Benzene

Light-induced infrared emission spectroscopy (LIRES) is a novel technique that permits to receive high-quality spectra in the mid-infrared region. Low-intensity visible light connected to a highly sensitive FTIR spectrometer is more advantageous for studying any samples, including biological samples without any damage. This technique permits obtaining unique information on the molecule structure via vibrational excitation fundamental frequencies, overtones, and combination modes. It also enables a direct observation of vibrational radiation transitions in vibrationally excited molecules as well as the channels of vibration energy redistribution, which is not allowed with any other method. In this work, the LIRES is being tested as a technique for studying of vibrationally-excited molecules of carbon tetrachloride and benzene in the liquid phase. On the other hand, using transparent liquids, we had tried to understand some of the physical phenomena that can drive emission in mid-IR. The characteristics of the infrared emission of both liquid species produced by different wavelength radiation from various types of light systems (100 - watt Xe-lamp and Nd:YAG laser;lambda = 1064 nm (8 mW) and lambda = 532 nm (4 mW)) are presented. We demonstrated that the IR-signal, as well as spectral properties of carbon tetrachloride and benzene, was dependent on the wavelength and power of excitation beam. Results obtained with different light sources show that the visible light produces a nonlinear IR-emission signal in transparent liquids. We believe that the visible light is the source of the nonlinear response and is producing the vibration excitation as well as photostimulated transformations of the molecules possessing the high activity for the nonlinear response.

A Deep Learning Based Broadcast Approach for Image Semantic Communication over Fading Channels

We consider an image semantic communication system in a time-varying fading Gaussian MIMO channel,with a finite number of channel states.A deep learning-aided broadcast approach scheme is proposed to benefit the adaptive semantic transmission in terms of different channel states.We combine the classic broadcast approach with the image transformer to implement this adaptive joint source and channel coding(JSCC)scheme.Specifically,we utilize the neural network(NN)to jointly optimize the hierarchical image compression and superposition code mapping within this scheme.The learned transformers and codebooks allow recovering of the image with an adaptive quality and low error rate at the receiver side,in each channel state.The simulation results exhibit our proposed scheme can dynamically adapt the coding to the current channel state and outperform some existing intelligent schemes with the fixed coding block.

Effective Capacity of URLLC over Parallel Fading Channels with Imperfect Channel State Information

This paper investigates the effective capacity of a point-to-point ultra-reliable low latency communication(URLLC)transmission over multiple parallel sub-channels at finite blocklength(FBL)with imperfect channel state information(CSI).Based on reasonable assumptions and approximations,we derive the effective capacity as a function of the pilot length,decoding error probability,transmit power and the sub-channel number.Then we reveal significant impact of the above parameters on the effective capacity.A closed-form lower bound of the effective capacity is derived and an alternating optimization based algorithm is proposed to find the optimal pilot length and decoding error probability.Simulation results validate our theoretical analysis and show that the closedform lower bound is very tight.In addition,through the simulations of the optimized effective capacity,insights for pilot length and decoding error probability optimization are provided to evaluate the optimal parameters in realistic systems.

Energy efficiency aware dynamic rate and power adaptation in carrier sensing based WLANs under Rayleigh fading and shadowing

We consider the problem of energy efficiency aware dynamic adaptation of data transmission rate and transmission power of the users in carrier sensing based Wireless Local Area Networks(WLANs)in the presence of path loss,Rayleigh fading and log-normal shadowing.For a data packet transmission,we formulate an optimization problem,solve the problem,and propose a rate and transmission power adaptation scheme with a restriction methodology of data packet transmission for achieving the optimal energy efficiency.In the restriction methodology of data packet transmission,a user does not transmit a data packet if the instantaneous channel gain of the user is lower than a threshold.To evaluate the performance of the proposed scheme,we develop analytical models for computing the throughput and energy efficiency of WLANs under the proposed scheme considering a saturation traffic condition.We then validate the analytical models via simulation.We find that the proposed scheme provides better throughput and energy efficiency with acceptable throughput fairness if the restriction methodology of data packet transmission is included.By means of the analytical models and simulations,we demonstrate that the proposed scheme provides significantly higher throughput,energy efficiency and fairness index than a traditional non-adaptive scheme and an existing most relevant adaptive scheme.Throughput and energy efficiency gains obtained by the proposed scheme with respect to the existing adapting scheme are about 75%and 103%,respectively,for a fairness index of 0.8.We also study the effect of various system parameters on throughput and energy efficiency and provide various engineering insights.

Analysis of GPS ionospheric scintillation signal amplitude fading characteristics at low latitude

The received satellite signal amplitude is attenuated greatly due to the strong ionospheric scintillation for lowlatitude regions, which causes the GPS tracking loop＇s loss of lock, the positioning errors to increase, and navigation to be interrupted. To solve the above problems, a novel signal processing algorithm is proposed based on the GPS L1 software receiver during strong ionospheric scintillation using the multi-channel intermediate frequency（IF） data sampling system. Tens of thousands of fading events are obtained based on the signal intensity measurement. The amplitude fading characteristics in the lowlatitude region are analyzed,including fading duration, time separation between fades and the numbers of signal intensity fading events. The fading thresholds are set to be 15 and 10 dB, respectively. The main fading time is very short in- 15 dB fading threshold, which generally is less than 20 ms. The main time separation between fades is less than 2 s in a single one-hour period from the time 23： 00 to 24： 00. Therefore, it has the characteristic of a short reacquisition time for the receiver designed to reduce the probability of simultaneous loss of lock for some satellites.Subsequently, the acquisition, tracking and PVT（position,velocity and time） calculations are completed by the customdesigned software receiver. The results show that the impact analysis of ionospheric scintillation on GPS amplitude attenuation in the lowlatitude region is helpful for designing the advanced tracking algorithm and to improve the robustness and accuracy of the GPS receiver.

Closed BER expression of multi-user DS UWB systemsin indoor fading channel

The bit error rate （BER） performance of multi-user direct spreading bi-phase shift keying （DSBPSK） direct impulse ultra wideband （UWB） systems is analyzed and simulated based on a statistical indoor multi-path fading channel model. The BER of the system is theoretically derived and given in closed form, which is expressed in terms of channel parameters and system parameters such as pulse width parameter, pulse repeat period, user number and pulse waveform. With this BER expression, the effect of these parameters on the system performance can be evaluated in a uniform way. Simulation results well match the theory numerical results, and prove that the multi-access interference （MAI） of DS-BPSK UWB is a normal distribution.

电子音乐中Fade In及Fade Out效果应用

在电子音乐处理手法多如牛毛的今天,人们对电子音乐审美正随着电子音乐地发展而提高。但劣质CD音乐同时抑制着电子音乐的整体发展,影响人们的音乐审美。因此,本文通过对音乐Fade-In及Fade-Out音频前期制作中的情绪辅助表达、录音过程中的音频剪辑、CD成品刻录中的防止爆破三种作用的研究,力图在尽量保持电子音乐高品质的同时,不断的尝试新的操作构思,为电子音乐地发展创新锦上添花。

Electrochemical behavior and cyclic fading mechanism of LiNi_(0.5) Mn_(0.5) O_2 electrode in LiNO_3 electrolyte

Electrochemical behavior of layered LiNi0.5Mn0.5O2 in LiNO3 aqueous solution and its cyclic fading mechanism in electrolytes with different pH values were investigated. CV results show that LiNi0.5Mn0.5O2 has good electrochemical reversible behaviors in 5 mol/L LiNO3 solution. Meanwhile, the electrode in 5 mol/L LiNO3 with pH value of 12 demonstrates the best electrochemical stability. Based on the electrochemical impedance spectroscopy （EIS）, X-ray diffraction （XRD） and scanning electron microscopy （SEM） results, it is proposed that suppressed charge-transfer resistance is the major reason, which is probably ascribed to the more stable electrode surface and less structure change.

无编程和填表制导开发环境FADE

本文介绍无编程软件应用系统开发环境FADE的设计思想,论述无编程开发工具的类型和特点,填表式制导开发方式的应用系统的生成过程,并给出了表格数据库的文法和语义描述。

Concatenated Trellis Coding and CPM for DS/SSMA Communications in Rayleigh Fading Channel

In this paper, direct sequence spread spectrum multiple access (DS/SSMA) communication system employing serially concatenated trellis coded modulation (TCM) and continuous phase modulation (CPM) over flat Rayleigh fading channel are presented. The performance of this concatenated TCM/CPM DS/SSMA system is exploited by the theoretical analysis and numerical simulations. The results demonstrate that significant improvements in error probability of this DS/SSMA system over the system with single TCM or CPM of different modulation indices can be achieved under the same conditions.

应用FADE品质改善模式改善新入院病人护理细节质量

目的应用FADE[focus(确认问题);analyze(问题分析,指出需要了解的事项,并收集资料以决定影响因素);develop(建立计划以解决问题);execute(执行改善计划并追综检讨,FADE]品质改善模式,持续改进新入院病人护理细节质量,确保病人安全。方法 2014年11月—2015年6月应用FADE品质改善模式,确认改进问题为"新入院病人护理细节质量",找出影响新入院病人护理细节质量的主要问题,并针对问题进行根因分析找出影响因素,制定新入院病人护理细节质量标准、改进目标及改进策略,执行计划并追踪检讨持续改进,运用数据评价改进效果。结果实施改进前2014年11月新入院病人护理细节质量合格率为77.9%,实施改进后,2015年1—6月共检查6次,新入院病人护理细节质量平均合格率为92.2%,实施前后合格率比较,差异有统计学意义(P<0.01),有效改进了新入院病人护理工作中存在的问题。结论应用FADE品质改善模式,有效改进了新入院病人护理中存在的问题,提高了新入院病人护理细节质量,确保了病人安全。