A general transition‐metal‐free photoinduced acetalation‐pyridylation of alkenes using diethoxyacetic acid and cyanopyridine was developed under mild conditions.By employing 4CzIPN as the photocatalyst and Cs_(2)CO...A general transition‐metal‐free photoinduced acetalation‐pyridylation of alkenes using diethoxyacetic acid and cyanopyridine was developed under mild conditions.By employing 4CzIPN as the photocatalyst and Cs_(2)CO_(3) as the base,a diverse range of styrene derivatives and cyanopyridines worked well to give the desired products.The versatility of this method is highlighted by its application in the construction of various functional groups and the late‐stage modification of drugs.Importantly,some of the synthesized compounds showed good in vitro antitumor activity,indicating that this protocol is of significance and potential for antitumor drug development.展开更多
China’s light industry hasdeveloped rapidly since thereform and opening drivebegan.In 1994,the total outputvalue of light industry wasRMB490.2 billion,and theexport volume of lightindustrial products wasUS＄35.6 bill...China’s light industry hasdeveloped rapidly since thereform and opening drivebegan.In 1994,the total outputvalue of light industry wasRMB490.2 billion,and theexport volume of lightindustrial products wasUS＄35.6 billion,one third ofChina’s total export volume.In the first half of 1995,thetotal output value of lightindustry increased 14.7%,andthe export volume of lightindustrial products wasUS＄18.9 billion,43% over thesame period of 1994.展开更多
The visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described.This protocol provides an effective and practical access ...The visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described.This protocol provides an effective and practical access to sulfonylmethylated imidazopyridines with good functional group tolerance.The desired products were provided in moderate to excellent yields for 50 examples at room temperature.The method could also be an attractive strategy to install a methyl group on imidazopyridines.展开更多
文摘A general transition‐metal‐free photoinduced acetalation‐pyridylation of alkenes using diethoxyacetic acid and cyanopyridine was developed under mild conditions.By employing 4CzIPN as the photocatalyst and Cs_(2)CO_(3) as the base,a diverse range of styrene derivatives and cyanopyridines worked well to give the desired products.The versatility of this method is highlighted by its application in the construction of various functional groups and the late‐stage modification of drugs.Importantly,some of the synthesized compounds showed good in vitro antitumor activity,indicating that this protocol is of significance and potential for antitumor drug development.
文摘China’s light industry hasdeveloped rapidly since thereform and opening drivebegan.In 1994,the total outputvalue of light industry wasRMB490.2 billion,and theexport volume of lightindustrial products wasUS＄35.6 billion,one third ofChina’s total export volume.In the first half of 1995,thetotal output value of lightindustry increased 14.7%,andthe export volume of lightindustrial products wasUS＄18.9 billion,43% over thesame period of 1994.
基金financially supported by the National Natural Science Foundation of China (No.21602046)the MOST of China (No.2016YFE0132600)the Doctor’s Scientific Research Foundation of Henan University of Chinese Medicine (No.BSJJ2016-12)
文摘The visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described.This protocol provides an effective and practical access to sulfonylmethylated imidazopyridines with good functional group tolerance.The desired products were provided in moderate to excellent yields for 50 examples at room temperature.The method could also be an attractive strategy to install a methyl group on imidazopyridines.
