Shock waves,characterized by abrupt changes in pressure,temperature,and density,play a significant role in various materials science processes involving fluids.These high-energy phenomena are utilized across multiple ...Shock waves,characterized by abrupt changes in pressure,temperature,and density,play a significant role in various materials science processes involving fluids.These high-energy phenomena are utilized across multiple fields and applications to achieve unique material properties and facilitate advanced manufacturing techniques.Accurate simulations of these phenomena require numerical schemes that can represent shock waves without spurious oscillations and simultaneously capture acoustic waves for a wide range of wavelength scales.This work suggests a high-order discontinuous Galerkin(DG)method with a finite volume(FV)subcell limiting strategies to achieve better subcell resolution and lower numerical diffusion properties.By switching to the FV discretization on an embedded sub-cell grid,the method displays advantages with respect to both DG accuracy and FV shock-capturing ability.The FV scheme utilizes a class of high-fidelity schemes that are built upon the boundary variation diminishing(BVD)reconstruction paradigm.The method is therefore able to resolve discontinuities and multi-scale structures on the subcell level,while preserving the favorable properties of the high-order DG scheme.We have tested the present DG method up to the 6th-order accuracy for both smooth and discontinuous noise problems.展开更多
AIM:To compare the efficacy of pars plana vitrectomy(PPV)combined with internal limiting membrane(ILM)and silicone oil or sterile air tamponade for the treatment of myopic foveoschisis(MF)in highly myopic eyes.METHODS...AIM:To compare the efficacy of pars plana vitrectomy(PPV)combined with internal limiting membrane(ILM)and silicone oil or sterile air tamponade for the treatment of myopic foveoschisis(MF)in highly myopic eyes.METHODS:This retrospective study included 48 myopic eyes of 40 patients with MF and axial lengths(ALs)ranging from 26-32 mm treated between January 2020 and January 2022.All patients were underwent PPV combined with ILM peeling followed by sterile air or silicone oil tamponade and followed up at least 12mo.Based on the features on spectral-domain optical coherence tomography(SD-OCT),the eyes were divided into the MF-only group(Group A,n=15 eyes),MF with central foveal detachment group(Group B,n=20 eyes),and MF with lamellar macular hole group(Group C,n=13 eyes).According to AL,eyes were further divided into three groups:Group D(26.01-28.00 mm,n=12 eyes),Group E(28.01-30.00 mm,n=26 eyes),and Group F(30.01-32.00 mm,n=10 eyes).The best-corrected visual acuity(BCVA),central foveal thickness(CFT),and complications were recorded.RESULTS:The patients included 16 males and 24 females with the mean age of 56±9.82y.The BCVA and CFT improved in all groups after surgery(P<0.01),while there was no significant difference of the CFT in Group A,B,and C postoperatively(P>0.05).The intergroup differences of BCVA and CFT postoperatively were statistically significant in Group D,E,and F.Twenty eyes were injected with sterile air,and 28 eyes were injected with silicone oil for tamponade based on the AL.However,there was no statistically significant difference among Groups D,E,and F in terms of the results of sterile air or silicone oil tamponade.The mean recovery time was 5.9mo for MF patients subjected to silicone oil tamponade and 7.7mo for patients subjected to sterile air tamponade,and the difference was not statistically significant.CONCLUSION:PPV and ILM peeling combined with silicone oil or sterile air tamponade can achieve good results for MF in highly myopic eyes with ALs≤32 mm.展开更多
BACKGROUND Diabetic macular edema(DME),a chronic microvascular complication of diabetes,is a leading cause of visual impairment and blindness.Pars plana vitrectomy(PPV)can restore the normal macular structure and redu...BACKGROUND Diabetic macular edema(DME),a chronic microvascular complication of diabetes,is a leading cause of visual impairment and blindness.Pars plana vitrectomy(PPV)can restore the normal macular structure and reduce macular edema,whereas internal limiting membrane(ILM)peeling is used to treat tractional macular diseases.Despite the advantages,there is limited research on the combined effects of PPV with ILM peeling.AIM To observe the effects of PPV combined with ILM peeling on postoperative central macular thickness(CMT),best-corrected visual acuity(BCVA),cystoid macular edema(CME)volume,and complications in patients with DME.METHODS Eighty-one patients(92 eyes)diagnosed with DME at the Beijing Shanqu Liangxiang Hospital between January and December 2022 were randomly divided to undergo PPV alone(control group:41 patients,47 eyes)or PPV+ILM peeling(stripping group:40 patients,45 eyes);a single surgeon performed all surgeries.The two groups were compared preoperatively and 1 and 3 months postoperatively.RESULTS Preoperatively,both groups had comparable values of CMT,BCVA,and CME volume(P>0.05).After surgery(both 1 and 3 months),both groups showed significant reductions in CMT,BCVA,and CME volume compared to preoperative levels,with the stripping group showing more significant reductions compared to the control group(P<0.05).Further repeated-measures ANOVA analysis for within-group differences revealed significant effects of group and time,and interaction effects for CMT,BCVA,and CME volume(P<0.05).There were no significant differences in the incidence of complications between the groups(retinal detachment:control=2,stripping=1;endophthalmitis:Control=4,stripping=1;no cases of secondary glaucoma or macular holes;χ^(2)=0.296,P=0.587).CONCLUSION PPV with ILM peeling can significantly improve the visual acuity of patients with DME,reduce CMT,and improve CME with fewer complications.展开更多
This study evaluates the distribution of travel-limiting disabilities across genders and geographic locations in the United States. This study aims to describe and compare the socioeconomic and demographic variables o...This study evaluates the distribution of travel-limiting disabilities across genders and geographic locations in the United States. This study aims to describe and compare the socioeconomic and demographic variables of the people with and without travel-limiting disabilities across geographic locations and gender. The study further evaluates the trip purpose and impact of Covid-19 fourth wave pandemic on the use of public transit and travel to physical workplace for the people with and without travel-limiting disabilities across gender and geographic locations. The study uses the 2022 weighted National Household Travel Survey dataset and employs descriptive statistics. Results reaffirm the findings from previous literature that there are more people with travel-limiting disabilities in urban areas and among women. Over 50 percent of people aged 65 and above have a form of travel-limiting disabilities. The most trip for people with travel-limiting disabilities is made for shopping and medical purposes. Across all categories, rural areas, urban areas, male and female for the people without travel-limiting disabilities, COVID-19 fourth wave did not change the pattern of trips made to physical workplace as pre-COVID-19 era. This pattern is also observable for the people with travel-limiting disabilities in rural and urban areas. Females with travel-limiting disabilities reported making less trips to physical workplaces while male reported doing the same as before COVID-19 era. The study concludes that the quantification of travel-limiting disabilities across geographic location and gender is vital in disability study and could drive policy implementation for improved accessibility for the vulnerable population.展开更多
Expected to be of the highest survey power telescope in the northern hemisphere,the Wide Field Survey Telescope(WFST)will begin its routine observations of the northern sky since 2023.WFST will produce a lot of scient...Expected to be of the highest survey power telescope in the northern hemisphere,the Wide Field Survey Telescope(WFST)will begin its routine observations of the northern sky since 2023.WFST will produce a lot of scientific data to support the researches of time-domain astronomy,asteroids and the solar system,galaxy formation and cosmology and so on.We estimated that the 5σlimiting magnitudes of WFST with 30 s exposure are u=22.31mag,g=23.42 mag,r=22.95 mag,i=22.43 mag,z=21.50 mag,w=23.61 mag.The above values are calculated for the conditions of airmass=1.2,seeing=075,precipitable water vapor=2.5 mm and Moon-object separation=45°at the darkest New Moon night of the Lenghu site(V=22.30 mag,Moon phaseθ=0°).The limiting magnitudes in different Moon phase conditions are also calculated.The calculations are based on the empirical transmittance data of WFST optics,the vendor provided CCD quantum efficiency,the atmospherical model transmittance and spectrum of the site.In the absence of measurement data such as sky transmittance and spectrum,we use model data.展开更多
INTRODUCTION The Italian anatomist Filippo Pacini discovered the internal limiting membrane(ILM) in 1844[1]. The ILM is the basement membrane of the retinal Müller cells representing the structural interface betw...INTRODUCTION The Italian anatomist Filippo Pacini discovered the internal limiting membrane(ILM) in 1844[1]. The ILM is the basement membrane of the retinal Müller cells representing the structural interface between the retina and the vitreous. The macular ILM is thickest, measuring 2.5 μm and progressively thins to 0.5 μm at the vitreous base[2].展开更多
The author traces his experience with the application of computers in clinical microbiology over the past 60 years,specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the...The author traces his experience with the application of computers in clinical microbiology over the past 60 years,specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s)that could be used to treat those infections.Appropriate use of antibiotics will result in reduced antimicrobial resistance,which is increasing worldwide.An early form of AI,Mycin(1976),a system based on rules provided by experts designed to propose antibiotic regimens for central nervous system infections,was never applied due to the limitations in the number of rules that could be incorporated into the clinical workflow.Machine learning(ML)was developed to overcome the limitations of expert systems.Several variables that influence the outcome bacteria/drug interaction,such as the source of the infection,absence of antimicrobial resistance markers,patients’health profile,and the historical susceptibility within the hospital and the local area are incorporated in the proposed comprehensive AI/ML program.The role of AI in the discovery of new antimicrobial agents is also addressed.展开更多
We study the strong nonlinear optical dynamics of nanosecond pulsed Laguerre–Gaussian laser beams of high-order radial modes with zero orbital angular momentum propagating in the fullerene C60molecular medium. It is ...We study the strong nonlinear optical dynamics of nanosecond pulsed Laguerre–Gaussian laser beams of high-order radial modes with zero orbital angular momentum propagating in the fullerene C60molecular medium. It is found that the spatiotemporal profile of the incident pulsed Laguerre–Gaussian laser beam is strongly reshaped during its propagation in the C60molecular medium. The centrosymmetric temporal profile of the incident pulse gradually evolves into a noncentrosymmetric meniscus shape, and the on-axis pulse duration is clearly depressed. Furthermore, the field intensity is distinctly attenuated due to the field-intensity-dependent reverse saturable absorption, and clear optical power limiting behavior is observed for different orders of the input pulsed Laguerre–Gaussian laser beams before the takeover of the saturation effect;the lower the order of the Laguerre–Gaussian beam, the lower the energy transmittance.展开更多
This paper mainly analyzes the main limiting factors in the development of biological herbicides,such as narrow herbicidal spectrum,vulnerable to environmental impacts,difficulties in preparing dosage forms,difficult ...This paper mainly analyzes the main limiting factors in the development of biological herbicides,such as narrow herbicidal spectrum,vulnerable to environmental impacts,difficulties in preparing dosage forms,difficult separation and low yield of active substances,biological safety,etc.Moreover,countermeasures and suggestions are put forward,including strengthening the study of biological screening of herbicidal activity,microbial metabolites and their use as lead compounds,dosage forms,fungi complex formulation,fungi and herbicide complex formulation,and fermentation technology.展开更多
Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,t...Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,the failure mode and the earth pressure acting on the rigid retaining wall with EPS geofoam inclusions and granular backfills(henceforth referred to as EPS-wall),under limited surcharge loading are investigated through two-and three-dimensional model tests.The testing results show that different from the sliding of almost all the backfill in the EPS-wall under semi-infinite surcharge loading,only an approximately triangular backfill slides in the wall under limited surcharge loading.The distribution of the lateral earth pressure on the EPS-wall under limited surcharge loading is non-linear,and the distribution changes from the increase of the wall depth to the decrease with the increase of the limited surcharge loading.An approach based on the force equilibrium of a differential element is developed to predict the lateral earth pressure behind the EPS-wall subjected to limited surcharge loading,and its performance was fully validated by the three-dimensional model tests.展开更多
In this work,the microstructure,hydrogen storage properties,anti-oxide ability and rate limiting step of Zr(Cr_(1−x)Co_(x))_(2)(x=0,0.2,0.4 and 0.6)alloys have been investigated.After studying the crystal structure,we...In this work,the microstructure,hydrogen storage properties,anti-oxide ability and rate limiting step of Zr(Cr_(1−x)Co_(x))_(2)(x=0,0.2,0.4 and 0.6)alloys have been investigated.After studying the crystal structure,we found that all alloy samples could show C14-type phase but the alloy sample x=0 could also show a small amount of Cr phase.Rietveld fitting showed that lattice parameter and unit cell volume of C14-type phase decreased with increasing x.After further research,it was clear that the first hydrogen absorption capacity decreased with increasing x.But introducing more Co content had a positive influence on the effective hydrogen storage capacity and cyclic hydrogen absorption and desorption properties of the alloy sample.We also found that adding Co to ZrCr_(2)alloy could improve its anti-oxide ability.In addition to this,the rate limiting step model was also studied.展开更多
Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor materials.This capability may overcome the short-channel effect,sp...Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor materials.This capability may overcome the short-channel effect,sparking significant advancements in electronic devices that utilize 2D TMDs.Exploring the dimension and performance limits of transistors based on 2D TMDs has gained substantial importance.This review provides a comprehensive investigation into these limits of the single 2D-TMD transistor.It delves into the impacts of miniaturization,including the reduction of channel length,gate length,source/drain contact length,and dielectric thickness on transistor operation and performance.In addition,this review provides a detailed analysis of performance parameters such as source/drain contact resistance,subthreshold swing,hysteresis loop,carrier mobility,on/off ratio,and the development of p-type and single logic transistors.This review details the two logical expressions of the single 2D-TMD logic transistor,including current and voltage.It also emphasizes the role of 2D TMD-based transistors as memory devices,focusing on enhancing memory operation speed,endurance,data retention,and extinction ratio,as well as reducing energy consumption in memory devices functioning as artificial synapses.This review demonstrates the two calculating methods for dynamic energy consumption of 2D synaptic devices.This review not only summarizes the current state of the art in this field but also highlights potential future research directions and applications.It underscores the anticipated challenges,opportunities,and potential solutions in navigating the dimension and performance boundaries of 2D transistors.展开更多
Collisions between a moving mass and an anti-collision device increase structural responses and threaten structural safety.An active mass damper(AMD)with stroke limitations is often used to avoid collisions.However,a ...Collisions between a moving mass and an anti-collision device increase structural responses and threaten structural safety.An active mass damper(AMD)with stroke limitations is often used to avoid collisions.However,a strokelimited AMD control system with a fixed limited area shortens the available AMD stroke and leads to significant control power.To solve this problem,the design approach with variable gain and limited area(VGLA)is proposed in this study.First,the boundary of variable-limited areas is calculated based on the real-time status of the moving mass.The variable gain(VG)expression at the variable limited area is deduced by considering the saturation of AMD stroke.Then,numerical simulations of a stroke-limited AMD control system with VGLA are conducted on a high-rise building structure.These numerical simulations show that the proposed approach has superior strokelimitation performance compared with a stroke-limited AMD control system with a fixed limited area.Finally,the proposed approach is validated through experiments on a four-story steel frame.展开更多
I.SUPPLEMENTARY NOTE 1:THEORETICAL MATERIALS.The quantum speed limit(QSL)is essential for quantum computing and quantum communication,referring to the minimum time required for a quantum system to evolve from one stat...I.SUPPLEMENTARY NOTE 1:THEORETICAL MATERIALS.The quantum speed limit(QSL)is essential for quantum computing and quantum communication,referring to the minimum time required for a quantum system to evolve from one state to another.Two well-known forms of the QSL are the Mandelstam-Tamm(MT)relation TqsL≥πh/2△E[S1]and the Margolus-Levitin(ML)relation TqsL≥πh/2(E)[S2]where Tqst is denoted as the QSL time,h is the reduced Planck's constant,△E is the energy uncertainty(standard deviation)of the system,and(E)is the average energy of the system above its ground state.Both of relations provide a lower bound on the evolution time.展开更多
A hypothetical photon mass m_(γ) can produce a frequency-dependent vacuum dispersion of light, which leads to an additional time delay between photons with different frequencies when they propagate through a fixed di...A hypothetical photon mass m_(γ) can produce a frequency-dependent vacuum dispersion of light, which leads to an additional time delay between photons with different frequencies when they propagate through a fixed distance. The dispersion measure and redshift measurements of fast radio bursts(FRBs) have been widely used to constrain the rest mass of the photon. However, all current studies analyzed the effect of the frequency-dependent dispersion for massive photons in the standard ΛCDM cosmological context. In order to alleviate the circularity problem induced by the presumption of a specific cosmological model based on the fundamental postulate of the masslessness of photons, here we employ a new model-independent smoothing technique, artificial neural network(ANN), to reconstruct the Hubble parameter H(z) function from 34 cosmic-chronometer measurements.By combining observations of 32 well-localized FRBs and the H(z) function reconstructed by ANN, we obtain an upper limit of m_(γ) ≤ 3.5 × 10^(-51)kg, or equivalently m_(γ) ≤ 2.0 × 10^(-15)eV/c^(2)(m_(γ) ≤ 6.5 × 10^(-51)kg, or equivalently m_(γ) ≤ 3.6 × 10^(-15)eV/c_(2)) at the 1σ(2σ) confidence level. This is the first cosmology-independent photon mass limit derived from extragalactic sources.展开更多
Speed limit measures are ubiquitous due to the complexity of the road environment,which can be supplied with the help of vehicle to everything(V2X)communication technology.Therefore,the influence of speed limit on tra...Speed limit measures are ubiquitous due to the complexity of the road environment,which can be supplied with the help of vehicle to everything(V2X)communication technology.Therefore,the influence of speed limit on traffic system will be investigated to construct a two-lane lattice model accounting for the speed limit effect during the lane change process under V2X environment.Accordingly,the stability condition and the mKdV equation are closely associated with the speed limit effect through theory analysis.Moreover,the evolution of density and hysteresis loop is simulated to demonstrate the positive role of the speed limit effect on traffic stability in the cases of strong reaction intensity and high limited speed.展开更多
Phaeocystis globosa is an important unicellular eukaryotic alga that can also form colonies.P.globosa can cause massive harmful algal blooms and plays an important role in the global carbon or sulfur cycling.Thus far,...Phaeocystis globosa is an important unicellular eukaryotic alga that can also form colonies.P.globosa can cause massive harmful algal blooms and plays an important role in the global carbon or sulfur cycling.Thus far,the ecophysiology of P.globosa has been investigated by numerous studies.However,the proteomic response of P.globosa to nitrogen depletion remains largely unknown.We compared four protein preparation methods of P.globosa for two-dimensional electrophoresis(2-DE)(Urea/Triton X-100 with trichloroacetic acid(TCA)/acetone precipitation;TCA/acetone precipitation;Radio Immuno Precipitation Assay(RIPA)with TCA/acetone precipitation;and Tris buffer).Results show that the combination of RIPA with TCA/acetone precipitation had a clear gel background and showed the best protein spot separation effect,based on which the proteomic response to nitrogen depletion was studied using 2-DE.In addition,we identified six differentially expressed proteins whose relative abundance increased or decreased more than 1.5-fold(P<0.05).Most proteins could not be identified,which might be attributed to the lack of genomic sequences of P.globosa.Under nitrogen limitation,replication protein-like,RNA ligase,and sn-glycerol-3-phosphate dehydrogenase were reduced,which may decrease the DNA replication level and ATP production in P.globosa cells.The increase of endonucleaseⅢand transcriptional regulator enzyme may affect the metabolic and antioxidant function of P.globosa cells and induce cell apoptosis.These findings provide a basis for further proteomic study of P.globosa and the optimization of protein preparation methods of marine microalgae.展开更多
A seismic-induced landslide is a common geological catastrophe that occurs in nature.The Wangjiayan landslide,which was triggered by the Wenchuan earthquake,is a typical case in point.The Wanjiayan landslide caused ma...A seismic-induced landslide is a common geological catastrophe that occurs in nature.The Wangjiayan landslide,which was triggered by the Wenchuan earthquake,is a typical case in point.The Wanjiayan landslide caused many casualties and resulted in enormous property loss.This study constructs a simple surficial failure model based on the upper bound approach of three-dimensional(3D)limit analysis to evaluate the slope stability of the Wangjiayan case,while a traditional two-dimensional(2D)analysis is also conducted as a reference for comparison with the results of the 3D analysis.A quasi-static calculation is used to study the effect of the earthquake in terms of horizontal ground acceleration,while a parametric study is conducted to evaluate the critical cohesion of slopes.Rather than employing a 3D analysis,using the 2D analysis yields an underestimation regarding the safety factor.In the Wangjiayan landslide,the difference in the factors of safety between the 3D and 2D analyses can reach 20%.The sliding surface morphology as determined by the 3D method is similar to actual morphology,and the parameters of both are also compared to analyze the reliability of the proposed 3D method.展开更多
This paper deals with the problem of limit cycles for the whirling pendulum equation x=y,y=sin x(cosx-r)under piecewise smooth perturbations of polynomials of cos x,sin x and y of degree n with the switching line x=0....This paper deals with the problem of limit cycles for the whirling pendulum equation x=y,y=sin x(cosx-r)under piecewise smooth perturbations of polynomials of cos x,sin x and y of degree n with the switching line x=0.The upper bounds of the number of limit cycles in both the oscillatory and the rotary regions are obtained using the Picard-Fuchs equations,which the generating functions of the associated first order Melnikov functions satisfy.Furthermore,the exact bound of a special case is given using the Chebyshev system.At the end,some numerical simulations are given to illustrate the existence of limit cycles.展开更多
The sinking of diatoms is critic al to the formation of oceanic biological pumps and coastal hypoxic zones.However,little is known about the effects of different nutrient restrictions on diatom sinking.In this study,w...The sinking of diatoms is critic al to the formation of oceanic biological pumps and coastal hypoxic zones.However,little is known about the effects of different nutrient restrictions on diatom sinking.In this study,we measured the sinking velocity(SV) of Thalassiosira weissflogii using a new phytoplankton video observation instrument and analyzed major biochemical components under varying nutrient conditions.Our results showed that the SV of T.weissflogii under different nutrient limitation conditions varied substantially.The highest SV of(1.77±0.02) m/d was obtained under nitrate limitation,signific antly surpassing that under phosphate limitation at(0.98±0.13) m/d.As the nutrient limitation was released,the SV steadily decreased to(0.32±0.03) m/d and(0.15±0.05) m/d,respectively.Notably;under conditions with limited nitrate and phosphate concentrations,the SV values of T.weissflogii significantly positively correlated with the lipid content(P <0.001),with R^(2) values of 0.86 and 0.69,respectively.The change of the phytoplankton SV was primarily related to the intracellular compo sition,which is controlled by nutrient conditions but did not significantly correlate with transparent extracellular polymer and biosilica contents.The results of this study help to understand the regulation of the vertical sinking process of diatoms by nutrient restriction and provide new insights into phytoplankton dynamics and their relationship with the marine nutrient structure.展开更多
基金supported by the National Natural Science Foundation of China under Grant Nos.92252201 and 11721202support by the Laboratory of Aerodynamic Noise Control under Grant No.2301ANCL20230303 and the Fundamental Research Funds for the Central Universities.
文摘Shock waves,characterized by abrupt changes in pressure,temperature,and density,play a significant role in various materials science processes involving fluids.These high-energy phenomena are utilized across multiple fields and applications to achieve unique material properties and facilitate advanced manufacturing techniques.Accurate simulations of these phenomena require numerical schemes that can represent shock waves without spurious oscillations and simultaneously capture acoustic waves for a wide range of wavelength scales.This work suggests a high-order discontinuous Galerkin(DG)method with a finite volume(FV)subcell limiting strategies to achieve better subcell resolution and lower numerical diffusion properties.By switching to the FV discretization on an embedded sub-cell grid,the method displays advantages with respect to both DG accuracy and FV shock-capturing ability.The FV scheme utilizes a class of high-fidelity schemes that are built upon the boundary variation diminishing(BVD)reconstruction paradigm.The method is therefore able to resolve discontinuities and multi-scale structures on the subcell level,while preserving the favorable properties of the high-order DG scheme.We have tested the present DG method up to the 6th-order accuracy for both smooth and discontinuous noise problems.
基金Supported by the Natural Science Basic Research Program in Shaanxi Province(No.2020JM-683).
文摘AIM:To compare the efficacy of pars plana vitrectomy(PPV)combined with internal limiting membrane(ILM)and silicone oil or sterile air tamponade for the treatment of myopic foveoschisis(MF)in highly myopic eyes.METHODS:This retrospective study included 48 myopic eyes of 40 patients with MF and axial lengths(ALs)ranging from 26-32 mm treated between January 2020 and January 2022.All patients were underwent PPV combined with ILM peeling followed by sterile air or silicone oil tamponade and followed up at least 12mo.Based on the features on spectral-domain optical coherence tomography(SD-OCT),the eyes were divided into the MF-only group(Group A,n=15 eyes),MF with central foveal detachment group(Group B,n=20 eyes),and MF with lamellar macular hole group(Group C,n=13 eyes).According to AL,eyes were further divided into three groups:Group D(26.01-28.00 mm,n=12 eyes),Group E(28.01-30.00 mm,n=26 eyes),and Group F(30.01-32.00 mm,n=10 eyes).The best-corrected visual acuity(BCVA),central foveal thickness(CFT),and complications were recorded.RESULTS:The patients included 16 males and 24 females with the mean age of 56±9.82y.The BCVA and CFT improved in all groups after surgery(P<0.01),while there was no significant difference of the CFT in Group A,B,and C postoperatively(P>0.05).The intergroup differences of BCVA and CFT postoperatively were statistically significant in Group D,E,and F.Twenty eyes were injected with sterile air,and 28 eyes were injected with silicone oil for tamponade based on the AL.However,there was no statistically significant difference among Groups D,E,and F in terms of the results of sterile air or silicone oil tamponade.The mean recovery time was 5.9mo for MF patients subjected to silicone oil tamponade and 7.7mo for patients subjected to sterile air tamponade,and the difference was not statistically significant.CONCLUSION:PPV and ILM peeling combined with silicone oil or sterile air tamponade can achieve good results for MF in highly myopic eyes with ALs≤32 mm.
基金Youth Project of Liangxiang Hospital Fangshan District Beijing,No.2022-11.
文摘BACKGROUND Diabetic macular edema(DME),a chronic microvascular complication of diabetes,is a leading cause of visual impairment and blindness.Pars plana vitrectomy(PPV)can restore the normal macular structure and reduce macular edema,whereas internal limiting membrane(ILM)peeling is used to treat tractional macular diseases.Despite the advantages,there is limited research on the combined effects of PPV with ILM peeling.AIM To observe the effects of PPV combined with ILM peeling on postoperative central macular thickness(CMT),best-corrected visual acuity(BCVA),cystoid macular edema(CME)volume,and complications in patients with DME.METHODS Eighty-one patients(92 eyes)diagnosed with DME at the Beijing Shanqu Liangxiang Hospital between January and December 2022 were randomly divided to undergo PPV alone(control group:41 patients,47 eyes)or PPV+ILM peeling(stripping group:40 patients,45 eyes);a single surgeon performed all surgeries.The two groups were compared preoperatively and 1 and 3 months postoperatively.RESULTS Preoperatively,both groups had comparable values of CMT,BCVA,and CME volume(P>0.05).After surgery(both 1 and 3 months),both groups showed significant reductions in CMT,BCVA,and CME volume compared to preoperative levels,with the stripping group showing more significant reductions compared to the control group(P<0.05).Further repeated-measures ANOVA analysis for within-group differences revealed significant effects of group and time,and interaction effects for CMT,BCVA,and CME volume(P<0.05).There were no significant differences in the incidence of complications between the groups(retinal detachment:control=2,stripping=1;endophthalmitis:Control=4,stripping=1;no cases of secondary glaucoma or macular holes;χ^(2)=0.296,P=0.587).CONCLUSION PPV with ILM peeling can significantly improve the visual acuity of patients with DME,reduce CMT,and improve CME with fewer complications.
文摘This study evaluates the distribution of travel-limiting disabilities across genders and geographic locations in the United States. This study aims to describe and compare the socioeconomic and demographic variables of the people with and without travel-limiting disabilities across geographic locations and gender. The study further evaluates the trip purpose and impact of Covid-19 fourth wave pandemic on the use of public transit and travel to physical workplace for the people with and without travel-limiting disabilities across gender and geographic locations. The study uses the 2022 weighted National Household Travel Survey dataset and employs descriptive statistics. Results reaffirm the findings from previous literature that there are more people with travel-limiting disabilities in urban areas and among women. Over 50 percent of people aged 65 and above have a form of travel-limiting disabilities. The most trip for people with travel-limiting disabilities is made for shopping and medical purposes. Across all categories, rural areas, urban areas, male and female for the people without travel-limiting disabilities, COVID-19 fourth wave did not change the pattern of trips made to physical workplace as pre-COVID-19 era. This pattern is also observable for the people with travel-limiting disabilities in rural and urban areas. Females with travel-limiting disabilities reported making less trips to physical workplaces while male reported doing the same as before COVID-19 era. The study concludes that the quantification of travel-limiting disabilities across geographic location and gender is vital in disability study and could drive policy implementation for improved accessibility for the vulnerable population.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(grant Nos.XDB 41000000 and XDB 41010105)the National Science Foundation of China(NSFC,grant Nos.12233008,12173037 and 11973038)+1 种基金the China Manned Space Project(No.CMS-CSST-2021-A07)the Cyrus Chun Ying Tang Foundations。
文摘Expected to be of the highest survey power telescope in the northern hemisphere,the Wide Field Survey Telescope(WFST)will begin its routine observations of the northern sky since 2023.WFST will produce a lot of scientific data to support the researches of time-domain astronomy,asteroids and the solar system,galaxy formation and cosmology and so on.We estimated that the 5σlimiting magnitudes of WFST with 30 s exposure are u=22.31mag,g=23.42 mag,r=22.95 mag,i=22.43 mag,z=21.50 mag,w=23.61 mag.The above values are calculated for the conditions of airmass=1.2,seeing=075,precipitable water vapor=2.5 mm and Moon-object separation=45°at the darkest New Moon night of the Lenghu site(V=22.30 mag,Moon phaseθ=0°).The limiting magnitudes in different Moon phase conditions are also calculated.The calculations are based on the empirical transmittance data of WFST optics,the vendor provided CCD quantum efficiency,the atmospherical model transmittance and spectrum of the site.In the absence of measurement data such as sky transmittance and spectrum,we use model data.
文摘INTRODUCTION The Italian anatomist Filippo Pacini discovered the internal limiting membrane(ILM) in 1844[1]. The ILM is the basement membrane of the retinal Müller cells representing the structural interface between the retina and the vitreous. The macular ILM is thickest, measuring 2.5 μm and progressively thins to 0.5 μm at the vitreous base[2].
文摘The author traces his experience with the application of computers in clinical microbiology over the past 60 years,specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s)that could be used to treat those infections.Appropriate use of antibiotics will result in reduced antimicrobial resistance,which is increasing worldwide.An early form of AI,Mycin(1976),a system based on rules provided by experts designed to propose antibiotic regimens for central nervous system infections,was never applied due to the limitations in the number of rules that could be incorporated into the clinical workflow.Machine learning(ML)was developed to overcome the limitations of expert systems.Several variables that influence the outcome bacteria/drug interaction,such as the source of the infection,absence of antimicrobial resistance markers,patients’health profile,and the historical susceptibility within the hospital and the local area are incorporated in the proposed comprehensive AI/ML program.The role of AI in the discovery of new antimicrobial agents is also addressed.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11974108 and 11574082)Fundamental Research Funds for the Central Universities (Grant No. 2021MS046)the Natural Science Foundation of Shandong Province, China (Grant No. ZR2019MA020)。
文摘We study the strong nonlinear optical dynamics of nanosecond pulsed Laguerre–Gaussian laser beams of high-order radial modes with zero orbital angular momentum propagating in the fullerene C60molecular medium. It is found that the spatiotemporal profile of the incident pulsed Laguerre–Gaussian laser beam is strongly reshaped during its propagation in the C60molecular medium. The centrosymmetric temporal profile of the incident pulse gradually evolves into a noncentrosymmetric meniscus shape, and the on-axis pulse duration is clearly depressed. Furthermore, the field intensity is distinctly attenuated due to the field-intensity-dependent reverse saturable absorption, and clear optical power limiting behavior is observed for different orders of the input pulsed Laguerre–Gaussian laser beams before the takeover of the saturation effect;the lower the order of the Laguerre–Gaussian beam, the lower the energy transmittance.
文摘This paper mainly analyzes the main limiting factors in the development of biological herbicides,such as narrow herbicidal spectrum,vulnerable to environmental impacts,difficulties in preparing dosage forms,difficult separation and low yield of active substances,biological safety,etc.Moreover,countermeasures and suggestions are put forward,including strengthening the study of biological screening of herbicidal activity,microbial metabolites and their use as lead compounds,dosage forms,fungi complex formulation,fungi and herbicide complex formulation,and fermentation technology.
基金funding support from National Natural Science Foundation of China(Grant No.52179109)Jiangsu Provincial Natural Science Foundation(Grant No.BK20230967)Open Research Fund of State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures,Shijiazhuang Tiedao University(Grant No.KF2022-02).
文摘Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,the failure mode and the earth pressure acting on the rigid retaining wall with EPS geofoam inclusions and granular backfills(henceforth referred to as EPS-wall),under limited surcharge loading are investigated through two-and three-dimensional model tests.The testing results show that different from the sliding of almost all the backfill in the EPS-wall under semi-infinite surcharge loading,only an approximately triangular backfill slides in the wall under limited surcharge loading.The distribution of the lateral earth pressure on the EPS-wall under limited surcharge loading is non-linear,and the distribution changes from the increase of the wall depth to the decrease with the increase of the limited surcharge loading.An approach based on the force equilibrium of a differential element is developed to predict the lateral earth pressure behind the EPS-wall subjected to limited surcharge loading,and its performance was fully validated by the three-dimensional model tests.
基金supported by Natural Science Foundation of Jiangxi Province(20202BABL214003)Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation(JXMS202008 and JXMS202009)+4 种基金Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices(PMND201902)Engineering Research Center of Nuclear Technology Application(East China University of Technology)Ministry of Education(HJSJYB2019–5)Science and Technology Project Founded by Education Department of Jiangxi Province(GJJ190406)Research Foundation for Advanced Talents of East China University of Technology(DHBK2019091).
文摘In this work,the microstructure,hydrogen storage properties,anti-oxide ability and rate limiting step of Zr(Cr_(1−x)Co_(x))_(2)(x=0,0.2,0.4 and 0.6)alloys have been investigated.After studying the crystal structure,we found that all alloy samples could show C14-type phase but the alloy sample x=0 could also show a small amount of Cr phase.Rietveld fitting showed that lattice parameter and unit cell volume of C14-type phase decreased with increasing x.After further research,it was clear that the first hydrogen absorption capacity decreased with increasing x.But introducing more Co content had a positive influence on the effective hydrogen storage capacity and cyclic hydrogen absorption and desorption properties of the alloy sample.We also found that adding Co to ZrCr_(2)alloy could improve its anti-oxide ability.In addition to this,the rate limiting step model was also studied.
基金supported by the National Key R&D Plan of China(Grant 2021YFB3600703)the National Natural Science Foundation(Grant 62204137)of China for Youth,the Open Research Fund Program of Beijing National Research Centre for Information Science and Technology(BR2023KF02009)+1 种基金the National Natural Science Foundation of china(U20A20168,61874065,and 51861145202)the Research Fund from Tsinghua University Initiative Scientific Research Program,the Center for Flexible Electronics Technology of Tsinghua University,and a grant from the Guoqiang Institute,Tsinghua University.
文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor materials.This capability may overcome the short-channel effect,sparking significant advancements in electronic devices that utilize 2D TMDs.Exploring the dimension and performance limits of transistors based on 2D TMDs has gained substantial importance.This review provides a comprehensive investigation into these limits of the single 2D-TMD transistor.It delves into the impacts of miniaturization,including the reduction of channel length,gate length,source/drain contact length,and dielectric thickness on transistor operation and performance.In addition,this review provides a detailed analysis of performance parameters such as source/drain contact resistance,subthreshold swing,hysteresis loop,carrier mobility,on/off ratio,and the development of p-type and single logic transistors.This review details the two logical expressions of the single 2D-TMD logic transistor,including current and voltage.It also emphasizes the role of 2D TMD-based transistors as memory devices,focusing on enhancing memory operation speed,endurance,data retention,and extinction ratio,as well as reducing energy consumption in memory devices functioning as artificial synapses.This review demonstrates the two calculating methods for dynamic energy consumption of 2D synaptic devices.This review not only summarizes the current state of the art in this field but also highlights potential future research directions and applications.It underscores the anticipated challenges,opportunities,and potential solutions in navigating the dimension and performance boundaries of 2D transistors.
基金This research was founded by the Funds for Creative Research Groups of National Natural Science Foundation of China(Grant No.51921006)the National Natural Science Foundations of China(Grant No.51978224)+2 种基金the National Major Scientific Research Instrument Development Program of China(Grant No.51827811)the National Natural Science Foundation of China,(Grant No.52008141)the Shenzhen Technology Innovation Program(Grant Nos.JCYJ20170811160003571,JCYJ20180508152238111 and JCYJ20200109112803851).
文摘Collisions between a moving mass and an anti-collision device increase structural responses and threaten structural safety.An active mass damper(AMD)with stroke limitations is often used to avoid collisions.However,a strokelimited AMD control system with a fixed limited area shortens the available AMD stroke and leads to significant control power.To solve this problem,the design approach with variable gain and limited area(VGLA)is proposed in this study.First,the boundary of variable-limited areas is calculated based on the real-time status of the moving mass.The variable gain(VG)expression at the variable limited area is deduced by considering the saturation of AMD stroke.Then,numerical simulations of a stroke-limited AMD control system with VGLA are conducted on a high-rise building structure.These numerical simulations show that the proposed approach has superior strokelimitation performance compared with a stroke-limited AMD control system with a fixed limited area.Finally,the proposed approach is validated through experiments on a four-story steel frame.
基金supported by the National Natural Science Foundation of China(Grant Nos.92165206 and 11974330)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301603)the Fundamental Research Funds for the Central Universities。
文摘I.SUPPLEMENTARY NOTE 1:THEORETICAL MATERIALS.The quantum speed limit(QSL)is essential for quantum computing and quantum communication,referring to the minimum time required for a quantum system to evolve from one state to another.Two well-known forms of the QSL are the Mandelstam-Tamm(MT)relation TqsL≥πh/2△E[S1]and the Margolus-Levitin(ML)relation TqsL≥πh/2(E)[S2]where Tqst is denoted as the QSL time,h is the reduced Planck's constant,△E is the energy uncertainty(standard deviation)of the system,and(E)is the average energy of the system above its ground state.Both of relations provide a lower bound on the evolution time.
基金supported by the National SKA Program of China (2022SKA0130100)the National Natural Science Foundation of China (Grant Nos. 12373053, 12321003, and 12041306)+4 种基金the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (Grant No. ZDBSLY-7014)the International Partnership Program of Chinese Academy of Sciences for Grand Challenges (Grant No. 114332KYSB20210018)the CAS Project for Young Scientists in Basic Research (Grant No. YSBR-063)the CAS Organizational Scientific Research Platform for National Major Scientific and Technological Infrastructure: Cosmic Transients with FASTthe Natural Science Foundation of Jiangsu Province (Grant No. BK20221562)。
文摘A hypothetical photon mass m_(γ) can produce a frequency-dependent vacuum dispersion of light, which leads to an additional time delay between photons with different frequencies when they propagate through a fixed distance. The dispersion measure and redshift measurements of fast radio bursts(FRBs) have been widely used to constrain the rest mass of the photon. However, all current studies analyzed the effect of the frequency-dependent dispersion for massive photons in the standard ΛCDM cosmological context. In order to alleviate the circularity problem induced by the presumption of a specific cosmological model based on the fundamental postulate of the masslessness of photons, here we employ a new model-independent smoothing technique, artificial neural network(ANN), to reconstruct the Hubble parameter H(z) function from 34 cosmic-chronometer measurements.By combining observations of 32 well-localized FRBs and the H(z) function reconstructed by ANN, we obtain an upper limit of m_(γ) ≤ 3.5 × 10^(-51)kg, or equivalently m_(γ) ≤ 2.0 × 10^(-15)eV/c^(2)(m_(γ) ≤ 6.5 × 10^(-51)kg, or equivalently m_(γ) ≤ 3.6 × 10^(-15)eV/c_(2)) at the 1σ(2σ) confidence level. This is the first cosmology-independent photon mass limit derived from extragalactic sources.
基金Project supported by the Guangxi Natural Science Foundation,China(Grant No.2022GXNSFDA035080)the Central Government Guidance Funds for Local Scientific and Technological Development,China(Grant No.Guike ZY22096024)the National Natural Science Foundation,China(Grant No.61963008).
文摘Speed limit measures are ubiquitous due to the complexity of the road environment,which can be supplied with the help of vehicle to everything(V2X)communication technology.Therefore,the influence of speed limit on traffic system will be investigated to construct a two-lane lattice model accounting for the speed limit effect during the lane change process under V2X environment.Accordingly,the stability condition and the mKdV equation are closely associated with the speed limit effect through theory analysis.Moreover,the evolution of density and hysteresis loop is simulated to demonstrate the positive role of the speed limit effect on traffic stability in the cases of strong reaction intensity and high limited speed.
基金the National Natural Science Foundation of China(Nos.42176142,41906111,41806127)the Marine Economic Development Project of Guangdong Province(No.2023B1111050011)+1 种基金the Basic and Applied Basic Research Project of Guangzhou(Nos.2023A04J1548,2023A04J1549)the Outstanding Innovative Talents Cultivation Funded Programs for Doctoral Students of Jinan University(No.2021CXB010)。
文摘Phaeocystis globosa is an important unicellular eukaryotic alga that can also form colonies.P.globosa can cause massive harmful algal blooms and plays an important role in the global carbon or sulfur cycling.Thus far,the ecophysiology of P.globosa has been investigated by numerous studies.However,the proteomic response of P.globosa to nitrogen depletion remains largely unknown.We compared four protein preparation methods of P.globosa for two-dimensional electrophoresis(2-DE)(Urea/Triton X-100 with trichloroacetic acid(TCA)/acetone precipitation;TCA/acetone precipitation;Radio Immuno Precipitation Assay(RIPA)with TCA/acetone precipitation;and Tris buffer).Results show that the combination of RIPA with TCA/acetone precipitation had a clear gel background and showed the best protein spot separation effect,based on which the proteomic response to nitrogen depletion was studied using 2-DE.In addition,we identified six differentially expressed proteins whose relative abundance increased or decreased more than 1.5-fold(P<0.05).Most proteins could not be identified,which might be attributed to the lack of genomic sequences of P.globosa.Under nitrogen limitation,replication protein-like,RNA ligase,and sn-glycerol-3-phosphate dehydrogenase were reduced,which may decrease the DNA replication level and ATP production in P.globosa cells.The increase of endonucleaseⅢand transcriptional regulator enzyme may affect the metabolic and antioxidant function of P.globosa cells and induce cell apoptosis.These findings provide a basis for further proteomic study of P.globosa and the optimization of protein preparation methods of marine microalgae.
基金National Natural Science Foundation of China under Grant Nos.52378335 and 52322808.
文摘A seismic-induced landslide is a common geological catastrophe that occurs in nature.The Wangjiayan landslide,which was triggered by the Wenchuan earthquake,is a typical case in point.The Wanjiayan landslide caused many casualties and resulted in enormous property loss.This study constructs a simple surficial failure model based on the upper bound approach of three-dimensional(3D)limit analysis to evaluate the slope stability of the Wangjiayan case,while a traditional two-dimensional(2D)analysis is also conducted as a reference for comparison with the results of the 3D analysis.A quasi-static calculation is used to study the effect of the earthquake in terms of horizontal ground acceleration,while a parametric study is conducted to evaluate the critical cohesion of slopes.Rather than employing a 3D analysis,using the 2D analysis yields an underestimation regarding the safety factor.In the Wangjiayan landslide,the difference in the factors of safety between the 3D and 2D analyses can reach 20%.The sliding surface morphology as determined by the 3D method is similar to actual morphology,and the parameters of both are also compared to analyze the reliability of the proposed 3D method.
基金supported by the Natural Science Foundation of Ningxia(2022AAC05044)the National Natural Science Foundation of China(12161069)。
文摘This paper deals with the problem of limit cycles for the whirling pendulum equation x=y,y=sin x(cosx-r)under piecewise smooth perturbations of polynomials of cos x,sin x and y of degree n with the switching line x=0.The upper bounds of the number of limit cycles in both the oscillatory and the rotary regions are obtained using the Picard-Fuchs equations,which the generating functions of the associated first order Melnikov functions satisfy.Furthermore,the exact bound of a special case is given using the Chebyshev system.At the end,some numerical simulations are given to illustrate the existence of limit cycles.
基金The Key R&D Program of Zhejiang under contract No.2023C03120the Science Foundation of Donghai Laboratory under contract No.DH-2022KF0215+2 种基金the National Key Research and Development Program of China under contract No.2021YFC3101702the National Programme on Global Change and Air-Sea Interaction (PhaseⅡ)—Hypoxia and Acidification Monitoring Warning Project in the Changjiang EstuaryLong-term Observation and Research Plan in the Changjiang Estuary and Adjacent East China Sea (LORCE) Project under contract No.SZ2001。
文摘The sinking of diatoms is critic al to the formation of oceanic biological pumps and coastal hypoxic zones.However,little is known about the effects of different nutrient restrictions on diatom sinking.In this study,we measured the sinking velocity(SV) of Thalassiosira weissflogii using a new phytoplankton video observation instrument and analyzed major biochemical components under varying nutrient conditions.Our results showed that the SV of T.weissflogii under different nutrient limitation conditions varied substantially.The highest SV of(1.77±0.02) m/d was obtained under nitrate limitation,signific antly surpassing that under phosphate limitation at(0.98±0.13) m/d.As the nutrient limitation was released,the SV steadily decreased to(0.32±0.03) m/d and(0.15±0.05) m/d,respectively.Notably;under conditions with limited nitrate and phosphate concentrations,the SV values of T.weissflogii significantly positively correlated with the lipid content(P <0.001),with R^(2) values of 0.86 and 0.69,respectively.The change of the phytoplankton SV was primarily related to the intracellular compo sition,which is controlled by nutrient conditions but did not significantly correlate with transparent extracellular polymer and biosilica contents.The results of this study help to understand the regulation of the vertical sinking process of diatoms by nutrient restriction and provide new insights into phytoplankton dynamics and their relationship with the marine nutrient structure.