Assessment of posterior vitreous detachment on enhanced high density line optical coherence tomography

The state of the vitreo-retinal interface affects various retinal diseases, and the presence or absence of a posterior vitreous detachment （PVD） is one of the most important factors. As such, various studies studying PVD in relation to retinal disease have been performed.

Systematic variation in observing altitude of enhanced ion line by the pump near fifth gyroharmonic

The observation of ultra high frequency radar during an ionospheric experiment carrying out at the European Incoherent Scatter Scientific Association, demonstrates a systematic variation in the altitude of the pump enhanced ion line, which is quite remarkably dependent on the pump frequency, that is, when the pump frequency sweeps above the fifth gyroharrnonic, the altitude of the enhanced ion line is ～3 to ～6 kin lower than that at the pump frequency very close to the fifth gyroharmonic. The analysis shows that the systematic variation in the altitude of the pump enhanced ion line is principally dependent on the enhanced electron temperature, although the changes in the profile of the electron density brought about by the ionospheric heating are not independent of those systematic altitude variations.

Line Spectrum Enhancement of Underwater Acoustic Signals Using Kalman Filter

To detect weak underwater acoustic signals radiated by submarines and other underwater equipment,an effective line spectrum enhancement algorithm based on Kalman filter and FFT processing is proposed.The proposed algorithm first determines the frequency components of the weak underwater signal and then filters the signal to enhance the line spectrum,thereby improving the signal-to-noise ratio(SNR).This paper discussed two cases:one is a simulated signal consisting of a dual-frequency sinusoidal periodic signal and Gaussian white noise,and the signal is received after passing through a Rayleigh fading channel;the other is a ship signal recorded from the South China Sea.The results show that the line spectrum of the underwater acoustic signal could be effectively enhanced in both cases,and the filtered waveform is smoother.The analysis of simulated signals and ship signal reflects the effectiveness of the proposed algorithm.

Chip Layout for Adaptive Line Enhancer Design using Adaptive Filtering Algorithms and Metrics Computation for Auscultation Signal Separation

Currently,the growth of micro and nano(very large scale integration-ultra large-scale integration)electronics technology has greatly impacted biomedical signal processing devices.These high-speed micro and nano technology devices are very reliable despite their capacity to operate at tremendous speed,and can be designed to consume less power in minimum response time,which is particularly useful in biomedical products.The rapid technological scaling of the metal-oxide-semi-conductor(MOS)devices aids in mapping multiple applications for a specific purpose on a single chip which motivates us to design a sophisticated,small and reliable application specific integrated circuit(ASIC)chip for future real time medical signal separation and processing(digital stetho-scopes and digital microelectromechanical systems(MEMS)microphone).In this paper,ASIC level implementation of the adaptive line enhancer design using adaptive filtering algorithms(least mean square(LMS)and normalized least mean square(NLMS))integrated design is used to separate the real-time auscultation sound signals effectively.Adaptive line enhancer(ALE)design is imple-mented in Verilog hardware description language(HDL)language to obtain both the network and adaptive algorithm in cadence Taiwan Semiconductor Manufacturing Company(TSMC)90 nm standard cell library environment for ASIC level implementation.Native compiled simulator(NC)sim and RC lab were used for functional verification and design constraints and the physical design is implemented in Encounter to obtain the Geometric Data Stream(GDS II).In this architecture,the area occupied is 0.08 mm,the total power consumed is 5.05 mW and the computation time of the proposed system is 0.82μs for LMS design and the area occupied is 0.14 mm,the total power consumed is 4.54 mW and the computation time of the proposed system is 0.03μs for NLMS design that will pave a better way in future electronic stethoscope design.

The labeling of C57BL/6j derived embryonic stem cells with enhanced green fluorescent protein

Objective To labele MESPU35, a embryonic stem (ES) cell line derived from C57BL/6j mouse, with enhanced green fluorescent protein (EGFP) for further application.Methods The EGFP gene was controlled by the hybrid CA promoter/enhancer (CMV enhancer/ chicken beta-actin promoter/ beta-actin intron) to construct the vector of the transgene, pCA-EGFP. The vector was transfected into MESPU35 by electroporation.Results We generated EGFP expressing ES cells demonstrating normal properties. The green fluorescence of EGFP expressing cells was maintained in propagation of the ES cells for more than 30 passages as well as in differentiated cells. Cultured in suspension, the 'green' ES cells aggregated, and formed embryoid bodies maintaining the green fluorescence at varying developmental stages. The 'green' embryoid bodies could expand and differentiate into various types of cells, exhibiting ubiquitous green fluorescence. Conclusions The hybrid CA promoter/enhancer used to control the EGFP expressing ES cells, resulted in more intense and ubiquitous activity. The EGFP transfected cells yield bright green fluorescence, which can be visualized in real time and in situ. In addition, the ES cells, MESPU35, are derived from C57BL/6j mice, which are the most widely used in oncology, physiology and genetics. Compared to 129 substrains, C57BL/6j mice avoid a number of potential problems apparent in the other strains.

An improvement of adaptive line enhancer by means of coherent accumulation algorithm

It is well known that the adaptive line enhancer (ALE) is effective detector of CW signal with unknown frequency in the background of white noise. The system processing gain of ALE, when the LMS algorithm is used, however, is not satisfactory because of the presence of iterative noise and weight noise. In this paper, the coherent accumulation algorithm of ALE, called as ALECA, is suggested. It is shown that the adaptive filter employing this new algorithm possesses the ARMA structure. The experimental results also show that the processing gain of ALECA is about 14dB higher than that of conventional ALE.