The therapeutic options for patients with metastatic renal cell carcinoma(mRCC) have completely changed during the last ten years. With the sequential use of targeted therapies, median overall survival has increased i...The therapeutic options for patients with metastatic renal cell carcinoma(mRCC) have completely changed during the last ten years. With the sequential use of targeted therapies, median overall survival has increased in daily practice and now it is not uncommon to see patients surviving kidney cancer for more than four to five years. Once treatment fails with the first line targeted therapy, head to head comparisons have shown that cabozantinib, nivolumab and the combination of lenvatinib plus everolimus are more effective than everolimus alone and that axitinib is more active than sorafenib. Unfortunately, it is very unlikely that we will ever have prospective data comparing the activity of axitinib, cabozantinib, lenvatinib or nivolumab. It is frustrating to observe the lack of biomarkers that we have in this field, thus there is no firm recommendation about the optimal sequence of treatment in the second line. In the absence of reliable biomarkers, there are several clinical endpoints that can help physicians to make decisions for an individual patient, such as the tumor burden, the expected response rate and the time to achieve the response to each agent, the prior response to the agent administered, the toxicity profile of the different compounds and patient preference. Here, we propose the introduction of the tumor-growth rate(TGR) during first-line treatment as a new tool to be used to select the second line strategy in m RCC. The rapidness of TGR before the onset of the treatment reflects the variability between patients in terms of tumor growth kinetics and it could be a surrogate marker of tumor aggressiveness that may guide treatment decisions.展开更多
Groundwater is reported to account for 87% of all drinking water resources in Dhaka which has suffered a decline of up to 75 m in some specific location. Over-extraction of groundwater is an extensive social problem i...Groundwater is reported to account for 87% of all drinking water resources in Dhaka which has suffered a decline of up to 75 m in some specific location. Over-extraction of groundwater is an extensive social problem in Dhaka and Gazipur city which needs to be investigating thoroughly. This study presents the diagnosis of groundwater depletion pattern and the yearly rate of decline over the last three decades for Dhaka and Gazipur metropolitan area. Groundwater data were collected from the relevant institutions in order to analyse the trend line and the rate of decline of groundwater levels for more than 30 years period to understand the long-time variability. Ten individual stations datasets for GWL have been analyzed for Dhaka and Gazipur within a selected reference time period (1980-2012). The highest depleted GWL were found in the Mirpur station which is now 68 m below ground. To find out the time span when the depletion rate is highest, the rate of decline of all datasets has been computed which shows that 1998-2005 is the consecutive eight years time span with the fastest depletion rate. On the other hand, the annual trend-line analysis shows rapid depletion pattern after the year 2000.展开更多
We analyze the topside ionosphere power line radiation(PLR)at 60 Hz over the US using electric field data collected by CSES satellite between January 2019 and December 2022.The study aimed to further investigate the m...We analyze the topside ionosphere power line radiation(PLR)at 60 Hz over the US using electric field data collected by CSES satellite between January 2019 and December 2022.The study aimed to further investigate the month-to-month variation characteristic of PLR occurrence rate observed by satellite and its several influencing factors,including solar radiation,lightning activity,and try to clarify the influence of electricity consumption.The results show that the solar radiation(solar zenith angle and F10.7)plays a major role in the variation of the PLR occurrence rate,and that there is no direct connection with the number of lightning.For the relationship between PLR occurrence rate and electricity consumption,the low occurrence rate associated with decreased weekend electricity consumption was not observed in the US.However,there is a significant difference in PLR occurrence rate between the East and West Coasts of the US at the same latitude during the same time period,suggesting that the significant difference in PLR occurrence rate is caused by the significant difference in electricity consumption between the two coasts.After excluding the effect of solar radiation on PLR occurrence rate,we concluded that only a significant difference in regional electricity consumption could lead to a corresponding change in PLR occurrence rate detected by the Low-Earth-Orbit satellite.Finally,we also found there is seasonal variation in the diurnal differences of the PLR occurrence rate caused by seasonal variation of the lower ionosphere.展开更多
文摘The therapeutic options for patients with metastatic renal cell carcinoma(mRCC) have completely changed during the last ten years. With the sequential use of targeted therapies, median overall survival has increased in daily practice and now it is not uncommon to see patients surviving kidney cancer for more than four to five years. Once treatment fails with the first line targeted therapy, head to head comparisons have shown that cabozantinib, nivolumab and the combination of lenvatinib plus everolimus are more effective than everolimus alone and that axitinib is more active than sorafenib. Unfortunately, it is very unlikely that we will ever have prospective data comparing the activity of axitinib, cabozantinib, lenvatinib or nivolumab. It is frustrating to observe the lack of biomarkers that we have in this field, thus there is no firm recommendation about the optimal sequence of treatment in the second line. In the absence of reliable biomarkers, there are several clinical endpoints that can help physicians to make decisions for an individual patient, such as the tumor burden, the expected response rate and the time to achieve the response to each agent, the prior response to the agent administered, the toxicity profile of the different compounds and patient preference. Here, we propose the introduction of the tumor-growth rate(TGR) during first-line treatment as a new tool to be used to select the second line strategy in m RCC. The rapidness of TGR before the onset of the treatment reflects the variability between patients in terms of tumor growth kinetics and it could be a surrogate marker of tumor aggressiveness that may guide treatment decisions.
文摘Groundwater is reported to account for 87% of all drinking water resources in Dhaka which has suffered a decline of up to 75 m in some specific location. Over-extraction of groundwater is an extensive social problem in Dhaka and Gazipur city which needs to be investigating thoroughly. This study presents the diagnosis of groundwater depletion pattern and the yearly rate of decline over the last three decades for Dhaka and Gazipur metropolitan area. Groundwater data were collected from the relevant institutions in order to analyse the trend line and the rate of decline of groundwater levels for more than 30 years period to understand the long-time variability. Ten individual stations datasets for GWL have been analyzed for Dhaka and Gazipur within a selected reference time period (1980-2012). The highest depleted GWL were found in the Mirpur station which is now 68 m below ground. To find out the time span when the depletion rate is highest, the rate of decline of all datasets has been computed which shows that 1998-2005 is the consecutive eight years time span with the fastest depletion rate. On the other hand, the annual trend-line analysis shows rapid depletion pattern after the year 2000.
基金supported by the Specialized Research Fund for State Key Laboratories,National Space Science Center,Chinese Academy of Sciences,Talent startup research grants from National Space Science Center,Chinese Academy of Sciences(Grant Nos.2023000034,E3RC2TQ4,and E3RC2TQ5)the National Natural Science Foundation of China(Grant No.41704156)+2 种基金the China Research Institute of Radiowave Propagation(Research on low ionosphere satellite detection)a project funded by China National Space Administration(CNSA)the China Earthquake Administration(CEA)。
文摘We analyze the topside ionosphere power line radiation(PLR)at 60 Hz over the US using electric field data collected by CSES satellite between January 2019 and December 2022.The study aimed to further investigate the month-to-month variation characteristic of PLR occurrence rate observed by satellite and its several influencing factors,including solar radiation,lightning activity,and try to clarify the influence of electricity consumption.The results show that the solar radiation(solar zenith angle and F10.7)plays a major role in the variation of the PLR occurrence rate,and that there is no direct connection with the number of lightning.For the relationship between PLR occurrence rate and electricity consumption,the low occurrence rate associated with decreased weekend electricity consumption was not observed in the US.However,there is a significant difference in PLR occurrence rate between the East and West Coasts of the US at the same latitude during the same time period,suggesting that the significant difference in PLR occurrence rate is caused by the significant difference in electricity consumption between the two coasts.After excluding the effect of solar radiation on PLR occurrence rate,we concluded that only a significant difference in regional electricity consumption could lead to a corresponding change in PLR occurrence rate detected by the Low-Earth-Orbit satellite.Finally,we also found there is seasonal variation in the diurnal differences of the PLR occurrence rate caused by seasonal variation of the lower ionosphere.
