According to New York Times on November 19, as retailers battle to draw customers into their stores on Black Friday, online merchants are plotting a cunning ambush, offering an arsenal of mobile-only deals intended to...According to New York Times on November 19, as retailers battle to draw customers into their stores on Black Friday, online merchants are plotting a cunning ambush, offering an arsenal of mobile-only deals intended to pick off shoppers as they wait in line. The Gilt Groupe, for example, which展开更多
Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II studies.The aim of this study was to summarize al...Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II studies.The aim of this study was to summarize all those phase II studies with the hope to get a comprehensive understanding of gemcitabine efficacy.Methods:The PubMed database was used to search all the papers on NSCLC associated with gemcitabine used as single agent in the first line setting till to March 31st,2010.And the medians and their 95% CI of overall response rate (ORR),disease control rate (DCR),progression free survival (PFS),and overall survival (OS) were calculated.Results:1.There were 7 papers including 410 patients with performance status (PS) ≤ 2 and advanced stage collected.2.The dose-intensities of gemcitabine were 843.75 mg/m 2 /week-1125 mg/m 2 /week in the 4-week schedule,and 666.7 mg/m 2 /week in the 3-week schedule.3.The median age was 73.8 (95% CI was 72.44,75.16) years old;36.1% (95% CI:31.4%,40.7%) of patients with stage IIIB and 60.5% (95% CI:55.8%,65.2%) of patients with stage IV;35.9% (95% CI:31.2%,40.5%) patients were adenocarcinomas and 43.7% (95% CI:38.9%,48.5%) patients were squamous cell carcinomas (SCCs).4.The ORR,DCR,PFS/TTP,and OS were 22.3% (95% CI:18.2%,26.5%),58.4% (95% CI:53.5%,63.4%),3.6 (95% CI:2.9,5.15) months and 6.68 (95% CI:5.4,8.11) months,respectively.Conclusion:Gemcitabine as single agent applied in this special population was effective and can be well tolerated under different doses and usage.展开更多
Aiming at the problem that the vehicles always turn left in advance which causes heavy conflicts in the intersection and effected traffic efficiency,the solution of the left-turn lane’s stop line backwards setting wa...Aiming at the problem that the vehicles always turn left in advance which causes heavy conflicts in the intersection and effected traffic efficiency,the solution of the left-turn lane’s stop line backwards setting was proposed,and the critical conditions on the stop line’s setting were studied.Firstly,we studied the characteristics of trajectories distribution in the release process of turning left in advance vehicles.Based on that,we proposed to move the stop line backwards to solve the problem of turning left in advance.Considering the intersection’s geometric features and the vehicle operation features,the geometric critical condition was given for setting the position of left-turn lane’s stop line.And then the model of left-turn vehicles’queuing length was established based on queuing theory and traffic wave theory.By using queuing length model,the flow restrictions of stop line backwards could be found.Assuming left-turn vehicles’arrival rate is stable in a certain period of time,the minimum green time and the maximum red time of left-turn phase were given after the stop line was set up.According to the changes of the vehicles’turning paths,the shortest yellow setting recommendation was given.Finally,the application of the critical limits used in stop line backwards setting was demonstrated.The research result could provide a theoretical basis for traffic signs and markings’setting and perfect the relevant laws and regulations.展开更多
Heading date in rice is a typical quantitative trait controlled by multiple quantitative trait loci （QTLs）. It is mainly regulated by environmental factors such as photoperiod and temperature （Izawa, 2007）. Many Q...Heading date in rice is a typical quantitative trait controlled by multiple quantitative trait loci （QTLs）. It is mainly regulated by environmental factors such as photoperiod and temperature （Izawa, 2007）. Many QTLs for heading date have been identified using different mapping populations and methods （http：// www.gramene.org/qtl）. Up to date, several major heading date QTLs have been cloned by map-based cloning strategy （Yano et al., 2000; Takahashi et al., 2001; Kojima et al., 2002; Doi et al., 2004; Xue et al., 2008; Wei et al., 2010; Yan et al.,展开更多
A four-dimensional memristive system is constructed using a novel ideal memristor with cosine memductance. Due to the special memductance nonlinearity, this memristive system has a line equilibrium set(0, 0, 0, δ) lo...A four-dimensional memristive system is constructed using a novel ideal memristor with cosine memductance. Due to the special memductance nonlinearity, this memristive system has a line equilibrium set(0, 0, 0, δ) located along the coordinate of the inner state variable of the memristor, whose stability is periodically varied with a change of δ. Nonlinear and one-dimensional initial offset boosting behaviors, which are triggered by not only the initial condition of the memristor but also other two initial conditions, are numerically uncovered. Specifically, a wide variety of coexisting attractors with different positions and topological structures are revealed along the boosting route. Finally, circuit simulations are performed by Power SIMulation(PSIM) to confirm the unique dynamical features.展开更多
文摘According to New York Times on November 19, as retailers battle to draw customers into their stores on Black Friday, online merchants are plotting a cunning ambush, offering an arsenal of mobile-only deals intended to pick off shoppers as they wait in line. The Gilt Groupe, for example, which
基金Support by a grant from Major Science and Technology Project of"National Significant New Drug Creation"(No. 2008ZX09312-002)
文摘Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II studies.The aim of this study was to summarize all those phase II studies with the hope to get a comprehensive understanding of gemcitabine efficacy.Methods:The PubMed database was used to search all the papers on NSCLC associated with gemcitabine used as single agent in the first line setting till to March 31st,2010.And the medians and their 95% CI of overall response rate (ORR),disease control rate (DCR),progression free survival (PFS),and overall survival (OS) were calculated.Results:1.There were 7 papers including 410 patients with performance status (PS) ≤ 2 and advanced stage collected.2.The dose-intensities of gemcitabine were 843.75 mg/m 2 /week-1125 mg/m 2 /week in the 4-week schedule,and 666.7 mg/m 2 /week in the 3-week schedule.3.The median age was 73.8 (95% CI was 72.44,75.16) years old;36.1% (95% CI:31.4%,40.7%) of patients with stage IIIB and 60.5% (95% CI:55.8%,65.2%) of patients with stage IV;35.9% (95% CI:31.2%,40.5%) patients were adenocarcinomas and 43.7% (95% CI:38.9%,48.5%) patients were squamous cell carcinomas (SCCs).4.The ORR,DCR,PFS/TTP,and OS were 22.3% (95% CI:18.2%,26.5%),58.4% (95% CI:53.5%,63.4%),3.6 (95% CI:2.9,5.15) months and 6.68 (95% CI:5.4,8.11) months,respectively.Conclusion:Gemcitabine as single agent applied in this special population was effective and can be well tolerated under different doses and usage.
基金the National Natural Science Foundation of China(Nos.51108208,512782520 and 51278220)
文摘Aiming at the problem that the vehicles always turn left in advance which causes heavy conflicts in the intersection and effected traffic efficiency,the solution of the left-turn lane’s stop line backwards setting was proposed,and the critical conditions on the stop line’s setting were studied.Firstly,we studied the characteristics of trajectories distribution in the release process of turning left in advance vehicles.Based on that,we proposed to move the stop line backwards to solve the problem of turning left in advance.Considering the intersection’s geometric features and the vehicle operation features,the geometric critical condition was given for setting the position of left-turn lane’s stop line.And then the model of left-turn vehicles’queuing length was established based on queuing theory and traffic wave theory.By using queuing length model,the flow restrictions of stop line backwards could be found.Assuming left-turn vehicles’arrival rate is stable in a certain period of time,the minimum green time and the maximum red time of left-turn phase were given after the stop line was set up.According to the changes of the vehicles’turning paths,the shortest yellow setting recommendation was given.Finally,the application of the critical limits used in stop line backwards setting was demonstrated.The research result could provide a theoretical basis for traffic signs and markings’setting and perfect the relevant laws and regulations.
基金supported by grants from the Ministry of Science and Technology of China(No. 2010CB125901)the National Natural Science Foundation of China(No.31271315)the Bill & Melinda Gates Foundation
文摘Heading date in rice is a typical quantitative trait controlled by multiple quantitative trait loci （QTLs）. It is mainly regulated by environmental factors such as photoperiod and temperature （Izawa, 2007）. Many QTLs for heading date have been identified using different mapping populations and methods （http：// www.gramene.org/qtl）. Up to date, several major heading date QTLs have been cloned by map-based cloning strategy （Yano et al., 2000; Takahashi et al., 2001; Kojima et al., 2002; Doi et al., 2004; Xue et al., 2008; Wei et al., 2010; Yan et al.,
基金the National Natural Science Foundation of China(Nos.61601062,5177016,51607013,and 61801054)the Natural Science Foundation of Jiangsu Province,China(No.BK20191451)。
文摘A four-dimensional memristive system is constructed using a novel ideal memristor with cosine memductance. Due to the special memductance nonlinearity, this memristive system has a line equilibrium set(0, 0, 0, δ) located along the coordinate of the inner state variable of the memristor, whose stability is periodically varied with a change of δ. Nonlinear and one-dimensional initial offset boosting behaviors, which are triggered by not only the initial condition of the memristor but also other two initial conditions, are numerically uncovered. Specifically, a wide variety of coexisting attractors with different positions and topological structures are revealed along the boosting route. Finally, circuit simulations are performed by Power SIMulation(PSIM) to confirm the unique dynamical features.
