In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line sp...In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line spectrum and background noise,a weighted line spectrum detection algorithm based on the phase variance is proposed in frequency domain.After phase difference alignment,the phase variance of line spectrum and the phase of background noise,respectively,are small and big in frequency domain,this method utilizes the weighted statistical algorithm to cumulate the frequency spectrum based on the phase variance,which can restrain the background noise disturbance,and enhance the signal to noise ratio（SNR）.The theory analysis and experimental results both verify that the proposed method can well enhance the energy of line spectrum,restrain the energy of background noise,and have better detection performance under lower SNR.展开更多
Performance of traditional adaptive line enhancer （ALE） in suppressing Gaussian noise is low and can get worse at low input signal-to-noise ratio（SNR）. For greatly overcoming these disadvantages, feature of fourth...Performance of traditional adaptive line enhancer （ALE） in suppressing Gaussian noise is low and can get worse at low input signal-to-noise ratio（SNR）. For greatly overcoming these disadvantages, feature of fourth-order cumulant （FOC） different slices for quasi-stationary random process is analyzed, fourth order cumulant（FOC） different slice-based adaptive dynamic line enhancer is presented, and output SNR of the proposed enhancer is derived and bigger than that of the ALE via theoretical analysis. Simulation tests with the underwater moving target-radiated data have shown that the proposed enhancer outperforms the ALE in suppressing Gaussian noise and enhancing dynamic line spectrum feature.展开更多
Advanced gastric cancer(a GC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve s...Advanced gastric cancer(a GC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve survival and tumor related symptoms in the frontline setting, second-line therapy(SLT) is subject to much debate in the scientific community, mainly because of the debilitating effects of GC, which would impede the administration of cytotoxic therapy. Recent data has provided sufficient evidence for the safe use of SLT in patients with an adequate performance status. Taxanes, Irinotecan and even some Fluoropyrimidine analogs were found to provide a survival advantage in this subset of patients. Most importantly, quality of life measures were also improved through the use of adequate therapy. Even more pertinent were the findings involving antiangiogenic agents, which would add measurable improvements without significantly jeopardizing the patients' well-being. Further lines of therapy are cause for much more debate nowadays, but specific targeted agents have shown considerable promise in this context. We herein review noteworthy published data involving the use of additional lines of the therapy after failure of standard frontline therapies in patients with a GC.展开更多
Second-line therapy for advanced colorectal cancer is an integral part of the treatment strategy that needs to be set from the beginning for each patient, bearing in mind the expected toxicities of chosen treatments, ...Second-line therapy for advanced colorectal cancer is an integral part of the treatment strategy that needs to be set from the beginning for each patient, bearing in mind the expected toxicities of chosen treatments, the patient's clinical condition, comorbidities, preferences, the aims of the treatment and the molecular status. Furthermore, the distinction between lines of therapy is no longer absolute. The perspective of "continuum of care" includes switching chemotherapy prior to disease progression, maintenance therapy, drug "holidays" if needed, surgical resection of metastases in selected patients, and seems to allow a tailored treatment, in which patients are more likely to benefit from exposure to all active agents, which is known to correlate with overall survival. The scenario of second-line treatment has changed dramatically over the years and could currently benefit from several options including chemotherapy with a single agent or in combination and the addition of molecular-targeted agents developed in the last decade, such as epidermal growth factor receptor antibodies(cetuximab, panitumumab) and vascular endothelial growth factor-targeting agents(bevacizumab, aflibercept), with the possibility of bevacizumab use even beyond first progression. The purpose of this review is to summarize the most important scientific data supporting the use of chemotherapy and the new biologic agents in the second-line setting in advanced colorectal cancer.展开更多
在目标-攻击弹-防御弹群(target-attacker-defenders,TADs)系统中,防御弹群通过与目标(载机)异构协同、弹群间同构协同以保护载机并降低单弹脱靶的风险。针对TADs系统在二维平面下的协同主动防御模型进行了研究,采用机/弹协同和防御弹...在目标-攻击弹-防御弹群(target-attacker-defenders,TADs)系统中,防御弹群通过与目标(载机)异构协同、弹群间同构协同以保护载机并降低单弹脱靶的风险。针对TADs系统在二维平面下的协同主动防御模型进行了研究,采用机/弹协同和防御弹群协同的两层制导策略。在机弹协同方面,防御弹领弹与载机进行异构协同,考虑载机及防御弹领弹的机动能力限制,采用协同视线制导律(cooperative line of sight guidance,CLOSG)分别得到载机和防御弹领弹的制导指令;在防御弹群协同方面,考虑单弹计算能力约束,拦截时间约束和加速度约束,设计出基于分布式模型预测控制(distributed model predictive control,DMPC)的算法实现弹群从弹和防御弹领弹协同同时抵达并拦截攻击弹。仿真结果表明,多防御弹协同一致拦截制导算法能够实现TADs系统中载机和防御弹群的异构协同主动防御,并实现防御弹群的一致性同时拦截,以降低单弹脱靶的风险。展开更多
基金supported by the National Natural Science Foundation of China(61372180)the Young Talent Frontier Project of Institute of Acoustics of Chinese Academy of Sciences(Y454341261)
文摘In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line spectrum and background noise,a weighted line spectrum detection algorithm based on the phase variance is proposed in frequency domain.After phase difference alignment,the phase variance of line spectrum and the phase of background noise,respectively,are small and big in frequency domain,this method utilizes the weighted statistical algorithm to cumulate the frequency spectrum based on the phase variance,which can restrain the background noise disturbance,and enhance the signal to noise ratio（SNR）.The theory analysis and experimental results both verify that the proposed method can well enhance the energy of line spectrum,restrain the energy of background noise,and have better detection performance under lower SNR.
基金Project supported by the National Natural Science Foundation of China (No.40171065)the National High Technology Research and Development Program of China (Nos.2002AA130010-2-7 and 2003AA131020-04-06).
文摘Performance of traditional adaptive line enhancer （ALE） in suppressing Gaussian noise is low and can get worse at low input signal-to-noise ratio（SNR）. For greatly overcoming these disadvantages, feature of fourth-order cumulant （FOC） different slices for quasi-stationary random process is analyzed, fourth order cumulant（FOC） different slice-based adaptive dynamic line enhancer is presented, and output SNR of the proposed enhancer is derived and bigger than that of the ALE via theoretical analysis. Simulation tests with the underwater moving target-radiated data have shown that the proposed enhancer outperforms the ALE in suppressing Gaussian noise and enhancing dynamic line spectrum feature.
文摘Advanced gastric cancer(a GC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve survival and tumor related symptoms in the frontline setting, second-line therapy(SLT) is subject to much debate in the scientific community, mainly because of the debilitating effects of GC, which would impede the administration of cytotoxic therapy. Recent data has provided sufficient evidence for the safe use of SLT in patients with an adequate performance status. Taxanes, Irinotecan and even some Fluoropyrimidine analogs were found to provide a survival advantage in this subset of patients. Most importantly, quality of life measures were also improved through the use of adequate therapy. Even more pertinent were the findings involving antiangiogenic agents, which would add measurable improvements without significantly jeopardizing the patients' well-being. Further lines of therapy are cause for much more debate nowadays, but specific targeted agents have shown considerable promise in this context. We herein review noteworthy published data involving the use of additional lines of the therapy after failure of standard frontline therapies in patients with a GC.
文摘Second-line therapy for advanced colorectal cancer is an integral part of the treatment strategy that needs to be set from the beginning for each patient, bearing in mind the expected toxicities of chosen treatments, the patient's clinical condition, comorbidities, preferences, the aims of the treatment and the molecular status. Furthermore, the distinction between lines of therapy is no longer absolute. The perspective of "continuum of care" includes switching chemotherapy prior to disease progression, maintenance therapy, drug "holidays" if needed, surgical resection of metastases in selected patients, and seems to allow a tailored treatment, in which patients are more likely to benefit from exposure to all active agents, which is known to correlate with overall survival. The scenario of second-line treatment has changed dramatically over the years and could currently benefit from several options including chemotherapy with a single agent or in combination and the addition of molecular-targeted agents developed in the last decade, such as epidermal growth factor receptor antibodies(cetuximab, panitumumab) and vascular endothelial growth factor-targeting agents(bevacizumab, aflibercept), with the possibility of bevacizumab use even beyond first progression. The purpose of this review is to summarize the most important scientific data supporting the use of chemotherapy and the new biologic agents in the second-line setting in advanced colorectal cancer.
文摘在目标-攻击弹-防御弹群(target-attacker-defenders,TADs)系统中,防御弹群通过与目标(载机)异构协同、弹群间同构协同以保护载机并降低单弹脱靶的风险。针对TADs系统在二维平面下的协同主动防御模型进行了研究,采用机/弹协同和防御弹群协同的两层制导策略。在机弹协同方面,防御弹领弹与载机进行异构协同,考虑载机及防御弹领弹的机动能力限制,采用协同视线制导律(cooperative line of sight guidance,CLOSG)分别得到载机和防御弹领弹的制导指令;在防御弹群协同方面,考虑单弹计算能力约束,拦截时间约束和加速度约束,设计出基于分布式模型预测控制(distributed model predictive control,DMPC)的算法实现弹群从弹和防御弹领弹协同同时抵达并拦截攻击弹。仿真结果表明,多防御弹协同一致拦截制导算法能够实现TADs系统中载机和防御弹群的异构协同主动防御,并实现防御弹群的一致性同时拦截,以降低单弹脱靶的风险。
