Toward a Direct Measurement of the Cosmic Acceleration:The Pilot Observation of HI 21 cm Absorption Line at FAST

This study presents results on detecting neutral atomic hydrogen(H I)21 cm absorption in the spectrum of PKS PKS1413+13 at redshift z=0.24670041.The observation was conducted by FAST,with a spectral resolution of10 Hz,using 10 minutes of observing time.The global spectral profile is examined by modeling the absorption line using a single Gaussian function with a resolution of 10 kHz within a 2 MHz bandwidth.The goal is to determine the rate of the latest cosmic acceleration by directly measuring the redshift evolution of the H I 21 cm absorption line with Hubble flow toward a common background quasar over a decade or longer time span.This will serve as a detectable signal generated by the accelerated expansion of the Universe at redshift z<1,referred to as redshift drift z(5)or the SL effect.The measured H I gas column density in this DLA system is approximately equivalent to the initial observation value,considering uncertainties of the spin temperature of a spiral host galaxy.The high signal-to-noise ratio of 57,obtained at a 10 kHz resolution,strongly supports the feasibility of using the H I 21 cm absorption line in DLA systems to accurately measure the redshift drift rate at a precision level of around 10~(-10)per decade.

Observation of HⅠaround three Satellite Galaxies of M31 with FAST:AndromedaⅡ,NGC 205,and NGC 185

With the exceptional sensitivity of the Five-hundred-meter Aperture Spherical radio Telescope,we conducted observations of the neutral hydrogen(HⅠ)in the circumgalactic medium of Andromeda’s(M31)satellite galaxies,specifically AndromedaⅡ,NGC 205,and NGC 185.Initially,three drift scans were executed for these satellites,with a detection limit of 4×10^(18)cm^(-2)(approximately 1.88×10^(3)M_Θof HⅠmass),followed by a more in-depth scan of a specific region.We discovered a C-shaped HⅠarc structure sharing a position and line-of-sight velocity similar to a stellar ring structure around AndromedaⅡ,hinting at a potential connection with AndromedaⅡ.In the context of NGC 205,we identified two mass concentrations in the northeast direction,which could be indicative of tidal streams resulting from the interaction between this galaxy and M31.These new lumps discovered could be very helpful in solving the missing interstellar medium problem for NGC 205.Observations regarding NGC 185are consistent with previous studies,and we did not detect any additional HⅠmaterial around this galaxy.These observational results enhance our understanding of the evolution of these satellite galaxies and provide insight into their historical interactions with the galaxy M31.

HI in High Gas-phase Metallicity Dwarf Galaxy WISEA J230615.06+143927.9

We present resolved Giant Metrewave Radio Telescope H I observations of the high gas-phase metallicity dwarf galaxy WISEA J230615.06+143927.9(z = 0.005)(hereafter J2306) and investigate whether it could be a Tidal Dwarf Galaxy(TDG) candidate. TDGs are observed to have higher metallicities than normal dwarfs. J2306 has an unusual combination of a blue g-r color of 0.23 mag, irregular optical morphology and high-metallicity(12 +log(O/H) = 8.68 ± 0.14), making it an interesting galaxy to study in more detail. We find J2306 to be an H I rich galaxy with a large extended, unperturbed rotating H I disk. Using our H I data we estimated its dynamical mass and found the galaxy to be dark matter(DM) dominated within its H I radius. The quantity of DM, inferred from its dynamical mass, appears to rule out J2306 as an evolved TDG. A wide area environment search reveals J2306 to be isolated from any larger galaxies which could have been the source of its high gas metallicity. Additionally, the H I morphology and kinematics of the galaxy show no indication of a recent merger to explain the high-metallicity.Further detailed optical spectroscopic observations of J2306 might provide an answer to how a seemingly ordinary irregular dwarf galaxy achieved such a high level of metal enrichment.

Evaluation of red soil-bentonite mixtures for compacted clay liners

Compacted clay liners are an integral part of the waste landfills,which are provided to contain the leachate within the landfills and protect the surrounding environment.Generally,locally available natural soils are used for the construction of compacted clay liners if they satisfy the design criteria.However,not all soils in their natural state satisfy all the design criteria for the liner materials.Thus,there is a definite need to modify the locally available natural soils by blending with bentonite to meet the required design criteria for the liners.In view of this,the present study evaluates the suitability of an Indian red soil enhanced with bentonite as a liner material.To achieve this,a series of experiments were carried out using locally available red soil and bentonite.First,the suitability of the red soil was evaluated as a liner material.The experimental results showed that the red soil met all the selection criteria stipulated by the Environmental Protection Agencies(EPAs)for the liners except the hydraulic conductivity criterion.Therefore,the red soil was mixed with bentonite contents of 10%,20%and 30%,and the red soil-bentonite mixtures were evaluated for their suitability for liners in their compacted state.Further,as the liners in the arid and semi-arid regions are subjected to moisture variations due to seasonal moisture fluctuations and other factors,the red soil-bentonite mixtures were subjected to wetdry cycles,and their suitability was evaluated after wet-dry cycles.The experimental results revealed that all the red soil-bentonite mixtures met the stipulated EPA criteria for the liners in the as-compacted state.However,the red soil-bentonite mixtures with 20%and 30%bentonite contents only satisfied the hydraulic conductivity requirement even after wet-dry cycles.The experimental findings were supplemented with the microstructural insights captured through digital camera images,scanning electron microscopy(SEM),and mercury intrusion porosimetry(MIP)studies.

Fine mapping and characterization of a major QTL for grain length,QGl.cau-2D.1,that has pleiotropic effects in synthetic allohexaploid wheat

Grain size is one of the determinants of grain yield,and identifying the genetic loci that control grain size will be helpful for increasing grain yield.In our previous study,a quantitative trait locus(QTL)for grain length(GL),QGl.cau-2D.1,was identified from an F2 population developed from the cross between the natural(TAA10)and synthetic(XX329)allohexaploid wheat.In the present study,we mainly fine mapped and validated its genetic effects.To this end,multiple near-isogenic lines(NILs)were obtained through marker-assisted selection with TAA10 as the recurrent parent.The secondary populations derived from 25 heterozygous recombinants were used for fine mapping of QGl.cau-2D.1,and the allele from XX329 significantly increased GL,thousand-grain weight(TGW),total spikelet number per spike(TSN)and spike compactness(SC).Using NILs for XX329(2D+)and TAA10(2D−),we determined the genetic and pleiotropic effects of QGl.cau-2D.1.The target sequences were aligned with the wheat reference genome RefSeq v2.1 and spanned an~0.9 Mb genomic region.TraesCS2D03G0114900(ortholog of Os03g0594700)was predicted as the candidate gene based on whole-genome re-sequencing and expression analyses.In summary,the map-based cloning of QGl.cau-2D.1 will be useful for improving grain weight with enhanced GL and TSN.

Characterization of the infectivity of an Indonesian Zika virus strain in mammalian cell lines

Objective:To characterize the infection patterns and growth characteristics of the Zika virus(ZIKV)strain JMB-185 from Indonesia in various mammalian cell lines.Methods:ZIKV was grown in human(A549,HEK293,HepG2,Huh7,Jurkat,and THP-1)and non-human mammalian(RAW264.7,Vero,and Vero76)cell lines.Viral replication kinetics were measured using plaque assay,while intra-and extracellular viral RNA concentrations were assessed using RT-PCR.Flow cytometry was used to quantify the infected cells and cell viability was measured using an MTT assay.The ability of ZIKV to infect cell lines was visualized using a fluorescence immunostaining assay.Results:This ZIKV strain preferentially infected the lung,kidney,and liver cell lines A549,HEK293,Huh7,Vero,and Vero76,but not the immune cells Jurkat,RAW264.7,and THP-1.By contrast,the ZIKV showed no sign of infection in HepG2 cells,while maintaining viral titer over 3 days post-infection,with no infection recorded in immunostaining,no increase in viral RNA,and no indication of cell deterioration.Conclusions:The Indonesian ZIKV strain has a similar infection profile as other strains,except for its poor infectivity on HepG2 cells.Information on the growth characteristics of Indonesia ZIKV will help expand our understanding of the biology of ZIKV which will be useful for various applications including antiviral discovery.

对称系泊半潜平台在各种可能系泊组合下的动力学分析

In this technologically advancing world,the demand for more energy,oil and gas production is rapidly escalating.To accomplish this,people have inclined more towards completely floating offshore structures,deployed in deep waters.A semi-submersible is selected in the present study,due to its better response characteristics and stability under harsh environmental conditions.The semi-submersible is position restrain with spread mooring lines incorporated with submerged buoy at different locations has been studied.A detailed numerical analysis is carried out using Ansys Aqwa for dynamic response analysis of semi-submersible under the combination of wind,wave,and current forces for 0°,45°,and 90°directions.It was observed that damping ratios and natural periods had been affected based on the position and number of submerged buoys in the mooring system.Also,reduction in mooring force after incorporating buoy in the mooring lines was observed.Subsequently,a Matlab code based on the S-N curve approach was generated and employed to investigate the fatigue damage of mooring lines under dynamic variation of mooring forces.When pegged with submerged buoys,fatigue life of mooring lines is increased under intact and postulated damaged mooring conditions.Moreover,coupling of motion responses of semi-submersible is observed,and unbounded response is not seen in any degrees-offreedom,even during damaged condition of mooring lines.

Long-term Integration Ability of the Submillimeter Wave Astronomy Satellite(SWAS)Spectral Line Receivers

The Submillimeter Wave Astronomy Satellite(SWAS)was the first space telescope capable of high spectral resolution observations of terahertz spectral lines.We have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit operation.The CI,O_(2),H_(2)O,and^(13)CO spectra taken toward all observed Galactic sources were analyzed.The present results are based on spectra with a total integration time of up to 2.72×10~4hr(■10~8s).The noise in the spectra is generally consistent with that expected from the radiometer equation,without any sign of approaching a noise floor.This noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

EP Aquarii:A New Picture of the Circumstellar Envelope

New analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different interpretation of the morpho-kinematics of the circumstellar envelope.The birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been obtained.Close to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the equator.It implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is difficult.In particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its center.It proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its wake.High Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined within 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar medium.We estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite(SWAS)survey.We obtained an averaged O_(2)spectrum based on this sample using the(SWAS)survey data(O_(2),487.249 GHz,N=3-1,J=3-2).No emission or absorption feature is seen around the supposed central velocity with a total integration time of t_(total)=8.67×10^(3)hr and an rms noise per channel of 1.45 m K.Assuming a kinetic temperature T_(kin)=30 K,we derive the 3σupper limit of the O_(2)column density to be 3.3×10^(15)cm^(-2),close to the lowest values reported in Galactic massive star formation regions in previous studies.The corresponding O_(2)abundance upper limit is6.7×10^(-8),lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation regions.On a galactic scale,our statistical results confirm a generally low O_(2)abundance for Galactic massive star formation regions.This abundance is also lower than results reported in extragalactic sources.

Summary of a Life in Observational Ultraviolet/Optical Astronomy

I reminisce on my early life in Section 1;on my education in Sections 2 and 3;on the years at Princeton as a research astronomer in Section 4;on the years on the faculty at Chicago in Section 5;on research on Diffuse Interstellar Bands(DIBs) in Section 6;on construction of the 3.5 m telescope at Apache Point Observatory(APO)in Section 7;on work on the Sloan Digital Sky Survey(SDSS) in Section 8;on work in public education in Chicago in Section 9;and on my travels in Section 10. My main science research is of an observational nature,concerning Galactic and intergalactic interstellar gas. Highlights for me included my work on the orbiting telescope Copernicus, including the discovery of interstellar deuterium;early observations of absorption associated with fivetimes ionized oxygen;and discoveries concerning the phases of gas in the local interstellar medium, based on previously unobservable interstellar UV spectral lines. With other instruments and collaborations, I extended interstellar UV studies to the intergalactic cool gas using quasi-stellar object QSO absorption lines redshifted to the optical part of the spectrum;provided a better definition of the emission and morphological character of the source of absorption lines in QSO spectra;and pursued the identification of the unidentified DIBs. For several of these topics, extensive collaborations with many scientists were essential over many years. The conclusions developed slowly, as I moved from being a graduate student at Chicago, to a research scientist position at Princeton and then to a faculty position at Chicago. At each stage of life, I was exposed to new technologies adaptable to my science and to subsequent projects. From high school days, I encountered several management opportunities which were formative. I have been extremely fortunate both in scientific mentors I had and in experimental opportunities I encountered.

Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally low.AIM To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using meta-analysis.METHODS PubMed,Web of Science,and EMBASE were searched for studies.Two trained researchers selected the studies and extracted data.STATA 17.0 software was used for meta-analysis of the incidence of each outcome event.The adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included studies.Funnel plots and Egger’s test were used to detect publication bias.Subgroup analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging system.RESULTS Eight studies with a pooled success rate of 66.6%were included.GCOs derived from women and men had success rates of 67%and 46.7%,respectively.GCOs from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,respectively.GCOs of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,respectively.GCOs with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,respectively.GCOs generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM stage.Omitting Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.

Quantized Redshift and its Significance for Recent Observation

With the recent observational evidence in extragalactic astronomy,the interpretation of the nature of quasar redshift continues to be a research interest.Very high redshifts are being detected for extragalactic objects that are presumably very distant and young while also exhibiting properties that are characteristic of a more mature galaxy such as ours.According to Halton Arp and Geoffrey Burbidge,redshift disparities consist of an intrinsic component and are related to an evolutionary process.Karlsson observed redshift periodicity at integer multiples of0.089 in log scale and Burbidge observed redshift periodicity at integer multiples of 0.061 in linear scale.Since Singular Value Decomposition based periodicity estimation is known to be superior for noisy data sets,especially when the data contain multiple harmonics and overtones,mainly irregular in nature,we have chosen it to be our primary tool for analysis of the quasar-galaxy pair redshift data.We have observed a fundamental periodicity of0.051 with a confidence interval of 95%in linear scale with the site-available Sloan Digital Sky Survey Data Release 7(SDSS DR7)quasar-galaxy pair data set.We have independently generated quasar-galaxy pair data sets from both 2d F and SDSS and found fundamental periodicities of 0.077 and 0.089,respectively,in log scale with a confidence interval of 95%.

Canine Myofascial Kinetic Lines: A Descriptive Dissection Study Including Related Function and Locomotion and Comparison of the Human and Equine Myofascial Kinetic Lines

Aim: This dissection study was conducted to verify if the Myofascial kinetic lines, outlined in detail in humans and recently documented in horses, were present in dogs. These dynamic lines present rows of interconnected muscles, myofascia and other fascia structures, which influence the biomechanics of the spine and limbs. Methods: Forty-two dogs of different breeds and genders were dissected, imaged, and videoed. Results: Similar kinetic lines were verified in the dog, as described in humans and horses, and additionally, three new branches of the lines were discovered. The kinetic lines described were three superficial lines: Dorsal, Ventral, and Lateral, which all started in the hindlimb and ended in the temporal and occipital regions. These lines act respectively in spinal extension, flexion, and lateral flexion. Three profound lines, which started in the tail and ended in the head. The Deep Dorsal Line followed the transversospinal myofascia. The Deep Ventral Line showed an additional start deep in the medial hind limb, continued in the hypaxial myofascia, and enveloped all the viscera. Also, the Deep Lateral Line started in the hindlimb but parted along the trunk in the deep lateral myofascial structures. Two helical lines crossed the midline two or three times and served to rotate the spine. The Functional Line established a sling from the axilla to the contralateral stifle and presented a new ipsilateral branch. The Spiral Line connected the head and the ipsilateral tarsus and additionally presented a new straight branch. The four front limb lines describe their motion: the Front Limb Protraction and Retraction, Adduction, and Abduction Lines. Conclusion: The canine lines mirrored the equine and human lines with exceptions due to differences in anatomy, foot posture, lumbosacral flexibility, and their biomechanical constitution as predator versus prey animals. Additionally, three new canine branches were verified and described.

Co-variability Between the Broad Absorption Lines and Narrow Absorption Lines

We investigate the relationship between the variability of broad absorption lines(BALs)or narrow absorption lines(NALs)and that of continuum using a data set of two-epoch SDSS spectra containing 134 C IV NAL-BAL pairs.Our analysis reveals an anti-correlation between the fractional equivalent width(EW)variations in NALs(or BALs)and the fractional flux variations of the continuum,with Spearman rank correlation coefficients of r=-0.47(p=1E-08)and r=-0.58(p=1E-13),respectively.In addition,we find a positive correlation between the fractional EW variations in NALs and BALs(r=0.72,p=1E-22),and derive a regression equation ΔEW_(NAL)/<EW_(NAL)>=0.803ΔEW_(BAL)/<EW_(BAL)>+0.008,with an intrinsic scatter of 0.14.These results suggest that the variability in the ionizing continuum may play a significant role in the observed changes in C IV NALs and BALs,supporting the idea of photoionization-driven variability.The co-variability between C IV NALs and BALs may imply that they originate from outflows with similar physical conditions.

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ANKRD26.However,the positive regulators of ANKRD26 are still unknown.AIM To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 transcription.METHODS Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family POTE.According to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activity of the mitogen activated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways,which are potentially involved in the regulation of thrombopoietin-dependent signaling and further impair proplatelet formation by megakaryocytes(MKs)[11].However,the positive regulators of ANKRD26,which might be associated with THC2 pathology,are still unknown.

Pulsed lavage in joint arthroplasty: A systematic review and metaanalysis

BACKGROUND Knee and hip osteoarthritis affects millions of people around the world and is expected to rise even more in frequency as the population ages.Joint arthroplasty is the surgical management of choice in these articulations.Heterotopic ossi-fication and radiolucent lines formation are two frequent problems faced in hip and knee replacements respectively.Some studies show that the usage of pulsed lavage may prevent their formation.AIM To compare pulsed lavage to standard lavage in joint arthroplasty.METHODS PubMed,Cochrane,and Google Scholar(page 1-20)were searched till December 2023.Only comparative studies were included.The clinical outcomes evaluated were the heterotopic ossification formation in hip replacements,radiolucent lines formation,and functional knee scores in knee replacements.RESULTS Four studies met the inclusion criteria and were included in this meta-analysis.Pulsed lavage was shown to reduce the formation of radiolucent lines(P=0.001).However,no difference was seen in the remaining outcomes CONCLUSION Pulsed lavage reduced the formation of radiolucent lines in knee replacements.No difference was seen in the remaining outcomes.Furthermore,the clinical significance of these radiolucent lines is poorly understood.Better conducted randomized controlled studies and cost-effectivity studies are needed to reinforce these findings.

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed in manic patients compared to controls, and dysregulation of miR-134,-152,-607,-633,-652,-155 occurred in euthymic patients compared to controls. Finally, microRNAs such as miR-34a,-34b,-34c,-137, and-140-3p,-21-3p,-30d-5p,-330-5p,-378a-5p,-134,-19b-3p were shown to have diagnostic potential in distinguishing bipolar disorder patients from schizophrenia or major depressive disorder patients, respectively. Further studies are warranted with adolescents and young adults having bipolar disorder and consideration should be given to using animal models of the disorder to investigate the effects of suppressing or overexpressing specific microRNAs.

Multi-Branch Fault Line Location Method Based on Time Difference Matrix Fitting

The distribution network exhibits complex structural characteristics,which makes fault localization a challenging task.Especially when a branch of the multi-branch distribution network fails,the traditional multi-branch fault location algorithm makes it difficult to meet the demands of high-precision fault localization in the multi-branch distribution network system.In this paper,the multi-branch mainline is decomposed into single branch lines,transforming the complex multi-branch fault location problem into a double-ended fault location problem.Based on the different transmission characteristics of the fault-traveling wave in fault lines and non-fault lines,the endpoint reference time difference matrix S and the fault time difference matrix G were established.The time variation rule of the fault-traveling wave arriving at each endpoint before and after a fault was comprehensively utilized.To realize the fault segment location,the least square method was introduced.It was used to find the first-order fitting relation that satisfies the matching relationship between the corresponding row vector and the first-order function in the two matrices,to realize the fault segment location.Then,the time difference matrix is used to determine the traveling wave velocity,which,combined with the double-ended traveling wave location,enables accurate fault location.

Efficient utilization of ecological and cultural-tourism resources:Taking Guangzhou Cultural Park as an example

Land space is precious resource and carrier of various economic activities.Ecosystem Product Value Realization and Cultural Tourism is new economic growth point for green and low-carbon development.It is necessary to study how to intensively and efficiently utilize ecological and cultural-tourism resources under"Three zones three lines for land use"(3Z3L),which is basic land space planning policy.However,there are few research and cases due to difficulties of interdisciplinary research.This article adopts the methods of policies research,graphic analysis,and visiting,to study efficient utilization of ecological and cultural-tourism resources.This study found that the development of land spaces of ecology,agriculture,and urban areas is 3D trend,multi-purpose resource utilization can be achieved by improving the utilization efficiency of 3D space and differentiating spatial utilization in different periods.Taking Guangzhou Cultural Park as an example,the research object has improved the efficiency of ecological and cultural-tourism resource utilization by its managements and technology,such as“house under the tree,tree inside the house”.However,there are shortcomings just as planning and protection policies with it.We proposed to optimize the spatial planning and regulations,and improve the protection of overlapping areas of 3Z3L by planning and regulations,improve the utilization efficiency of ecological and cultural-tourism space,meet the urban young people's multiple needs such as culture and ecology in 3D space,use new technologies to improve ecological services quality such as biological methods,strengthen the coordination of multiple management departments with the concept of nature based solutions,develop the“Reversed Transmission Effect”,keep the boundary of urban development strictly.