硼氢化三苯基苄基Ling的制备及还原性研究

用苄基三苯基氯化Ling与硼氢化钠反应制备硼氢化三苯基苄基Ling（简写BTPBP），还原醛、酮和酰氯等羧基化合物为相应的醇，具有良好的还原选择性和较好的产率并探讨了其反应过程。

基于LINGO10的单级圆柱齿轮减速器优化设计

将优化建模软件LINGO10应用于单级圆柱齿轮减速器的优化设计,在对单级圆柱齿轮减速器进行分析的基础上,以体积最小为目标建立结构优化设计的数学模型,并采用LINGO10进行求解。优化结果表明,利用LINGO10求解优化问题,能获得比MATLAB更好的优化结果,算法简单可靠,非常实用。

一种Ling选择进位加法器

设计一种Ling选择进位加法器,组间采用Ling进位代替传统的进位,利用内部连线与节点扇出平衡的并行前缀逻辑产生进位机制,并对通常的进位选择模块进行调整,以使其适合Ling进位。该加法器兼具了Ling加法器的快速性,又避免了逻辑产生的复杂性。实验结果表明,与超前进位加法器相比,该加法器的速度提高12%左右。

Ling classification describes endoscopic progressive process of achalasia and successful peroral endoscopy myotomy prevents endoscopic progression of achalasia

AIM To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy (POEM) to prevent endoscopic progression of achalasia. METHODS We retrospectively reviewed the endoscopic findings, symptom duration, and manometric data in patients with achalasia. A total of 359 patients (197 women, 162 men) with a mean age of 42.1 years (range, 12-75 years) were evaluated. Symptom duration ranged from 2 to 360 mo, with a median of 36 mo. Patients were classified with Ling type I (n = 119), II a (n = 106),II b (n = 60),II c (n = 60), or III (n = 14), according to the Ling classification. Of the 359 patients, 349 underwent POEM, among whom 21 had an endoscopic follow-up for more than 2 years. Pre-treatment and post-treatment Ling classifications of these 21 patients were compared. RESULTS Symptom duration increased significantly with increasing Ling classification (from I to III) (p < 0.05), whereas lower esophageal sphincter pressure decreased with increasing Ling type (from I to III) (p < 0.05). There was no difference in sex ratio or onset age among the Ling types, although the age at time of diagnosis was higher in Ling types I c and III than in Ling types I, IIa, and I b. Of the 21 patients, 19 underwent high-resolution manometry both before and after treatment. The mean preoperative and postoperative lower esophageal sphincter pressure were 34.6 mmHg (range, 15.3-59.4 mmHg) and 15.0 mmHg (range, 2.1-21.6 mmHg), respectively, indicating a statistically significant decrease after POEM. All of the 21 patients were treated successfully by POEM (postoperative Eckardt score <= 3) and still had the same Ling type during a mean follow-up period of 37.8 mo (range, 24-51 mo). CONCLUSION The Ling classification represents the endoscopic progressive process of achalasia and may be able to serve as an endoscopic assessment criterion for achalasia. Successful POEM (Eckardt score <= 3) seems to have the ability to prevent endoscopic evolvement of achalasia. However, studies with larger populations are warranted to confirm our findings.

Mechanical and thermal postbuckling of FGM thick circular cylindrical shells reinforced by FGM stiffener system using higher-order shear deformation theory

The postbuckling of the eccentrically stiffened circular cylindrical shells made of functionally graded materials （FGMs）, subjected to the axial compressive load and external uniform pressure and filled inside by the elastic foundations in the thermal environments, is investigated with an analytical method. The shells are reinforced by FGM stringers and rings. The thermal elements of the shells and stiffeners in the fundamental equations are considered. The equilibrium and nonlinear stability equations in terms of the displacement components for the stiffened shells are derived with the third-order shear deformation theory and Leckhniskii smeared stiffener technique. The closed-form expressions for determining the buckling load and postbuckling load-deflection curves are obtained with the Galerkin method. The effects of the stiffeners, the foundations, the material and dimensional parameters, and the pre-existent axial compressive and thermal load are considered.

Mechanics of rib spalling of high coal walls under fully-mechanized mining

In order to solve the problem of rib spalling of high coal walls in fully-mechanized（HCWFM）mines,we used the principle of damage mechanics to analyze coal wall rib spalling.The results show that coal wall rib spalling is,to a certain degree,a macro-performance of the development of micro-cracks.We built a mechanical model to simulate the damage to the front of coal walls,carried out theoretical calculations of the damage parameters,analyzed the effect of mining height,original cracks,seam strength,horizontal stress,vertical displacement of the coal walls and other parameters on coal wall rib spalling, which conform well with the results of our field measurements and numerical simulation.The key to control coal wall rib spalling is to control the development of cracks in coal walls.Accelerating the speed of advancing the working face,improving the setting load of support and the horizontal force of the guard board,strengthening coal walls and other technical measures can effectively reduce the degree of damage to the coal walls and control coal wall rib spalling at HCWFM faces.

100 Cases of Obstinate Insominia of Curative Effect by Acupuncture Da Ling Point

１００ＣａｓｅｓｏｆＯｂｓｔｉｎａｔｅＩｎｓｏｍｉｎｉａｏｆＣｕｒａｔｉｖｅＥｆｆｅｃｔｂｙＡｃｕｐｕｎｃｔｕｒｅＤａＬｉｎｇＰｏｉｎｔ￥ＬｅｅＷｅｎｂｅｎ（ＴｈｅｆｉｒｓｔｐｅＯＰｌｅｈｏｓｐｉｔａｌｏｆＹｕＣｉＣｉｔｙ０３０６００）Ｉｎｓｏｍｎｉ...

EXPERIMENTAL AND CLINICAL STUDIES OF “SHEN YAN LING” IN TREATMENT OF CHRONIC GLOMERULONEPHRITIS

“Shen Yan Ling”(SYL 肾炎灵) is a compoundherbal preparation consisting of 16 ingredients:HerbaEcliptae,Radix Rhemanniae,Rhizoma Cibotii,RadixAngelica Sinensis,Rhizoma Ligustici Chuanxiong,Radix Paeoniac Rubra,Rhizoma Diosocoreae,Poria,Radix Sanguisorbae,Radix Rubiae,Herba Portulacae,Fructus Gardeniae,Herba Cirsii Japonici,HerbaCephalanoploris.etc.In animal experiments,SYLwas shown to have therapeutic effect for Masugi’snephritis models.It has also been used with satis-factory results in the treatment of 314 cases of chronicglomerulonephritis of the common type with manifes-tations of Yin deficiency and endogenous heat.

Two New Eremophilane Sesquiterpene Lactones from Ligularia myriocephala Ling

Two new eremophilane sesquiterpene lactones, 1β-angeloyloxy-6β, 10β-dihydroxy-8β- methoxyeremophila-7（ll）en-8α,12-olide and 1β-angeloyloxy-6β,10α-dihydroxy-8α-methoxyeremo- phila-7（ 11）en-8β, 12-olide were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques （COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESIMS.

Mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease based on network pharmacology and experimental verification

Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.

RETRACTED:Exploring the Mechanism of Wu Ling San plus Flavor for the Treatment of Diabetic Macular Edema Based on Network Pharmacology and Molecular Docking Techniques

Short Retraction Notice The paper does not meet the standards of “Chinese Medicine ". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Editor guiding this retraction: Prof. Maythem Saeed (EiC of CM) The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".

Efficacy and safety of Shen Zhi Ling oral liquid(a Chinese patent)for Alzheimer's disease:A meta-analysis of randomized controlled trials

Objective:To evaluate the efficacy and safety of Shen Zhi Ling oral liquid(SZL)alone or combined with basic treatment in treating Alzheimer's Disease(AD).Methods:Databases including PubMed,the Cochrane Library,Embase,Web of science,China National Knowledge Infrastructure(CNKI),Wanfang Database and the Chinese Science and Technology Journal Database(VIP)were searched from inception to September 20,2020 to collect relevant randomized controlled trials(RCTs)comparing SZL with other nootropic drugs for AD.The primary clinical outcomes were scores of the Mini Mental State Examination(MMSE)and the Activities of Daily Living(ADL)during treatment.The secondary outcomes of our study included other neuropsychological scale scores including Rapid Verbal Retrieve(RVR),Digit Span(DS),Fuld Object-Memory Evaluation(FOM)and adverse events or reactions.Two authors searched and screened the literature independently,then extracted the data and evaluated the methodological quality by using the handbook of Cochrane Collaboration,and analyzed the data via the Review Manager 5.3 software.Results:In total,we included four studies,covering 217 participants.All studies were in a low methodological quality.The result of MMSE score,ADL score,RVR score,DS score and FOM score in the meta-analysis showed that no statistically significant difference(P>0.05)between the treatment groups and control groups,and the statistical heterogeneity of all meta-analyses was small(I2<50%).SZL was indicated no better than other nootropic drugs.Among the included studies,no study described adverse events.Conclusions:Considering the low quality of the included trials and the different levels of AD patients,we are unable to come to any conclusion about the efficacy and safety of SZL compared with other nootropic drugs.Moreover,we still need rigorously designed,multi-center,large-scale trials to further confirm the efficacy and safety of SZL.

Discussion on the Writing Techniques and Female Image Creation of Ling Shuhua＇s Novels

In the female writers of ＂5.4＂ , the quantity of Ling Shuhua＇ s works is not large, but the achievement isn＇t low because of her practiced skill and acute observation. By taking the novels for example, it is a reflection on three aspects： a kind of sad feeling under the poetic charm; the contrast of backward and new thought; the concealed comment and revealed value judgment. From these contrasts, people can know the Chinese female＇ s true state in the transition and the writer＇ s skill of fiction creation.

法国家具品牌Linge Roset

＂未来实质上扎根于每个人对于生活的期望＂,Linge Roset的总监Pierre and Michel Roset以寄于回忆、趣事的写实手法架起了Linge Roset过去与未来的桥梁。Linge Roset的设计思维是：新鲜事物会培育设计文化。比如,菲利普·尼格罗的Confluences座椅系列和弗朗索瓦·巴其特的罗马人储藏类家具系列项目都体现了Linge Roset的情感概念。

Unit 1 of Ling’ao Nuclear Power Plant phase II underwent hot functional test successfully

On February 25, the Unit 1 of Ling’ao Nuclear Power Plant phase II underwent a 41-day-long hot functional test successfully with its major systems satisfying the requirements for

Soong Ching Ling and Her Magazine-An Interview with Israel Epstein, Editor-in-Chief Emeritus of China Today

Last May 29 was the 20th anniversary of the death Of Mme Soong Ching Ling. In memory of this great woman of the 20th century the Soong Ching Ling Foundation sponsored a series of commemorative activities at her former residence in Beijing, including an exhibition of events in her life and a seminar Israel Epstein, editor-in-chief emeritus of China Today and vice-chairman of the Soong Ching Ling Foundation, was once a close friend of Mme Soong. He gave an interview to China Today on her memorial day. - Ed.

Ling'ao Nuclear Power Plant is progressing as scheduled

Construction of Ling’ao Nuclear Power Plant in Guangdong Province, the country’s second-largest nuclear power project between 1996-2000, chalked up notable progress this year. On July, 15, all foreign suppliers in the project were given official notice that both sides should start to implement the contracts. "The move marked a significant step forward in the project’s construction," said Zeng Wenxing, General Manager of Ling’ ao Nuclear Power Co Ltd, set up in