To reduce heat loss and save cost, a combination decision model of reverb aluminum holding furnace linings in aluminum casting industry was established based on economic thickness method, and was resolved using simula...To reduce heat loss and save cost, a combination decision model of reverb aluminum holding furnace linings in aluminum casting industry was established based on economic thickness method, and was resolved using simulated annealing. Meanwhile, a three-dimensional mathematical model of aluminum holding furnace linings was developed and integrated with user-defined heat load distribution regime model. The optimal combination was as follows: side wall with 80 mm alumino-silicate fiber felts, 232 mm diatomite brick and 116 mm chamotte brick; top wall with 50 mm clay castables, 110 mm alumino-silicate fiber felts and 200 mm refractory concrete;and bottom wall with 232 mm high-alumina brick, 60 mm clay castables and 68 mm diatomite brick. Lining temperature from high to low was successively bottom wall, side wall, and top wall. Lining temperature gradient in increasing order of magnitude was refractory layer and insulation layer. It was indicated that the results of combination optimization of aluminum holding furnace linings were valid and feasible, and its thermo-physical mechanism and cost characteristics were reasonably revealed.展开更多
For long-distance water conveyance shield tunnels in operation,the high internal water pressure may cause excessive deformation of composite linings,affecting their structural integrity and serviceability.However,the ...For long-distance water conveyance shield tunnels in operation,the high internal water pressure may cause excessive deformation of composite linings,affecting their structural integrity and serviceability.However,the deformation and failure characteristics of lining structures under internal water pressure are not well investigated in the literature,particularly for three-layer composite linings.This study presents an in situ experimental investigation on the response of two types of composite linings(i.e.separated and combined lining structures)subjected to internal pressures,in which a fiber optic nerve system(FONS)equipped with distributed strain and displacement sensing nerves was employed to monitor the performance of the two composite linings during testing.The experimental results clearly show that the damage of the tunnel lining under different internal pressures was mainly located in the self-compaction concrete layer.The separated lining structure responded more aggressively to the variations in internal pressures than the combined one.Moreover,two evaluation indices,i.e.radial displacement and effective stiffness coefficient,are proposed for describing the changes in the structural bearing performance.The effective stiffness coefficients of the two types of lining structures were reduced by 39.4%and 29.5%,respectively.Considering the convenience of field monitoring,it is suggested that the average strains at different layers can be used as characteristic parameters for estimating the health conditions of lining structures in service.The analysis results provide a practical reference for the design and health evaluation of water conveyance shield tunnels with composite linings.展开更多
This paper represented the numerical analysis of the FRP (fiber reinforced plastics) tunnel lining which was used for maintaining the old tunnel. An old tunnel covered with a concrete is prone to deteriorate due to ...This paper represented the numerical analysis of the FRP (fiber reinforced plastics) tunnel lining which was used for maintaining the old tunnel. An old tunnel covered with a concrete is prone to deteriorate due to an aging effect and a v^ater penetration. In the rehabilitation of lining concrete, a steel plate and FRP or carbon sheet have been applied. However, these sheets show small flexural rigidity and do not flow out the penetrating water. In this paper, FRP corrugate sheet was proposed. The tunnel lining was made by FRP corrugate sheet that supported the lining concrete in the tunnel and flowed the water and the moisture swept on the tunnel surface. The FRP corrugate sheet was supported by the anchor bolts. In numerical analyses, the finite element degenerate shell was adopted to represent the FRP sheet behavior. Assuming that the concrete liner at the top was fallen down, the peeled concrete was applied as the load. From the numerical analysis, the effectiveness of the FRO corrugate sheet was confirmed.展开更多
The nanoporous thermal insulating material was prepared by using fumed silica,SiC powder and glass fiber as starting materials,the appropriate thickness of the nanoporous thermal insulating material lined in ladle was...The nanoporous thermal insulating material was prepared by using fumed silica,SiC powder and glass fiber as starting materials,the appropriate thickness of the nanoporous thermal insulating material lined in ladle was discussed by the simulation method,and the effect of its application as ladle lining was investigated.The results show that the thermal conductivity of the nanoporous thermal insulating material prepared in composition of fumed silica: SiC powder: glass fiber =75: 20:5 (in mass) is 0.023 W · m^-1 · K^-1 at 1 000 ℃,the appropriate thickness of the nanoporous thermal insulating material lined in ladle is ≤ 5 mm and the average temperature of the ladle outside surface when lined with the nanoporous thermal insulating material is 95 ℃ lower than that with the ordinary thermal insulating material.展开更多
During construction,the shield linings of tunnels often face the problem of local or overall upward movement after leaving the shield tail in soft soil areas or during some large diameter shield projects.Differential ...During construction,the shield linings of tunnels often face the problem of local or overall upward movement after leaving the shield tail in soft soil areas or during some large diameter shield projects.Differential floating will increase the initial stress on the segments and bolts which is harmful to the service performance of the tunnel.In this study we used a random forest(RF)algorithm combined particle swarm optimization(PSO)and 5-fold cross-validation(5-fold CV)to predict the maximum upward displacement of tunnel linings induced by shield tunnel excavation.The mechanism and factors causing upward movement of the tunnel lining are comprehensively summarized.Twelve input variables were selected according to results from analysis of influencing factors.The prediction performance of two models,PSO-RF and RF(default)were compared.The Gini value was obtained to represent the relative importance of the influencing factors to the upward displacement of linings.The PSO-RF model successfully predicted the maximum upward displacement of the tunnel linings with a low error(mean absolute error(MAE)=4.04 mm,root mean square error(RMSE)=5.67 mm)and high correlation(R^(2)=0.915).The thrust and depth of the tunnel were the most important factors in the prediction model influencing the upward displacement of the tunnel linings.展开更多
Robotic-based technologies such as automated spraying or extrusion-based 3-dimensional(3D)concrete printing can be used to build tunnel linings,aiming at reducing labor and mitigating the associated safety issues,espe...Robotic-based technologies such as automated spraying or extrusion-based 3-dimensional(3D)concrete printing can be used to build tunnel linings,aiming at reducing labor and mitigating the associated safety issues,especially in the high-geothermal environment.Extrusion-based 3D concrete printing(3DCP)has additional advantages over automated sprayings,such as improved surface quality and no rebound.However,the effect of different temperatures on the adhesion performance of 3D-printed materials for tunnel linings has not been investigated.This study developed several alkali-activated slag mixtures with different activator modulus ratios to avoid the excessive use of Portland cement and enhance sustainability of 3D printable materials.The thermal responses of the mixtures at different temperatures of 20 and 40℃ were studied.The adhesion strength of the alkali-activated material was evaluated for both early and later ages.Furthermore,the structural evolution of the material exposed to different temperatures was measured.This was followed by microstructure characterization.Results indicate that elevated temperatures accelerate material reactions,resulting in improved early-age adhesion performance.Moreover,higher temperatures contribute to the development of a denser microstructure and enhanced mechanical strength in the hardened stage,particularly in mixtures with higher silicate content.展开更多
High-speed railway tunnels in various countries have continuously reported accidents of vault falling concrete blocks.Once the concrete block falling occurs,serious consequences follow,and traffic safety may be endang...High-speed railway tunnels in various countries have continuously reported accidents of vault falling concrete blocks.Once the concrete block falling occurs,serious consequences follow,and traffic safety may be endangered.The aerodynamic shockwave evolves from the initial compression wave may be an important inducement causing the tunnel lining cracks to grow and form falling concrete blocks.A joint calculation framework is established based on ANSYS Fluent,ABAQUS,and FRANC3D for calculating the crack tip field under the aerodynamic shockwave.The intensification effect of aerodynamic shockwaves in the crack is revealed,and the evolution characteristics of the crack tip field and the influence factors of stress intensity factor(SIF)are analyzed.Results show that(1)the aerodynamic shockwave intensifies after entering the crack,resulting in more significant pressure in the crack than the input pressure.The maximum pressure of the inclined and longitudinal cracks is higher than the corresponding values of the circumferential crack,respectively.(2)The maximum SIF of the circumferential,inclined,and longitudinal crack appears at 0.5,0.68,and 0.78 times the crack front length.The maximum SIF of the circumferential crack is higher than that of the inclined and longitudinal crack.The possibility of crack growth of the circumferential crack is the highest under aerodynamic shockwaves.(3)The influence of train speed on the SIF of the circumferential crack is more than 40%.When the train speed,crack depth,and crack length change,the change of pressure in the crack is the direct cause of the change of SIF.展开更多
Metro(subway)is an advanced public transport infrastructure system in urban areas with high capacity.The traffic operation of a metro is not affected by other vehicle traffic thanks to underground tunnels.With these b...Metro(subway)is an advanced public transport infrastructure system in urban areas with high capacity.The traffic operation of a metro is not affected by other vehicle traffic thanks to underground tunnels.With these benefits metro lines are preferred to solve the traffic problem in urbanized cities such as Istanbul,which is the focus of this study.Metro projects require huge amounts of budgets to be built.Putting these projects into service in targeted time is of great importance.The objective of this study is to minimize total metro construction project time by utilizing fiber reinforcement in tunnel linings.In this research,using fiber reinforcement to construct primary(initial)tunnel linings and secondary(final)tunnel linings of the metro projects are analyzed in terms of project duration.After comparison of two railway tunnel projects,evaluations and observations of a completed metro project revealed that using fiber reinforcement for either the primary lining or the final lining of tunnels reduces construction time of metro station tunnels by 25%.In addition,using fiber reinforcement to construct both the final lining and the primary lining of tunnels reduces construction time of the metro station tunnels and the whole metro project by 47% and 22%,respectively.The results of this study can be useful for completing challenging metro projects and putting it into service within the targeted time.展开更多
The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytica...The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical shells.By taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue equations.Besides,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are investigated.It is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.展开更多
Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarke...Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed in manic patients compared to controls, and dysregulation of miR-134,-152,-607,-633,-652,-155 occurred in euthymic patients compared to controls. Finally, microRNAs such as miR-34a,-34b,-34c,-137, and-140-3p,-21-3p,-30d-5p,-330-5p,-378a-5p,-134,-19b-3p were shown to have diagnostic potential in distinguishing bipolar disorder patients from schizophrenia or major depressive disorder patients, respectively. Further studies are warranted with adolescents and young adults having bipolar disorder and consideration should be given to using animal models of the disorder to investigate the effects of suppressing or overexpressing specific microRNAs.展开更多
Cement channel linings in an urban stream in St. Louis, Missouri increase event water contributions during flooding, shorten transport times, and magnify geochemical variability on both short and seasonal timescales d...Cement channel linings in an urban stream in St. Louis, Missouri increase event water contributions during flooding, shorten transport times, and magnify geochemical variability on both short and seasonal timescales due to disruption of hyporheic flowpaths. Detailed analyses of water isotopes, major and trace elements, and in situ water quality data for an individual flood event reveal that baseflow contributions rise by 8% only 320 m downstream of the point where this particular channel changes from cement-lined to unlined. However, additional hydrograph separations indicate baseflow contributions are variable and can be much higher(average baseflow increase is 16%). Stream electrical conductivity(EC) and solute concentrations in the lined reach were up to 25% lower during peak flow than in the unlined channel, indicating a greater event flow fraction. In contrast, during low flow, stream EC and solute concentrations in the lined reach were up to 30% higher due to the restricted inflow of more dilute groundwater. Over longer timescales, EC, solute concentrations, turbidity, and bacterial loads decrease downstream signifying increasing contributions of dilute baseflow. The decreased connectivity of surface waters and groundwaters along the hyporheic zone in lined channels increases the hydrologic and geochemical variability of urban streams.展开更多
Powdery mildew is a serious disease caused by Blumeria graminis f.sp.tritici(Bgt)that critically threatens the yield and quality of wheat(Triticum aestivum L.).Using effective powdery mildew resistance genes is the op...Powdery mildew is a serious disease caused by Blumeria graminis f.sp.tritici(Bgt)that critically threatens the yield and quality of wheat(Triticum aestivum L.).Using effective powdery mildew resistance genes is the optimal method for controlling this disease.Against the background of high genetic homogeneity among the modern commercial cultivars that are mainly derived from conventional interbreeding,the resistance genes from wheat relatives have especially prominent advantages.Octoploid triticale,produced from common wheat and rye(Secale cereale L.)through distant hybridization,is a new synthetic species and valuable gene donor for wheat improvement.In this study,we developed the wheat-rye line YT5 through the hybridization of octaploid triticale and two wheat lines.YT5 was confirmed to be a 6RL ditelosomic addition and 1R(1B)substitution line using genomic in situ hybridization(GISH),multicolor fluorescence in situ hybridization(mc-FISH),multicolor GISH(mc-GISH)and molecular marker analysis.Genetic analysis showed that the powdery mildew resistance in YT5 was derived from the rye chromosome arm 6RL.After inoculation with different Bgt isolates at the seedling stage,YT5 had compound reaction patterns with both obvious spores and hypersensitivity,and it gradually became highly resistant until the adult-plant stage,thus showing a resistance response significantly different from the reported Pm genes from rye chromosome 6RL.YT5 also showed promising agronomic performance,so it is expected to be an elite resistance donor for wheat improvement.To promote the transfer of the chromosome arm 6RL of YT5 in marker-assisted selection(MAS)breeding,we selected and verified two 6RL-specific kompetitive allelespecific PCR(KASP)markers that can be applied to efficiently detect this chromosome arm in different wheat backgrounds.展开更多
BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metasta...BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metastatic colorectal cancer(mCRC).Several studies have also demonstrated the benefit of anti-EGFR therapy in sub-sequent line settings for this patient population.However,direct evidence com-paring the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited,leaving a crucial gap in guiding optimal treatment strategies.AIM To compare overall survival(OS)between frontline and subsequent anti-EGFR treatment in patients with unresectable,RAS and BRAF wild-type,left-sided mCRC.METHODS We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital,Thailand,between January 2013 and April 2023.Patients were classified into two groups based on the sequence of their anti-EGFR treatment.The primary endpoint was OS.RESULTS Among 222 patients with a median follow-up of 29 months,no significant difference in OS was observed between the frontline and subsequent-line groups(HR 1.03,95%CI:0.73-1.46,P=0.878).The median OS was 35.53 months(95%CI:26.59-44.47)for the frontline group and 31.60 months(95%CI:27.83-35.37)for the subsequent-line group.In the subsequent-line group,71 patients(32.4%)who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months(95%CI:12.87-26.53).CONCLUSION Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable,RAS/BRAF wild-type,left-sided mCRC patients,but early exposure is vital for those unlikely to receive subsequent therapy.展开更多
Full-scale loading tests were performed on shield segmental linings bearing a high earth pressure and high inner water pressure,focus-ing on the effects of the inner water load and assembly manner on the mechanical pr...Full-scale loading tests were performed on shield segmental linings bearing a high earth pressure and high inner water pressure,focus-ing on the effects of the inner water load and assembly manner on the mechanical properties of the segmental linings.The test results indicate that the deep-buried segmental linings without inner pressure have a high safety reserve.After the action of high inner water pressure,the lining deformation will increase with the reduction of the safety reserve,caused by the significant decrease in the axial force in the linings.Because the bending moment at the segmental joints is transferred to the segment sections in the adjacent ling rings,the convergence deformation,openings of segmental joints,and bolt strains are smaller for the stagger-jointed lining than those for the continuous-jointed lining;however,dislocations appear in the circumferential joints owing to the stagger-jointed assembly.Although it significantly improves the mechanical performance of the segmental lining,stagger-jointed assembly results in compromising the water-proofing safety of circumferential joints.The stagger-jointed assembly manner can be considered to improve the service performance of shield tunnels bearing high inner water pressure on the premise that circumferential joint waterproofing is satisfied.展开更多
Model tests and numerical calculations were adopted based on the New Yuanliangshan tunnel project to investigate the water pressure resistance of lining construction joints in high-pressure and water-rich karst tunnel...Model tests and numerical calculations were adopted based on the New Yuanliangshan tunnel project to investigate the water pressure resistance of lining construction joints in high-pressure and water-rich karst tunnels.A large-scale model test was designed and conducted,innovatively transforming the external water pressure of the lining construction joint into internal water pressure.The effects of the embedded position and waterstop type on the water pressure resistance of the construction joint were analyzed,and the reliability of the model test was verified via numerical calculations.The results show that using waterstops can significantly improve the water pressure resistance of lining construction joints.The water pressure resistance of the lining construction joint is positively correlated with the lining thickness and embedded depth of the waterstop.In addition,the type of waterstop significantly influences the water pressure resistance of lining construction joints.The test results show that the water pressure resistance of the embedded transverse reinforced waterstop is similar to that of the steel plate waterstop,and both have more advantages than the rubber waterstop.The water pressure resistance of the construction joint determined via numerical calculations is similar to the model test results,indicating that the model test results have high accuracy and reliability.This study provides a reference for similar projects and has wide applications.展开更多
It is important to be able to measure stresses in tunnel linings to verify design assumptions and validate numerical models.For sprayed concrete-lined tunnels,continuous monitoring of stresses from the time of sprayin...It is important to be able to measure stresses in tunnel linings to verify design assumptions and validate numerical models.For sprayed concrete-lined tunnels,continuous monitoring of stresses from the time of spraying onwards is desirable,and this can only be achieved using pressure cells installed on and in the sprayed concrete lining.Although there has been some success in using radial pressure cells between the ground and the lining,a method for obtaining reliable absolute values of stress from tangential pressure cells embedded in the sprayed concrete has not been available.This paper describes numerical and experimental studies of the behavior of pressure cells for monitoring stresses in a sprayed concrete lining and describes an original methodology to achieve reliable results.In particular,data from tangential pressure cells require careful interpretation,as they are sensitive to temperature,and this temperature sensitivity is found in parametric numerical analyses to vary as the stiffness of the concrete and its coefficient of thermal expansion evolve at early age.Tangential pressure cells are also sensitive to shrinkage strains in the concrete,and a methodology for removing this effect is described.Using the approach described in this paper,it is now possible to use pressure cells to measure absolute values of stresses in and on sprayed concrete tunnel linings from early age into the long-term.An example of radial and tangential pressure cells installed in the Heathrow Terminal 4 concourse tunnel is used to illustrate the methodology.展开更多
Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion resistance.During installation and operation,the pipe may undergo severe bending deformation,which cau...Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion resistance.During installation and operation,the pipe may undergo severe bending deformation,which causes the liner to separate from the outer pipe and buckles,affecting the stability of the whole line.In this paper,the buckling response of MLP subjected to bending is investigated to clarify its bending characteristics by employing both experiments,numerical simulation,as theoretical methods.Two types of MLPs were manufactured with GB 45 carbon steel(SLP)and Al 6061(ALP)used as the outer pipe material,respectively.The hydraulic expansion and bending experiments of small-scale MLPs are conducted.In addition to the ovalized shape of the cross-section for the SLP specimens,the copper liner was found to wrinkle on the compressive side.In contrast,the liner of ALP remains intact without developing any wrinkling and collapse mode.In addition,a dedicated numerical framework and theoretical models were also established.It was found both the manufacturing and bending responses of the MLP can be well reproduced,and the predicted maximum moment and critical curvatures are in good agreement with the experimental results.展开更多
Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when deal...Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when dealing with color fundus images due to issues like non-uniformillumination,low contrast,and variations in vessel appearance,especially in the presence of different pathologies.Furthermore,the speed of the retinal vessel segmentation system is of utmost importance.With the surge of now available big data,the speed of the algorithm becomes increasingly important,carrying almost equivalent weightage to the accuracy of the algorithm.To address these challenges,we present a novel approach for retinal vessel segmentation,leveraging efficient and robust techniques based on multiscale line detection and mathematical morphology.Our algorithm’s performance is evaluated on two publicly available datasets,namely the Digital Retinal Images for Vessel Extraction dataset(DRIVE)and the Structure Analysis of Retina(STARE)dataset.The experimental results demonstrate the effectiveness of our method,withmean accuracy values of 0.9467 forDRIVE and 0.9535 for STARE datasets,aswell as sensitivity values of 0.6952 forDRIVE and 0.6809 for STARE datasets.Notably,our algorithmexhibits competitive performance with state-of-the-art methods.Importantly,it operates at an average speed of 3.73 s per image for DRIVE and 3.75 s for STARE datasets.It is worth noting that these results were achieved using Matlab scripts containing multiple loops.This suggests that the processing time can be further reduced by replacing loops with vectorization.Thus the proposed algorithm can be deployed in real time applications.In summary,our proposed system strikes a fine balance between swift computation and accuracy that is on par with the best available methods in the field.展开更多
This study presents results on detecting neutral atomic hydrogen(H I)21 cm absorption in the spectrum of PKS PKS1413+13 at redshift z=0.24670041.The observation was conducted by FAST,with a spectral resolution of10 Hz...This study presents results on detecting neutral atomic hydrogen(H I)21 cm absorption in the spectrum of PKS PKS1413+13 at redshift z=0.24670041.The observation was conducted by FAST,with a spectral resolution of10 Hz,using 10 minutes of observing time.The global spectral profile is examined by modeling the absorption line using a single Gaussian function with a resolution of 10 kHz within a 2 MHz bandwidth.The goal is to determine the rate of the latest cosmic acceleration by directly measuring the redshift evolution of the H I 21 cm absorption line with Hubble flow toward a common background quasar over a decade or longer time span.This will serve as a detectable signal generated by the accelerated expansion of the Universe at redshift z<1,referred to as redshift drift z(5)or the SL effect.The measured H I gas column density in this DLA system is approximately equivalent to the initial observation value,considering uncertainties of the spin temperature of a spiral host galaxy.The high signal-to-noise ratio of 57,obtained at a 10 kHz resolution,strongly supports the feasibility of using the H I 21 cm absorption line in DLA systems to accurately measure the redshift drift rate at a precision level of around 10~(-10)per decade.展开更多
With the exceptional sensitivity of the Five-hundred-meter Aperture Spherical radio Telescope,we conducted observations of the neutral hydrogen(HⅠ)in the circumgalactic medium of Andromeda’s(M31)satellite galaxies,s...With the exceptional sensitivity of the Five-hundred-meter Aperture Spherical radio Telescope,we conducted observations of the neutral hydrogen(HⅠ)in the circumgalactic medium of Andromeda’s(M31)satellite galaxies,specifically AndromedaⅡ,NGC 205,and NGC 185.Initially,three drift scans were executed for these satellites,with a detection limit of 4×10^(18)cm^(-2)(approximately 1.88×10^(3)M_Θof HⅠmass),followed by a more in-depth scan of a specific region.We discovered a C-shaped HⅠarc structure sharing a position and line-of-sight velocity similar to a stellar ring structure around AndromedaⅡ,hinting at a potential connection with AndromedaⅡ.In the context of NGC 205,we identified two mass concentrations in the northeast direction,which could be indicative of tidal streams resulting from the interaction between this galaxy and M31.These new lumps discovered could be very helpful in solving the missing interstellar medium problem for NGC 205.Observations regarding NGC 185are consistent with previous studies,and we did not detect any additional HⅠmaterial around this galaxy.These observational results enhance our understanding of the evolution of these satellite galaxies and provide insight into their historical interactions with the galaxy M31.展开更多
基金Supported by the National Natural Science Foundation of China(51306001)the Natural Science Foundation of Anhui Province(1408085QG138)+1 种基金the Natural Science Foundation of Anhui Technology University(QZ201303,QS201304)the Student Research Training Program of Anhui University of Technology(AH201310360120)
文摘To reduce heat loss and save cost, a combination decision model of reverb aluminum holding furnace linings in aluminum casting industry was established based on economic thickness method, and was resolved using simulated annealing. Meanwhile, a three-dimensional mathematical model of aluminum holding furnace linings was developed and integrated with user-defined heat load distribution regime model. The optimal combination was as follows: side wall with 80 mm alumino-silicate fiber felts, 232 mm diatomite brick and 116 mm chamotte brick; top wall with 50 mm clay castables, 110 mm alumino-silicate fiber felts and 200 mm refractory concrete;and bottom wall with 232 mm high-alumina brick, 60 mm clay castables and 68 mm diatomite brick. Lining temperature from high to low was successively bottom wall, side wall, and top wall. Lining temperature gradient in increasing order of magnitude was refractory layer and insulation layer. It was indicated that the results of combination optimization of aluminum holding furnace linings were valid and feasible, and its thermo-physical mechanism and cost characteristics were reasonably revealed.
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.42225702 and 42077235)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.KYCX22_0162)the scientific research project of Guangdong Yue Hai Pearl River Delta Water Supply Co.,Ltd.The authors thank Guangqing Wei,Lixiang Jia,and Zhen Zhang,all of Suzhou Nanzee Sensing Co.,Ltd.,for their assistance in the tests.The valuable suggestions provided by Professor Baojun Wang,Nanjing University,are also gratefully acknowledged.
文摘For long-distance water conveyance shield tunnels in operation,the high internal water pressure may cause excessive deformation of composite linings,affecting their structural integrity and serviceability.However,the deformation and failure characteristics of lining structures under internal water pressure are not well investigated in the literature,particularly for three-layer composite linings.This study presents an in situ experimental investigation on the response of two types of composite linings(i.e.separated and combined lining structures)subjected to internal pressures,in which a fiber optic nerve system(FONS)equipped with distributed strain and displacement sensing nerves was employed to monitor the performance of the two composite linings during testing.The experimental results clearly show that the damage of the tunnel lining under different internal pressures was mainly located in the self-compaction concrete layer.The separated lining structure responded more aggressively to the variations in internal pressures than the combined one.Moreover,two evaluation indices,i.e.radial displacement and effective stiffness coefficient,are proposed for describing the changes in the structural bearing performance.The effective stiffness coefficients of the two types of lining structures were reduced by 39.4%and 29.5%,respectively.Considering the convenience of field monitoring,it is suggested that the average strains at different layers can be used as characteristic parameters for estimating the health conditions of lining structures in service.The analysis results provide a practical reference for the design and health evaluation of water conveyance shield tunnels with composite linings.
文摘This paper represented the numerical analysis of the FRP (fiber reinforced plastics) tunnel lining which was used for maintaining the old tunnel. An old tunnel covered with a concrete is prone to deteriorate due to an aging effect and a v^ater penetration. In the rehabilitation of lining concrete, a steel plate and FRP or carbon sheet have been applied. However, these sheets show small flexural rigidity and do not flow out the penetrating water. In this paper, FRP corrugate sheet was proposed. The tunnel lining was made by FRP corrugate sheet that supported the lining concrete in the tunnel and flowed the water and the moisture swept on the tunnel surface. The FRP corrugate sheet was supported by the anchor bolts. In numerical analyses, the finite element degenerate shell was adopted to represent the FRP sheet behavior. Assuming that the concrete liner at the top was fallen down, the peeled concrete was applied as the load. From the numerical analysis, the effectiveness of the FRO corrugate sheet was confirmed.
文摘The nanoporous thermal insulating material was prepared by using fumed silica,SiC powder and glass fiber as starting materials,the appropriate thickness of the nanoporous thermal insulating material lined in ladle was discussed by the simulation method,and the effect of its application as ladle lining was investigated.The results show that the thermal conductivity of the nanoporous thermal insulating material prepared in composition of fumed silica: SiC powder: glass fiber =75: 20:5 (in mass) is 0.023 W · m^-1 · K^-1 at 1 000 ℃,the appropriate thickness of the nanoporous thermal insulating material lined in ladle is ≤ 5 mm and the average temperature of the ladle outside surface when lined with the nanoporous thermal insulating material is 95 ℃ lower than that with the ordinary thermal insulating material.
基金supported by the Basic Science Center Program for Multiphase Evolution in Hyper Gravity of the National Natural Science Foundation of China(No.51988101)the National Natural Science Foundation of China(No.52178306)the Zhejiang Provincial Natural Science Foundation of China(No.LR19E080002).
文摘During construction,the shield linings of tunnels often face the problem of local or overall upward movement after leaving the shield tail in soft soil areas or during some large diameter shield projects.Differential floating will increase the initial stress on the segments and bolts which is harmful to the service performance of the tunnel.In this study we used a random forest(RF)algorithm combined particle swarm optimization(PSO)and 5-fold cross-validation(5-fold CV)to predict the maximum upward displacement of tunnel linings induced by shield tunnel excavation.The mechanism and factors causing upward movement of the tunnel lining are comprehensively summarized.Twelve input variables were selected according to results from analysis of influencing factors.The prediction performance of two models,PSO-RF and RF(default)were compared.The Gini value was obtained to represent the relative importance of the influencing factors to the upward displacement of linings.The PSO-RF model successfully predicted the maximum upward displacement of the tunnel linings with a low error(mean absolute error(MAE)=4.04 mm,root mean square error(RMSE)=5.67 mm)and high correlation(R^(2)=0.915).The thrust and depth of the tunnel were the most important factors in the prediction model influencing the upward displacement of the tunnel linings.
基金the Industrial Research Fund(No.IOF.PRO.2022.0010.01).
文摘Robotic-based technologies such as automated spraying or extrusion-based 3-dimensional(3D)concrete printing can be used to build tunnel linings,aiming at reducing labor and mitigating the associated safety issues,especially in the high-geothermal environment.Extrusion-based 3D concrete printing(3DCP)has additional advantages over automated sprayings,such as improved surface quality and no rebound.However,the effect of different temperatures on the adhesion performance of 3D-printed materials for tunnel linings has not been investigated.This study developed several alkali-activated slag mixtures with different activator modulus ratios to avoid the excessive use of Portland cement and enhance sustainability of 3D printable materials.The thermal responses of the mixtures at different temperatures of 20 and 40℃ were studied.The adhesion strength of the alkali-activated material was evaluated for both early and later ages.Furthermore,the structural evolution of the material exposed to different temperatures was measured.This was followed by microstructure characterization.Results indicate that elevated temperatures accelerate material reactions,resulting in improved early-age adhesion performance.Moreover,higher temperatures contribute to the development of a denser microstructure and enhanced mechanical strength in the hardened stage,particularly in mixtures with higher silicate content.
基金funded by the National Natural Science Foundation of China(Grant Nos.51978670 and 52308419)the Science and Technology Research and Development Program of China railway group limited(Grant Nos.2021-Major-01 and 2022-Key-22)+3 种基金the Fundamental Research Funds for the Central Universities of Central South University(Grant No.2023ZZTS0369)the Guangdong Basic and Applied Basic Research Foundation Project(Grant No.2021B1515130006)the Innovation and Technology Commission of Hong Kong,China(Grant No.K-BBY1)the Hong Kong Polytechnic University’s Postdoc Matching Fund Scheme(Grant No.1-W21Q).
文摘High-speed railway tunnels in various countries have continuously reported accidents of vault falling concrete blocks.Once the concrete block falling occurs,serious consequences follow,and traffic safety may be endangered.The aerodynamic shockwave evolves from the initial compression wave may be an important inducement causing the tunnel lining cracks to grow and form falling concrete blocks.A joint calculation framework is established based on ANSYS Fluent,ABAQUS,and FRANC3D for calculating the crack tip field under the aerodynamic shockwave.The intensification effect of aerodynamic shockwaves in the crack is revealed,and the evolution characteristics of the crack tip field and the influence factors of stress intensity factor(SIF)are analyzed.Results show that(1)the aerodynamic shockwave intensifies after entering the crack,resulting in more significant pressure in the crack than the input pressure.The maximum pressure of the inclined and longitudinal cracks is higher than the corresponding values of the circumferential crack,respectively.(2)The maximum SIF of the circumferential,inclined,and longitudinal crack appears at 0.5,0.68,and 0.78 times the crack front length.The maximum SIF of the circumferential crack is higher than that of the inclined and longitudinal crack.The possibility of crack growth of the circumferential crack is the highest under aerodynamic shockwaves.(3)The influence of train speed on the SIF of the circumferential crack is more than 40%.When the train speed,crack depth,and crack length change,the change of pressure in the crack is the direct cause of the change of SIF.
文摘Metro(subway)is an advanced public transport infrastructure system in urban areas with high capacity.The traffic operation of a metro is not affected by other vehicle traffic thanks to underground tunnels.With these benefits metro lines are preferred to solve the traffic problem in urbanized cities such as Istanbul,which is the focus of this study.Metro projects require huge amounts of budgets to be built.Putting these projects into service in targeted time is of great importance.The objective of this study is to minimize total metro construction project time by utilizing fiber reinforcement in tunnel linings.In this research,using fiber reinforcement to construct primary(initial)tunnel linings and secondary(final)tunnel linings of the metro projects are analyzed in terms of project duration.After comparison of two railway tunnel projects,evaluations and observations of a completed metro project revealed that using fiber reinforcement for either the primary lining or the final lining of tunnels reduces construction time of metro station tunnels by 25%.In addition,using fiber reinforcement to construct both the final lining and the primary lining of tunnels reduces construction time of the metro station tunnels and the whole metro project by 47% and 22%,respectively.The results of this study can be useful for completing challenging metro projects and putting it into service within the targeted time.
基金supported by the National Natural Science Foundation of China(12172023).
文摘The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical shells.By taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue equations.Besides,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are investigated.It is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.
文摘Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed in manic patients compared to controls, and dysregulation of miR-134,-152,-607,-633,-652,-155 occurred in euthymic patients compared to controls. Finally, microRNAs such as miR-34a,-34b,-34c,-137, and-140-3p,-21-3p,-30d-5p,-330-5p,-378a-5p,-134,-19b-3p were shown to have diagnostic potential in distinguishing bipolar disorder patients from schizophrenia or major depressive disorder patients, respectively. Further studies are warranted with adolescents and young adults having bipolar disorder and consideration should be given to using animal models of the disorder to investigate the effects of suppressing or overexpressing specific microRNAs.
基金partially supported by a USEPA subcontract from the Watershed Management Plan Development Grant Program through the Missouri Department of Natural Resources to the University City Department of Public Works (No. G06-NPS-18)ICP-OES and ICP-MS analyses were performed at the Nano Research Facility (NRF) of Washington University+1 种基金a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the National Science Foundation (No. ECS-0335765)two anonymous reviewers for constructive comments that helped improve this manuscript
文摘Cement channel linings in an urban stream in St. Louis, Missouri increase event water contributions during flooding, shorten transport times, and magnify geochemical variability on both short and seasonal timescales due to disruption of hyporheic flowpaths. Detailed analyses of water isotopes, major and trace elements, and in situ water quality data for an individual flood event reveal that baseflow contributions rise by 8% only 320 m downstream of the point where this particular channel changes from cement-lined to unlined. However, additional hydrograph separations indicate baseflow contributions are variable and can be much higher(average baseflow increase is 16%). Stream electrical conductivity(EC) and solute concentrations in the lined reach were up to 25% lower during peak flow than in the unlined channel, indicating a greater event flow fraction. In contrast, during low flow, stream EC and solute concentrations in the lined reach were up to 30% higher due to the restricted inflow of more dilute groundwater. Over longer timescales, EC, solute concentrations, turbidity, and bacterial loads decrease downstream signifying increasing contributions of dilute baseflow. The decreased connectivity of surface waters and groundwaters along the hyporheic zone in lined channels increases the hydrologic and geochemical variability of urban streams.
基金supported by the National Key Research and Development Program of China(2021YFD1200600)the National Natural Science Foundation of China(32272105).
文摘Powdery mildew is a serious disease caused by Blumeria graminis f.sp.tritici(Bgt)that critically threatens the yield and quality of wheat(Triticum aestivum L.).Using effective powdery mildew resistance genes is the optimal method for controlling this disease.Against the background of high genetic homogeneity among the modern commercial cultivars that are mainly derived from conventional interbreeding,the resistance genes from wheat relatives have especially prominent advantages.Octoploid triticale,produced from common wheat and rye(Secale cereale L.)through distant hybridization,is a new synthetic species and valuable gene donor for wheat improvement.In this study,we developed the wheat-rye line YT5 through the hybridization of octaploid triticale and two wheat lines.YT5 was confirmed to be a 6RL ditelosomic addition and 1R(1B)substitution line using genomic in situ hybridization(GISH),multicolor fluorescence in situ hybridization(mc-FISH),multicolor GISH(mc-GISH)and molecular marker analysis.Genetic analysis showed that the powdery mildew resistance in YT5 was derived from the rye chromosome arm 6RL.After inoculation with different Bgt isolates at the seedling stage,YT5 had compound reaction patterns with both obvious spores and hypersensitivity,and it gradually became highly resistant until the adult-plant stage,thus showing a resistance response significantly different from the reported Pm genes from rye chromosome 6RL.YT5 also showed promising agronomic performance,so it is expected to be an elite resistance donor for wheat improvement.To promote the transfer of the chromosome arm 6RL of YT5 in marker-assisted selection(MAS)breeding,we selected and verified two 6RL-specific kompetitive allelespecific PCR(KASP)markers that can be applied to efficiently detect this chromosome arm in different wheat backgrounds.
文摘BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metastatic colorectal cancer(mCRC).Several studies have also demonstrated the benefit of anti-EGFR therapy in sub-sequent line settings for this patient population.However,direct evidence com-paring the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited,leaving a crucial gap in guiding optimal treatment strategies.AIM To compare overall survival(OS)between frontline and subsequent anti-EGFR treatment in patients with unresectable,RAS and BRAF wild-type,left-sided mCRC.METHODS We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital,Thailand,between January 2013 and April 2023.Patients were classified into two groups based on the sequence of their anti-EGFR treatment.The primary endpoint was OS.RESULTS Among 222 patients with a median follow-up of 29 months,no significant difference in OS was observed between the frontline and subsequent-line groups(HR 1.03,95%CI:0.73-1.46,P=0.878).The median OS was 35.53 months(95%CI:26.59-44.47)for the frontline group and 31.60 months(95%CI:27.83-35.37)for the subsequent-line group.In the subsequent-line group,71 patients(32.4%)who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months(95%CI:12.87-26.53).CONCLUSION Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable,RAS/BRAF wild-type,left-sided mCRC patients,but early exposure is vital for those unlikely to receive subsequent therapy.
基金supported by the National Natural Science Foundation of China(Grant No.52008308)the Postdoctoral Innovative Talents Supporting Program(Grant No.BX20200247)the China Postdoctoral Science Foundation(Grant No.2021M692447).
文摘Full-scale loading tests were performed on shield segmental linings bearing a high earth pressure and high inner water pressure,focus-ing on the effects of the inner water load and assembly manner on the mechanical properties of the segmental linings.The test results indicate that the deep-buried segmental linings without inner pressure have a high safety reserve.After the action of high inner water pressure,the lining deformation will increase with the reduction of the safety reserve,caused by the significant decrease in the axial force in the linings.Because the bending moment at the segmental joints is transferred to the segment sections in the adjacent ling rings,the convergence deformation,openings of segmental joints,and bolt strains are smaller for the stagger-jointed lining than those for the continuous-jointed lining;however,dislocations appear in the circumferential joints owing to the stagger-jointed assembly.Although it significantly improves the mechanical performance of the segmental lining,stagger-jointed assembly results in compromising the water-proofing safety of circumferential joints.The stagger-jointed assembly manner can be considered to improve the service performance of shield tunnels bearing high inner water pressure on the premise that circumferential joint waterproofing is satisfied.
基金the General Program of the National Natural Science Foundation of China(Grant No.51878037).
文摘Model tests and numerical calculations were adopted based on the New Yuanliangshan tunnel project to investigate the water pressure resistance of lining construction joints in high-pressure and water-rich karst tunnels.A large-scale model test was designed and conducted,innovatively transforming the external water pressure of the lining construction joint into internal water pressure.The effects of the embedded position and waterstop type on the water pressure resistance of the construction joint were analyzed,and the reliability of the model test was verified via numerical calculations.The results show that using waterstops can significantly improve the water pressure resistance of lining construction joints.The water pressure resistance of the lining construction joint is positively correlated with the lining thickness and embedded depth of the waterstop.In addition,the type of waterstop significantly influences the water pressure resistance of lining construction joints.The test results show that the water pressure resistance of the embedded transverse reinforced waterstop is similar to that of the steel plate waterstop,and both have more advantages than the rubber waterstop.The water pressure resistance of the construction joint determined via numerical calculations is similar to the model test results,indicating that the model test results have high accuracy and reliability.This study provides a reference for similar projects and has wide applications.
文摘It is important to be able to measure stresses in tunnel linings to verify design assumptions and validate numerical models.For sprayed concrete-lined tunnels,continuous monitoring of stresses from the time of spraying onwards is desirable,and this can only be achieved using pressure cells installed on and in the sprayed concrete lining.Although there has been some success in using radial pressure cells between the ground and the lining,a method for obtaining reliable absolute values of stress from tangential pressure cells embedded in the sprayed concrete has not been available.This paper describes numerical and experimental studies of the behavior of pressure cells for monitoring stresses in a sprayed concrete lining and describes an original methodology to achieve reliable results.In particular,data from tangential pressure cells require careful interpretation,as they are sensitive to temperature,and this temperature sensitivity is found in parametric numerical analyses to vary as the stiffness of the concrete and its coefficient of thermal expansion evolve at early age.Tangential pressure cells are also sensitive to shrinkage strains in the concrete,and a methodology for removing this effect is described.Using the approach described in this paper,it is now possible to use pressure cells to measure absolute values of stresses in and on sprayed concrete tunnel linings from early age into the long-term.An example of radial and tangential pressure cells installed in the Heathrow Terminal 4 concourse tunnel is used to illustrate the methodology.
基金Fofinancially supported by the National Natural Science Foundation of China(Grant No.52271288)Peiyang Scholar Initiation Fund from Tianjin University。
文摘Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion resistance.During installation and operation,the pipe may undergo severe bending deformation,which causes the liner to separate from the outer pipe and buckles,affecting the stability of the whole line.In this paper,the buckling response of MLP subjected to bending is investigated to clarify its bending characteristics by employing both experiments,numerical simulation,as theoretical methods.Two types of MLPs were manufactured with GB 45 carbon steel(SLP)and Al 6061(ALP)used as the outer pipe material,respectively.The hydraulic expansion and bending experiments of small-scale MLPs are conducted.In addition to the ovalized shape of the cross-section for the SLP specimens,the copper liner was found to wrinkle on the compressive side.In contrast,the liner of ALP remains intact without developing any wrinkling and collapse mode.In addition,a dedicated numerical framework and theoretical models were also established.It was found both the manufacturing and bending responses of the MLP can be well reproduced,and the predicted maximum moment and critical curvatures are in good agreement with the experimental results.
文摘Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when dealing with color fundus images due to issues like non-uniformillumination,low contrast,and variations in vessel appearance,especially in the presence of different pathologies.Furthermore,the speed of the retinal vessel segmentation system is of utmost importance.With the surge of now available big data,the speed of the algorithm becomes increasingly important,carrying almost equivalent weightage to the accuracy of the algorithm.To address these challenges,we present a novel approach for retinal vessel segmentation,leveraging efficient and robust techniques based on multiscale line detection and mathematical morphology.Our algorithm’s performance is evaluated on two publicly available datasets,namely the Digital Retinal Images for Vessel Extraction dataset(DRIVE)and the Structure Analysis of Retina(STARE)dataset.The experimental results demonstrate the effectiveness of our method,withmean accuracy values of 0.9467 forDRIVE and 0.9535 for STARE datasets,aswell as sensitivity values of 0.6952 forDRIVE and 0.6809 for STARE datasets.Notably,our algorithmexhibits competitive performance with state-of-the-art methods.Importantly,it operates at an average speed of 3.73 s per image for DRIVE and 3.75 s for STARE datasets.It is worth noting that these results were achieved using Matlab scripts containing multiple loops.This suggests that the processing time can be further reduced by replacing loops with vectorization.Thus the proposed algorithm can be deployed in real time applications.In summary,our proposed system strikes a fine balance between swift computation and accuracy that is on par with the best available methods in the field.
基金supported by the National SKA Program of China(2022SKA0110202)the National Natural Science Foundation of China(grants No.11929301)。
文摘This study presents results on detecting neutral atomic hydrogen(H I)21 cm absorption in the spectrum of PKS PKS1413+13 at redshift z=0.24670041.The observation was conducted by FAST,with a spectral resolution of10 Hz,using 10 minutes of observing time.The global spectral profile is examined by modeling the absorption line using a single Gaussian function with a resolution of 10 kHz within a 2 MHz bandwidth.The goal is to determine the rate of the latest cosmic acceleration by directly measuring the redshift evolution of the H I 21 cm absorption line with Hubble flow toward a common background quasar over a decade or longer time span.This will serve as a detectable signal generated by the accelerated expansion of the Universe at redshift z<1,referred to as redshift drift z(5)or the SL effect.The measured H I gas column density in this DLA system is approximately equivalent to the initial observation value,considering uncertainties of the spin temperature of a spiral host galaxy.The high signal-to-noise ratio of 57,obtained at a 10 kHz resolution,strongly supports the feasibility of using the H I 21 cm absorption line in DLA systems to accurately measure the redshift drift rate at a precision level of around 10~(-10)per decade.
基金support of the China National Key Program for Science and Technology Research and Development of China(2022YFA1602901)the National Natural Science Foundation of China(NSFC,Grant Nos.11988101 and 11873051)+3 种基金the CAS Project for Young Scientists in Basic Research grant(No.YSBR-062)the K.C.Wong Education Foundationthe science research grants from the China Manned Space Projectsupport from the Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CAS。
文摘With the exceptional sensitivity of the Five-hundred-meter Aperture Spherical radio Telescope,we conducted observations of the neutral hydrogen(HⅠ)in the circumgalactic medium of Andromeda’s(M31)satellite galaxies,specifically AndromedaⅡ,NGC 205,and NGC 185.Initially,three drift scans were executed for these satellites,with a detection limit of 4×10^(18)cm^(-2)(approximately 1.88×10^(3)M_Θof HⅠmass),followed by a more in-depth scan of a specific region.We discovered a C-shaped HⅠarc structure sharing a position and line-of-sight velocity similar to a stellar ring structure around AndromedaⅡ,hinting at a potential connection with AndromedaⅡ.In the context of NGC 205,we identified two mass concentrations in the northeast direction,which could be indicative of tidal streams resulting from the interaction between this galaxy and M31.These new lumps discovered could be very helpful in solving the missing interstellar medium problem for NGC 205.Observations regarding NGC 185are consistent with previous studies,and we did not detect any additional HⅠmaterial around this galaxy.These observational results enhance our understanding of the evolution of these satellite galaxies and provide insight into their historical interactions with the galaxy M31.