Urban Hierarchy of Innovation Capability and Inter-city Linkages of Knowledge in Post-reform China

The 2000s has witnessed increasing interests in cities′role of innovation in the era of knowledge-based economy.Compared with substantial empirical analysis on the world city hierarchy of innovation,this paper attempts to examine the national urban hierarchy of innovation capability in China,in terms of ranking systems,spatial pattern and inter-city linkages of knowledge during the post-reform period since the late 1970s.Based on quantitative analysis such as principal component factor analysis and clustering analysis,this paper identifies the five-tier hierarchy of in-novation,which is headed by Beijing and Shanghai,followed by the capital cities of each province and regional centre cities.The development of China′s urban hierarchy of innovation capability has been driven by such factors as the scale of innovation,scientific scale,innovation potential and innovation environment.The paper further investigates the inter-city linkages of knowledge measured by the number of co-authored papers among the cities.Beijing is positioned in the central position of the knowledge diffusion and knowledge cooperation innovation.More knowledge diffusion among high level cities has occurred than that among the low level cities as well as between the low level cities and high level cities,and provincial capital cities and the regional central cities.

Challenge, opportunity and development： Influencing factors and tendencies of curriculum innovation on undergraduate nursing education in the mainland of China

Background： As the deep influence of traditional medical education, many undergraduate nursing colleges and universities in China still keep the traditional disease-focused curriculum system. However, it became outdated as the Chinese high nursing education developed. Meanwhile, the increasing demand of nursing human resources stimulates the enrollment expansion of colleges. All of these bring more difficulties and opportunities for nurse educators who are endeavoring to reform the undergraduate curriculum. Methods： The authors retrospectively reviewed the related literature, illustrated the existing challenges and opportunities during the curriculum renewal process in China. This paper also analyzed the ten- dencies of Chinese baccalaureate curriculum innovation. Results： Chinese current undergraduate nursing curriculum has larger proportion of basic medical courses, which brings great challenge for nursing educators. In the meantime, the expansion of enroll- ment brings conflicts with existing nursing education resources in China. Integration, humanization, internationalization and diversification are main tendencies leading the future nursing curriculum innovation in China. Conclusions： The more effective teaching innovations in the nursing education system are in great demand.

An Evaluation of the Coupling Coordination of Technological Innovation System in China’s Marine Biopharmaceutical Industry

The marine biopharmaceutical industry(MBI)has been considered as an important part of the blue economy.The high-quality development of this industry depends on the high-level coordinated development of technological innovation system(TIS).In the present study,the coupling mechanism of industrial innovation input subsystem and innovation output subsystem was analyzed for the first time.On this basis,the development level and coupling coordination level of TIS in China’s MBI during 2008-2018 were empirically evaluated with the capacity coupling coordination model.Then,the obstacle factors were diagnosed and recognized with the obstacle model.The results showed that the innovation input index fluctuated at a low level in China’s MBI.The innovation output index has basically maintained a growth trend,whereas the quality of development was not high.Although the coupling coordination level of TIS showed a positive change as mild disordered→primary coordinated→well-coordinated,the development type of innovation system has changed from the lagging output of innovation into the lagging input of innovation.Insufficient input of innovation factors remained the main obstacle to the improvement of coordination level.Based on the above analysis,suggestions were put forward from the perspectives of policy and fund guarantees to improve the coupling coordination level in China’s MBI.

Analysis of Impact Factors on Agricultural SMEs′ Technological Innovation Capacity——Case Study of Wenzhou City

The paper investigates impact factors of agricultural SMEs′ technological innovation by questionnaire on the survey of more than 100 agricultural SMEs of Wenzhou City of Jiangsu Province. It selects 14 major factors that influence agricultural SMEs′ technological innovation, they are capital source, enterprise culture, support from leaders, government policy support, effect of key research personnel, communication inside organization, enterprise strategy, technological development level, organizing and coordination inside organization, related information acquisition capacity, external cooperation, association and communication with consumers, change of external market and incentive measures to research personnel. Putting these factors in introductionance ordering by scores, we find out comparatively big impact factors influence agricultural SMEs′ technological innovation among them, they are technological development level, incentive measures to research personnel, capital source, government policy support and enterprise strategy. The paper also puts forward corresponding measures and suggestions: further enhance innovation consciousness and improve technological innovation level of agricultural SMEs; increase incentive measures, strengthen construction of talents team of technological innovation; express scientific research strength of local scientific research institutes and agricultural institution of higher learning, realize integration of industries, universities and research; sound government guiding and pushing mechanism, improve new policy environment of agricultural SMEs′ technological innovation.

Risk factors in familial forms of celiac disease

Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in the America and Australia where immigration of Eu-ropeans has occurred. Moreover, an increasing number of celiac disease patients are being identified in many Asian countries, including China and India. Finally, celiac disease has also been detected in Asian immigrants and their descendants to other countries, such as Canada. Within these so-called "general" celiac populations, however, there are specific high risk groups that have an even higher prevalence of celiac disease. Indeed, the single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted. Risk is even greater if a specific family has 2 siblings affected, particularly if a male carries the human leukocyte antigen-DQ2. Both structural changes in the small bowel architecture occur along with func-tional changes in permeability, even in asymptomatic first-degree relatives. Even if celiac disease is not evident, the risk of other autoimmune disorders seems significantly increased in first-degree relatives as well as intestinal lymphoma. Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated.

Spatial Organization of Innovation in the Oil Equipment Manufacturing Industry: Case of Dongying, China

As innovation and technological change have become increasingly important for the competitiveness and sustainable growth of firms,cooperative innovation is now crucial for traditional industries in the context of globalization.This paper proposes a framework for analyzing the spatial pattern of cooperative innovation for traditional industries in developing countries.Based on in-depth interviews with 35 firms in the oil equipment manufacturing industry in Dongying City,China,this study argues that different firms in the innovation pyramid have various innovation activity preferences and spatial patterns.Firms with high innovation abilities tend to cooperate with various partners that are geographically dispersed and continuously expanding,while firms with inferior abilities usually cooperate with nearby fixed partners.Due to the differences in innovation environment and actor locations,firms tend to make different choices regarding innovation types and models,which highlight the importance of personnel training and basic scientific research at the global scale and practical product research and development at the national scale.Additionally,talent flow is the most important way to realize relationships for firm innovation activity.

A study on the allocation of productive factors of Chinese agriculture

Chinese agriculture is undergoing a transformation process from traditional agriculture into modern agricultrue.This article discusses how land. labor, fertilizer, machinery etc. are used in agricultural production of different regions. reveals the influence of natural conditions and economic level on the utilization of modern agricultural factors. It proposes a system of allocation hoes of regional agricultural productive factors and points out the development stage and tendency of allocation of agricultural productive factors in different regions.

Innovation in the Manufacturing Sector： The Case of Serbia

The paper presents the results of research on innovation activities of manufacturing firms in Serbia. In order to answer the question how innovation takes place in one transition country, key influencing factors were identify （i.e., firm＇s size, age, ownership, industry sector, personnel qualifications and experience）. Based on the analysis of a sample comprising 73 firms, the study tried to highlight certain innovation barriers, which may have a negative impact on the total efficiency of economic performance, and growth and development of manufacturing firms in Serbia. Comparing overall innovation activities of Serbian firms to the other transition countries, it can be concluded that majority of the fhnns had innovation performances below the level EU-27. This study draws out the potential contributions to existing literature of managing innovation in Serbia.

Innovation, Competitiveness and Prosperity： A Factor Analysis of Innovation Indicators in Spain

Competitiveness is a wide concept applied to many fields, especially in economics. The study of tourism competitiveness has been focused on different factors that can enhance the prosperity of a destination. One of these factors is innovation. Innovation makes destination＇s enterprises more advanced and efficient, therefore more productive. Innovation is an enhancer of competitiveness and a generator of prosperity because innovation in every aspect （technology, knowledge, organization, and processes） will provide a better quality of life for the inhabitants of the destination. The incidence of innovation on these concepts is validated by a structural equation model. We measure innovation by a range of indicators and through a factor analysis; we get the most relevant indicators of innovation for the model developed in Spain.

Influence of Farmer Capacity Building in Institutional Linkages on Performance of Smallholder Irrigation Projects in Migori County, Kenya

The smallholder irrigation sector in Kenya is considered inadequately developed. The study views unawareness of critical success factors in the smallholder irrigation sector as contributing to poor performance of smallholder irrigation projects. Consequently, the study investigated influence of farmer capacity building in institutional linkages on performance of smallholder irrigation projects in Migori County, Kenya. The study embraced a pragmatic view of philosophy, and used cross sectional and correlation research design. The target population was 2815, and comprised farmers drawn from fifteen smallholder irrigation projects that receive water from River Kuja through Lower Kuja Project. The sample size was 341. The study used systematic random sampling procedure to draw the sample, and collected data using questionnaire. Data was analysed using descriptive and inferential statistics. The study established that farmer capacity building in institutional linkages has a significant influence on performance of smallholder irrigation projects (r = 0.803, R2 = 0.645, F (5, 331) = 120.254 and p < 0.000 < 0.05). Thus, the study recommends that Migori County Government come up with policies that link smallholder irrigation projects in Lower Kuja Project to institutions that provide land ploughing services, certified seeds and fertilisers, control of crop pests and diseases, transportation of farm produce and marketing of farm produce.

A Meta-analysis of the Effects of Firm’s Social Capital on Innovation Performance

Despite a surge of studies examining the impact of firm’s social capital on the innovation performance,empirical research shows controversial results.To resolve this problem,this paper conducted a meta-analysis to restudy the impact of the firm’s social capital and its three dimensions on innovation performance based on the previous empirical research results of independent samples.This paper also explored some moderators affecting this relationship from culture,industry,firm and methodology.The results indicated that the firm’s social capital and its three-dimension had positive impact on innovation performance.At the same time,the age of the firm and the cultural context can also affect the impact of social capital on innovation performance to a large extent.Based on these findings,this paper developed recommendations for future research.

Collaborative Performance Analysis and the Establishement of Main Body of Agricutlural Technology Innovation

Relying on the relevant data from China Statistical Yearbook and Chinese Rural Statistical Yearbook,the coolabarative performance of main body of agricutlural technology innovation is evaluated by taking quaternary-parties innovation body as the sujects and by establishing the index system from the perspectives of input and output.The results show serious dislocation of main body and bad collabrative performance.On the basis,the quaternary-parties motivation system cocerning agricutlural enterpises,agricutlural science and technology acanamy,rural hosueholds and governments is established.The system is capable of integrating market,sciencetific reserch and diffusion collection into a whole part and solving the seperation of agricutlural innovation supply and demand.

Study of Impacts of Small Business Innovation Research Programs

The development and commercialization of new technologies are important to the global economy. In this paper, the author first addresses Small Business Innovation Research （SBIR） background ; then, implicitly defines SBIR ; finally, I also analyze the impacts of smaU business innovation research programs. There are four aspects ： entrepreneurial orientation; environmental factors; organizational factors and performanee.

Kinematic-mapping-model-guided analysis and optimization of 2-PSS&1-RR circular-rail parallel mechanism for fully steerable phased array antennas

This paper presents a systematic methodology for analyzing and optimizing an innovative antenna mount designed for phased array antennas, implemented through a novel 2-PSS&1-RR circular-rail parallel mechanism. Initially, a comparative motion analysis between the 3D model of the mount and its full-scale prototype is conducted to validate effectiveness. Given the inherent complexity, a kinematic mapping model is established between the mount and the crank-slider linkage, providing a guiding framework for subsequent analysis and optimization. Guided by this model, feasible inverse and forward solutions are derived, enabling precise identification of stiffness singularities. The concept of singularity distance is thus introduced to reflect the structural stiffness of the mount. Subsequently, also guided by the mapping model, a heuristic algorithm incorporating two backtracking procedures is developed to reduce the mount's mass. Additionally, a parametric finite-element model is employed to explore the relation between singularity distance and structural stiffness. The results indicate a significant reduction(about 16%) in the antenna mount's mass through the developed algorithm, while highlighting the singularity distance as an effective stiffness indicator for this type of antenna mount.

E-innovation绩效影响因素研究

随着经济全球化和信息化高速发展,电子化创新成为企业创新的有效途径之一.以研究电子化创新项目绩效影响因素为主题,探索了如何通过控制关键影响因素来提高电子化创新项目的成功绩效.通过对国内四十余家实施电子化创新的企业进行调查和问卷收集的定量分析,得出影响电子化创新的战略、组织、资源和环境四个方面八个因素,进一步验证这些因素与电子化创新成功绩效之间的关系,进而找出其关键影响因素,构建影响因素与创新绩效的关系模型,为我国企业实施电子化创新提供理论依据和技术指导.

Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer

Growth factors and their corresponding receptors are commonly overexpressed and/or dysregulated in many cancers including hepatocellular cancer （HCC）. Clinical trials indicate that growth factor receptors and their related signalling pathways play important roles in HCC cancer etiology and progression, thus providing rational targets for innovative cancer therapies. A number of strategies including monoclonal antibodies, tyrosine kinase inhibitors （＂small molecule inhibitors＂） and antisense oligonucleotides have already been evaluated for their potency to inhibit the activity and downstream signalling cascades of these receptors in HCC. First clinical trials have also shown that multi-kinase inhibition is an effective novel treatment strategy in HCC. In this respect sorafenib, an inhibitor of Raf-, VEGF- and PDGF-signalling, is the first multi-kinase inhibitor that has been approved by the FDA for the treatment of advanced HCC. Moreover, the serine-threonine kinase of mammalian target of rapamycin （mTOR） upon which the signalling of several growth factor receptors converge plays a central role in cancer cell proliferation, roTOR inhibition of HCC is currently also being studied in preclinical trials. As HCCs represent hypervascularized neoplasms, inhibition of tumour vessel formation via interfering with the VEGF/VEGFR system is another promising approach in HCC treatment. This review will summarize the current status of the various growth factor receptor-based treatment strategies and in view of the multitude of novel targeted approaches, the rationale for combination therapies for advanced HCC treatment will also be taken into account.

Technological innovation paths toward green industry in China

With the environmental carrying capacity reaching its limits and the decreasing margin benefits of traditional production factors, the green transformation and green development through technological innovations has been a major direction for the future development of Chinese industries. However, the characteristics and heterogeneities of various types of industries call for different approaches regarding technological innovations. How to choose the most effective mode of technological innovation according to the characteristics of a certain industry has been a key issue. This paper measures the green total factor productivity of 32 industrial trades using the Slacks Based Measure(SBM)-DDF method. The effects of three innovation modes in the green transformation of industrial industry, including the independent innovation(Ⅱ), the technology introduction(TI), and the government support(GS), are empirically analyzed based on industry heterogeneity. Results indicate that the green total factor productivities of different industries show significant differences if taking into account the energy input and the undesirable output of pollutant emissions. The green total factor productivities of traditional high input,high pollution, and high energy consumption industrial trades were significantly lower than those with obvious green features. The year of 2009 is a leap year for the industrial green transformation in China. For resource-intensive industries, the II and the GS are the important ways to achieve green transformation. For labor-intensive industries, the TI is the best path to achieve green transformation, while for technology-intensive industries, the II is the primary driving force for the promotion of green developments. In addition, the innovation-compensating effect of the current Chinese environmental regulations to the resource-intensive industries has been revealed. Improving the overall scale and the industrial concentration of the industries is also beneficial for the green transformation of the industries.

TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis ina Chinese population

BACKGROUND： The tumor necrosis factor recepter associated factor （TRAF） 6 is an important intracellular adapter protein that plays a pivotal role in activating multiple inflammatory and immune related processes induced by cytokines. TRAF6 represents a strong candidate susceptibility factor for sepsis. We investigated whether polymorphisms at the TRAF6 gene are associated with the susceptibility to and severity of sepsis.METHODS： A hospital-based case-control study was conducted with 255 patients with sepsis and 260 controls who were recruited from Zhengzhou, China. Haplotype tagging single nucleotide polymorphisms （htSNPs） were selected from the HapMap database and genotyped using the SNPstream genotyping platform. The associations with the susceptibility and disease severity of sepsis were estimated by logistic regression, and adjusted for age, sex, smoking, drinking, chronic diseases status, APACHEII score and critical illness status.RESULTS： A total of 13 TRAF6 SNPs were tagged by 7 htSNPs. Five htSNPs （rs5030490, rs5030411, rs5030416, rs5030445 and rs3740961） were genotyped in the case control study. Genotype frequencies of the htSNPs were conformed to the Hardy-Weinberg equilibrium in both patients and controls. No significant association was found between the 5 htSNPs and the susceptibility to and severity of sepsis. Compared with the main haplotype -11120A/-10688T/-9423A/805G/12967G, no certain haplotype was associated with the signi？ cantly susceptibility to or severity of sepsis.CONCLUSION： TRAF6 gene polymorphisms might not play a major role in mediating the susceptibility to and severity of sepsis in the Chinese population. A larger population-based case-control study is warranted.

Identification of hepatitis B virus and liver cancer bridge molecules based on functional module network

BACKGROUND The potential role of chronic inflammation in the development of cancer has been widely recognized.However,there has been little research fully and thoroughly exploring the molecular link between hepatitis B virus(HBV)and hepatocellular carcinoma(HCC).AIM To elucidate the molecular links between HBV and HCC through analyzing the molecular processes of HBV-HCC using a multidimensional approach.METHODS First,maladjusted genes shared between HBV and HCC were identified by disease-related differentially expressed genes.Second,the protein-protein interaction network based on dysfunctional genes identified a series of dysfunctional modules and significant crosstalk between modules based on the hypergeometric test.In addition,key regulators were detected by pivot analysis.Finally,targeted drugs that have regulatory effects on diseases were predicted by modular methods and drug target information.RESULTS The study found that 67 genes continued to increase in the HBV-HCC process.Moreover,366 overlapping genes in the module network participated in multiple functional blocks.It could be presumed that these genes and their interactions play an important role in the relationship between inflammation and cancer.Correspondingly,significant crosstalk constructed a module level bridge for HBV-HCC molecular processes.On the other hand,a series of non-coding RNAs and transcription factors that have potential pivot regulatory effects on HBV and HCC were identified.Among them,some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192,microRNA-215,and microRNA-874,and early growth response 2,FOS,and Kruppel-like factor 4.Therefore,the study concluded that these pivots are the key bridge molecules outside the module.Last but not least,a variety of drugs that may have some potential pharmacological or toxic side effects on HBV-induced HCC were predicted,but their mechanisms still need to be further explored.CONCLUSION The results suggest that the persistent inflammatory environment of HBV can be utilized as an important risk factor to induce the occurrence of HCC,which is supported by molecular evidence.

Targeted medical therapy of biliary tract cancer:Recent advances and future perspectives

The limited efficacy of cytotoxic therapy for advanced biliary tract and gallbladder cancers emphasizes the need for novel and more effective medical treatment options. A better understanding of the specific biological features of these neoplasms led to the development of new targeted therapies, which take the abundant expression of several growth factors and cognate tyrosine kinase receptors into account. This review will briefly summarize the status and future perspectives of antiangiogenic and growth factor receptor-based pharmacological approaches for the treatment of biliary tract and gallbladder cancers. In view of multiple novel targeted approaches, the rationale for innovative therapies, such as combinations of growth factor (receptor)-targeting agents with cytotoxic drugs or with other novel anticancer drugs will be highlighted.