Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual impairment.The therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced stages.In keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe procedure.CXL consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks formation.The aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment protocols.Finally,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

Kinematic analysis of flexible bipedal robotic systems

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of interest for numerous researchers.What distinguishes the present research from similar works is the consideration of flexibility in the constituent links of this type of robotic systems.This is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases considerably.Moreover,the human leg bones that are involved in walking are supported by viscoelastic muscles and ligaments.Therefore,for achieving more exact results,it is essential to model the robot links with viscoelastic properties.To this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of motion.The most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational force.The extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned goal.To overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is presented in this paper to obtain an eigenvalue problem.By solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are determined.The effects of the characteristic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of robotic systems are also studied.The findings of this parametric study reveal that the increase in the Kelvin-Voigt coefficient enhances the stability of the robotic system,while the increase in the modulus of elasticity has an opposite effect.

SHEL:a semantically enhanced hardware-friendly entity linking method

With the help of pre-trained language models,the accuracy of the entity linking task has made great strides in recent years.However,most models with excellent performance require fine-tuning on a large amount of training data using large pre-trained language models,which is a hardware threshold to accomplish this task.Some researchers have achieved competitive results with less training data through ingenious methods,such as utilizing information provided by the named entity recognition model.This paper presents a novel semantic-enhancement-based entity linking approach,named semantically enhanced hardware-friendly entity linking(SHEL),which is designed to be hardware friendly and efficient while maintaining good performance.Specifically,SHEL's semantic enhancement approach consists of three aspects:(1)semantic compression of entity descriptions using a text summarization model;(2)maximizing the capture of mention contexts using asymmetric heuristics;(3)calculating a fixed size mention representation through pooling operations.These series of semantic enhancement methods effectively improve the model's ability to capture semantic information while taking into account the hardware constraints,and significantly improve the model's convergence speed by more than 50%compared with the strong baseline model proposed in this paper.In terms of performance,SHEL is comparable to the previous method,with superior performance on six well-established datasets,even though SHEL is trained using a smaller pre-trained language model as the encoder.

Fault diagnosis method of link control system for gravitational wave detection

To maintain the stability of the inter-satellite link for gravitational wave detection,an intelligent learning monitoring and fast warning method of the inter-satellite link control system failure is proposed.Different from the traditional fault diagnosis optimization algorithms,the fault intelligent learning method pro-posed in this paper is able to quickly identify the faults of inter-satellite link control system despite the existence of strong cou-pling nonlinearity.By constructing a two-layer learning network,the method enables efficient joint diagnosis of fault areas and fault parameters.The simulation results show that the average identification time of the system fault area and fault parameters is 0.27 s,and the fault diagnosis efficiency is improved by 99.8%compared with the traditional algorithm.

Complex systems and network science:a survey

Complex systems widely exist in nature and human society.There are complex interactions between system elements in a complex system,and systems show complex features at the macro level,such as emergence,self-organization,uncertainty,and dynamics.These complex features make it difficult to understand the internal operation mechanism of complex systems.Networked modeling of complex systems is a favorable means of understanding complex systems.It not only represents complex interactions but also reflects essential attributes of complex systems.This paper summarizes the research progress of complex systems modeling and analysis from the perspective of network science,including networked modeling,vital node analysis,network invulnerability analysis,network disintegration analysis,resilience analysis,complex network link prediction,and the attacker-defender game in complex networks.In addition,this paper presents some points of view on the trend and focus of future research on network analysis of complex systems.

Clinical usefulness of linked color imaging in identifying Helicobacter pylori infection:A systematic review and meta-analysis

BACKGROUND Accurate diagnosis of Helicobacter pylori(H.pylori)infection status is a crucial premise for eradication therapy,as well as evaluation of risk for gastric cancer.Recent progress on imaging enhancement endoscopy(IEE)made it possible to not only detect precancerous lesions and early gastrointestinal cancers but also to predict H.pylori infection in real time.As a novel IEE modality,linked color imaging(LCI)has exhibited its value on diagnosis of lesions of gastric mucosa through emphasizing minor differences of color tone.AIM To compare the efficacy of LCI for H.pylori active infection vs conventional white light imaging(WLI).METHODS PubMed,Embase,Embase and Cochrane Library were searched up to the end of April 11,2022.The random-effects model was adopted to calculate the diagnostic efficacy of LCI and WLI.The calculation of sensitivity,specificity,and likelihood ratios were performed;symmetric receiver operator characteristic(SROC)curves and the areas under the SROC curves were computed.Quality of the included studies was chosen to assess using the quality assessment of diagnostic accuracy studies-2 tool.RESULTS Seven original studies were included in this study.The pooled sensitivity,specificity,positive likelihood rate,and negative likelihood rate of LCI for the diagnosis of H.pylori infection of gastric mucosa were 0.85[95%confidence interval(CI):0.76-0.92],0.82(95%CI:0.78-0.85),4.71(95%CI:3.7-5.9),and 0.18(95%CI:0.10-0.31)respectively,with diagnostic odds ratio=26(95%CI:13-52),SROC=0.87(95%CI:0.84-0.90),which showed superiority of diagnostic efficacy compared to WLI.CONCLUSION Our results showed LCI can improve efficacy of diagnosis on H.pylori infection,which represents a useful endoscopic evaluation modality for clinical practice.

Exploring the Potential Of ESG in China By Guo Xixian China’s environmental,social,and governance(ESG)rating system is still fresh and will undergo standard and regulated development

Broad consensus on climate change has made many countries set carbon peaking and carbon neutrality goals,which inspired Environmental,Social,and Governance(ESG)investment.Advocates of the concept seek to foster sustainable development of enterprises in terms of environment,society,and corporate governance.A bond linking the capital market and financing entities,credit rating agencies that evaluate corporate credit risk have gradually incorporated ESG factors into the credit rating system,which has boosted the development of ESG investment.China’s ESG investment started comparatively late,but it has been gaining momentum thanks to improved regulations and policies.Currently,ESG investment in China still faces multiple problems and challenges including underdeveloped infrastructure,inconsistent evaluation standards,and varied evaluation results.

宫颈病变患者病耻感现状及其相关影响因素分析

目的 调查宫颈病变患者的病耻感现状,探索其影响因素。方法 采用自行设计一般资料调查问卷和Link病耻感量表(8个维度)对2020年12月—2021年12月在河北医科大学第二医院东院区妇科二科门诊及住院治疗的163例宫颈病变患者进行调查,分析影响宫颈病变患者病耻感的相关因素。结果 回收有效问卷150份,宫颈病变患者的Link病耻感量表总分为(118.82±17.64)分,各维度得分分别为贬低-歧视感知(2.78±0.95)分、挑战(2.94±0.83)分、教育(2.90±0.85)分、分离(2.55±0.73)分、保密(2.41±0.79)分、退缩(2.38±0.69)分、误解(2.83±0.80)分、不同/羞耻(1.99±0.61)分,贬低-歧视感知、挑战、教育、误解维度得分均显著高于量表中点2.5分(P均<0.05),保密、退缩、不同/羞耻维度得分均显著低于量表中点2.5分(P均<0.05)。患者年龄、文化程度、病理活检结果、治疗次数是其病耻感的主要影响因素(P均<0.05)。结论 患者普遍因宫颈病变存在病耻感,且其影响因素较多。患者年龄越小、文化水平越高、病理活检结果级别越高、治疗次数越多,病耻感就越高。

面向Link16的QualNet与虚拟机信息交互接口设计与实现

Link16是美国国防部采用的高速视距战术数据链,广泛应用于美国海军、联合部队和北约部队,针对其开展测试评估具有重要军事意义。通过硬件在环技术将Link16实物设备接入到仿真测试中,可有效提高测试结果的真实性和准确性。然而当测试场景需要进行实物设备组网测试时,仍会带来成本问题。为此,提出一种面向QualNet MAC层的Link16专属模型以及与之匹配的虚拟机信息交互接口。该模型可高逼真模拟Link16通信行为,实现Link16节点竞争接入、时隙划分、NPG分组等功能。并基于数据分布式服务实现了虚拟机交互接口,将运行在虚拟机的Link16设备模型接入QualNet测试场景。实验测试结果表明,所设计模型具有较高真实性和准确性且接口引入延时不超过1 ms,为大规模数据链网络测试提供一种新方法。

On the apparent line-of-sight alignment of the peak X-ray intensity of the magnetosheath and the tangent to the magnetopause,as viewed by SMILE-SXI

The Soft X-ray Imager(SXI)on board the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)spacecraft will be able to view the Earth’s magnetosheath in soft X-rays.Simulated images of the X-ray emission visible from the position of SMILE are created for a range of solar wind densities by using 3 years of the SMILE mission orbit,together with models of the expected X-ray emissivity from the Earth’s magnetosheath.Results from global magnetohydrodynamic simulations and a simple model for exospheric neutral densities are used to compare the locations of the lines of sight along which integrated soft X-ray intensities peak with the lines of sight lying tangent to surfaces(defined here to be the magnetopause)along which local soft X-ray intensities peak or exhibit their strongest gradients,or both,for strongly southward interplanetary magnetic field conditions when no depletion or low-latitude boundary layers are expected.Where,in the parameter space of the various times and seasons,orbital phases,solar wind conditions,and magnetopause models,the alignment of the X-ray emission peak with the magnetopause tangent is good,or is not,is presented.The main results are as follows.The spacecraft needs to be positioned well outside the magnetopause;low-altitude times near perigee are not good.In addition,there are seasonal aspects:dayside-apogee orbits are generally very good because the spacecraft travels out sunward at high altitude,but nightside-apogee orbits,behind the Earth,are bad because the spacecraft only rarely leaves the magnetopause.Dusk-apogee and dawnapogee orbits are intermediate.Dayside-apogee orbits worsen slightly over the first three mission years,whereas nightside-apogee orbits improve slightly.Additionally,many more times of good agreement with the peak-to-tangent hypothesis occur when the solar wind is in a high-density state,as opposed to a low-density state.In a high-density state,the magnetopause is compressed,and the spacecraft is more often a good distance outside the magnetopause.

WiFense:从衍射模型到边界监控

近年来,随着普适计算概念的深入人心,智能感知技术已成为研究者们关注的焦点,且基于WiFi的非接触式感知因其优秀的普适性、低廉的部署成本以及良好的用户体验越来越受到学术界和工业界的青睐.典型的WiFi非接触式感知工作有手势识别、呼吸检测、入侵检测、行为识别等,这些工作若实际部署,需首先避免其他无关区域中无关行为的干扰,因此需要判断目标是否进入到特定的感知区域中.这意味着系统应具备精准判断目标在界线哪一侧的能力,然而现有工作未能找到一个可以对某个自由设定的边界进行精确监控的方法,这阻碍了WiFi感知应用的实际落地.基于这一关键问题,从电磁波衍射的物理本质出发,结合菲涅尔衍射模型(Fresnel diffraction model),找到一种目标穿越link(收发设备天线的连线)时的信号特征(Rayleigh distribution in Fresnel diffraction model,RFD),并揭示该信号特征与人体活动之间的数学关系;之后以link作为边界,结合天线间距带来的波形时延以及AGC(automatic gain control)在link被遮挡时的特征,通过越线检测实现对边界的监控.在此基础上,还实现了两个实际应用,即入侵检测系统和居家状态监测系统,前者的精确率超过89%、召回率超过91%,后者的准确率超过89%.在验证所提边界监控算法的可用性和鲁棒性的同时,也展示了所提方法与其他WiFi感知技术相结合的巨大潜力,为WiFi感知技术的实际部署提供了思考方向.

Using restored two-dimensional X-ray images to reconstruct the three-dimensional magnetopause

Astronomical imaging technologies are basic tools for the exploration of the universe,providing basic data for the research of astronomy and space physics.The Soft X-ray Imager(SXI)carried by the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)aims to capture two-dimensional(2-D)images of the Earth’s magnetosheath by using soft X-ray imaging.However,the observed 2-D images are affected by many noise factors,destroying the contained information,which is not conducive to the subsequent reconstruction of the three-dimensional(3-D)structure of the magnetopause.The analysis of SXI-simulated observation images shows that such damage cannot be evaluated with traditional restoration models.This makes it difficult to establish the mapping relationship between SXIsimulated observation images and target images by using mathematical models.We propose an image restoration algorithm for SXIsimulated observation images that can recover large-scale structure information on the magnetosphere.The idea is to train a patch estimator by selecting noise–clean patch pairs with the same distribution through the Classification–Expectation Maximization algorithm to achieve the restoration estimation of the SXI-simulated observation image,whose mapping relationship with the target image is established by the patch estimator.The Classification–Expectation Maximization algorithm is used to select multiple patch clusters with the same distribution and then train different patch estimators so as to improve the accuracy of the estimator.Experimental results showed that our image restoration algorithm is superior to other classical image restoration algorithms in the SXI-simulated observation image restoration task,according to the peak signal-to-noise ratio and structural similarity.The restoration results of SXI-simulated observation images are used in the tangent fitting approach and the computed tomography approach toward magnetospheric reconstruction techniques,significantly improving the reconstruction results.Hence,the proposed technology may be feasible for processing SXI-simulated observation images.

一种改进的Link16信号检测方法

直接序列扩频、高速跳频与跳时相结合的技术,造成了对Link16信号的检测具有相当的难度。文中针对突发Link16信号脉冲宽度强规律性,借鉴双滑动窗算法在突发信号检测上的应用,提出了改进后基于相关处理的双滑动窗Link16信号检测方法,该方法可实现复杂电磁环境下对Link16信号的高灵敏度、高概率检测,同时正确估算出脉宽、码速率等参数信息。仿真实验数据验证了理论分析的正确性和所述方法的有效性,相较于其他Link16信号检测方法,改进后的基于相关处理的双滑动窗检测算法明显提高了在低信噪比下对Link16信号的检测能力。

Simulation of the SMILE Soft X-ray Imager response to a southward interplanetary magnetic field turning

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)Soft X-ray Imager(SXI)will shine a spotlight on magnetopause dynamics during magnetic reconnection.We simulate an event with a southward interplanetary magnetic field turning and produce SXI count maps with a 5-minute integration time.By making assumptions about the magnetopause shape,we find the magnetopause standoff distance from the count maps and compare it with the one obtained directly from the magnetohydrodynamic(MHD)simulation.The root mean square deviations between the reconstructed and MHD standoff distances do not exceed 0.2 RE(Earth radius)and the maximal difference equals 0.24 RE during the 25-minute interval around the southward turning.

Analysis of the joint detection capability of the SMILE satellite and EISCAT-3D radar

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)satellite is a small magnetosphere–ionosphere link explorer developed cooperatively between China and Europe.It pioneers the use of X-ray imaging technology to perform large-scale imaging of the Earth’s magnetosheath and polar cusp regions.It uses a high-precision ultraviolet imager to image the overall configuration of the aurora and monitor changes in the source of solar wind in real time,using in situ detection instruments to improve human understanding of the relationship between solar activity and changes in the Earth’s magnetic field.The SMILE satellite is scheduled to launch in 2025.The European Incoherent Scatter Sciences Association(EISCAT)-3D radar is a new generation of European incoherent scatter radar constructed by EISCAT and is the most advanced ground-based ionospheric experimental device in the high-latitude polar region.It has multibeam and multidirectional quasi-real-time three-dimensional(3D)imaging capabilities,continuous monitoring and operation capabilities,and multiple-baseline interferometry capabilities.Joint detection by the SMILE satellite and the EISCAT-3D radar is of great significance for revealing the coupling process of the solar wind–magnetosphere–ionosphere.Therefore,we performed an analysis of the joint detection capability of the SMILE satellite and EISCAT-3D,analyzed the period during which the two can perform joint detection,and defined the key scientific problems that can be solved by joint detection.In addition,we developed Web-based software to search for and visualize the joint detection period of the SMILE satellite and EISCAT-3D radar,which lays the foundation for subsequent joint detection experiments and scientific research.

Biodiversity metrics on ecological networks: Demonstrated with animal gastrointestinal microbiomes

Biodiversity has become a terminology familiar to virtually every citizen in modern societies.It is said that ecology studies the economy of nature,and economy studies the ecology of humans;then measuring biodiversity should be similar with measuring national wealth.Indeed,there have been many parallels between ecology and economics,actually beyond analogies.For example,arguably the second most widely used biodiversity metric,Simpson(1949)’s diversity index,is a function of familiar Gini-index in economics.One of the biggest challenges has been the high“diversity”of diversity indexes due to their excessive“speciation”-there are so many indexes,similar to each country’s sovereign currency-leaving confused diversity practitioners in dilemma.In 1973,Hill introduced the concept of“numbers equivalent”,which is based on Renyi entropy and originated in economics,but possibly due to his abstruse interpretation of the concept,his message was not widely received by ecologists until nearly four decades later.What Hill suggested was similar to link the US dollar to gold at the rate of$35 per ounce under the Bretton Woods system.The Hill numbers now are considered most appropriate biodiversity metrics system,unifying Shannon,Simpson and other diversity indexes.Here,we approach to another paradigmatic shift-measuring biodiversity on ecological networks-demonstrated with animal gastrointestinal microbiomes representing four major invertebrate classes and all six vertebrate classes.The network diversity can reveal the diversity of species interactions,which is a necessary step for understanding the spatial and temporal structures and dynamics of biodiversity across environmental gradients.

A Survey of Knowledge Graph Construction Using Machine Learning

Knowledge graph(KG)serves as a specialized semantic network that encapsulates intricate relationships among real-world entities within a structured framework.This framework facilitates a transformation in information retrieval,transitioning it from mere string matching to far more sophisticated entity matching.In this transformative process,the advancement of artificial intelligence and intelligent information services is invigorated.Meanwhile,the role ofmachine learningmethod in the construction of KG is important,and these techniques have already achieved initial success.This article embarks on a comprehensive journey through the last strides in the field of KG via machine learning.With a profound amalgamation of cutting-edge research in machine learning,this article undertakes a systematical exploration of KG construction methods in three distinct phases:entity learning,ontology learning,and knowledge reasoning.Especially,a meticulous dissection of machine learningdriven algorithms is conducted,spotlighting their contributions to critical facets such as entity extraction,relation extraction,entity linking,and link prediction.Moreover,this article also provides an analysis of the unresolved challenges and emerging trajectories that beckon within the expansive application of machine learning-fueled,large-scale KG construction.

Influencing Factors on Cardiovascular Health in China

The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in China.This is the first section of the report,which dissects influential factors across diverse domains.The investigation identifies tobacco use as a paramount concern,portraying China as the global epicenter of tobacco consumption.Cigarette smoking,exacerbated by second-hand smoke exposure,emerges as a critical and preventable risk factor,contributing to a surge in attributable deaths over the past three decades.In the realm of dietary nutrition,the study discerns an overall improvement,yet discerns worrisome deviations,notably an escalating fat intake surpassing recommended guidelines.The shifting dietary structure reveals diminished consumption of cereals and vegetables juxtaposed with an uptick in animal foods,while excessive intake of cooking oil and salt persists,straying substantially from endorsed levels.The exploration of physical activity patterns unfolds a nuanced narrative.Varied trends are observed among students,with concerns arising from sedentary behaviors and inadequate adherence to recommended guidelines.The analysis spans a trajectory of declining physical activity in Chinese adults,coupled with an alarming surge in sedentary leisure time,ultimately linking these factors to heightened risks of cardiovascular diseases and increased adiposity.An examination of overweight and obesity trends uncovers a relentless upward trajectory,projecting substantial prevalence by 2030.Noteworthy prevalence rates underscore the imperative for targeted interventions to curtail this burgeoning health crisis,with the anticipated prevalence extending to nearly two-thirds of the adult population.Psychological factors,notably depression,constitute an integral facet of cardiovascular health.Prevalence rates among patients with coronary artery disease and acute myocardial infarction underscore the intricate interplay between mental health and cardiovascular outcomes.Additionally,persistent depressive symptoms are shown to significantly elevate the risk of cardiovascular diseases and mortality.This first section underscores the multifaceted challenges facing cardiovascular health in China,emphasizing the imperative for tailored interventions across tobacco control,dietary habits,physical activity,obesity management,and psychological well-being to mitigate the escalating burden of cardiovascular diseases in the population.

Time Transfer in a 1839-km Telecommunication Fiber Link Demonstrating a Picosecond-Scale Stability

An implementation of high-precision time transfer over a 1839-km field fiber loop back link between two provincial capitals of China,Xi’an and Taiyuan,is reported.Time transfer stabilities of 6.5 ps at averaging time of 1 s and 4.6 ps at 40000 s were achieved.The uncertainty for the time transfer system was evaluated,showing a budget of 56.2 ps.These results stand for a significant milestone in achieving high-precision time transfer over a field fiber link spanning thousands of kilometers,signifying a record-breaking achievement for the real-field time transfer in both stability and distance,which paves the way for constructing the nationwide high-precision time service via fiber network.

Dilation,discrimination and Uhlmann's theorem of link products of quantum channels

We establish the Stinespring dilation theorem of the link product of quantum channels in two different ways,discuss the discrimination of quantum channels,and show that the distinguishability can be improved by self-linking each quantum channel n times as n grows.We also find that the maximum value of Uhlmann's theorem can be achieved for diagonal channels.