Considering only the wave aspect, we determine the energy of a bond between 2 nucleons;this quantified energy is associated with a standing wave. Then, starting from the mass loss corresponding to this energy, we dete...Considering only the wave aspect, we determine the energy of a bond between 2 nucleons;this quantified energy is associated with a standing wave. Then, starting from the mass loss corresponding to this energy, we determine the number of bonds in this nucleus. The mass defect value for a link is used to determine a specific length at that link. Fixing a precise distance between nucleons makes it possible to determine a geometry of the nucleus and its dimensions. It makes it possible to understand when this bond is stronger than the electrostatic force and allows deducing a shell model built in a precise order. The calculation on the mass defect will also make it possible to determine that one or more nucleons concerned by the radioactivity will be bound by a single bond to the rest of the nucleus or, on the contrary, bound by several bonds which induce short 1/2 lives or, on the contrary, very long. The analysis of the bonds on H, He and C make it possible to write formulae which are then applied to the nuclei to find the radioactive 1/2 lives. To find by equations the radioactive 1/2 lives does not call into question the standard model since it concerns only the defect of mass of the nuclei with energies that are not used to find the main particles of the standard model. This model, which favours a geometric approach to the detriment of a mathematical approach based on differential equations, can lead to theoretical questions about the possibility of interpreting the structure of the nucleus in a more undulatory way. It is possible to explain radioactivity in a more deterministic way.展开更多
The estimate of dental caries among Chinese children at the microscale level using standard methodology remains unclear. In this study, we assessed and analyzed the disease burden of childhood dental caries in China b...The estimate of dental caries among Chinese children at the microscale level using standard methodology remains unclear. In this study, we assessed and analyzed the disease burden of childhood dental caries in China by extracting data from the Global Burden of Disease, Injuries, and Risk Factors Study 2016 (GBD 2016). In 2016, the number of cases, prevalence, years lived with disability (YLD), and age-standardized YLD rate of dental caries was 93.0 million, 43.0%, 32,200 person years, and 14.8 per 100,000, respectively. Across 33 provincial units, the disease burden was highest in Hubei (YLD rate 28.6 per 100,000), lowest in Macao (9.1 per 100,000), while geographical clustering was not observed. Compared with 1990, the prevalence in 2016 decreased from 46.8% to 43.0%, and the YLD rate decreased from 16.5 per 100,000 to 14.8 per 100,000. Given the slight decrease in dental caries burden, the prevalence and disease burden remained high among Chinese children. Strategies for addressing the spatial inequity of childhood dental caries require geographical targeting.展开更多
To detect retrospectively the phenotype and stability of the E-protein gene in Japanese Encephalitis (JE) virus strain SA14-14-2 used in the live-attenuated JE vaccine prepears, the viral titer was titrated by plaqu...To detect retrospectively the phenotype and stability of the E-protein gene in Japanese Encephalitis (JE) virus strain SA14-14-2 used in the live-attenuated JE vaccine prepears, the viral titer was titrated by plaque formation in BHK-21 cell cultures, and the neuro-virulence of viruses was assayed in mice with body weight of 12-14 g by intracerebral inoculation. Meanwhile, the total RNA of virus gene was extracted and amplified by RT-PCR with the designed primers, and then it was purified and cloned to the expression vector pGEM-T. The recombinant plasmid was purified and sequenced. It was found that the loss of viral titer of vaccines stored in -20℃ for longer than 10 years was less than 0.5 Lg PFU/ml. No mice inoculated intracerebrally showed signs of illness or even death. The size of plagues of the vaccine virus remained to be small, and the E genes of primary virus seed SA14-14-2 and the vaccines prepared at different years (1987-2001) were unchanged, in- cluding the 8 critical amino acid sites which were different from the parent wild virus strain SA14 and the related neuro-virulence. These results indicate that the genotypic and biological characteristics of the attenuated JE virus strain SA14-14-2 and its vaccines sion noted. prepared are quite stable without any reversion noted.展开更多
The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,...The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,1-diphenylethylene (DPE) capped 2-chloro-2,4,4-trimethylpentane (TMPCl) was formed in situ in conjunction with titanium tetrachloride (TiCl(4)). The Lewis acidity of TiCl(4) was decreased by the addition of titanium(IV) isopropoxide (Ti(OiPr)(4)) to accomplish living polymerization of TBDMES. Hydrolysis of poly(TBDMES) in the presence of tetra-butylammonium fluoride yielded poly[4-(2-hydroxyethyl)styrene] (poly(HOES)). FT-IR, NMR and DSC demonstrated the hydrolysis was complete.展开更多
Identification of waste characteristics is an important step towards improving waste recovery. The aim of this research was to determine the physical and physico-chemical characteristics of waste of Abomey–Calavi cit...Identification of waste characteristics is an important step towards improving waste recovery. The aim of this research was to determine the physical and physico-chemical characteristics of waste of Abomey–Calavi city and to study the relationship between standard of living and average ratio of daily waste generated by each person. In this study the methodology used French standards to characterize particle size and typology of solid waste generated by the population of Calavi City in Benin, West Africa. According to home criteria, the study area was stratified into three distinct levels of standard of living called: high standing, medium standing and low standing;Waste from 60 households was weighed daily. The total waste produced by each household was collected seven (7) days a week, for a period of three weeks. Waste characterization was performed using ratio, size granulometry and typological composition. Physico- Chemical analysis including organic mater, pH, Total Organic Carbon, total Kjeldahl nitrogen and metal trace element were also performed. To better assess waste compostability, water extractable organic matter was quantified and qualitative identification was made with XAD8 and XAD4 resins. Results show that the amount of waste increases with the standard of living;the average ratio of daily waste generated is 0.89 kg day-1 person-1. Independently of the standard of living, fermentable compounds represent the largest proportion of waste materials (45%). Qualitative difference of waste content in organic matter is shown as a function of the population’s living standards. These results could be explained by a higher consumption of meat in the households with a higher standard of living, reflecting a greater proportion of transphilic (TPI), and hydrophilic (HPI) fractions. The C/N ratio is lower in the high standing households than in low ones. Metal trace element analysis showed a low but still significant pollution, whereas high iron and alu minum concentrations were found in all standings. In conclusion we propose a strategy for waste management in Abomey-Calavi based on sorting at the source to eliminate plastic waste and valorization of wastes via composting.展开更多
AIM:To investigate the evidence of homogeneous phenomenon on CYP3A5*3 MDR1-3435 and CYP3A4*18of the liver graft after living donor liver transplantation(LDLT).METHODS:We identified the proportional change of the CYP3A...AIM:To investigate the evidence of homogeneous phenomenon on CYP3A5*3 MDR1-3435 and CYP3A4*18of the liver graft after living donor liver transplantation(LDLT).METHODS:We identified the proportional change of the CYP3A5*3,MDR1-3435 and CYP3A4*18 from the peripheral blood mononuclear cell of 41 pairs recipient/donor with different genotype polymorphisms and 119liver graft biopsy samples used with the pyrosequencing technique after LDLT.Polymerase chain reaction/ligase detection reaction assay and restriction fragment length polymorphism was employed for genotyping the CYP3A5*3 and CYP3A4*18 single nucleotide poly-morphisms(SNPs).All of the recipients and donors expressed with the similar SNP genotype of CYP3A5*3,MDR1-3435 or CYP3A4*18 were excluded.RESULTS:The final genetic polymorphisms of the liver graft biopsy samples of CYP3A5*3,MDR1-3435 and CYP3A4*18 was predominated depends on the donor with restriction fragment length polymorphism and seems to be less related to the recipient.The proportional changes of G to A alleles of the 119 samples of CYP3A5*3(included A】A/G,A/G】A,A/G】G,G】A,G】A/G and A】G),C to T alleles of the 108 samples of MDR1-3435(included C】C/T,C/T】C,C/T】T,T】C/T and T】C),and T to C alleles of 15 samples of CYP3A4*18(included T/C】T and T】C/T)were significant different between the recipients and the liver graft biopsy samples(P【0.0001)and less difference when compared with the donors in the pyrosequencing analysis after LDLT.CONCLUSION:The CYP3A5*3,MDR1-3435 and CYP3A4*18 of the recipient could be modified by the donor so-called homogenous phenomenon when the recipient’s blood drained into the liver graft.展开更多
In this work, the exp(-φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to...In this work, the exp(-φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to be special values, the solitary wave solutions are derived from the exact traveling wave solutions. The validity and reliability of the method are tested by its applications to Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs which play an important role in biology.展开更多
目的调查活体肝移植供者健康相关生活质量,并与大样本健康人群做比较。方法采用横断面调查研究设计,基于欧洲五维健康量表(euro quality of life five-dimension questionnaire,EQ-5D-5L)制定调查问卷,采集数据并进行统计分析,具体方法...目的调查活体肝移植供者健康相关生活质量,并与大样本健康人群做比较。方法采用横断面调查研究设计,基于欧洲五维健康量表(euro quality of life five-dimension questionnaire,EQ-5D-5L)制定调查问卷,采集数据并进行统计分析,具体方法为多个独立样本比较的秩和检验(Kruskal-Wallis H)及两独立样本的非参数检验(Mann-Whitney U秩和检验)。结果本研究中活体肝移植供者共纳入77例活体肝移植供者,男性占比23.4%,女性占比76.6%,平均身高为(161.9±9.0)cm。存在问题最多的是焦虑或沮丧维度,占比68.8%,其次是疼痛或不舒服维度,占比32.5%。问题最少的是自我照顾维度,仅占1.3%。被调查者视觉模拟标尺VAS评分为(77.97±17.78)分。调查数据显示,VAS评分最低为36分,占比1.3%,最高100分,占比9.1%。婚姻状况在自我照顾维度、不同性别在焦虑或沮丧维度上存在显著差异。活体肝移植供者和健康对照人群的行动能力、自我照顾、日常生活维度没有显著差异,而疼痛或不舒服、焦虑或沮丧维度及VAS得分有显著差异,且健康对照人群优于活体肝移植供者。结论活体肝移植供者的健康相关生活质量较好,婚姻、性别是生活质量的影响因素。活体肝移植供者与健康对照人群相比,生活质量存在差距。展开更多
文摘Considering only the wave aspect, we determine the energy of a bond between 2 nucleons;this quantified energy is associated with a standing wave. Then, starting from the mass loss corresponding to this energy, we determine the number of bonds in this nucleus. The mass defect value for a link is used to determine a specific length at that link. Fixing a precise distance between nucleons makes it possible to determine a geometry of the nucleus and its dimensions. It makes it possible to understand when this bond is stronger than the electrostatic force and allows deducing a shell model built in a precise order. The calculation on the mass defect will also make it possible to determine that one or more nucleons concerned by the radioactivity will be bound by a single bond to the rest of the nucleus or, on the contrary, bound by several bonds which induce short 1/2 lives or, on the contrary, very long. The analysis of the bonds on H, He and C make it possible to write formulae which are then applied to the nuclei to find the radioactive 1/2 lives. To find by equations the radioactive 1/2 lives does not call into question the standard model since it concerns only the defect of mass of the nuclei with energies that are not used to find the main particles of the standard model. This model, which favours a geometric approach to the detriment of a mathematical approach based on differential equations, can lead to theoretical questions about the possibility of interpreting the structure of the nucleus in a more undulatory way. It is possible to explain radioactivity in a more deterministic way.
文摘The estimate of dental caries among Chinese children at the microscale level using standard methodology remains unclear. In this study, we assessed and analyzed the disease burden of childhood dental caries in China by extracting data from the Global Burden of Disease, Injuries, and Risk Factors Study 2016 (GBD 2016). In 2016, the number of cases, prevalence, years lived with disability (YLD), and age-standardized YLD rate of dental caries was 93.0 million, 43.0%, 32,200 person years, and 14.8 per 100,000, respectively. Across 33 provincial units, the disease burden was highest in Hubei (YLD rate 28.6 per 100,000), lowest in Macao (9.1 per 100,000), while geographical clustering was not observed. Compared with 1990, the prevalence in 2016 decreased from 46.8% to 43.0%, and the YLD rate decreased from 16.5 per 100,000 to 14.8 per 100,000. Given the slight decrease in dental caries burden, the prevalence and disease burden remained high among Chinese children. Strategies for addressing the spatial inequity of childhood dental caries require geographical targeting.
文摘To detect retrospectively the phenotype and stability of the E-protein gene in Japanese Encephalitis (JE) virus strain SA14-14-2 used in the live-attenuated JE vaccine prepears, the viral titer was titrated by plaque formation in BHK-21 cell cultures, and the neuro-virulence of viruses was assayed in mice with body weight of 12-14 g by intracerebral inoculation. Meanwhile, the total RNA of virus gene was extracted and amplified by RT-PCR with the designed primers, and then it was purified and cloned to the expression vector pGEM-T. The recombinant plasmid was purified and sequenced. It was found that the loss of viral titer of vaccines stored in -20℃ for longer than 10 years was less than 0.5 Lg PFU/ml. No mice inoculated intracerebrally showed signs of illness or even death. The size of plagues of the vaccine virus remained to be small, and the E genes of primary virus seed SA14-14-2 and the vaccines prepared at different years (1987-2001) were unchanged, in- cluding the 8 critical amino acid sites which were different from the parent wild virus strain SA14 and the related neuro-virulence. These results indicate that the genotypic and biological characteristics of the attenuated JE virus strain SA14-14-2 and its vaccines sion noted. prepared are quite stable without any reversion noted.
基金supported by the Beijing Municipal Project for Developing Advanced Human Resources for Higher Education(Elastomers and Biomaterials).
文摘The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,1-diphenylethylene (DPE) capped 2-chloro-2,4,4-trimethylpentane (TMPCl) was formed in situ in conjunction with titanium tetrachloride (TiCl(4)). The Lewis acidity of TiCl(4) was decreased by the addition of titanium(IV) isopropoxide (Ti(OiPr)(4)) to accomplish living polymerization of TBDMES. Hydrolysis of poly(TBDMES) in the presence of tetra-butylammonium fluoride yielded poly[4-(2-hydroxyethyl)styrene] (poly(HOES)). FT-IR, NMR and DSC demonstrated the hydrolysis was complete.
文摘Identification of waste characteristics is an important step towards improving waste recovery. The aim of this research was to determine the physical and physico-chemical characteristics of waste of Abomey–Calavi city and to study the relationship between standard of living and average ratio of daily waste generated by each person. In this study the methodology used French standards to characterize particle size and typology of solid waste generated by the population of Calavi City in Benin, West Africa. According to home criteria, the study area was stratified into three distinct levels of standard of living called: high standing, medium standing and low standing;Waste from 60 households was weighed daily. The total waste produced by each household was collected seven (7) days a week, for a period of three weeks. Waste characterization was performed using ratio, size granulometry and typological composition. Physico- Chemical analysis including organic mater, pH, Total Organic Carbon, total Kjeldahl nitrogen and metal trace element were also performed. To better assess waste compostability, water extractable organic matter was quantified and qualitative identification was made with XAD8 and XAD4 resins. Results show that the amount of waste increases with the standard of living;the average ratio of daily waste generated is 0.89 kg day-1 person-1. Independently of the standard of living, fermentable compounds represent the largest proportion of waste materials (45%). Qualitative difference of waste content in organic matter is shown as a function of the population’s living standards. These results could be explained by a higher consumption of meat in the households with a higher standard of living, reflecting a greater proportion of transphilic (TPI), and hydrophilic (HPI) fractions. The C/N ratio is lower in the high standing households than in low ones. Metal trace element analysis showed a low but still significant pollution, whereas high iron and alu minum concentrations were found in all standings. In conclusion we propose a strategy for waste management in Abomey-Calavi based on sorting at the source to eliminate plastic waste and valorization of wastes via composting.
基金Supported by A grant from Chang Gung Memorial Hospital,CMRPG8A0631 to Chiu KW of Taiwan
文摘AIM:To investigate the evidence of homogeneous phenomenon on CYP3A5*3 MDR1-3435 and CYP3A4*18of the liver graft after living donor liver transplantation(LDLT).METHODS:We identified the proportional change of the CYP3A5*3,MDR1-3435 and CYP3A4*18 from the peripheral blood mononuclear cell of 41 pairs recipient/donor with different genotype polymorphisms and 119liver graft biopsy samples used with the pyrosequencing technique after LDLT.Polymerase chain reaction/ligase detection reaction assay and restriction fragment length polymorphism was employed for genotyping the CYP3A5*3 and CYP3A4*18 single nucleotide poly-morphisms(SNPs).All of the recipients and donors expressed with the similar SNP genotype of CYP3A5*3,MDR1-3435 or CYP3A4*18 were excluded.RESULTS:The final genetic polymorphisms of the liver graft biopsy samples of CYP3A5*3,MDR1-3435 and CYP3A4*18 was predominated depends on the donor with restriction fragment length polymorphism and seems to be less related to the recipient.The proportional changes of G to A alleles of the 119 samples of CYP3A5*3(included A】A/G,A/G】A,A/G】G,G】A,G】A/G and A】G),C to T alleles of the 108 samples of MDR1-3435(included C】C/T,C/T】C,C/T】T,T】C/T and T】C),and T to C alleles of 15 samples of CYP3A4*18(included T/C】T and T】C/T)were significant different between the recipients and the liver graft biopsy samples(P【0.0001)and less difference when compared with the donors in the pyrosequencing analysis after LDLT.CONCLUSION:The CYP3A5*3,MDR1-3435 and CYP3A4*18 of the recipient could be modified by the donor so-called homogenous phenomenon when the recipient’s blood drained into the liver graft.
文摘In this work, the exp(-φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to be special values, the solitary wave solutions are derived from the exact traveling wave solutions. The validity and reliability of the method are tested by its applications to Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs which play an important role in biology.
文摘目的调查活体肝移植供者健康相关生活质量,并与大样本健康人群做比较。方法采用横断面调查研究设计,基于欧洲五维健康量表(euro quality of life five-dimension questionnaire,EQ-5D-5L)制定调查问卷,采集数据并进行统计分析,具体方法为多个独立样本比较的秩和检验(Kruskal-Wallis H)及两独立样本的非参数检验(Mann-Whitney U秩和检验)。结果本研究中活体肝移植供者共纳入77例活体肝移植供者,男性占比23.4%,女性占比76.6%,平均身高为(161.9±9.0)cm。存在问题最多的是焦虑或沮丧维度,占比68.8%,其次是疼痛或不舒服维度,占比32.5%。问题最少的是自我照顾维度,仅占1.3%。被调查者视觉模拟标尺VAS评分为(77.97±17.78)分。调查数据显示,VAS评分最低为36分,占比1.3%,最高100分,占比9.1%。婚姻状况在自我照顾维度、不同性别在焦虑或沮丧维度上存在显著差异。活体肝移植供者和健康对照人群的行动能力、自我照顾、日常生活维度没有显著差异,而疼痛或不舒服、焦虑或沮丧维度及VAS得分有显著差异,且健康对照人群优于活体肝移植供者。结论活体肝移植供者的健康相关生活质量较好,婚姻、性别是生活质量的影响因素。活体肝移植供者与健康对照人群相比,生活质量存在差距。