Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A t...Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A total of 102 patients with primary hypertension due to liver-fire flaming-up were randomly divided into a Taichong (LR 3) group, a Neiguan (PC 6) group and a Qiaogong (Extra) group according to the random number table, with 34 cases in each group. Patients in the three groups received 4-week tuina treatment with the corresponding acupoint respectively. The blood pressure was recorded by ben chtop mercury sphygmoma no meter before tuina, immediately after tuina treatment, 30 min and 60 min after tuina treatment with the patient in a supine position in a quiet treatment room. The total effective rate was observed. Results: The systolic and diastolic blood pressures of the three groups all decreased after treatment (all P<0.05). The decrease of systolic and diastolic blood pressure at different time points after treatment in the Qiaogong (Extra) group and the Taichong (LR 3) group were better than those in the Neiguan (PC 6) group (all P<0.05). Qiaogong (Extra) group had the highest total effective rate though there was no statistical differenee in the total effective rate among the three groups (P>0.05). Con elusion: Treati ng primary hypertensi on due to liver-fire flami ng-up with tuina at Taich ong (LR 3), Neigua n (PC 6) and Qiaogong (Extra) can reduce systolic and diastolic blood pressure respectively, among which Qiaogong (Extra) has the highest total effective rate.展开更多
Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristi...Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristics of the molecular network from gene level.Materials and Methods: Applying Gen CLip 2.0 online platform to retrieve the up-to-date literature referred to essential hypertension from PubMed database, cluster the abnormal expression of essential hypertension-related genes and analyze their function, combining Kyoto encyclopedia of genes and genomes-pathway analysis to investigate the closely related genes and the signaling molecules.Based on the genes closely related to hypertension, standard diagnostic symptoms of liver-fire hyperactivity were used as keywords to conduct hypertension liver-fire hyperactivity-related gene cluster analysis.Results: The top 1000 genes of essential hypertension were retrieved from GenCLip 2.0 online platform, which mainly clustered in the regulation of ambulatory blood pressure, regulation of renin-angiotensin-aldosterone system(RAAS), and sympathetic nervous system activity, as well as endothelial dysfunction; the closely related genes of hypertension with liver-fire hyperactivity are related to RAAS, gene REN, angiotensin converting enzyme, angiotensinogen, and cytochrome P450 family CYP2D6.Conclusion: A combination of literature mining and data mining can construct the gene network of hypertension and the syndrome-related genes, which provides a new method for the study of the biological basis of hypertension from the genetic level.展开更多
Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were ra...Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were randomly divided into a twirling reducing method group(35 cases),a needle retaining group(33 cases)and展开更多
文摘Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A total of 102 patients with primary hypertension due to liver-fire flaming-up were randomly divided into a Taichong (LR 3) group, a Neiguan (PC 6) group and a Qiaogong (Extra) group according to the random number table, with 34 cases in each group. Patients in the three groups received 4-week tuina treatment with the corresponding acupoint respectively. The blood pressure was recorded by ben chtop mercury sphygmoma no meter before tuina, immediately after tuina treatment, 30 min and 60 min after tuina treatment with the patient in a supine position in a quiet treatment room. The total effective rate was observed. Results: The systolic and diastolic blood pressures of the three groups all decreased after treatment (all P<0.05). The decrease of systolic and diastolic blood pressure at different time points after treatment in the Qiaogong (Extra) group and the Taichong (LR 3) group were better than those in the Neiguan (PC 6) group (all P<0.05). Qiaogong (Extra) group had the highest total effective rate though there was no statistical differenee in the total effective rate among the three groups (P>0.05). Con elusion: Treati ng primary hypertensi on due to liver-fire flami ng-up with tuina at Taich ong (LR 3), Neigua n (PC 6) and Qiaogong (Extra) can reduce systolic and diastolic blood pressure respectively, among which Qiaogong (Extra) has the highest total effective rate.
基金supported by the National Natural Science Foundation of China (81503382), (81603499), (81473521)the National Basic Research Program of China (973 Program) under Grant No.2011CB505106scientific research project of Beijing University of Chinese Medicine (2015-JYB-JSMS036) and (2018-JYB-XJQ009)
文摘Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristics of the molecular network from gene level.Materials and Methods: Applying Gen CLip 2.0 online platform to retrieve the up-to-date literature referred to essential hypertension from PubMed database, cluster the abnormal expression of essential hypertension-related genes and analyze their function, combining Kyoto encyclopedia of genes and genomes-pathway analysis to investigate the closely related genes and the signaling molecules.Based on the genes closely related to hypertension, standard diagnostic symptoms of liver-fire hyperactivity were used as keywords to conduct hypertension liver-fire hyperactivity-related gene cluster analysis.Results: The top 1000 genes of essential hypertension were retrieved from GenCLip 2.0 online platform, which mainly clustered in the regulation of ambulatory blood pressure, regulation of renin-angiotensin-aldosterone system(RAAS), and sympathetic nervous system activity, as well as endothelial dysfunction; the closely related genes of hypertension with liver-fire hyperactivity are related to RAAS, gene REN, angiotensin converting enzyme, angiotensinogen, and cytochrome P450 family CYP2D6.Conclusion: A combination of literature mining and data mining can construct the gene network of hypertension and the syndrome-related genes, which provides a new method for the study of the biological basis of hypertension from the genetic level.
文摘Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were randomly divided into a twirling reducing method group(35 cases),a needle retaining group(33 cases)and
