Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor prognosis.This treatment uses the same drug doses as conventional chemotherap...Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor prognosis.This treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals,allowing for promising clinical outcomes with intensive treatment.However,the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance,limiting therapeutic efficacy and clinical benefit.Here,we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with timeprogrammed pulsatile release profiles.The implantable device can control the time between drug releases based on its internal microstructure design,which can be used to control dose density.The device is made of biodegradable materials for clinical convenience and designed for minimally invasive implantation via a trocar.Dose density variation of local chemotherapy using programmable release enhances anti-cancer effects in vitro and in vivo.Under the same dose density conditions,device-based chemotherapy shows a higher anticancer effect and less toxic response than intratumoral injection.We demonstrate local chemotherapy utilizing the implantable device that simulates the drug dose,number of releases,and treatment duration of the dose-dense AC(doxorubicin and cyclophosphamide)regimen preferred for TNBC treatment.Dose density modulation inhibits tumor growth,metastasis,and the expression of drug resistance-related proteins,including p-glycoprotein and breast cancer resistance protein.To the best of our knowledge,local dose-dense chemotherapy has not been reported,and our strategy can be expected to be utilized as a novel alternative to conventional therapies and improve anti-cancer efficiency.展开更多
Synthetic aperture radar(SAR)three-dimensional(3D)imaging technology can reconstruct the complete structure of observed targets and has been a hot topic.Compared with tomographic SAR,array interferometric SAR,and circ...Synthetic aperture radar(SAR)three-dimensional(3D)imaging technology can reconstruct the complete structure of observed targets and has been a hot topic.Compared with tomographic SAR,array interferometric SAR,and circular SAR,curve SAR can use less data to achieve 3D positioning of targets.Most existing algorithms for estimating Doppler frequency modulation(FM)rate are based on sub aperture partitioning,resulting in low computational efficiency.To address this,this article establishes a target height estimation model,which reflects the relation-ship between the height and the residual Doppler FM rate for spaceborne curve SAR.Then,a fast SAR 3D localization processing flow based on fractional Fourier transform(FrFT)is proposed.Experimental verification demonstrates that this method can estimate the Doppler FM of the target column by column,and the 3D position error for non-overlapping targets is controlled within 1 m.For overlapping points with an intensity ratio greater than 1.5,the root mean square error(RMSE)of the estimation results is around 5 m.If the separation between overlapping points is greater than 35 m,the RMSE decreases to approximately 2 m.展开更多
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
In the process of indoor localization,the existence of the non-line of sight(NLOS)error will greatly reduce the localization accuracy.To reduce the impact of this error,a 3 dimensional(3D)indoor localization algorithm...In the process of indoor localization,the existence of the non-line of sight(NLOS)error will greatly reduce the localization accuracy.To reduce the impact of this error,a 3 dimensional(3D)indoor localization algorithm named LMR(LLS-Minimum-Residual)is proposed in this paper.We first estimate the NLOS error and use it to correct the measurement distances,and then calculate the target location with linear least squares(LLS)solution.The final nodes location can be obtained accurately by NLOS error mitigation.Our algorithm can work efficiently in both indoor 2D and 3D environments.The simulation results show that the proposed algorithm has better performance than traditional algorithms and it can significantly improve the localization accuracy.展开更多
To overcome the shortcomings of 1 D and 2 D Otsu’s thresholding techniques, the 3 D Otsu method has been developed.Among all Otsu’s methods, 3 D Otsu technique provides the best threshold values for the multi-level ...To overcome the shortcomings of 1 D and 2 D Otsu’s thresholding techniques, the 3 D Otsu method has been developed.Among all Otsu’s methods, 3 D Otsu technique provides the best threshold values for the multi-level thresholding processes. In this paper, to improve the quality of segmented images, a simple and effective multilevel thresholding method is introduced. The proposed approach focuses on preserving edge detail by computing the 3 D Otsu along the fusion phenomena. The advantages of the presented scheme include higher quality outcomes, better preservation of tiny details and boundaries and reduced execution time with rising threshold levels. The fusion approach depends upon the differences between pixel intensity values within a small local space of an image;it aims to improve localized information after the thresholding process. The fusion of images based on local contrast can improve image segmentation performance by minimizing the loss of local contrast, loss of details and gray-level distributions. Results show that the proposed method yields more promising segmentation results when compared to conventional1 D Otsu, 2 D Otsu and 3 D Otsu methods, as evident from the objective and subjective evaluations.展开更多
The leakage current behaviours of polycrystalline BiFeO3 thin films are investigated by using both conductive atomic force microscopy and current-voltage characteristic measurements. The local charge transport pathway...The leakage current behaviours of polycrystalline BiFeO3 thin films are investigated by using both conductive atomic force microscopy and current-voltage characteristic measurements. The local charge transport pathways are found to be located mainly at the grain boundaries of the films. The leakage current density can be tuned by changing the post-annealing temperature, the annealing time, the bias voltage and the light illumination, which can be used to improve the performances of the ferroelectric devices based on the BiFeOa films. A possible leakage mechanism is proposed to interpret the charge transports in the polycrystalline BiFeO3 films.展开更多
In the process of human behavior recognition, the traditional dense optical flow method has too many pixels and too much overhead, which limits the running speed. This paper proposed a method combing YOLOv3 (You Only ...In the process of human behavior recognition, the traditional dense optical flow method has too many pixels and too much overhead, which limits the running speed. This paper proposed a method combing YOLOv3 (You Only Look Once v3) and local optical flow method. Based on the dense optical flow method, the optical flow modulus of the area where the human target is detected is calculated to reduce the amount of computation and save the cost in terms of time. And then, a threshold value is set to complete the human behavior identification. Through design algorithm, experimental verification and other steps, the walking, running and falling state of human body in real life indoor sports video was identified. Experimental results show that this algorithm is more advantageous for jogging behavior recognition.展开更多
The mixed-valent Pb3Rh7O15 undergoes a Verwey-type transition at Tv≈180K, below which the development of Rh3＋3＋/Rh4＋4＋ charge order induces an abrupt conductor-to-insulator transition in resistivity. Here we inve...The mixed-valent Pb3Rh7O15 undergoes a Verwey-type transition at Tv≈180K, below which the development of Rh3＋3＋/Rh4＋4＋ charge order induces an abrupt conductor-to-insulator transition in resistivity. Here we investigate the effect of pressure on the Verwey-type transition of Pb3Rh7O15 by measuring its electrical resistivity under hydrostatic pressures up to 8GPa with a cubic anvil cell apparatus. We find that the application of high pressure can suppress the Verwey-type transition around 3GPa, above which a metallic state is realized at temperatures below ～70K, suggesting the melting of charge order by pressure. Interestingly, the low-temperature metallic region shrinks gradually upon further increasing pressure and disappears completely at P〉7GPa, which indicates that the charge carriers in Pb3Rh7O15 undergo a reentrant localization under higher pressures. We have constructed a temperature-pressure phase diagram for Pb3Rh7O15 and compared to that of Fe3O4, showing an archetype Verwey transition.展开更多
Two new metal-organic frameworks（MOFs）, namely, [Co_2（L_1）（bix）（μ_3-OH）]·2H_2O（1） and [Co_2（L_2）（bix）（μ_3-OH）]·2.5H_2O（2）（H_3L_1 = 5-oxyacetate isophthalic acid, H_3L_2 = 3,5-bis-oxyacet...Two new metal-organic frameworks（MOFs）, namely, [Co_2（L_1）（bix）（μ_3-OH）]·2H_2O（1） and [Co_2（L_2）（bix）（μ_3-OH）]·2.5H_2O（2）（H_3L_1 = 5-oxyacetate isophthalic acid, H_3L_2 = 3,5-bis-oxyacetate-benzoic acid, bix = 1,4-bis（imidazol-1-ylmethyl）benzene）, have been synthesized under hydrothermal conditions. Their structures were determined by single-crystal X-ray diffraction analysis and further characterized by elemental analysis, IR spectra, and powder X-ray diffraction（PXRD） analysis. Both complexes 1 and 2 demonstrate identical three-dimensional（3D）（3,8）-connected tfz-d nets with（4~3）_2（4~6·6^（18）·8~4） topologies, where the tetranuclear [Co_4（μ_3-OH）_2] clusters act as 8-connected nodes and aromatic multicarboxylic ligands as 3-connected nodes. The results show that the ligands with different geometrical conformations can form products with the same topological structures. Their thermal and magnetic properties were also investigated.展开更多
A much simpler and self-consistent derivation of the non-linear component Gu×Gv of the quantum chromodynamic SU(3) field tensor is given which does not require the postulate of color confinement to complete the d...A much simpler and self-consistent derivation of the non-linear component Gu×Gv of the quantum chromodynamic SU(3) field tensor is given which does not require the postulate of color confinement to complete the derivation and which mirrors SU(2)’s formal development.展开更多
In order to find better simplicity measurements for 3D object recognition, a new set of local regularities is developed and tested in a stepwise 3D reconstruction method, including localized minimizing standard deviat...In order to find better simplicity measurements for 3D object recognition, a new set of local regularities is developed and tested in a stepwise 3D reconstruction method, including localized minimizing standard deviation of angles（L-MSDA）, localized minimizing standard deviation of segment magnitudes（L-MSDSM）, localized minimum standard deviation of areas of child faces （L-MSDAF）, localized minimum sum of segment magnitudes of common edges （L-MSSM）, and localized minimum sum of areas of child face （L-MSAF）. Based on their effectiveness measurements in terms of form and size distortions, it is found that when two local regularities： L-MSDA and L-MSDSM are combined together, they can produce better performance. In addition, the best weightings for them to work together are identified as 10% for L-MSDSM and 90% for L-MSDA. The test results show that the combined usage of L-MSDA and L-MSDSM with identified weightings has a potential to be applied in other optimization based 3D recognition methods to improve their efficacy and robustness.展开更多
Functional research on biological macromolecules must fcus on specific loca regions.PDBlocal is aweb-based tool developed to overcome the limitations of traditional molecular visualization tools forthre-dimensional(3D...Functional research on biological macromolecules must fcus on specific loca regions.PDBlocal is aweb-based tool developed to overcome the limitations of traditional molecular visualization tools forthre-dimensional(3D)inspection of local regions.PDBlocal provides an intuitive and easy-to-manipulate web page interface and some new useful functions.It can kep loca regions flashing,display sequence text that is dynamically consistent with the 3D structure in local appearance undermultiple local manipulations,use two scenes to help users inspect the same local region withdifferent statuses,list all historical manipulation statuses with a tree structure,llow users toannotate regions ofinterest,and save ll historical statuses and other data to a web server for futureresearch.PDBlocal has met expectations and shown satisfactory performance for both expert andnovice users.This tool is available at http:/labsystem.scuec.edu.cn/pdblocal/.展开更多
Local chemistry plays an important role in determining the cohesive strength of grain boundaries in Ni3Al. Doping with B increases the room temperature ductility and changes the fracture mode from intergranular to tra...Local chemistry plays an important role in determining the cohesive strength of grain boundaries in Ni3Al. Doping with B increases the room temperature ductility and changes the fracture mode from intergranular to transgranular, while doping with Zr increases the ductility but leaves the fracture mode predominantly intergranular.Electron Energy Loss Spectroscopy (EELS) and Energy Dispersive X-ray Spectroscopy (EDS) were used to probe the changes in local bonding (and hence the cohesive strength) produced by changes in local chemistry at large angle boundaries in Ni3Al.In addition , small angle tilt boundaries were studied to correlate structure with Nienrichment at the interface. B segregation to Ni-rich grain boundaries was shown to make the bonding similar to that of the bulk, thereby increasing their fracture resistance. Ni-enrichment does not occur in the presence of Zr segregation to grain boundaries. Ni-enrichment to antiphase boundaries (APB) in small angle tilt boundaries lowers the APB energy by reducing the number of high energy Al-Al interactions across the interface. Ni-enrichment to large angle boundaries is expected to produce a similar effect on energy.展开更多
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Ministry of Science and ICT(MSIT)(No.2021R1A2C2012808)Technology Innovation Program(Alchemist Project)(No.20012378)funded by the Ministry of Trade,Industry&Energy(MOTIE),South Korea.
文摘Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor prognosis.This treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals,allowing for promising clinical outcomes with intensive treatment.However,the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance,limiting therapeutic efficacy and clinical benefit.Here,we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with timeprogrammed pulsatile release profiles.The implantable device can control the time between drug releases based on its internal microstructure design,which can be used to control dose density.The device is made of biodegradable materials for clinical convenience and designed for minimally invasive implantation via a trocar.Dose density variation of local chemotherapy using programmable release enhances anti-cancer effects in vitro and in vivo.Under the same dose density conditions,device-based chemotherapy shows a higher anticancer effect and less toxic response than intratumoral injection.We demonstrate local chemotherapy utilizing the implantable device that simulates the drug dose,number of releases,and treatment duration of the dose-dense AC(doxorubicin and cyclophosphamide)regimen preferred for TNBC treatment.Dose density modulation inhibits tumor growth,metastasis,and the expression of drug resistance-related proteins,including p-glycoprotein and breast cancer resistance protein.To the best of our knowledge,local dose-dense chemotherapy has not been reported,and our strategy can be expected to be utilized as a novel alternative to conventional therapies and improve anti-cancer efficiency.
基金supported in part by the National Key Research and Development Program of China(No.SQ2022YFB 3900055)in part by the National Natural Science Foundation of China(No.62101039)+1 种基金in part by the Shandong Excellent Young Scientists Fund Program(Overseas)in part by China Postdoctoral Science Foundation(No.2022M720443).
文摘Synthetic aperture radar(SAR)three-dimensional(3D)imaging technology can reconstruct the complete structure of observed targets and has been a hot topic.Compared with tomographic SAR,array interferometric SAR,and circular SAR,curve SAR can use less data to achieve 3D positioning of targets.Most existing algorithms for estimating Doppler frequency modulation(FM)rate are based on sub aperture partitioning,resulting in low computational efficiency.To address this,this article establishes a target height estimation model,which reflects the relation-ship between the height and the residual Doppler FM rate for spaceborne curve SAR.Then,a fast SAR 3D localization processing flow based on fractional Fourier transform(FrFT)is proposed.Experimental verification demonstrates that this method can estimate the Doppler FM of the target column by column,and the 3D position error for non-overlapping targets is controlled within 1 m.For overlapping points with an intensity ratio greater than 1.5,the root mean square error(RMSE)of the estimation results is around 5 m.If the separation between overlapping points is greater than 35 m,the RMSE decreases to approximately 2 m.
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
基金supported in part by the foundation of Nanjing University of Posts and Telecommunications (No. NY215164)by the National Experimental Teaching Demonstration Centre Reform Project: Virtual 201106+2 种基金supported by the Key University Science Research Project of Jiangsu Province under Grant (No. 14KJA510003)supported by the Postgraduate Research & Practice Innovation Program of Jiangsu Province under Grant No. SJCX19_0275supported by the National Natural Science Foundation under grant No. 61771257, No. 61605085 and No.61571233, No.61871232
文摘In the process of indoor localization,the existence of the non-line of sight(NLOS)error will greatly reduce the localization accuracy.To reduce the impact of this error,a 3 dimensional(3D)indoor localization algorithm named LMR(LLS-Minimum-Residual)is proposed in this paper.We first estimate the NLOS error and use it to correct the measurement distances,and then calculate the target location with linear least squares(LLS)solution.The final nodes location can be obtained accurately by NLOS error mitigation.Our algorithm can work efficiently in both indoor 2D and 3D environments.The simulation results show that the proposed algorithm has better performance than traditional algorithms and it can significantly improve the localization accuracy.
文摘To overcome the shortcomings of 1 D and 2 D Otsu’s thresholding techniques, the 3 D Otsu method has been developed.Among all Otsu’s methods, 3 D Otsu technique provides the best threshold values for the multi-level thresholding processes. In this paper, to improve the quality of segmented images, a simple and effective multilevel thresholding method is introduced. The proposed approach focuses on preserving edge detail by computing the 3 D Otsu along the fusion phenomena. The advantages of the presented scheme include higher quality outcomes, better preservation of tiny details and boundaries and reduced execution time with rising threshold levels. The fusion approach depends upon the differences between pixel intensity values within a small local space of an image;it aims to improve localized information after the thresholding process. The fusion of images based on local contrast can improve image segmentation performance by minimizing the loss of local contrast, loss of details and gray-level distributions. Results show that the proposed method yields more promising segmentation results when compared to conventional1 D Otsu, 2 D Otsu and 3 D Otsu methods, as evident from the objective and subjective evaluations.
基金supported by the Chinese Academy of Sciencesthe State Key Project of Fundamental Research of Chinathe Natural Science Foundation of Ningbo,China
文摘The leakage current behaviours of polycrystalline BiFeO3 thin films are investigated by using both conductive atomic force microscopy and current-voltage characteristic measurements. The local charge transport pathways are found to be located mainly at the grain boundaries of the films. The leakage current density can be tuned by changing the post-annealing temperature, the annealing time, the bias voltage and the light illumination, which can be used to improve the performances of the ferroelectric devices based on the BiFeOa films. A possible leakage mechanism is proposed to interpret the charge transports in the polycrystalline BiFeO3 films.
文摘In the process of human behavior recognition, the traditional dense optical flow method has too many pixels and too much overhead, which limits the running speed. This paper proposed a method combing YOLOv3 (You Only Look Once v3) and local optical flow method. Based on the dense optical flow method, the optical flow modulus of the area where the human target is detected is calculated to reduce the amount of computation and save the cost in terms of time. And then, a threshold value is set to complete the human behavior identification. Through design algorithm, experimental verification and other steps, the walking, running and falling state of human body in real life indoor sports video was identified. Experimental results show that this algorithm is more advantageous for jogging behavior recognition.
基金Supported by the"Shi-Pei Ji Hua",the National Science Foundation of China under Grant Nos 51402019 and 11574377the Beijing Natural Science Foundation under Grant No 2152011+5 种基金the National Basic Research Program of China under Grants No2014CB921500the Strategic Priority Research ProgramKey Research Program of Frontier Sciences of the Chinese Academy of Sciences under Grant Nos XDB07020100 and QYZDB-SSW-SLH013the U.S.Department of Energy,Office of Science,Basic Energy Sciences,Materials Sciences and Engineering Divisionthe CEMNSF MRSEC under Grant No DMR-1420451
文摘The mixed-valent Pb3Rh7O15 undergoes a Verwey-type transition at Tv≈180K, below which the development of Rh3＋3＋/Rh4＋4＋ charge order induces an abrupt conductor-to-insulator transition in resistivity. Here we investigate the effect of pressure on the Verwey-type transition of Pb3Rh7O15 by measuring its electrical resistivity under hydrostatic pressures up to 8GPa with a cubic anvil cell apparatus. We find that the application of high pressure can suppress the Verwey-type transition around 3GPa, above which a metallic state is realized at temperatures below ～70K, suggesting the melting of charge order by pressure. Interestingly, the low-temperature metallic region shrinks gradually upon further increasing pressure and disappears completely at P〉7GPa, which indicates that the charge carriers in Pb3Rh7O15 undergo a reentrant localization under higher pressures. We have constructed a temperature-pressure phase diagram for Pb3Rh7O15 and compared to that of Fe3O4, showing an archetype Verwey transition.
基金supported by the application basis research key project of Yunnan Province science and technology department(201401CB00299)the major project of Qujing Normal University(2012ZD002)
文摘Two new metal-organic frameworks（MOFs）, namely, [Co_2（L_1）（bix）（μ_3-OH）]·2H_2O（1） and [Co_2（L_2）（bix）（μ_3-OH）]·2.5H_2O（2）（H_3L_1 = 5-oxyacetate isophthalic acid, H_3L_2 = 3,5-bis-oxyacetate-benzoic acid, bix = 1,4-bis（imidazol-1-ylmethyl）benzene）, have been synthesized under hydrothermal conditions. Their structures were determined by single-crystal X-ray diffraction analysis and further characterized by elemental analysis, IR spectra, and powder X-ray diffraction（PXRD） analysis. Both complexes 1 and 2 demonstrate identical three-dimensional（3D）（3,8）-connected tfz-d nets with（4~3）_2（4~6·6^（18）·8~4） topologies, where the tetranuclear [Co_4（μ_3-OH）_2] clusters act as 8-connected nodes and aromatic multicarboxylic ligands as 3-connected nodes. The results show that the ligands with different geometrical conformations can form products with the same topological structures. Their thermal and magnetic properties were also investigated.
文摘A much simpler and self-consistent derivation of the non-linear component Gu×Gv of the quantum chromodynamic SU(3) field tensor is given which does not require the postulate of color confinement to complete the derivation and which mirrors SU(2)’s formal development.
文摘In order to find better simplicity measurements for 3D object recognition, a new set of local regularities is developed and tested in a stepwise 3D reconstruction method, including localized minimizing standard deviation of angles（L-MSDA）, localized minimizing standard deviation of segment magnitudes（L-MSDSM）, localized minimum standard deviation of areas of child faces （L-MSDAF）, localized minimum sum of segment magnitudes of common edges （L-MSSM）, and localized minimum sum of areas of child face （L-MSAF）. Based on their effectiveness measurements in terms of form and size distortions, it is found that when two local regularities： L-MSDA and L-MSDSM are combined together, they can produce better performance. In addition, the best weightings for them to work together are identified as 10% for L-MSDSM and 90% for L-MSDA. The test results show that the combined usage of L-MSDA and L-MSDSM with identified weightings has a potential to be applied in other optimization based 3D recognition methods to improve their efficacy and robustness.
基金supported by the International Science and Technology Cooperation Key Projects of the Chinese Ministry of Science and Technology(2009DFB30340)National Major Projects of China(2016ZX08010004-004)+2 种基金National Natural Sciences Foundation of China(81373379)Natural Science Foundation of Hubei Province of China(2012FFB07402)Fundamental Research Funds for the Central Universities in China(SouthCentral University for Nationalities,CZY12004).
文摘Functional research on biological macromolecules must fcus on specific loca regions.PDBlocal is aweb-based tool developed to overcome the limitations of traditional molecular visualization tools forthre-dimensional(3D)inspection of local regions.PDBlocal provides an intuitive and easy-to-manipulate web page interface and some new useful functions.It can kep loca regions flashing,display sequence text that is dynamically consistent with the 3D structure in local appearance undermultiple local manipulations,use two scenes to help users inspect the same local region withdifferent statuses,list all historical manipulation statuses with a tree structure,llow users toannotate regions ofinterest,and save ll historical statuses and other data to a web server for futureresearch.PDBlocal has met expectations and shown satisfactory performance for both expert andnovice users.This tool is available at http:/labsystem.scuec.edu.cn/pdblocal/.
文摘Local chemistry plays an important role in determining the cohesive strength of grain boundaries in Ni3Al. Doping with B increases the room temperature ductility and changes the fracture mode from intergranular to transgranular, while doping with Zr increases the ductility but leaves the fracture mode predominantly intergranular.Electron Energy Loss Spectroscopy (EELS) and Energy Dispersive X-ray Spectroscopy (EDS) were used to probe the changes in local bonding (and hence the cohesive strength) produced by changes in local chemistry at large angle boundaries in Ni3Al.In addition , small angle tilt boundaries were studied to correlate structure with Nienrichment at the interface. B segregation to Ni-rich grain boundaries was shown to make the bonding similar to that of the bulk, thereby increasing their fracture resistance. Ni-enrichment does not occur in the presence of Zr segregation to grain boundaries. Ni-enrichment to antiphase boundaries (APB) in small angle tilt boundaries lowers the APB energy by reducing the number of high energy Al-Al interactions across the interface. Ni-enrichment to large angle boundaries is expected to produce a similar effect on energy.
