Outcomes of palliative local treatment in metastatic colorectal cancer patients receiving chemotherapy plus bevacizumab

Objective The aim of this study was to assess the value of palliative local treatment of incurable metastatic lesions in colorectal cancer(CRC) patients receiving chemotherapy plus bevacizumab.Methods Data of 105 patients with histologically confirmed synchronous or metachronous metastatic CRC who received bevacizumab treatment from January 1, 2011 to January 31, 2017 were retrospectively reviewed. Sixteen(15%) patients who were treated with bevacizumab for less than 4 cycles were excluded, and finally, 89(85%) patients were enrolled. Among them, 33(37%) patients who received palliative local treatment were categorized into the palliative local treatment group, and the remaining 56(63%) patients were categorized into the chemotherapy plus bevacizumab group. The primary endpoint was overall survival(OS), which was calculated using Kaplan-Meier survival analyses. Factors possibly influencing survival were evaluated by univariate and multivariate analyses. Adverse events(AEs) were graded according to Common Terminology Criteria for Adverse Events, version 4.0. Grades 1–2 and 3–4 AEs of the two groups were compared and analyzed using the Fisher's exact test and χ~2 analysis.Results The median follow-up period was 20.4 months, ranging from 1 to 60 months. The median OS in the palliative local treatment group was 36.3 months(95% CI, 33.5–39.2), and that in the chemotherapy plus bevacizumab group was 20.5 months(95% CI, 17.6–23.4). Both the univariate(HR 0.13, 95% CI, 0.05–0.30, P < 0.001) and multivariate(HR 0.16, 95% CI, 0.07–0.39, P < 0.001) analyses showed that the addition of palliative local treatment could prolong survival compared with chemotherapy plus bevacizumab alone. There were no significant differences in the rates of common chemotherapy-or bevacizumab-related AEs between the two groups.Conclusion These findings suggest palliative local treatment is an effective and safe method for treating patients with incurable metastatic CRC receiving chemotherapy plus bevacizumab.

Efficacy of capecitabine and oxaliplatin regimen for extrahepatic metastasis of hepatocellular carcinoma following local treatments

AIM: To investigate the efficacy and safety of capecitabine and oxaliplatin (CapeOx) for extrahepatic metastasis after local treatment of hepatocellular carcinoma (HCC). METHODS: Thirty-two patients with extrahepatic metastasis of HCC after local treatment were prospectively enrolled. The CapeOx regimen consisted of capecitabine 1000 mg/m 2 taken orally twice daily on days 1-14, and oxaliplatin was administered at a total dose of 100 mg/m 2 on day 1. The treatment was repeated every 3 wk until disease progression or unaccetablle toxicity. Efficacy and safety were assessable for all enrolled patients. The primary objective of this study was to assess the overall response rate. The secondary objectives were to evaluate the overall survival (OS), the time to tumor progression (TTP) and the toxicity profile of the combined strategy. TTP and OS were assessed by the Kaplan-Meier method and differences between the curves were analyzed using the log-rank test. The statistical software SPSS version 15.0 for Windows (SPSS Inc., Chicago, IL, United States) was used for statistical analysis. All P values were 2-tailed, with statistical significance defined byP ≤ 0.05. RESULTS: Thirty-two patients were assessable for efficacy and toxicity. The median follow-up duration was 15 mo (range, 12-20 mo). At the cut-off date of March 31, 2012, 27 patients died due to tumor progression and one patient died of myocardial infarction. Four patients were still alive (three patients with disease progression). OR was 21.9% (n = 7), the stabilization rate was 40.6% (n = 13), and the disease control rate was 62.5%. The responses lasted from 4 to 19 mo (median, 6 mo). Median TTP was 4.2 mo (95%CI: 2.5-7.4), and the median OS time was 9.2 mo (95%CI: 6.5-17.8). The 1-year survival rate was 43.6% (95%CI: 29.0-66.0). In a multivariate analysis, OS was significantly longer in patients with a Child-Pugh class A compared with class B patients (P = 0.014), with a median OS of 10.1 mo vs 5.4 mo, and there were trends towards longer OS (P = 0.065) in patients without portal vein tumor thrombosis. There were no significant effects of age, gender, performance status, cirrhosis, metastatic sites, and level of alpha fetoprotein (AFP) or hepatitis B virus-DNA on OS. Among the 22 patients with elevated AFP levels at baseline (≥ 400 ng/mL), the level fell by more than 50% during treatment in 6 patients (27.3%). The most frequent treatment-related grade 3 to 4 toxicities included leucopenia/neutropenia, transient elevation of aminotransferases, handfoot syndrome and fatigue. CONCLUSION: CapeOx showed modest anti-tumor activity in metastatic HCC. However, the manageable toxicity profile and the encouraging disease control rate deserve further study for these patients.

Miramistinum and metronidazole in the local treatment of the experimental purulent wounds

Objective To study the wound-healting ability of immobilized forms of miramistinum and metronidazole,based on a sodium salt of carboxymethylcellulose.Methods The research was made on an experimental model of a purulent wound and levomecol was used for comparison.Results During the experiment antimicrobial activity of made drugs was evaluated and the planimetric assessment of the process of epithelialization of the wound’s surface,bacterial load,morphometric examination of histological drugs for wounds and were made.ConclusionThe benefits of combination miramistinum and metronidazole,immobilized on a sodium salt of carboxymethylcellulose,compared with the drug levomecol.

Local treatment of osteoporosis with alendronate-loaded calcium phosphate cement

Background A new treatment strategy is to target specific areas of the skeletal system that are prone to clinically significant osteoporotic fractures.We term this strategy as the ＂local treatment of osteoporosis＂.The study was performed to investigate the effect of alendronate-loaded calcium phosphate cement （CPC） as a novel drug delivery system for local treatment of osteoorosis.Methods An in vitro study was performed using CPC fabricated with different concentrations of alendronate （ALE,0,2,5,10 weight percent （wt％））.The microstructure,setting time,infrared spectrum,biomechanics,drug release,and biocompatibility of the composite were measured in order to detect changes when mixing CPC with ALE.An in vivo study was also performed using 30 Sprague-Dawley rats randomly divided into six groups：normal,Sham （ovariectomized （OVX） ＋ Sham）,CPC with 2％ ALE,5％ALE,and 10％ ALE groups.At 4 months after the implantation of the composite,animals were sacrificed and the caudal vertebrae （levels 4-7） were harvested for micro-CT examination and biomechanical testing.Results The setting time and strength of CPC was significantly faster and greater than the other groups.The ALE release was sustained over 21 days,and the composite showed good biocompatibility.In micro-CT analysis,compared with the Sham group,there was a significant increase with regard to volumetric bone mineral density （BMD） and trabecular number （Tb.N） in the treated groups （P ＜0.05）.Trabecular spacing （Tb.Sp） showed a significant increase in the Sham group compared to other groups （P ＜0.01）.However,trabecular thickness （Tb.Th） showed no significant difference among the groups.In biomechanical testing,the maximum compression strength and stiffness of trabecular bone in the Sham group were lower than those in the experimental groups.Conclusions The ALE-loaded CPC displayed satisfactory properties in vitro,which can reverse the OVX rat vertebral trabecular bone microarchitecture and biomechanical properties in vivo.

Therapeutic response and safety of different treatments for cutaneous leishmaniasis in patients: A retrospective cross-sectional study

Objective:To analyze the therapeutic response and safety of different treatments for cutaneous leishmaniasis,received by patients in the Program for the Study and Control of Tropical Diseases-PECET-Medellín-Colombia.Methods:This is a retrospective cross-sectional study of patients attended at PECET Research Center during 2016-2021.Relevant information regarding sociodemographic characteristics,history of leishmaniasis,characterization of current infection,treatment received,follow-up of therapeutic response and safety was collected from the medical records.Data were analyzed with Pearson's Chi-square association tests and Mann-Whitney U test using statistical software.Results:A total of 486 clinical records of patients were analyzed,and 356 received treatment.Eight different therapeutic alternatives(systemic,local and in combination)were analyzed.The therapeutic response of the different alternatives used(except thermotherapy)was higher than 50%.Most frequent adverse events were myalgias,arthralgias and headache,and vesicles for systemic and local treatment,respectively.Conclusions:Safety profile and performance of local therapeutic alternatives and combined schemes for the treatment of uncomplicated cutaneous leishmaniasis are an interesting option for the management of the disease.

Effects of Electron Beam Local Postweld Heat Treatment on Microstructure and Properties of 30CrMnSiNi2A Steel Welded Joints

To improve the microstructure and properties of the electron beam welded joints, the vacuum or furnace whole post weld heat treatment (FWPWHT) usually should be done on it. The electron beam local post weld heat treatment (EBLPWHT) is a rather new heat treatment procedure that provides the advantages of high precision, flexibility and efficiency, energy saving and higher productivity. In this paper, the microstructure, mechanical properties, fracture toughness and fatigue properties of electron beam welded joints of 30CrMnSiNi2A steel in as-welded (AW) and EBLPWHT conditions have been investigated respectively. The results show that the microstructures of different zones of joints in as-welded condition are changed by EBLPWHT procedure, in which the welds from coarse needle martensite into lath-shaped martensite; the main structures of heat affected zones (HAZ) from lath-shaped martensite into lower bainite. The properties of welded joints can be improved by the EBLPWHT in some extent, especially the fracture toughness of the welds and the fatigue crack resistance of welded joints can be sufficiently improved. However, more appropriate heat treatment parameters of the EBLPWHT have to be studied in order to increase the mechanical properties of base metal near by the HAZ.

Temperature field analysis of main steam pipe under local post weld heat treatment

In local post weld heat treatment, the temperature difference is the criterion of the process. The temperature field in the main stream pipe under local post weld heat treatment is simulated by finite element method. A close-loop control program is designed to simulate the temperature field of two different pipes. Both the skin effect of induction heating and electro-thermal coupled effect are considered in the heating model. The local heat treatment temperature difference at the inner and outer side of the pipe is analyzed and the different convection conditions are also considered. The simulation results show that in appropriate induction heating process, the temperature difference in the pipe can be controlled within 30 ℃.

NUMERICAL ANALYSIS OF RESIDUAL STRESSES IN TITANIUM ALLOY DURING ELECTRON BEAM LOCAL POST-WELD HEAT TREATMENT

The distributions of temperature and residual stresses in thin plates of BT20titanium alloy are numerically analyzed by three-dimensional finite element software duringelectron beam welding and electron beam local post-weld heat treatment (EBLPWHT). Combined withnumerical calculating results, the effects of different EBLPWHT mode and parameters, including heattreating position, heating width and heating time, on the distribution of welding residual stressesare analyzed. The results show that, the residual tensile stresses in weld center can be largelydecreased when the weld is heat treated at back preface of the plate. The numerical results alsoindicated that the magnitude of the residual longitudinal stresses of the weld and the zone vicinityof the weld is decreased, and the range of the residual longitudinal stresses is increased alongwith the increase of heating width and heating time.

TREATMENT OF LOCAL RECURRENCE OF NASOPHARYN-GEAL CARCINOMA WITH REIRRADIATION

From 1975 to 1987, 112 patients with loco-regional recurrence of nasopharyngeal carcinoma (N P C) were treated again with radiation at our hospital. All cases were proven histologically by biopsy. Of these patients, 92 had their recurrence in the nasopharynx only, 13 had additional involvement of the base of the skull, and 7 had tumor recurrences simultaneously in the nasopharynx as well as the cervical lymph nodes. Radiotherapy adopted in this series was 60Co external irradiation (X R Te) and/ or betatron in 96 patients, X R Te plus intracavitary 60Co irradiation (X R Ti) in 12 patients and X R Ti alone in the other 4 patients. The 1-, 3-, and 5-year survival rates were 86.3%, 45.8% and 30.2% respectively after the start of recurrence retreatment. The 63 patients who survived for 5 years or more were analyzed. The prognosis of the patient was related to the histological type, clinical stage, modality of treatment, and disease interval to recurrence and site of recurrence. No serious complications occurred. It is suggested that re-irradiation is appropriate in the treatment of loco-regional recurrent N P C.

Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer:A pictorial review

High-resolution pelvic magnetic resonance imaging(MRI) is the primary method for staging rectal cancer.MRI is highly accurate in the primary staging of rectal cancer;however,it has not proven to be effective in restaging,especially in complete response evaluation after neoadjuvant therapy.Neoadjuvant chemoradiotherapy produces many changes in rectal tumors and on adjacent area,as a result,local tumor extent may not be accurately determined.However,adding diffusion-weighted sequences to the standard approach can improve diagnostic accuracy.In this pictorial review,an overview of the situation of MRI in the staging and re-staging of rectal cancer is exhibited as a pictorial assay.An experience-and literature-based discussion of limitations and difficulties in interpretation are also presented.

Salvage Photodynamic Therapy Is an Effective and Safe Treatment for Patients with Local Failure after Definitive Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

Although chemoradiotherapy (CRT) is one curative treatment option for patients with esophageal squamous cell carcinoma (ESCC), local failure after CRT remains a major problem for patients’ curability. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy (PDT) as a salvage treatment for local failure. From August 2007 to March 2012, 193 consecutive ESCC patients were treated with definitive CRT in Kyoto University Hospital. Eighteen of the patients with T2 or earlier T-stage local failure after CRT underwent salvage PDT. After the salvage PDT, 11 patients (61.1%) achieved a complete response at the primary site. Over a median follow-up period of 28.3 months, the 1-year survival and progression-free survival rates were 77.8% and 38.9%, respectively;and the 2-year survival and progression-free survival rates were 60.6% and 33.3%, respectively. Adverse events were mild esophageal stricture in seven (38.9%), esophageal obstruction because of necrotic tissue in nine (50.0%), and photosensitivity in three (16.7%) patients. There were no severe complications or treatment-related deaths. Salvage PDT may be a promising treatment option for the patients with a local residual or recurrent tumor after CRT for ESCC when the lesion is suspected to be in T2 or earlier.

Palliative Treatment of Locally Advanced Non Metastatic Lung Cancer

Introduction: To determine the proportion and the reasons which lead to palliative treatment in patients initially a candidate for concomitant chemoradiotherapy (CCRT). Methods: A retrospective study including patients followed for locally advanced lung cancer newly diagnosed from April 1, 2016, to 12/31/2017 in the radiotherapy department of the National Oncology Institute who received palliative treatment. Results: We collected 52 patients out of a total of 225 stage III patients (23%) followed by lung cancer candidates for CCRT who had undergone palliative treatment. The mean age in our series was 61.23 years [22 - 81] with 86% male. The majority of patients (71%) had Performance Status (PS) ≤ 2. Histological confirmation was obtained by pathological examination in all our patients. It was an adenocarcinoma (ADK) in 54% of cases;squamous cell carcinoma in 46% of cases. The reasons for palliative treatment were mainly due to dosimetric constraints: large tumor volume 22/52 (42%);the tumor location close to the bone marrow in 15 of 52 (29%) patients;and general Performance Status impairment (29%) in 15 of 52 patients. Palliative treatment consisted of palliative chemotherapy in 37 of 52 patients (71%), among whom 19 (51%) were stable after 2 months of chemotherapy, in palliative dose chest radiotherapy on the pulmonary parenchyma and/or mediastinum in 10 of 52 (19%) patients, and supportive care in 5 (10 %) patients. We observed 40/52 (77%) cases of stationary course, 04/52 (8%) cases of progress to metastases, and 08/52 (15%) deaths before radiotherapy. Conclusion: A large proportion of patients followed for locally advanced non-metastatic lung cancer are not eligible for curative treatment. The reasons for the palliative treatment of patients followed for lung cancer candidates for CCRT are variable but for a large proportion of patients due to the deterioration of their state of health during their diagnostic journey. Hence, there is the need to improve the early diagnosis and early management of patients with lung cancer to avoid delayed care.

Local metothrexate treatment of cesarean scar ectopic pregnancy

Myometrial pregnancy developing in a previous caesarean section scar is the rarest of all ectopic pregnancies (EP) and probably one of the most dangerous of all because of the risk of rupture and hemorrhage. The recent recognition of this problem means that diagnosis and management are still in their infancy, and there is no consensus regarding the best management of CSP. Methotrexate (MTX) can be administered systemically or locally, or in both ways, with the aid of ultrasound. Patients diagnosed with caesarean scar pregnancies (CSP) in our clinic underwent transvaginal treatment of ectopic pregnancy. Safe and short treatment under transvaginal ultrasonographic (USG) guidance was performed uneventfully in all cases. The operating time ranged from 5 to 10 minutes with no blood loss. Serum β-hCG (β-subunit of human chorionic gonadotrophin) levels declined to normal levels within a month, and patients were discharged without further complications in two or three hours after the procedure. Our cases show that this treatment is effective, safe, and minimally invasive for patients diagnosed with CSP.

THE FACTORS AND TREATMENT OF LOCAL RECURRENCE AFTER RADICAL RESECTION RESERVING THE ANUS IN THE PATIENTS WITH RECTAL CANCER

Of seventy-one patients with rectal cancer after radical resection retaining the anus, 15 developed local recurrence with a recurrence rate of 21.1%. Local recurrence was correlated with improper safety margin from the lower edge of cancer to the anal end. There was statistical significant difference between 3 cm or more and 2 cm or less. The local recurrence was also related to the pathologic stage, histologic differentiation and implant of free cancer cells. It is suggested that the surgical indication of saving the anus be strict and without stretching, the safety margin from the lower edge of cancer to the anal end should not be less than 2 cm in early rectal cancer and not less than 4 cm in advanced lesions. During the operation, no touching tumor technique, thorough rinsing of the peritoneal cavity and pre- or post-operative radiotherapy are important for prevention of local recurrence. Early local recurrent rectal cancer can be detected by periodic examinations.

“候鸟”老年人急诊异地就医真实体验的质性研究

目的了解“候鸟”老年人急诊异地就医的真实体验,为强化“候鸟”老年人异地就医保障、改善其就医体验提供参考。方法采用目的抽样法,选取2022年1月—2023年2月在海南省某三级甲等医院急诊科就诊的“候鸟”老年人作为研究对象,对其进行半结构式深入访谈,采用Colaizzi现象学7步分析法对访谈资料进行分析、归纳及提炼主题。结果“候鸟”老年人急诊异地就医真实体验可划分为3个亚主题:救治服务与患者需求存在差距、医保异地报销政策有待进一步落地、树立积极认知。结论异地就医的“候鸟”老年人面临诸多挑战,各级管理部门应强化“候鸟”老年人异地就医保障、提高社会支持和参与力度,协助患者应对异地就医中的困境,为异地急诊就医的“候鸟”老年人提供最佳照护。

皮下免疫治疗对局部变应性鼻炎伴哮喘患者的疗效及安全性评价

目的探究皮下免疫治疗(subcutaneous immunotherapy,SCIT)对局部变应性鼻炎(local allergic rhinitis,LAR)伴哮喘患者的疗效,并评价其安全性。方法2019年6月~2022年6月间绵阳市中心医院收治的LAR伴哮喘患者,观察组36例,对照组35例,两组患者均接受哮喘规范化治疗,观察组另给予SCIT,对照组给予安慰剂。治疗12个月后评估患者临床疗效,评估患者症状评分、用药评分,检测并比较治疗前、后血清特异性IgG4(sIgG4)和特异性IgE(sIgE)水平,采用鼻结膜炎相关生活质量问卷(rhinoconjunctivitis quality of life questionnaire,RQLQ)评估患者生活质量,统计治疗期间不良事件发生情况。结果与治疗前比较,两组患者治疗12个月时哮喘症状总评分(total asthma symptom score,TASS)和鼻部症状总评分(total nasal symptom score,TNSS)均降低(P均<0.05),观察组TASS和TNSS均较对照组降低(P均<0.05);与治疗3个月比较,两组患者治疗12个月时用药积分(total medication score,TMS)均降低(P均<0.05),观察组TMS较对照组降低(P<0.05);两组患者治疗12个月时sIgG4水平升高(P<0.05),sIgE降低水平(P<0.05);观察组sIgG4水平较对照组升高(P<0.05),两组sIgE水平无显著差异(P>0.05);两组患者治疗12个月时RQLQ评分降低(P<0.05),观察组RQLQ评分较对照组降低(P<0.05);观察组和对照组治疗期间不良事件发生率分别为16.67%和8.57%,二者比较差异无显著性(P>0.05)。结论SCIT能够有效改善LAR伴哮喘患者的临床症状,减轻Ⅰ型变态反应,提高患者生活质量,安全性较高。

卡瑞利珠单抗联合仑伐替尼治疗对晚期肝癌局部治疗后患者的有效性及安全性分析

目的探讨卡瑞利珠单抗联合仑伐替尼治疗对晚期肝癌局部治疗后患者的有效性以及安全性。方法回顾性收集2021年1月~2022年12月在某院接受诊治及随访的晚期肝癌患者病例资料进行研究,根据治疗方案将这些患者分为试验组(58例)和对照组(52例),试验组接受卡瑞利珠单抗联合仑伐替尼治疗,对照组接受仑伐替尼单药治疗,两组均至少接受42 d治疗。评价指标包括疾病缓解率、生存时间以及药品不良反应。结果试验组客观缓解率(ORR)为53.45%,高于对照组32.69%;疾病控制率(DCR)为79.31%,高于对照组57.69%(P<0.05)。随访时间为5~20个月,中位随访时间为13.00(9.00,20.00)个月。试验组总生存时间(OS)、无进展生存时间(PFS)均高于对照组,总生存率高于对照组(P<0.05)。试验组肝肾损伤发生率高于对照组(P<0.05)。结论卡瑞利珠单抗联合仑伐替尼治疗对晚期肝癌局部治疗后患者能够提高疾病缓解率,延长生存时间,但治疗期间容易加重肝肾损害。

T4a期甲状腺癌外科治疗的临床经验报告

目的分析T4a期甲状腺癌的临床特点及外科治疗策略。方法回顾性纳入2004年1月至2021年5月间在四川省肿瘤医院头颈外科住院手术的甲状腺恶性肿瘤患者,共计纳入T4a的甲状腺癌病例303例,分析患者的病理分型、受侵器官、手术方式、生存时间等。分析患者的总生存率,使用Kaplan Meier法分析患者术后生存曲线。结果在入组的303例患者中,共计53例患者失访,1年总生存率为98.4%(246/250),3年总生存率为97.0%(224/231),5年总生存率为90.2%(92/102)。其中喉返神经单独受侵94例,失访13例,1年总生存率为100%(81/81),3年总生存率为98.7%(77/78),5年总生存率为97.4%(38/39)。喉返神经合并气管/喉/食道受侵151例,失访31例,1年总生存率为96.7%(116/120),3年总生存率为95.3%(101/106),5年总生存率为82.2%(37/45)。在生存曲线分析中,喉返神经单独受侵组较喉返神经合并气管、喉或食道等器官受侵组在总生存时间上存在优势。结论T4a期甲状腺癌如果有手术机会,应该首选手术切除,通过合理的手术策略,根治性手术的同时重视重要组织器官的一期修复重建,患者可获得较好的生活质量和预后。

3D打印导板定位微球囊压迫术治疗原发性三叉神经痛的临床随机对照研究

目的 分析3D打印导板定位微球囊压迫术(PMC)与常规PMC治疗原发性三叉神经痛(PTN)的临床疗效及安全性。方法 选择廊坊市人民医院神经外科2020年1月—2022年12月收治的80例PTN患者作为研究对象,使用随机数字表法分成观察组与对照组各40例。对照组行常规PMC治疗,观察组行3D打印导板定位PMC治疗。比较两组手术一般情况、术后即刻疗效、手术前后不同时点疼痛视觉模拟量表(VAS)评分、术后12个月复发情况及术后并发症情况。结果 观察组首次穿刺成功率97.50%显著高于对照组27.50%(P<0.05)。观察组穿刺成功时间、手术总时间、住院时间、住院费用均显著优于对照组(P<0.05)。观察组术后即刻总有效率97.50%与对照组95.00%比较,差异无统计学意义(P>0.05)。两组术前及术后1、2周的VAS评分组间比较(P>0.05)显示,观察组术后4周时疼痛VAS评分显著低于同期对照组(P<0.05)。术后12个月,观察组合计复发率5.00%显著低于对照组合计复发率20.00%(P<0.05)。观察组术后面部麻木、咬肌无力、口唇疱疹发生率与对照组比较,差异无统计学意义(P>0.05)。结论 3D打印导板定位PMC较常规PMC能显著提高首次穿刺成功率,缩短穿刺时间与手术总时间,且术后即刻疗效及远期疗效均显著。

高耐折瓦楞纸板局部处理涂料的制备及性能研究

目的瓦楞纸板因其低成本、轻质、易加工、高强度和良好的印刷适应性,在包装行业应用广泛。但其耐折性差,尤其在加工时易在压痕处爆裂,是行业面临的难题之一。本研究通过表面成膜和增强纤维结合力,并考虑含水量对耐折度的影响,开发一种提高瓦楞纸板耐折性的局部处理涂料。方法本文以聚乙烯醇(PVA)为基材,开发了PVA/CMC-Na、PVA/Gly、PVA/Gly/JFC 3种涂料,并进行不同比例和浓度的性能测试。结果PVA/CMC-Na涂料虽然提升了纸板的撕裂度、抗张强度和耐破度,但由于含水量降低,耐折性改善效果有限。PVA/Gly涂料在Gly质量分数约为11%时,其耐折度提高效果最佳,但在高浓度时会导致纸板强度下降。PVA/Gly/JFC涂料在JFC质量分数为0.05%~0.15%时,瓦楞纸板的双向折叠次数显著提高,且不影响纸板的基本强度性能。结论PVA/Gly/JFC涂料仅需处理纸板压痕部分即可提高纸板折痕处的含水量和保水效果,增强表面成膜和增强纤维结合力,显著提升瓦楞纸板耐折性能,同时保持了纸板的正常使用性能,为瓦楞纸箱行业提供了一种有效的解决方案。