Research on the Balanced Development of Urban and Rural Compulsory Education Through Education Resource Allocation

With the rapid development of our country’s economy,education has gradually become the focus of social attention.The problem of unbalanced distribution of urban and rural educational resources has become increasingly prominent,urban educational resources are relatively rich,while rural educational resources are relatively scarce,and the balanced development of urban and rural compulsory education has become an urgent task.This paper mainly investigates and studies the distribution of urban and rural educational resources,discusses the unbalanced distribution of urban and rural educational resources and analyzes the reasons,and puts forward a series of corresponding solutions to promote the balanced development of urban and rural compulsory education.

Optimized Allocation Model for Regional Agricultural Fertilizer Resources in Southern Xinjiang from the Perspective of Sustainable Development

[Objective] This study was to establish an optimized model for the allocation of agricultural fertilizer resources in Southern Xinjiang from the perspective of sustainable development.[Method] An optimized model for the allocation of agricultural fertilizer resources was established based on their allocation structure.Combined with the actual agricultural production in Aksu areas of Southern Xinjiang,by establishing a rational evaluation index system,under the premise of considering the planting area constraints,the total water resources constraints and the security constraints of food production,we established the empirical optimal allocation model of the regional agricultural fertilizer resources in Aksu area of Southern Xinjiang.Moreover,we solved the model by using the search algorithm of computer and lingo programming.[Result] The increased economic benefit was near to 1.8 billion Yuan by adopting the optimal allocation methods,with a relative increment of about 34.4%.[Conclusion] Our results provided theoretical basis for achieving the sustainable development of agricultural economy in Southern Xinjiang.

New aspects of a small GTPase RAB35 in brain development and function

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

Review of Techniques for Integrating Security in Software Development Lifecycle

Software-related security aspects are a growing and legitimate concern,especially with 5G data available just at our palms.To conduct research in this field,periodic comparative analysis is needed with the new techniques coming up rapidly.The purpose of this study is to review the recent developments in the field of security integration in the software development lifecycle(SDLC)by analyzing the articles published in the last two decades and to propose a way forward.This review follows Kitchenham’s review protocol.The review has been divided into three main stages including planning,execution,and analysis.From the selected 100 articles,it becomes evident that need of a collaborative approach is necessary for addressing critical software security risks(CSSRs)through effective risk management/estimation techniques.Quantifying risks using a numeric scale enables a comprehensive understanding of their severity,facilitating focused resource allocation and mitigation efforts.Through a comprehensive understanding of potential vulnerabilities and proactive mitigation efforts facilitated by protection poker,organizations can prioritize resources effectively to ensure the successful outcome of projects and initiatives in today’s dynamic threat landscape.The review reveals that threat analysis and security testing are needed to develop automated tools for the future.Accurate estimation of effort required to prioritize potential security risks is a big challenge in software security.The accuracy of effort estimation can be further improved by exploring new techniques,particularly those involving deep learning.It is also imperative to validate these effort estimation methods to ensure all potential security threats are addressed.Another challenge is selecting the right model for each specific security threat.To achieve a comprehensive evaluation,researchers should use well-known benchmark checklists.

Astronomical influence of the development of Paleogene thin coal seam groups in offshore Lacustrine basins:A case study of the ZhuⅠDepression's Enping Formation located in the northern South China Sea

The development of the Paleogene coal seams in China's offshore basin areas generally had the characteristics of coal measures with large thicknesses,large numbers of coal seams,thin single coal seams,poor stability,scattered vertical distribution,and a wide distribution range.This study selected the Enping Formation of the ZhuⅠDepression in the northern section of the South China Sea as an example to determine the macro-control factors of the development of the Paleogene coal seam groups.An analysis was carried out on the influencing effects and patterns of the astronomical cycles related to the development of the thin coal seam groups in the region.A floating astronomical time scale of the Enping Formation was established,and the sedimentary time limit of the Enping Formation was determined to be approximately 6.15 Ma±.In addition,the cyclostratigraphy analysis results of the natural gamma-ray data of Well XJ in the Enping Formation of the Xijiang Sag revealed that the development of the thin coal seams had probably been affected by short eccentricity and precession factors.The formation process of coal seams was determined to have been affected by high seasonal contrast,precipitation,and insolation.During the periods with high values of short eccentricity,the seasonal contrasts tended to be high.During those periods,fluctuations in the precession controls resulted in periodic volume changes in precipitation and insolation of the region,resulting in the development of thin coal seams.It was also found that the periods with low precession were the most conducive to coal seam development.On that basis,combined with such factors as sedimentary environmental conditions conducive to the development of thin coal seam groups,this study established a theoretical model of the comprehensive influences of short eccentricity and precession on the development and distribution of Paleogene thin coal seam groups in offshore lacustrine basins.The patterns of the Paleogene astronomical periods and paleoclimate evolution,along with the control factors which impacted the development of thin coal seam groups in offshore lacustrine basins,were revealed.

Resource allocation optimization of equipment development task based on MOPSO algorithm

Resource allocation for an equipment development task is a complex process owing to the inherent characteristics,such as large amounts of input resources,numerous sub-tasks,complex network structures,and high degrees of uncertainty.This paper presents an investigation into the influence of resource allocation on the duration and cost of sub-tasks.Mathematical models are constructed for the relationships of the resource allocation quantity with the duration and cost of the sub-tasks.By considering the uncertainties,such as fluctuations in the sub-task duration and cost,rework iterations,and random overlaps,the tasks are simulated for various resource allocation schemes.The shortest duration and the minimum cost of the development task are first formulated as the objective function.Based on a multi-objective particle swarm optimization(MOPSO)algorithm,a multi-objective evolutionary algorithm is constructed to optimize the resource allocation scheme for the development task.Finally,an uninhabited aerial vehicle(UAV)is considered as an example of a development task to test the algorithm,and the optimization results of this method are compared with those based on non-dominated sorting genetic algorithm-II(NSGA-II),non-dominated sorting differential evolution(NSDE)and strength pareto evolutionary algorithm-II(SPEA-II).The proposed method is verified for its scientific approach and effectiveness.The case study shows that the optimization of the resource allocation can greatly aid in shortening the duration of the development task and reducing its cost effectively.

Development of a new high resolution waveform migration location method and its applications to induced seismicity

Locating seismic events is a central task for earthquake monitoring.Compared to arrival-based location methods,waveformbased location methods do not require picking phase arrivals and are more suitable for locating seismic events with noisy waveforms.Among waveform-based location methods,one approach is to stack different attributes of P and S waveforms around arrival times corresponding to potential event locations and origin times,and the maximum stacking values are assumed to indicate the correct event location and origin time.In this study,to obtain a high-resolution location image,we improve the waveform-based location method by applying a hybrid multiplicative imaging condition to characteristic functions of seismic waveforms.In our new stacking method,stations are divided into groups;characteristic functions of seismic waveforms recorded at stations in the same group are summed,and then multiplied among groups.We find that this approach can largely eliminate the cumulative effects of noise in the summation process and thus improve the resolution of location images.We test the new method and compare it to three other stacking methods,using both synthetic and real datasets that are related to induced seismicity occurring in petroleum/gas production.The test results confirm that the new stacking method can provide higher-resolution location images than those derived from currently used methods.

Expression and location of α-fetoprotein during rat colon development

AIM： To investigate the expression of α-fetoprotein （AFP）, a cancer-associated fetal glycoprotein, and its involvement during rat colon development. METHODS： Colons from Sprague-Dawley rat fetuses, young and adult （8 wk old） animals were used in this study. Expression levels of AFP in colons of different development stage were detected by reversetranscriptase PCR （RT-PCR） and Western blotting. To identify the cell location of AFP in the developing rat colons, double-immunofluorescent staining was performed using antibodies to specific cell markers and AFP, respectively. RESULTS： The highest levels of AFP mRNA were detected in colons of rats at embryonic day 18.5 （e18.5）. Compared to e18.5 d, the AFP expression was significantly decreased during rat development （85% for e20.5, P 〈 0.05, 58% for postnatal day 0.5 （P〈0.5）, P 〈 0.05, 37% for P7, P 〈 0.05, 24% for P14, P 〈 0.05, and 11% for P21, P 〈 0.05） and undetected in adult rats. Only the 72-kDa isoform of AFP was detected by Western blotting, the expression pattern was similar to AFP mRNA and conformed to the results of mRNA expression. The AFP positive staining was identical to different distribution patterns in fetuses, young and adult animals and positive staining for both AFP and vimentin was overlapped in mesenchymal cells at each stage tested. CONCLUSION： This study has for the first time demonstrated that AFP is localized in the mesenchyme of rat colon from the embryo to the weaning stage by immunofluorescence and presents 72-kDa isoform in the developing rat colons by Western blotting. The dynamic expression of AFP in the various developmental stages of the colon indicates that AFP might be involved in many aspects of colon development.

Research Developments and Prospects on Microseismic Source Location in Mines

Microseismic source location is the essential factor in microseismic monitoring technology, and its loca- tion precision has a large impact on the performance of the technique. Here, we discuss the problem of low-precision location identification for microseismic events in a mine, as may be obtained using conven-tional location methods that are based on arrival time. In this paper, microseismic location characteristics in mining are analyzed according to the characteristics of the mine＇s microseismic wavefield. We review research progress in mine-related microseismic source location methods in recent years, including the combination of the Geiger method with the linear method, combined microseismic event location method, optimization of relative location method, location method without pre-measured velocity, and location method without arrival time picking. The advantages and disadvantages of these methods are discussed, along with their feasible conditions. The influences of geophone distribution, first arrival time picking, and the velocity model on microseismic source location are analyzed, and measures are proposed to influence these factors. Approaches to solve the problem under study include adopting information fusion, combining and optimizing existing methods, and creating new methods to realize high-precision microseismic source location. Optimization of the velocity structure, along with applications of the time-reversal imaging technique, passive time-reversal mirror, and relative interferometric imag-ing, are expected to greatly improve microseismic location precision in mines. This paper also discusses the potential application of information fusion and deep learning methods in microseismic source location in mines. These new and innovative location methods for microseismic source location have extensive prospects for development.

Intensity Allocation Criteria of Carbon Emissions Permits and Regional Economic Development in China——Based on a 30-Province/Autonomous Region Computable General Equilibrium Model

The intensity allocation criteria of carbon emissions permits and its influence on China＇s regional development are analyzed through the 30-province/autonomous region computable general equilibrium （CGE） model. Simulation results show that： industrial intensity criteria without taking regional economic development into account deepen the unbalance of regional economic development; regional intensity criteria without taking industrial properties into account exert little negative impact on regional harmonious development, but relatively high negative influence on high-carbon emission industries. The two-step allocation scheme that the central government allocates emissions permits to provincial governments based on regional economic development and then provincial governments allocate emissions permits to emission resources or entities based on industrial properties is a feasible and operable choice.

The location analysis of real estate project development

Under the new situation of the macroscopic readjustment and control of the housing policy as well as the transformation of individual consumption ideas, this article has carded on the analysis on the housing location theory and its impact factors, and then emphatically pointed out the important impact of the housing location factors in the development of real estate project on urban development area and the built-up area＇s construction according to the theory, and it is expected that the developer of real estate project may benefit from the new background.

Location and expression of neurotrophin-3 and its receptor in the brain of human embryos during early development

BACKGROUND： Cell culture in vitro trials have demonstrated that neurotrophin-3 （NT-3） can enhance the survival of sensory neurons and sympathetic neurons, and can also support embryo-derived motor neurons. This effect is dependent on nerve growth factor on the surface of cells. Understanding the role of NT-3 and its receptor in the early development of human embryonic brains will help to investigate the correlation between early survival of nerve cells and the microenvironment of neural regeneration. OBJECTIVE： To observe the proliferation of cerebral neurons in the development of human embryonic brain, and to investigate the location, expression and distribution of NT-3 and its receptor TrkC during human brain development. DESIGN, TIME AND SETTING： An observation study on cells was performed in the Department of ttuman Anatomy, Histology and Embryology, Chengdu Medical College in September 2007. MATERIALS： Fifteen specimens of flesh human embryo, aged 6 weeks, were used in this study. METHODS： The proliferation of cerebral neurons was detected using proliferating cell nuclear antigen, and the immunocytochemistry ABC technique was applied to observe the location, expression and distribution of NT-3 and its receptor TrkC in the brain of the human embryo. MAIN OUTCOME MEASURES： Location, expression and distribution of NT-3 and its receptor in the brain of the human embryo. RESULTS： In the early period （aged 6 weeks） of human embryonic development, proliferating cell nuclear antigen-positive reactive substances were mainly observed in the nucleus of the forebrain ventricular zone and subventricular zone, and the intensity was stronger in the subventricular zone than the forebrain ventricle. NT-3 positive reactive substance was mainly distributed in the cytoblastema of the forebrain neuroepithelial layer and nerve cell process, while TrkC was mainly distributed in the cell membrane of the forebrain ventricular zone and subventricular zone. During embryonic development, NT-3 and TrkC showed a positive immune reaction to a greater or lesser extent in ependymal epithelium. CONCLUSION： During early human embryonic development, cerebral nerve cells proliferate in the ventricular zone and subventricular zone, and NT-3 is expressed in the neural axon. The results show that the highly expressed NT-3 could promote the proliferation of neural axons and maintain the neuron body＇s survival.

Development of Re-usable C＋＋ classes for Location Aware Management and Control Systems for Shipping Applications

Location aware management and location based automation are fast upcoming technologies which are facilitated by availability of reliable, accurate, and cheap global positioning systems and location based services. This paper discusses the development of C＋＋ classes, which may be used for development of software for location aware management and control, specifically in merchant shipping, so as to provide improved safety, increased automation, prevention of pollution and reducing the work burden of the crew. The GPS is used in conjunction with the regionally accessible nested global shorelines （RANGS） dataset for this purpose. The design of two main C＋＋ classes named CShorelines and CGPSInput have been discussed. A control system mandatory on all oil-tankers above 150 GRT （and few other vessels） called ODMCS has been made location aware using the novel software developed and the results obtained have been critically examined and presented.

Optimal allocation of land resources in the process of economic development

In this paper,the writer uses a mathematical model to analyze:a theoretical model of land resources optimal allocation with the constraint of sustainable development;equilibrium and defects of land resources allocation in a competitive market;and how effective governmental supervision can change the equilibrium in the market and promote the optimization of land resources allocation.The main points of this paper are:continuous and excessive conversions that change land resources from agricultural use to non-agricultural use in the process of economic development are economic rules;a competitive market is an important way to improve the efficiency of land resources allocation;effective governmental supervision can cover the shortage of market and promote the optimization of land resources allocation;a reasonable arrangement of land property rights can reduce the transaction costs of government management in optimizing land resources allocation;and,the targets of land resources optimal allocation are developing along with economic development.

Location Based Navigation Service Technology: Development of an Optimization Algorithm for Multivariate Contextual Cartographic Content in Location Based Navigation Service

User response or reaction to navigation applications is influenced by relevance in geographic information, in terms of cartographic context and content delivered within a definite time, providing a direct impact to outcome or consequence based on decision making and hence user reaction. Location Based Navigation Services (LBNS) have continuously advanced in cartographic visualization, making maps interpretation easy and ubiquitous to any user, as compared to pre-historic times when maps were a preserve of a few. Despite rapid growth in LBNS, there exist challenges that may be characterized as technical and non-technical challenges, among them being process of conveying geospatial information to user. LBNS system deliver appropriate information to a user through smartphone (mobile device) for effective decision making and response within a given time span. This research focuses on optimization of cartographic content for contextual information in LBNS to users, based on prevailing circumstances of various components that constitute it. The research looks into Geographic Information Retrieval (GIR), as a technical challenge centered on a non-technical issue of social being of user satisfaction, leading to decision making in LBNS, hence response and outcome. Though advanced technologically, current LBNS on information sourcing depends on user manual web pages navigation and maneuver, this can be painstaking and time consuming that it may cause unnecessary delay in information delivery, resulting to delayed information response time (DIRT). This in turn may lead to unappropriate decision making with erroneous reaction or response being taken, resulting in loss of opportunity, resources, time and even life. Optimization in LBNS is achieved by a mathematical relationship developed between user status, mobile device variables against cartographic content. The relationship is in turn applied in LBNS android application to fulfill optimization solution for user consumption.

FDI, Geographic Location and Their Impacts on the Pattern of Regional Economic Development in China

This paper states how the reciprocal matching of foreign direct investment （FDI） and geographic location generally determine the pattern of regional economic development in China by analyzing the co-relations among geographic location, FDI and regional economic development. Among various factors that affect FDI inflow into specific regions of China, it is believed that geographic location might be one of the most essential factors in shaping the overall trend of diversification in regional economic development in China. Examinations are followed for identifying the above judgment both with econometric models and data analysis.

Policy and Profit Allocation for the Cooperative Development of Natural Gas Resource on Chinese Offshore Continental Shelf

China has a wide sea waters with their offshore continental shelf covering over 1 million km?.Rich oil-gas resources are lying under the sea waters.In accordance with the conventional international assessment method for oil and gas resources,it is expected that the gas reserve volume in China is approximately 14000 billion cu.m.Particularly,the Yinggehai Basin,Qiongdo-ngnan Basin and Zhushan Depression in the Pearl River Mouth basin of the South China Sea are rapidly subsiding basins with more than 100 million km2 of prospects for exploration,where the geological conditions are favourable for generation of rich natural gas.

Towards an Eco-Efficient Development Strategy that Minimises the Risks Associated with the Location of Gas Stations in Human Settlements: A Fuzzy PROMETHEE Method

Evaluating real world situations in risky environments based on various qualitative/quantitative criteria in order to suggest a strategy/policy among available options is one of the critical challenges in incident management. Such is the case when considering an eco-efficient development strategy that can minimize the risk associated with the location of gas stations in human settlements. Taking the Douala city of Cameroon as an example, four actions were evaluated, including the options of relocating the gas stations, putting in place of emergency response plan in gas stations, and relocation of households subject to a group of four criteria. Data were collected via personal communication with decision-makers using a five-point Likert scale. The market values of buildings subject to expropriation were estimated based on order No. 0082/Y. 15.1/MNUH/D of 20 November 1987 of the ministry of Housing and Urban Development, Cameroon. The financial costs incurred in establishing a gas station were an average value obtained from a sample of 80 gas stations randomly selected among those whose locations do not comply with existing regulations. These amounts were obtained from their financial records, while the value of putting in place an emergency action plan was obtained from the current market value of the equipment required. The algorithm of PROMETHEE under the usual criterion function was implemented. The results suggested that putting in place an emergency response plan could minimize relocation costs, maximize profits/welfare, and maximize environmental quality, and minimize social impacts, and was therefore considered as the most preferred alternative. Sensitivity analyses of results further confirmed that implementation of emergency response plan is the most preferred alternative.