Unlocking Cellular Mysteries:Advancements in Single-Cell Omics Analysis with Genome-Scale Metabolic Modeling

The widespread applications of single-cell technologies have generated a large amount of single-cell data,resulting in a growing need for single-cell data analysis and interpretation methods.While methods such as machine learning allow for single-cell data analysis,they cannot interpret the data very well.

Dissipative soliton resonance within different dispersion regimes in a single mode-locked laser

Dissipative soliton resonance(DSR) was previously studied in separated mode-locked fiber lasers within different dispersion regimes including anomalous, near-zero and normal dispersion. Here we propose a method to study DSR in a single mode-locked laser in these different dispersion regimes. This is achieved by virtue of a waveshaper which can control the laser dispersion readily using software, avoiding the usual tedious cutback method. We find that dispersion has a negligible effect on DSR since the pulse duration keeps constant while dispersion is varied. Moreover, we examine the dynamics of DSR on the parameters of the SA including modulation depth and saturation power, and find that the pulse duration can be changed in a large range when the saturation power is decreased. Our numerical simulations could be important to guide relative experimental studies.

On the generation of high-quality Nyquist pulses in mode-locked fiber lasers

Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers.

Unlocking the Brain’s Gateway to Methamphetamine Addiction

What secret molecular key enables methamphetamine,or meth for short,to ruthlessly hijack the brain’s reward system,leading countless individuals down spiral paths of addiction?Thanks to innovative research reported this month in Nature,we finally have critical clues.

Phase-locked single-mode terahertz quantum cascade lasers array

We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 K.The device utilizes a Talbot cavity to achieve phase locking among five ridge lasers with first-order buried distributed feedback(DFB)grating,resulting in nearly five times amplification of the single-mode power.Due to the optimum length of Talbot cavity depends on wavelength,the combination of Talbot cavity with the DFB grating leads to better power amplification than the combination with multimode Fabry-Perot(F-P)cavities.The Talbot cavity facet reflects light back to the ridge array direction and achieves self-imaging in the array,enabling phase-locked operation of ridges.We set the spacing between adjacent elements to be 220μm,much larger than the free-space wavelength,ensuring the operation of the fundamental supermode throughout the laser's dynamic range and obtaining a high-brightness far-field distribution.This scheme provides a new approach for enhancing the single-mode power of THz QCLs.

A novel dual-channel thermo-optic locking method for the whispering gallery mode microresonator

Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,low integration costs,and self-locking,which shows great potential for application.However,the conventional single-channel microcavity thermal-locking method that relies solely on internal thermal balance will inevitably be disturbed by the external environment.This limitation affects the locking time and stability.Therefore,in this paper,we propose a new method for closed-loop thermal locking of a dual-channel microcavity.The thermal locking of the signal laser and the thermal regulation of the control laser are carried out respectively by synchronously drawing a dual-path tapered fiber.The theoretical model of the thermal dynamics of the dual-channel microcavity system is established,and the influence of the control-laser power on the thermal locking of the signal laser is confirmed.The deviation between the locking voltage of the signal laser and the set point value is used as a closed-loop feedback parameter to achieve long-term and highly stable mode locking of the signal laser.The results show that in the 2.63 h thermal-locking test,the locking stability is an order of magnitude higher than that of the single tapered fiber.This solution addresses the issue of thermal locking being disrupted by the external environment,and offers new possibilities for important applications such as spectroscopy and micro-optical sensor devices.

Early Treatment Outcome of Humeral Shaft Fracture Non-Union in Adults: Comparative Study of Plating versus Interlocking Nailing

Background: Fractures of humeral shaft in adults are common injuries. Humeral shafts non-union either from late presentation after initial treatment by traditional bone setters or failed non-operative orthodox care is a major problem in this part of the world. This non-union is a major treatment challenge with increased cost of care and morbidity in this part of the world. Humeral shaft non-union can be treated with locked intra-medullary nailing (LIMN) or dynamic compression plating (DCP). Study on comparison of these methods of fixation in this part of the world is scarce in literature search, hence the reason for this study. Objective: The objectives of this study are: (1) to compare early clinical outcome following fixation of humeral shaft fracture nonunion with DCP versus LIMN;(2) to compare the time of radiologic fracture union of DCP with LIMN;(3) to compare complications following fixation of humeral shaft fracture nonunion with DCP versus LIMN. Patients and Methods: This was a randomized control study done for 2 years in which fifty adult patients with humeral shaft non-union were recruited. The patients were grouped into 2 (P = DCP & N = LIMN). Forty five of the patients completed the follow up periods of the study and then analyzed. The P group had ORIF with DCP while the N group had ORIF with LIMN. Both groups had grafting with cancellous bones. Each patient was followed up for a period of 6 months at the time which radiographic union is expected. Any patient without clinical and/or radiographic evidence of union after six months of surgery was diagnosed as having recurrent non-union. The data generated was analyzed using SPSS Version 23. The results were presented in charts and tables. The paired t-test was used while considering p value Result: Forty five patients completed follow up. There was a male preponderance (4:1), right humerus predominated (3:2). Motor vehicular accidents were the commonest cause of the fractures (62%). Most non-union fractures occurred at the level of the middle 3rd of the humeral shaft (60%). Failed TBS treatment was the commonest indication for the osteosynthesis (71%). More patients had plating (53%) compared to 47% who had LIMN. Most patients (93.4%) had union between 3 to 6 months irrespective of fixation type with no significant statistical difference between the union rate of DCP and LIMN (p value 0.06) with similar functional outcome and complication rates irrespective of the type of fixation. Conclusion: This study showed that the success rates in term of fracture union, outcome functional grades and complication rates were not directly dependent on the types of the fixation: plating or locked intra-medullary nailing.

An Interruptable Lock and Unlock Algorithm

Generally, Lock and Unlock statements are primitives that should be wholly imple- mented,i.e.,the test of lock state and the operation of locking must be executed continuously without being interrupted. Different from nmormal lock operations, the lock and Unlock algorithm Presented in this paper can be interrupted anywhere by other processes The value of the algorithm in the implementation of concurrent control and mutually-exclusive operations was elucidated with one application of the algorithm in a heterogeneous datedbase united system.

Competing reduction induced homogeneous oxygen doping to unlock MoS_(2)basal planes for faster polysulfides conversion

The parasitic polysulfides shuttle effect greatly hinders the practical application of lithium sulfur batteries,and this issue can be addressed by promoting polysulfides conversion with catalytic materials such as Mo S_(2).However,the catalytic activity of Mo S_(2)mainly relies on edge sites,but is limited by inert basal planes.We herein report a novel,facile,ethylene glycol enabled competing reduction strategy to dope Mo S_(2)homogeneously with oxygen atoms so that its inert basal planes can be unlocked.Ethylene glycol works as a reducing agent and competes with thiourea to react with ammonium molybdate,leading to insufficient sulfuration of Mo,and consequent formation of O-Mo S_(2).Our theoretical and experimental investigations indicate that the homogeneously distributed O dopants can create abundant adsorption/-catalytic sites in the Mo S_(2)basal planes,enlarge the inter-plane distance to promote ion transport,and thus enhance the catalytic conversion of polysulfides.The oxygen doped Mo S_(2)(O-Mo S_(2))is supported on carbon nanosheets(CNS)and the composite(O-Mo S_(2)/CNS)is employed to modify the separator of Li-S battery.It gives the battery an initial discharge capacity of 1537 m Ah g-1at 0.2 C,and the battery retains a discharge capacity of 545 m Ah g-1after ultra-long 2000 cycles at 1 C,corresponding to a very small cyclic decay rate of 0.0237%.Even under a raising sulfur loading of 8.2 mg cm^(-2),the Li-S battery also delivers a high discharge capacity(554 m Ah g^(-1))with outstanding cycle stability(84.6%capacity retention)after 100 cycles at 0.5 C.Our work provides a novel,facile approach to fabricate highly catalytically active oxygen-doped Mo S_(2)for advanced Li-S batteries.

Partial Unlock for COVID-19-Like Epidemics Can Save 1 - 3 Million Lives Worldwide

Background: A large percentage of deaths in an epidemic or pandemic can be due to overshoot of population (herd) immunity, either from the initial peak or from planned or unplanned exit from lockdown or social distancing conditions. Objectives: We study partial unlock or reopening interaction with seasonal effects in a managed epidemic to quantify overshoot effects on small and large unlock steps and discover robust strategies for reducing overshoot. Methods: We simulate partial unlock of social distancing for epidemics over a range of replication factor, immunity duration and seasonality factor for strategies targeting immunity thresholds using overshoot optimization. Results: Seasonality change must be taken into account as one of the steps in an easing sequence, and a two-step unlock, including seasonal effects, minimizes overshoot and deaths. It may cause undershoot, which causes rebounds and assists survival of the pathogen. Conclusions: Partial easing levels, even low levels for economic relief while waiting on a vaccine, have population immunity thresholds based on the reduced replication rates and may experience overshoot as well. We further find a two-step strategy remains highly sensitive to variations in case ratio, replication factor, seasonality and timing. We demonstrate a three or more step strategy is more robust, and conclude that the best possible approach minimizes deaths under a range of likely actual conditions which include public response.

Dynamic behaviors of rockslides subjected to brittle failure of locked segments

Locked segments are recognized as a critical role that controls the stability of rock slopes but remain an unclear and challenging problem with respect to their role incorporated into the failure mechanism.In order to study the effect of the locked segments on the initial failure process of rockslides,thirty-six groups of locked segment specimens with three different lithologies were prepared,direct shear tests were carried out to obtain the accelerations caused by brittle failure of the locked segment specimens.Experiment results showed that the maximum accelerations caused by the brittle failure of locked segment specimens was 2.91 g in the horizontal direction,and 3.18 g in the vertical direction.We took the Wangjiayan rockslide in 2008 Wenchuan earthquake as an example,the critical balance condition of the sliding mass under combined effect of gravity and accelerations induced by brittle failure of locked segment was analyzed,which indicated that the initial failure process of the Wangjiayan rockslides was notably influenced by the existence of the locked segment.The departure acceleration and direction of the Wangjiayan rockslide were proposed.The study results can provide a new insight into the understanding of the initial failure mechanism of rockslides with locked segments.

Locking plates for distal fibula fractures in young and elderly patients:A retrospective study

BACKGROUND Ankle fractures are common injuries in the young and elderly populations.To prevent post-traumatic arthritis,an anatomic reconstruction of the ankle structure is mandatory.Open reduction and internal fixation is the treatment of choice among orthopaedics.Conventional plates allow stability of the fracture if bone quality is present.Locking plates might offer an advantage for the treatment of lateral malleolar fracture in patients with comminution,severe instability,distal fractures,or osteoporotic bone.Our hospital introduced a new locking plate for fracture of the distal fibula.AIM To evaluate locking plates in terms of outcomes and complications in young and elderly patients.METHODS We retrospectively reviewed a total of 67 patients treated for displaced distal fibula fractures.Demographic data,number of comorbidities,use of inter fragmentary screw,complication,time of fracture healing,partial or full weight bearing,and reoperation were recorded for all patients.Clinical outcome was assessed by the American Orthopedic Foot and Ankle Society clinical scoring system.Radiographs were obtained at 4,8,12,16,20,and 24 wk until radiographic union was obtained.RESULTS All patients displayed complete bony union on radiographic assessment,and no patients developed any serious complications.We observed two superficial infections,one delayed wound healing,and two plate intolerances.Significant differences were observed between the two age groups in terms of radiographic healing(11.9 wk in younger patients vs 13.7 wk in older patients;P=0.011)and in the American Orthopedic Foot and Ankle Society score at 6 mo after surgery(88.2 in younger patients vs 86.0 in older patients;P=0.001)and at 12 mo after surgery(92.6 in younger patients vs 90.0 in older patients;P=0.000).CONCLUSION Locking plates provide a stable and rigid fixation in multifragmentary and comminuted fractures or in the presence of poor bone quality.

Unlocking Gene Networks Behind Magnetosome Formation in Magnetotactic Bacteria

In a study,published online in National Science Review on October 28,researchers led by Dr.LI Jinhua at the Institute of Geology and Geophysics(IGG)of the Chinese Academy of Sciences have used an integrative genomic and phenomic analysis to explore the genetic basis of magnetosome biomineralization in magnetotactic bacteria(MTB).

Unlocking the Potential of China-ASEAN Wind Power Cooperation

Wind power, especially low-wind-speed power, has tremendous development potential in ASEAN countries, which has inspired Chinese enterprises to act ASEAN is among the regions most severely affected by climate change. It’s also highly dependent on fossil energy. Developing renewable energy and promoting energy transformation is essential for ASEAN countries to cope with climate change and achieve sustainable economic and social development.

We should Focus on Ways to Unlock Investment

The summit’s theme reflects the shared aspiration of G20 member states to steer the world economy towards a more sustainable path.A key success of the G20 in the aftermath of the financial crisis has been to significantly strengthen the resilience of the global financial system.Now we need to focus on ways in

删除有理 UnLocker痛删顽固文件

笔者是一个软件爱好者,几乎每天都会安装、测试一些新软件,由于软件质量良莠不齐,重装系统是常有的事,这本来没什么,但自从碰到某个文件夹加密的软件后(在这里就不公布软件的名称了,免得大家同时中招),这个软件在硬盘上留下了一些顽固的垃圾文件。

Unlocking Schizophrenia with Imaging Markers Related to Striatal Dysfunction

Around four in a thousand people worldwide suffer from schizophrenia,according to scientific estimates.The disease affects people from all walks of life,including Vincent van Gogh,the painter Agnes Martin,mathematician John Nash and Eduard Einstein,a son of the great physicist.

Unlocking Potential

IN December 2012, as corporate South Africa closed down for the holiday season, more than 4,500 members of the ruling African National Congress （ANC） descended on the city of Mangaung to elect their leadership for the next five years, and ultimately determine the future of South Africa＇s development.

Unlocking the Door to Understanding Xi’s book provides insight into China’s governance policy framework

The third volume of Xi Jinping:The Governance of China is a continuum of the elucidation of the thoughts,issues and policies that are central to the governance of contemporary China,as articulated in the two earlier volumes by Chinese President Xi Jinping,who is also general secretary of the Communist Party of China(CPC)Central Committee.

Unlocking Africa’s Potential

Investment remains the vital ingredient for Africa’s success WHILE there are meaningful objections to the nature and structure of much of the new investment in African agriculture,it is clear that the introduction of new capital,skills and technology is an essential component in unlocking the continent’s ultimate allure.