The problems like cracking of the girder in the mid-span and the ever-increasing vertical deflection appear during the long term usage of the long-span continuous rigid-flame bridge. Post-tension tendon with re- serve...The problems like cracking of the girder in the mid-span and the ever-increasing vertical deflection appear during the long term usage of the long-span continuous rigid-flame bridge. Post-tension tendon with re- served duct can increase the pre-stress of the main beam effectively, and decrease the long term span deflection in order to improve the performance of the girder. At the same time, the proper tension position is very crucial to optimise the stress distribution of the bridge and control the deflection increase. Combining with practical en- gineering, the authors analyze the influence of different positions of post-tension tendon ( including top-, web- and bottom plate tendons) on the stress and deflection of the main beam, and find out the optimal position of post tendon.展开更多
The long-term performance of moderate heat Portland cement with double-expansive sources (DE cement) in the system of high MgO clinker and gypsum was studied by XRD, SEM/EDAX and test methods for strength and expans...The long-term performance of moderate heat Portland cement with double-expansive sources (DE cement) in the system of high MgO clinker and gypsum was studied by XRD, SEM/EDAX and test methods for strength and expansion of cement. Results indicate that the periclase particle, whose size was 5-7.5μm in DE cement clinker containing 4.8 % MgO, existed individually. The periclase hydration in hardened DE cement paste started at about 60 days and completed up to 2 000 days, and ettringite in the paste was stable from 3 days to 2 000 days. Under the conditions of 4.5%-5.0 % MgO in clinker and 2.8%-3.4 %SO3 in cement, ettringite expansion and brucite expansion in DE cement paste had a continuity, entirety and stability. At the ages of 90, 365,730 and 2 000 days the expansion of the paste reached 0.07%-0.11%, 0.16%-0.21%, 0.21%-0.27 %, and 0.29%-0.38%, respectively. The results suggest that by using this cement in mass concrete it may compensate its temperature shrinkage and autogenous shrinkage to some extent.展开更多
Drainage layers provide permanent relief of hydrostatic water pressure, while the waterproof liner prevents any ingress of water into the tunnel. The durability and aging resistance of drainage membranes are of primar...Drainage layers provide permanent relief of hydrostatic water pressure, while the waterproof liner prevents any ingress of water into the tunnel. The durability and aging resistance of drainage membranes are of primary concern. This paper describes advantages and concerns related to the usage of, and the design with, polymeric drainboards in tunnel construction. Common degradation mechanisms associated with HDPE (high density polyethylene) sheets are described. The stringent requirements for the Gotthard Alpine Railway Tunnel through the Swiss Alps, e.g., high ambient temperatures of up to 45 ℃ and an expected service life of up to 100 years require outstanding aging resistance of polymeric drainage materials. The paper describes the methods deployed to investigate the long-term performance of HDPE drainboards, focusing on aging mechanisms. Details associated with the test procedures developed to reflect the specific properties of drainboards, as well as the results obtained, are presented. A summary table shows recommended product specifications needed to confine the aging properties of drainboards and to design a system performing adequately during the entire lifetime of the structure.展开更多
This paper presents a novel way to improve Transmission Control Protocol (TCP) performance of the users at the edge areas of the macro cells in Long Term Evolution Advanced (LTE-A) systems. Previous works on improving...This paper presents a novel way to improve Transmission Control Protocol (TCP) performance of the users at the edge areas of the macro cells in Long Term Evolution Advanced (LTE-A) systems. Previous works on improving wireless TCP performance are reviewed and current considerations on TCP in LTE-A are explained. However, those solutions are neither too complex nor limited to some presuppositions which are too restricting for the deployment of LTE-A networks. In this paper a substituted TCP acknowledgement transmission scheme based on Automatic Repeat reQuest (ARQ) information in layer 2 is proposed. The simulation result shows that the proposed method can reduce the delay and improve the throughput of the edging users of the cell, as well as reducing radio resources in LTE-A macro cells.展开更多
AIM: To evaluate the prognostic factors of long-term survival of more than 3 years in patients with advanced non-small cell lung cancer(NSCLC). METHODS: We retrospectively analyzed the records of 474 patients with adv...AIM: To evaluate the prognostic factors of long-term survival of more than 3 years in patients with advanced non-small cell lung cancer(NSCLC). METHODS: We retrospectively analyzed the records of 474 patients with advanced ⅢB/Ⅳ NSCLC who received chemotherapy as initial treatment between September 2002 and March 2007.RESULTS: The median survival time(MST) was 12.5 mo and the 3 year and 5 year survival rates were 14.6% and 5.3%, respectively. Long-term survival of more than 3 and 5 years was observed in 65 and 16 patients, respectively. The MST for the 65 patients was61.5 mo(range, 60.1-81.0 mo). In the 474 patients, a good performance status(PS), female sex, non-smoking status and adenocarcinoma histology were significantly associated with a favorable outcome. Furthermore, female sex, a good PS, non-smoking status and adenocarcinoma histology were significantly correlated with longterm survival of more than 3 years and most of these patients(89.2%, 58/65) received epidermal growth factor receptor-tyrosine kinase inhibitors as any line treatment. Survival analysis of long-term survivors showed that a PS of 0 was an independent prognostic factor for predicting favorable outcomes. CONCLUSION: Our results suggest that a good PS and adenocarcinoma histology play an important role in long-term survival of more than 3 years. A PS of 0 was an independent prognostic factor for predicting favorable outcomes in patients with advanced NSCLC who survived for more than 3 years.展开更多
为监测大坝运行过程中的异常状态,防范化解大坝溃坝等重大风险,基于大坝变形大样本、非线性监测数据,引入长短期记忆(Long Short Term Memory, LSTM)神经网络模型对大坝变形趋势进行预测,以测试样本的均方根误差最小为适应度函数,采用...为监测大坝运行过程中的异常状态,防范化解大坝溃坝等重大风险,基于大坝变形大样本、非线性监测数据,引入长短期记忆(Long Short Term Memory, LSTM)神经网络模型对大坝变形趋势进行预测,以测试样本的均方根误差最小为适应度函数,采用遗传算法(Genetic Algorithm, GA)优化LSTM模型参数,建立大坝变形GA-LSTM组合预测模型。以福建水口水电站大坝为例进行验证分析,并与LSTM模型和门控循环神经网络(Gated Recurrent Unit, GRU)模型预测结果进行对比分析。分析结果表明,GA-LSTM模型的预测效果和性能更佳,且相较于LSTM模型和GRU模型各测点预测误差均有减小,平均绝对误差减小量最高达6.92%。展开更多
This paper assesses 4 years of operation of a 1.75 kW roof top solar PV system installed in a Sydney suburban house. The system consists of 10 PV panels, a DC/AC inverter, and a grid connected gross meter. Solar elect...This paper assesses 4 years of operation of a 1.75 kW roof top solar PV system installed in a Sydney suburban house. The system consists of 10 PV panels, a DC/AC inverter, and a grid connected gross meter. Solar electricity delivered to grid is verified with the results from a computer simulation package (PVSYST) by adopting the installed component specifications, operation conditions, and weather data of the site. The results show high consistency between the values of energy delivered to the grid measured by the energy company and the energy estimated by system simulation. New system performance indicator is developed and called the optimum performance compliance ratio (PCR). It is a measure of the compliance of the output of the designed PV system with the output which would be produced by the same system with a solar tracker. This indicator provides system designers, contractors and energy providers with the actual capacity of the system that they can offer the end-users.展开更多
Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease...Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 days later, 10 or 100 ng fibroblast growth factor 20 was injected intracerebroventricularly. The electrophysiological changes in the mouse hippocampus were recorded using a full-cell patch clamp. Expression of Kv4.2 in the substantia nigra was analyzed using a western blot assay. Serum malondialdehyde levels were analyzed by enzyme-linked immunosorbent assay. The motor coordination of mice was evaluated using the rotarod test. The results showed that fibroblast growth factor 20 decreased A-type potassium current in neurons of the substantia nigra, increased long-term potentiation amplitude in the hippocampus, and downregulated Kv4.2 expression. A high dose of fibroblast growth factor 20 reduced serum malondialdehyde levels and enhanced the motor coordination of mice. These findings confirm that fibroblast growth factor 20 has a therapeutic effect on the toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and its mechanism of action is associated with the inhibition of A-type K+ currents and Kv4.2 expression. All animal procedures were approved by the Animal Care and Use Committee of Qilu Hospital of Shandong University, China in 2017(approval No. KYLL-2017-0012).展开更多
文摘The problems like cracking of the girder in the mid-span and the ever-increasing vertical deflection appear during the long term usage of the long-span continuous rigid-flame bridge. Post-tension tendon with re- served duct can increase the pre-stress of the main beam effectively, and decrease the long term span deflection in order to improve the performance of the girder. At the same time, the proper tension position is very crucial to optimise the stress distribution of the bridge and control the deflection increase. Combining with practical en- gineering, the authors analyze the influence of different positions of post-tension tendon ( including top-, web- and bottom plate tendons) on the stress and deflection of the main beam, and find out the optimal position of post tendon.
基金Funded by National Natural Science Foundation of China (No.59493604)Zhejiang Provincial Natural Science Foundation of China (No.597082)China Yangtze River Three Gorges General
文摘The long-term performance of moderate heat Portland cement with double-expansive sources (DE cement) in the system of high MgO clinker and gypsum was studied by XRD, SEM/EDAX and test methods for strength and expansion of cement. Results indicate that the periclase particle, whose size was 5-7.5μm in DE cement clinker containing 4.8 % MgO, existed individually. The periclase hydration in hardened DE cement paste started at about 60 days and completed up to 2 000 days, and ettringite in the paste was stable from 3 days to 2 000 days. Under the conditions of 4.5%-5.0 % MgO in clinker and 2.8%-3.4 %SO3 in cement, ettringite expansion and brucite expansion in DE cement paste had a continuity, entirety and stability. At the ages of 90, 365,730 and 2 000 days the expansion of the paste reached 0.07%-0.11%, 0.16%-0.21%, 0.21%-0.27 %, and 0.29%-0.38%, respectively. The results suggest that by using this cement in mass concrete it may compensate its temperature shrinkage and autogenous shrinkage to some extent.
文摘Drainage layers provide permanent relief of hydrostatic water pressure, while the waterproof liner prevents any ingress of water into the tunnel. The durability and aging resistance of drainage membranes are of primary concern. This paper describes advantages and concerns related to the usage of, and the design with, polymeric drainboards in tunnel construction. Common degradation mechanisms associated with HDPE (high density polyethylene) sheets are described. The stringent requirements for the Gotthard Alpine Railway Tunnel through the Swiss Alps, e.g., high ambient temperatures of up to 45 ℃ and an expected service life of up to 100 years require outstanding aging resistance of polymeric drainage materials. The paper describes the methods deployed to investigate the long-term performance of HDPE drainboards, focusing on aging mechanisms. Details associated with the test procedures developed to reflect the specific properties of drainboards, as well as the results obtained, are presented. A summary table shows recommended product specifications needed to confine the aging properties of drainboards and to design a system performing adequately during the entire lifetime of the structure.
基金Partly supported by the Key Project of National Natural Science Foundation of China(No.61231007)863 Hi Tech R&D Program of China(No.2012AA121604)ISTCP(No.2012DFG12010)
文摘This paper presents a novel way to improve Transmission Control Protocol (TCP) performance of the users at the edge areas of the macro cells in Long Term Evolution Advanced (LTE-A) systems. Previous works on improving wireless TCP performance are reviewed and current considerations on TCP in LTE-A are explained. However, those solutions are neither too complex nor limited to some presuppositions which are too restricting for the deployment of LTE-A networks. In this paper a substituted TCP acknowledgement transmission scheme based on Automatic Repeat reQuest (ARQ) information in layer 2 is proposed. The simulation result shows that the proposed method can reduce the delay and improve the throughput of the edging users of the cell, as well as reducing radio resources in LTE-A macro cells.
文摘AIM: To evaluate the prognostic factors of long-term survival of more than 3 years in patients with advanced non-small cell lung cancer(NSCLC). METHODS: We retrospectively analyzed the records of 474 patients with advanced ⅢB/Ⅳ NSCLC who received chemotherapy as initial treatment between September 2002 and March 2007.RESULTS: The median survival time(MST) was 12.5 mo and the 3 year and 5 year survival rates were 14.6% and 5.3%, respectively. Long-term survival of more than 3 and 5 years was observed in 65 and 16 patients, respectively. The MST for the 65 patients was61.5 mo(range, 60.1-81.0 mo). In the 474 patients, a good performance status(PS), female sex, non-smoking status and adenocarcinoma histology were significantly associated with a favorable outcome. Furthermore, female sex, a good PS, non-smoking status and adenocarcinoma histology were significantly correlated with longterm survival of more than 3 years and most of these patients(89.2%, 58/65) received epidermal growth factor receptor-tyrosine kinase inhibitors as any line treatment. Survival analysis of long-term survivors showed that a PS of 0 was an independent prognostic factor for predicting favorable outcomes. CONCLUSION: Our results suggest that a good PS and adenocarcinoma histology play an important role in long-term survival of more than 3 years. A PS of 0 was an independent prognostic factor for predicting favorable outcomes in patients with advanced NSCLC who survived for more than 3 years.
文摘为监测大坝运行过程中的异常状态,防范化解大坝溃坝等重大风险,基于大坝变形大样本、非线性监测数据,引入长短期记忆(Long Short Term Memory, LSTM)神经网络模型对大坝变形趋势进行预测,以测试样本的均方根误差最小为适应度函数,采用遗传算法(Genetic Algorithm, GA)优化LSTM模型参数,建立大坝变形GA-LSTM组合预测模型。以福建水口水电站大坝为例进行验证分析,并与LSTM模型和门控循环神经网络(Gated Recurrent Unit, GRU)模型预测结果进行对比分析。分析结果表明,GA-LSTM模型的预测效果和性能更佳,且相较于LSTM模型和GRU模型各测点预测误差均有减小,平均绝对误差减小量最高达6.92%。
文摘This paper assesses 4 years of operation of a 1.75 kW roof top solar PV system installed in a Sydney suburban house. The system consists of 10 PV panels, a DC/AC inverter, and a grid connected gross meter. Solar electricity delivered to grid is verified with the results from a computer simulation package (PVSYST) by adopting the installed component specifications, operation conditions, and weather data of the site. The results show high consistency between the values of energy delivered to the grid measured by the energy company and the energy estimated by system simulation. New system performance indicator is developed and called the optimum performance compliance ratio (PCR). It is a measure of the compliance of the output of the designed PV system with the output which would be produced by the same system with a solar tracker. This indicator provides system designers, contractors and energy providers with the actual capacity of the system that they can offer the end-users.
文摘Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 days later, 10 or 100 ng fibroblast growth factor 20 was injected intracerebroventricularly. The electrophysiological changes in the mouse hippocampus were recorded using a full-cell patch clamp. Expression of Kv4.2 in the substantia nigra was analyzed using a western blot assay. Serum malondialdehyde levels were analyzed by enzyme-linked immunosorbent assay. The motor coordination of mice was evaluated using the rotarod test. The results showed that fibroblast growth factor 20 decreased A-type potassium current in neurons of the substantia nigra, increased long-term potentiation amplitude in the hippocampus, and downregulated Kv4.2 expression. A high dose of fibroblast growth factor 20 reduced serum malondialdehyde levels and enhanced the motor coordination of mice. These findings confirm that fibroblast growth factor 20 has a therapeutic effect on the toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and its mechanism of action is associated with the inhibition of A-type K+ currents and Kv4.2 expression. All animal procedures were approved by the Animal Care and Use Committee of Qilu Hospital of Shandong University, China in 2017(approval No. KYLL-2017-0012).