Objective To investigate influence of immunosuppression strategy optimization on outcomes of renal transplant recipients in the last decades. Methods Data from 404 renal transplant recipients from Jan. 1st,2001 to Dec...Objective To investigate influence of immunosuppression strategy optimization on outcomes of renal transplant recipients in the last decades. Methods Data from 404 renal transplant recipients from Jan. 1st,2001 to Dec. 31st,2010 were analyzed retrospectively. The pa-展开更多
Background: In cardiology, it is controversial whether different therapy strategies influence prognosis after acute coronary syndrome. We examined and compared the long-term outcomes of invasive and conservative stra...Background: In cardiology, it is controversial whether different therapy strategies influence prognosis after acute coronary syndrome. We examined and compared the long-term outcomes of invasive and conservative strategies in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and characterized the patients selected for an invasive approach. Methods: A total of 976 patients with acute NSTEMI were collected from December 2006 to October 2012 in the First Affiliated Hospital of Dalian Medical University Hospital. They are divided into conservative strategy (586 patients) and invasive strategy (390 patients) group. Unified tbllow-up questionnaire was performed by telephone contact (cut-off date was November, 2013). The long-term clinical events were analyzed and related to the different treatment strategies. Results: The median follow-up time was 29 months. Mortality was 28.7% (n = 168) in the conservative group and 2.1% (n = 8) in the invasive management at long-term clinical follow-up. The secondary endpoint (the composite endpoint) was 59.0% (n = 346) in the conservative group and 30.3% (n = 118) in the invasive management. Multivariate analysis showed that patients in the conservative group had higher all-cause mortality rates than those who had the invasive management (adjusted risk ratio [RR] = 7.795; 95% confidence interval [CI]: 3.796 16.006, P 〈 0.001), and the similar result was also seen in tile secondary endpoint (adjusted RR : 2.102; 95% (7: 1.694-2.610, P 〈 0.001 ). In the subgroup analysis according to each Thrombolysis in Myocardial Infarction risk score (TRS), log-rank analysis showed lower mortality and secondary endpoint rates in the invasive group with the intermediate and high-risk patients (TRS 3-7). Conclusions: An invasive strategy could improve long-term outcomes for NSTEMI patients, especially for intermediate and high-risk ones (TRS 3- 7).展开更多
“双碳”背景下风电的渗透率不断提高,将对电力系统的形态和运行机制产生深刻影响。本文提出了一种基于双向长短期记忆Bi-LSTM(bidirectional long short-term memory)循环神经网络的风储系统控制策略。采用双向长短时循环神经网络提取...“双碳”背景下风电的渗透率不断提高,将对电力系统的形态和运行机制产生深刻影响。本文提出了一种基于双向长短期记忆Bi-LSTM(bidirectional long short-term memory)循环神经网络的风储系统控制策略。采用双向长短时循环神经网络提取控制结果与风电场实际出力以及储能状态间的时序信息,通过构建基于双向长短时记忆循环神经网络的控制模型,使得风电场在多种运行工况下能够快速、准确地得到储能系统调节结果。基于实际风电场数据仿真结果表明,本文所提控制策略能够保证在一定经济效益的前提下,将风储系统控制误差保持在0.50%~1.37%。展开更多
在医疗运作管理领域,合理的资源分配能够帮助更多的患者尽早就医,降低患者病情恶化和死亡的风险。本文设计了预约排队策略对患者占有资源的顺序进行分配,建立了基于长短时记忆(Long Short Term-Memory,LSTM)神经网络和遗传算法(Genetic ...在医疗运作管理领域,合理的资源分配能够帮助更多的患者尽早就医,降低患者病情恶化和死亡的风险。本文设计了预约排队策略对患者占有资源的顺序进行分配,建立了基于长短时记忆(Long Short Term-Memory,LSTM)神经网络和遗传算法(Genetic Algorithm,GA)的混合模型以优化排队策略。首先利用大数据和深度学习分析患者到达和医院服务情况,建立LSTM神经网络学习数据特征并预测未来数据,相比于排队论常用的随机分布方法取得了更好的效果.其次设计了基于排队系统仿真的排队策略优化算法,利用改进GA得到最优排队策略。实证研究表明,文本的方法可以明显降低患者的等待时间,最高可达59%。最后对排队策略进行敏感性分析,结果表明排队策略有效作用于仿真的各个时段。展开更多
小型棒控压水堆舍弃了可溶硼,并高度依赖控制棒与可燃毒物棒控制堆芯的反应性。为研究控制棒对堆芯关键性能的影响,本文以核动力破冰船用KLT-40模型为对象,以轴向功率偏移、堆芯寿期、燃料利用率与径向功率峰因子为指标,开展长寿期小型...小型棒控压水堆舍弃了可溶硼,并高度依赖控制棒与可燃毒物棒控制堆芯的反应性。为研究控制棒对堆芯关键性能的影响,本文以核动力破冰船用KLT-40模型为对象,以轴向功率偏移、堆芯寿期、燃料利用率与径向功率峰因子为指标,开展长寿期小型棒控压水堆控制棒布置与动作策略设计分析。首先,基于OpenMC程序开发带棒燃耗程序;其次,比较堆芯带控制棒与无控制棒运行时的堆芯寿期等指标;最后,分析不同动作策略对轴向功率偏移等指标的影响。结果表明:控制棒将堆芯寿期从590 EFPDs(等效满功率天,Effective full power days)延长至650~698 EFPDs;低价值棒组优先动作策略使轴向功率偏移程度由−0.69与+0.80分别下降至−0.29与+0.52。因此,要准确计算长寿期压水堆寿期必须采用带控制棒燃耗计算策略,并且通过合理的动作策略能够有效减小控制棒带来的轴向功率偏移。展开更多
文摘Objective To investigate influence of immunosuppression strategy optimization on outcomes of renal transplant recipients in the last decades. Methods Data from 404 renal transplant recipients from Jan. 1st,2001 to Dec. 31st,2010 were analyzed retrospectively. The pa-
文摘Background: In cardiology, it is controversial whether different therapy strategies influence prognosis after acute coronary syndrome. We examined and compared the long-term outcomes of invasive and conservative strategies in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and characterized the patients selected for an invasive approach. Methods: A total of 976 patients with acute NSTEMI were collected from December 2006 to October 2012 in the First Affiliated Hospital of Dalian Medical University Hospital. They are divided into conservative strategy (586 patients) and invasive strategy (390 patients) group. Unified tbllow-up questionnaire was performed by telephone contact (cut-off date was November, 2013). The long-term clinical events were analyzed and related to the different treatment strategies. Results: The median follow-up time was 29 months. Mortality was 28.7% (n = 168) in the conservative group and 2.1% (n = 8) in the invasive management at long-term clinical follow-up. The secondary endpoint (the composite endpoint) was 59.0% (n = 346) in the conservative group and 30.3% (n = 118) in the invasive management. Multivariate analysis showed that patients in the conservative group had higher all-cause mortality rates than those who had the invasive management (adjusted risk ratio [RR] = 7.795; 95% confidence interval [CI]: 3.796 16.006, P 〈 0.001), and the similar result was also seen in tile secondary endpoint (adjusted RR : 2.102; 95% (7: 1.694-2.610, P 〈 0.001 ). In the subgroup analysis according to each Thrombolysis in Myocardial Infarction risk score (TRS), log-rank analysis showed lower mortality and secondary endpoint rates in the invasive group with the intermediate and high-risk patients (TRS 3-7). Conclusions: An invasive strategy could improve long-term outcomes for NSTEMI patients, especially for intermediate and high-risk ones (TRS 3- 7).
文摘“双碳”背景下风电的渗透率不断提高,将对电力系统的形态和运行机制产生深刻影响。本文提出了一种基于双向长短期记忆Bi-LSTM(bidirectional long short-term memory)循环神经网络的风储系统控制策略。采用双向长短时循环神经网络提取控制结果与风电场实际出力以及储能状态间的时序信息,通过构建基于双向长短时记忆循环神经网络的控制模型,使得风电场在多种运行工况下能够快速、准确地得到储能系统调节结果。基于实际风电场数据仿真结果表明,本文所提控制策略能够保证在一定经济效益的前提下,将风储系统控制误差保持在0.50%~1.37%。
文摘在医疗运作管理领域,合理的资源分配能够帮助更多的患者尽早就医,降低患者病情恶化和死亡的风险。本文设计了预约排队策略对患者占有资源的顺序进行分配,建立了基于长短时记忆(Long Short Term-Memory,LSTM)神经网络和遗传算法(Genetic Algorithm,GA)的混合模型以优化排队策略。首先利用大数据和深度学习分析患者到达和医院服务情况,建立LSTM神经网络学习数据特征并预测未来数据,相比于排队论常用的随机分布方法取得了更好的效果.其次设计了基于排队系统仿真的排队策略优化算法,利用改进GA得到最优排队策略。实证研究表明,文本的方法可以明显降低患者的等待时间,最高可达59%。最后对排队策略进行敏感性分析,结果表明排队策略有效作用于仿真的各个时段。
文摘小型棒控压水堆舍弃了可溶硼,并高度依赖控制棒与可燃毒物棒控制堆芯的反应性。为研究控制棒对堆芯关键性能的影响,本文以核动力破冰船用KLT-40模型为对象,以轴向功率偏移、堆芯寿期、燃料利用率与径向功率峰因子为指标,开展长寿期小型棒控压水堆控制棒布置与动作策略设计分析。首先,基于OpenMC程序开发带棒燃耗程序;其次,比较堆芯带控制棒与无控制棒运行时的堆芯寿期等指标;最后,分析不同动作策略对轴向功率偏移等指标的影响。结果表明:控制棒将堆芯寿期从590 EFPDs(等效满功率天,Effective full power days)延长至650~698 EFPDs;低价值棒组优先动作策略使轴向功率偏移程度由−0.69与+0.80分别下降至−0.29与+0.52。因此,要准确计算长寿期压水堆寿期必须采用带控制棒燃耗计算策略,并且通过合理的动作策略能够有效减小控制棒带来的轴向功率偏移。