Different structure models of a long-period ordered phase in Fe-C martenstie formed during aging have been checked by computer simulation of electron diffraction(ED) patterns based on these models.The results showed t...Different structure models of a long-period ordered phase in Fe-C martenstie formed during aging have been checked by computer simulation of electron diffraction(ED) patterns based on these models.The results showed that the simulated ED pattern of γ'-FexC(Ⅱ) model proposed by the present authors is in good agreement with experimentally observed ED pattern.It was also confirmed that the incommensurate superperiod stems from the coexistence of several γ'-Fe_xC(H) phases with different superperiods.The Fe(144)C(24)(Fe6C) model proposed by Uwakweh et al.generated ED patterns remarkably different from the experimental ones.展开更多
Advanced basal cell carcinoma (aBCC) includes metastatic and locally advanced BCC that is inoperable (or with surgery contraindicated). We describe patient characteristics and treatment history for aBCC cases from com...Advanced basal cell carcinoma (aBCC) includes metastatic and locally advanced BCC that is inoperable (or with surgery contraindicated). We describe patient characteristics and treatment history for aBCC cases from community oncology. Nine cases of aBCC were found within the ACORN Data Warehouse, a community oncology database of >180,000 cancer patients. Data were summarized descriptively. Three illustrative case histories are presented. Patients were predominantly Caucasian (8/9), male (6/9), and over 60 (6/9). Four had metastatic disease;five had aBCC without metastasis. Five had a history of treatment for early stage BCC, including surgery (5/5), radiation (1/5), and none had chemotherapy. Those with history of early stage BCC had periods of apparent lack of follow-up and treatment. One had chemotherapy for aBCC (platinum based with radiation) and eight had radiation without chemotherapy. Patients had multiple comorbid serious medical conditions. Six were deceased, but only one was documented to have aBCC as cause of death. Advanced BCC is rare in community oncology settings. There appear to be gaps in the care and follow-up of patients with initial early stage BCC. More data and larger samples are needed from multi-specialty databases such as dermatology and head and neck surgery.展开更多
The γ-aminobutyric acid neurons（GABAergic neurons） in the inferior colliculus are classified into various patterns based on their intrinsic electrical properties to a constant current injection. Although this class...The γ-aminobutyric acid neurons（GABAergic neurons） in the inferior colliculus are classified into various patterns based on their intrinsic electrical properties to a constant current injection. Although this classification is associated with physiological function, the exact role for neurons with various firing patterns in acoustic processing remains poorly understood. In the present study, we analyzed characteristics of inferior colliculus neurons in vitro, and recorded responses to stimulation of the dorsal nucleus of the lateral lemniscus using the wholecell patch clamp technique. Seven inferior colliculus neurons were tested and were classified into two firing patterns： sustained-regular（n = 4） and sustained-adapting firing patterns（n = 3）. The majority of inferior colliculus neurons exhibited slight changes in response to stimulation and bicuculline. The responses of one neuron with a sustained-adapting firing pattern were suppressed after stimulation, but recovered to normal levels following application of the γ-aminobutyric acid receptor antagonist. One neuron with a sustained-regular pattern showed suppressed stimulation responses, which were not affected by bicuculline. Results suggest that GABAergic neurons in the inferior colliculus exhibit sustained-regular or sustained-adapting firing patterns. Additionally, GABAergic projections from the dorsal nucleus of the lateral lemniscus to the inferior colliculus are associated with sound localization. The different neuronal responses of various firing patterns suggest a role in sound localization. A better understanding of these mechanisms and functions will provide better clinical treatment paradigms for hearing deficiencies.展开更多
当前的位置预测方法大多没有考虑到用户行为信息,由于用户的访问时间、行为模式等能够在很大程度上反映所处位置,因此在对位置潜在向量进行预训练时有必要使用该信息。进行位置预测时,采样粒度较细的序列长度较长,难以捕获长距离依赖。...当前的位置预测方法大多没有考虑到用户行为信息,由于用户的访问时间、行为模式等能够在很大程度上反映所处位置,因此在对位置潜在向量进行预训练时有必要使用该信息。进行位置预测时,采样粒度较细的序列长度较长,难以捕获长距离依赖。针对这2个问题,提出了基于用户行为和上下文语义的分层时空长短期记忆网络(Hierarchical Spatiotemporal Long Short-Term Memory Based on User Behavior and Contextual Semantics,CHST-LSTM)模型。该模型通过Transformer编码层处理轨迹数据,将用户相关行为信息考虑在内,融合位置的上下文语义信息,通过预训练得到位置的嵌入表征。根据用户的行为状态分割轨迹阶段,采用编码器-解码器方式对ST-LSTM进行分段分层扩展,利用BiLSTM对全局信息建模,同时处理轨迹的长短期变化,解决长序列的长距离依赖问题。对外卖员用户群体的真实移动轨迹数据进行分析和实验,通过聚类发现其特有的工作模式,在预训练时加入工作模式信息与到访时间信息,得到位置的特征向量并用于预测模型。结果表明CHST-LSTM模型在预测用户下一位置时精度更高。展开更多
发现无线通信环境中用户的移动模式是移动对象管理中的一个关键问题.提出一种快速挖掘该模式的算法SAM(split and merge),用来挖掘移动对象所产生有序数据集中潜在的移动模式,从而为移动对象管理提供服务.该算法将自底向上搜索和自顶向...发现无线通信环境中用户的移动模式是移动对象管理中的一个关键问题.提出一种快速挖掘该模式的算法SAM(split and merge),用来挖掘移动对象所产生有序数据集中潜在的移动模式,从而为移动对象管理提供服务.该算法将自底向上搜索和自顶向下过滤技术相结合,采用图存储压缩数据集方法,利用非频繁项集分解子图和频繁长模式过滤数据集相结合的技术,大大减少了迭代次数,降低了CPU时间.最后给出了算法性能比较和算法分析.结果表明,该算法是有效的.展开更多
文摘Different structure models of a long-period ordered phase in Fe-C martenstie formed during aging have been checked by computer simulation of electron diffraction(ED) patterns based on these models.The results showed that the simulated ED pattern of γ'-FexC(Ⅱ) model proposed by the present authors is in good agreement with experimentally observed ED pattern.It was also confirmed that the incommensurate superperiod stems from the coexistence of several γ'-Fe_xC(H) phases with different superperiods.The Fe(144)C(24)(Fe6C) model proposed by Uwakweh et al.generated ED patterns remarkably different from the experimental ones.
文摘Advanced basal cell carcinoma (aBCC) includes metastatic and locally advanced BCC that is inoperable (or with surgery contraindicated). We describe patient characteristics and treatment history for aBCC cases from community oncology. Nine cases of aBCC were found within the ACORN Data Warehouse, a community oncology database of >180,000 cancer patients. Data were summarized descriptively. Three illustrative case histories are presented. Patients were predominantly Caucasian (8/9), male (6/9), and over 60 (6/9). Four had metastatic disease;five had aBCC without metastasis. Five had a history of treatment for early stage BCC, including surgery (5/5), radiation (1/5), and none had chemotherapy. Those with history of early stage BCC had periods of apparent lack of follow-up and treatment. One had chemotherapy for aBCC (platinum based with radiation) and eight had radiation without chemotherapy. Patients had multiple comorbid serious medical conditions. Six were deceased, but only one was documented to have aBCC as cause of death. Advanced BCC is rare in community oncology settings. There appear to be gaps in the care and follow-up of patients with initial early stage BCC. More data and larger samples are needed from multi-specialty databases such as dermatology and head and neck surgery.
基金supported by the National Natural Science Foundation of China,No.81271090
文摘The γ-aminobutyric acid neurons（GABAergic neurons） in the inferior colliculus are classified into various patterns based on their intrinsic electrical properties to a constant current injection. Although this classification is associated with physiological function, the exact role for neurons with various firing patterns in acoustic processing remains poorly understood. In the present study, we analyzed characteristics of inferior colliculus neurons in vitro, and recorded responses to stimulation of the dorsal nucleus of the lateral lemniscus using the wholecell patch clamp technique. Seven inferior colliculus neurons were tested and were classified into two firing patterns： sustained-regular（n = 4） and sustained-adapting firing patterns（n = 3）. The majority of inferior colliculus neurons exhibited slight changes in response to stimulation and bicuculline. The responses of one neuron with a sustained-adapting firing pattern were suppressed after stimulation, but recovered to normal levels following application of the γ-aminobutyric acid receptor antagonist. One neuron with a sustained-regular pattern showed suppressed stimulation responses, which were not affected by bicuculline. Results suggest that GABAergic neurons in the inferior colliculus exhibit sustained-regular or sustained-adapting firing patterns. Additionally, GABAergic projections from the dorsal nucleus of the lateral lemniscus to the inferior colliculus are associated with sound localization. The different neuronal responses of various firing patterns suggest a role in sound localization. A better understanding of these mechanisms and functions will provide better clinical treatment paradigms for hearing deficiencies.
文摘当前的位置预测方法大多没有考虑到用户行为信息,由于用户的访问时间、行为模式等能够在很大程度上反映所处位置,因此在对位置潜在向量进行预训练时有必要使用该信息。进行位置预测时,采样粒度较细的序列长度较长,难以捕获长距离依赖。针对这2个问题,提出了基于用户行为和上下文语义的分层时空长短期记忆网络(Hierarchical Spatiotemporal Long Short-Term Memory Based on User Behavior and Contextual Semantics,CHST-LSTM)模型。该模型通过Transformer编码层处理轨迹数据,将用户相关行为信息考虑在内,融合位置的上下文语义信息,通过预训练得到位置的嵌入表征。根据用户的行为状态分割轨迹阶段,采用编码器-解码器方式对ST-LSTM进行分段分层扩展,利用BiLSTM对全局信息建模,同时处理轨迹的长短期变化,解决长序列的长距离依赖问题。对外卖员用户群体的真实移动轨迹数据进行分析和实验,通过聚类发现其特有的工作模式,在预训练时加入工作模式信息与到访时间信息,得到位置的特征向量并用于预测模型。结果表明CHST-LSTM模型在预测用户下一位置时精度更高。
文摘发现无线通信环境中用户的移动模式是移动对象管理中的一个关键问题.提出一种快速挖掘该模式的算法SAM(split and merge),用来挖掘移动对象所产生有序数据集中潜在的移动模式,从而为移动对象管理提供服务.该算法将自底向上搜索和自顶向下过滤技术相结合,采用图存储压缩数据集方法,利用非频繁项集分解子图和频繁长模式过滤数据集相结合的技术,大大减少了迭代次数,降低了CPU时间.最后给出了算法性能比较和算法分析.结果表明,该算法是有效的.
