We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectiou...We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectious pulmonary complications. Among 174 patients undergoing transplantation for hematologic malignancies between May 1994 and December 2004, 81 long-term survivors were evaluated. Pulmonary function tests (PFTs) were performed before conditioning, 3 months and 1 year after transplantation, and then annually. Eight patients (10%) had abnormal pulmonary function before transplantation, but this was not associated with late changes in PFTs. Patients with chronic graft-versus-host disease (GVHD) showed a significant decline of lung function after 3 years when compared with patients without chronic GVHD. Abnormal pretransplantation lung function was associated with pulmonary chronic GVHD according to National Institutes of Health criteria (score 0, n = 58;score 1, n = 14;score 2, n = 6;score 3, n = 3). Five patients with late-onset noninfectious pulmonary complications showed a decline of lung function at 1 year after transplantation. Only chronic GVHD was significantly related to late-onset noninfectious pulmonary complications. In conclusion, abnormal lung function before transplantation may be associated with a decline in pulmonary function within 1 year after transplantation, but late-onset noninfectious pulmonary complications could not be predicted from pretransplantation lung function.展开更多
Communication of the various testing methods of COVID-19 is vital for English speakers within China and with the outside world.This research is set to find out the appropriate translation of the Chinese phrases referr...Communication of the various testing methods of COVID-19 is vital for English speakers within China and with the outside world.This research is set to find out the appropriate translation of the Chinese phrases referring to COVID-19 tests in English,in light of functional equivalence theory,which is expected to help correct mistakes and facilitate understanding between people speaking the two languages.展开更多
This article begins with a brief description of a final-term intensive reading test for students in a secondary vocational school in Shaoxing;then it argues about the test's validity and reliability.Most significa...This article begins with a brief description of a final-term intensive reading test for students in a secondary vocational school in Shaoxing;then it argues about the test's validity and reliability.Most significantly,it discusses the backwash effect of the textbook-based test in students' learning process.Finally,a conclusion is drawn that a final achievement test like this is valid,reliable and applicable to vocational students.Consequently,the textbook-based test is recommended for secondary vocational students(SVS)in their EFL learning.展开更多
It was found that the DNA-damaging agents N-methyl-N’-nitro-N-nitrosoguanidine（MNNG）,methyl-methanesulphonate（MMS）and 4-nitroquinoline-N-oxide（4NQO）could stimulate ADP-ribosyl transferase（ADPRT）activity and r...It was found that the DNA-damaging agents N-methyl-N’-nitro-N-nitrosoguanidine（MNNG）,methyl-methanesulphonate（MMS）and 4-nitroquinoline-N-oxide（4NQO）could stimulate ADP-ribosyl transferase（ADPRT）activity and reduce the cellular NAD content in a dose-dependent way.The reduction of NAD after DNA damage could be partially or completelyprevented by ADPRT inhibitors,3-aminobenzamide or nicotinamide,which showed noinfluence on reduction of NAD induced by metabolic blocking agents.Therefore,a simpleand specific method to detect DNA-damaging mutagens by measuring ADPRT-mediateddecrease of cellular NAD content was explored.Using β-naphthofiavone,a mixed functionoxygenase inducer,together with induced or uninduced human amnion FL cells,it was foundthat aflatoxin B<sub>1</sub>,benzo（a）pyrene,2-acetylaminofluorene,9,10-dimethylanthracene andethylcarbamate could induce the ADPRT-mediated decrease of cellular NAD content,while4-acetylaminofluorene,anthracene,isopropyl-N-（3-chlorophenyl）-carbamate,β-propiolactone,γ-butyrolactone,cyclophosphamide and safrol could not.The results indicate that this isa cheap and specific method to detect DNA damage caused by chemical carcinogens/mutagenswith a spccificity approaching that of the unscheduled DNA synthesis assay.展开更多
Aiming at the Four-Dimensional Variation source term inversion algorithm proposed earlier,the observation error regularization factor is introduced to improve the prediction accuracy of the diffusion model,and an impr...Aiming at the Four-Dimensional Variation source term inversion algorithm proposed earlier,the observation error regularization factor is introduced to improve the prediction accuracy of the diffusion model,and an improved Four-Dimensional Variation source term inversion algorithm with observation error regularization(OER-4DVAR STI model)is formed.Firstly,by constructing the inversion process and basic model of OER-4DVAR STI model,its basic principle and logical structure are studied.Secondly,the observation error regularization factor estimation method based on Bayesian optimization is proposed,and the error factor is separated and optimized by two parameters:error statistical time and deviation degree.Finally,the scientific,feasible and advanced nature of the OER-4DVAR STI model are verified by numerical simulation and tracer test data.The experimental results show that OER-4DVAR STI model can better reverse calculate the hazard source term information under the conditions of high atmospheric stability and flat underlying surface.Compared with the previous inversion algorithm,the source intensity estimation accuracy of OER-4DVAR STI model is improved by about 46.97%,and the source location estimation accuracy is improved by about 26.72%.展开更多
Heavy rain is a kind of severe weather, often causing floods and serious soil erosion, leading to engineering losses, embankment rupture and crop flooding and other significant economic losses. Especially for some low...Heavy rain is a kind of severe weather, often causing floods and serious soil erosion, leading to engineering losses, embankment rupture and crop flooding and other significant economic losses. Especially for some low-lying terrain areas, rainwater cannot quickly vent caused by farm water and soil moisture being too saturated, so it will cause more geological disasters. This article combines live and forecast data, aiming at the results of the mid-rainstorm forecast in North China during the period of 7.19-2016, and compares with the actual situation of rainstorm. We carry out the mid-term forecast of the rainstorm. The atmosphere is a kind of medium with various fluctuation phenomena, and its physical properties and changes are studied by the analysis of volatility which is an important research method. It is important to improve the accuracy of such severe weather forecasting rainstorms and to take precautionary measures in a timely manner to minimize the losses caused by rainstorms.展开更多
文摘We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectious pulmonary complications. Among 174 patients undergoing transplantation for hematologic malignancies between May 1994 and December 2004, 81 long-term survivors were evaluated. Pulmonary function tests (PFTs) were performed before conditioning, 3 months and 1 year after transplantation, and then annually. Eight patients (10%) had abnormal pulmonary function before transplantation, but this was not associated with late changes in PFTs. Patients with chronic graft-versus-host disease (GVHD) showed a significant decline of lung function after 3 years when compared with patients without chronic GVHD. Abnormal pretransplantation lung function was associated with pulmonary chronic GVHD according to National Institutes of Health criteria (score 0, n = 58;score 1, n = 14;score 2, n = 6;score 3, n = 3). Five patients with late-onset noninfectious pulmonary complications showed a decline of lung function at 1 year after transplantation. Only chronic GVHD was significantly related to late-onset noninfectious pulmonary complications. In conclusion, abnormal lung function before transplantation may be associated with a decline in pulmonary function within 1 year after transplantation, but late-onset noninfectious pulmonary complications could not be predicted from pretransplantation lung function.
基金2021 Undergraduate Innovation and Entrepreneurship Training Program(No.XJ2021284)。
文摘Communication of the various testing methods of COVID-19 is vital for English speakers within China and with the outside world.This research is set to find out the appropriate translation of the Chinese phrases referring to COVID-19 tests in English,in light of functional equivalence theory,which is expected to help correct mistakes and facilitate understanding between people speaking the two languages.
文摘This article begins with a brief description of a final-term intensive reading test for students in a secondary vocational school in Shaoxing;then it argues about the test's validity and reliability.Most significantly,it discusses the backwash effect of the textbook-based test in students' learning process.Finally,a conclusion is drawn that a final achievement test like this is valid,reliable and applicable to vocational students.Consequently,the textbook-based test is recommended for secondary vocational students(SVS)in their EFL learning.
文摘It was found that the DNA-damaging agents N-methyl-N’-nitro-N-nitrosoguanidine（MNNG）,methyl-methanesulphonate（MMS）and 4-nitroquinoline-N-oxide（4NQO）could stimulate ADP-ribosyl transferase（ADPRT）activity and reduce the cellular NAD content in a dose-dependent way.The reduction of NAD after DNA damage could be partially or completelyprevented by ADPRT inhibitors,3-aminobenzamide or nicotinamide,which showed noinfluence on reduction of NAD induced by metabolic blocking agents.Therefore,a simpleand specific method to detect DNA-damaging mutagens by measuring ADPRT-mediateddecrease of cellular NAD content was explored.Using β-naphthofiavone,a mixed functionoxygenase inducer,together with induced or uninduced human amnion FL cells,it was foundthat aflatoxin B<sub>1</sub>,benzo（a）pyrene,2-acetylaminofluorene,9,10-dimethylanthracene andethylcarbamate could induce the ADPRT-mediated decrease of cellular NAD content,while4-acetylaminofluorene,anthracene,isopropyl-N-（3-chlorophenyl）-carbamate,β-propiolactone,γ-butyrolactone,cyclophosphamide and safrol could not.The results indicate that this isa cheap and specific method to detect DNA damage caused by chemical carcinogens/mutagenswith a spccificity approaching that of the unscheduled DNA synthesis assay.
基金Ministry of Science and Technology of the People’s Republic of China for its support and guidance(Grant No.2018YFC0214100)。
文摘Aiming at the Four-Dimensional Variation source term inversion algorithm proposed earlier,the observation error regularization factor is introduced to improve the prediction accuracy of the diffusion model,and an improved Four-Dimensional Variation source term inversion algorithm with observation error regularization(OER-4DVAR STI model)is formed.Firstly,by constructing the inversion process and basic model of OER-4DVAR STI model,its basic principle and logical structure are studied.Secondly,the observation error regularization factor estimation method based on Bayesian optimization is proposed,and the error factor is separated and optimized by two parameters:error statistical time and deviation degree.Finally,the scientific,feasible and advanced nature of the OER-4DVAR STI model are verified by numerical simulation and tracer test data.The experimental results show that OER-4DVAR STI model can better reverse calculate the hazard source term information under the conditions of high atmospheric stability and flat underlying surface.Compared with the previous inversion algorithm,the source intensity estimation accuracy of OER-4DVAR STI model is improved by about 46.97%,and the source location estimation accuracy is improved by about 26.72%.
文摘Heavy rain is a kind of severe weather, often causing floods and serious soil erosion, leading to engineering losses, embankment rupture and crop flooding and other significant economic losses. Especially for some low-lying terrain areas, rainwater cannot quickly vent caused by farm water and soil moisture being too saturated, so it will cause more geological disasters. This article combines live and forecast data, aiming at the results of the mid-rainstorm forecast in North China during the period of 7.19-2016, and compares with the actual situation of rainstorm. We carry out the mid-term forecast of the rainstorm. The atmosphere is a kind of medium with various fluctuation phenomena, and its physical properties and changes are studied by the analysis of volatility which is an important research method. It is important to improve the accuracy of such severe weather forecasting rainstorms and to take precautionary measures in a timely manner to minimize the losses caused by rainstorms.
