A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human an...A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human and living structures,both for their structuration and behavior,explaining consciousness at human as the result of the activity of the Informational System of Human and Living Structures.For this,it is emphasized and discussed the informational structure of the eukaryotic cell,the basic/representative composing unit of the multicellular body of human,animals,and plants,showing that the composition and functions of the informational system are basically similar with that of human.To reveal the driving role of informational mechanisms in human and subhuman organisms,it is introduced the concept of matter-related information,showing that information can be hidden/“embodied”or released/“disembodied”in or from the elemental micro/macro components of the body,during the multiple chain/cascade interactions including transduction processes.It is shown that such interactions are initiated from two main categories of informational sources:implicit(genetic)and explicit(external/internal)sources,the first category leading to structuration of the body and the second the reactive behavior.Consciousness in human and subhuman organisms,expressed by two corresponding informational relations,is the result of the release of information by the mind,acting as an informational operator/device,the development degree of mind and consciousness depending on the complexity degree and adaptation.An analogy of this Informational Model of Human and Living Structures(IMHLS)with the ancient model of chakras is highlighted,showing that these models support each other,applied with beneficial effects in Reiki technique and music-based cognitive multi-task therapy for neuro-rehabilitation.展开更多
This work explores the axiology of consciousness in Mocombe’s consciousness field in the material world.The paper critically assesses Mocombe’s consciousness field theory(CFT)within the larger body of contemporary o...This work explores the axiology of consciousness in Mocombe’s consciousness field in the material world.The paper critically assesses Mocombe’s consciousness field theory(CFT)within the larger body of contemporary ontological debates regarding the nature,origin,and constitution of consciousness in the universe.The work goes on to highlight the manifestation of Mocombe’s consciousness field in the material resource framework that is the earth,and the nature and origins of ethics and values.展开更多
It is the matter for achievement of the low carbon transport system that the excessive use of private vehicles can be controlled appropriately.Not only improvement of service level of modes except private vehicle,but ...It is the matter for achievement of the low carbon transport system that the excessive use of private vehicles can be controlled appropriately.Not only improvement of service level of modes except private vehicle,but also consciousness for environmental problem of individual trip maker is important for eco-commuting promotion.On the other hand,consciousness for environment would be changed by influence of other person.Accordingly,it is aimed in the study that the structure of decision-making process for modal shift to the eco-commuting mode in the local city is described considering environmental consciousness and social interaction.For the purpose,the consciousness for the environment problem and the travel behavior of the commuter at the suburban area in the local city are investigated by the questionnaire survey.The covariance structure about the eco-consciousness is analyzed with the database of the questionnaire survey by structural equation modeling.As the result,it can be confirmed with the structural equation model that the individual environmental consciousness is strongly related with the intention of self-sacrifice and is influenced with the local interaction of the individual connections.On the other hand,the intention of modal shift for the commuting mode is analyzed with the database of the questionnaire survey.It can be found out that the environmental consciousness is not statistically significant for commuting mode choice with the present poor level of service of public transport.However,the intention of self-sacrifice for the prevention of the global warming is statistically confirmed as the factor of modal shift with the operation of eco-commuting bus service with the RP/SP integrated estimation method.As the result,the multi-agent simulation system with social interaction model for eco consciousness is developed to measure the effect of the eco-commuting promotion.For the purpose,the carbon dioxide emission is estimated based on traffic demand and road network condition in the traffic environment model.On the other hand,the relation between agents is defined based on the small world network.The proposed multi-agent simulation is applied to measure the effect of the eco-commuting promotion such as improvement of level of service on the public transport or education of eco-consciousness.The effect of the promotion plan can be observed with the proposed multi-agent system.Finally,it can be concluded that the proposed multi-agent simulation with social interaction for eco-consciousness is useful for planning of eco-commuting promotion.展开更多
Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI patients.Acupuncture has been used to improve neurological deficits in p...Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI patients.Acupuncture has been used to improve neurological deficits in patients with TBI.This meta-analysis aims to evaluate the effects and safety of acupuncture in improving consciousness in patients with TBI when compared with other therapies.Methods:A systematic search was conducted in electronic databases PubMed,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Allied and Complementary Medicine Database,WHO International Clinical Trials Registry Platform,ClinicalTrials.gov,and Google Scholar for randomized controlled trials that investigated the effect of acupuncture on patients with TBI.From the inception of databases to March 2023.Results:A total of 653 participants were included in nine trials.We found that acupuncture adjunct to routine treatment significantly improved the wakeup rate of patients in TBI when compared with routine treatment alone(relative risk=1.36,95%confidence interval:1.16 to 1.59,I2=4.78%,P=0).Additionally,we found that acupuncture is significantly associated with reduced impaired consciousness after TBI when adjunct to medicine therapy.As a safe intervention,acupuncture can also improve the activities of daily living for people with TBI(mean difference=15.71,95%confidence interval:9.19 to 22.22,I2=0%,P=0).Conclusion:Acupuncture can improve consciousness and braise wakeup of patients with TBI when adjunct to conventional treatment compared with routine treatment alone.Further high-quality studies are needed to confirm these findings and to determine the optimal acupuncture treatment parameter for TBI.展开更多
Inspired by Roger Nelson’s Global Consciousness Project (GCP), the Global Earth Healing Project (GEHP) uses a network of several hundred physical noise generators to amplify the combined intentions of their users in ...Inspired by Roger Nelson’s Global Consciousness Project (GCP), the Global Earth Healing Project (GEHP) uses a network of several hundred physical noise generators to amplify the combined intentions of their users in order to infuse positive affirmations into the global consciousness. As mentioned in the original study design, it was intended to use the GCP as a reference for the effectiveness of its activities. The data of the GEHP consisting of 21 events from 2013 to 2020 is analyzed and statistically compared to the data of the GCP. An astonishing synchronicity was observed, which suggests an interaction between the brain states of the observers and the physical noise generators of the GCP.展开更多
Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industri...Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industrialization started in the 1800s. World population interconnectedness is enhanced with love and mercy but disrupted with dishonest, lies and wars. Human species has been feeding on animal fat as the finest and prime source of energy for all human history. In 1953 Ancel Keys and collaborates illusionized human kind that their historical source of energy is toxic. Massive health, behavioral as well as economic consequences followed. Human hearts known historically to be the seat of spirit, soul and emotions is proven by our group to orchestrate with global energetic fields. Global consciousness as represented by the planetary electromagnetic fields is in critical need to be feed with awakening merciful information. Documents refuting Ancek Keys dogma and reverting humanity to the truth in their energy source is presented in this review. The harmony we expect is not only physiological but will affect our global planetary environment for the wellbeing of human species in earth.展开更多
BACKGROUND Disorders of consciousness including coma in non-trauma patients can be caused by a wide variety of pathologies affecting the central nervous system.They represent a frequent challenge in emergency medicine...BACKGROUND Disorders of consciousness including coma in non-trauma patients can be caused by a wide variety of pathologies affecting the central nervous system.They represent a frequent challenge in emergency medicine and are combined with a very high in-hospital mortality.Hence,early treatment of these patients is vital and increases the likelihood of a good outcome.AIM To identify the causes of altered consciousness presentation to the Emergency Department at Suez Canal University Hospital.METHODS This was a descriptive cross-sectional study conducted on 87 patients with acute non-traumatic disturbed level of consciousness(DLOC)at the Emergency Department.RESULTS The mean age of the studied patients was 60.5±13.6 years.Among them,60%were males and 40%were females.The most common cause of acute non-traumatic DLOC was systemic infection,such as sepsis and septic shock(25.3%),followed by respiratory causes(24.1%)and neurological causes(18.4%).CONCLUSION The most common cause of acute non-traumatic DLOC was systemic infections followed by respiratory and neurological causes.展开更多
Both consciousness and quantum phenomenon are subjective and indeterministic. In this paper, we propose consciousness is a quantum phenomenon. A quantum theory of consciousness (QTOC) is presented based on a new inter...Both consciousness and quantum phenomenon are subjective and indeterministic. In this paper, we propose consciousness is a quantum phenomenon. A quantum theory of consciousness (QTOC) is presented based on a new interpretation of quantum physics. We show that this QTOC can address the mind and body problem, the hard problem of consciousness. It also provides a physics foundation and mathematical formulation to study consciousness and neural network. We demonstrate how to apply it to develop and extend various models of consciousness. We show the predictions from this theory about the existence of a universal quantum vibrational field and the large-scale, nearly instantaneous synchrony of brainwaves among different parts of brain, body, people, and objects. The correlation between Schumann Resonances and some brainwaves is explained. Recent progress in quantum information theory, especially regarding quantum entanglement and quantum error correction code, is applied to study memory and shed new light in neuroscience.展开更多
The persistent environmental problems and the growing difficulty to achieve sustainable development require a re-evaluation of person’ sustainable knowledge, attitude, and behaviour. To go to where we want to go, we ...The persistent environmental problems and the growing difficulty to achieve sustainable development require a re-evaluation of person’ sustainable knowledge, attitude, and behaviour. To go to where we want to go, we must first assess where we are now. The study investigated the level of sustainability consciousness of students in India, and sustainability consciousness was expressed in sustainability knowledge, attitude, and behaviour. Sustainability consciousness was further examined using the three dimensions, such as environment, society, and economy. By drawing the perception map of students and studying the role of the locus of control, the reasons why sustainability knowledge does not appear in sustainability behaviour were analyzed. Quantitative analysis was conducted for a sample of 205 students from higher educational institutions across central India(Madhya Pradesh) from January to March in 2022. The data were analyzed using the SPSS 26 and Smart Partial Least Square(PLS) 3.0. The research revealed that sustainability attitude impacts sustainability behaviour more than sustainability knowledge. The results showed that respondents’ sustainability knowledge is higher than their sustainability attitude and behaviour. Moreover, it was discovered that economic concerns can lead to sustainability behaviour. In order to study respondents’ behaviour regarding sustainability consciousness, the study divided respondents into two groups according to the locus of control: the internal and external locus of control. It was found that most respondents thought whatever happened around them was beyond their control. Further, the locus of control influenced sustainability behaviour in groups with the internal locus of control. The study helps to explain why sustainability knowledge and attitude cannot translate into sustainability behaviour and provides a basis for achieving sustainable development. The conclusions of this study are crucial for governments, educational institutions, and organizations that empower youth to change their behaviour.展开更多
This study aims to discuss the possibility of becoming conscious of certain aspects of one’s own existence through creative activity.The discussion involves Piagetian constructivism and Steiner’s ideas about human d...This study aims to discuss the possibility of becoming conscious of certain aspects of one’s own existence through creative activity.The discussion involves Piagetian constructivism and Steiner’s ideas about human development and is justified by the contribution of creative activity to the development of autonomy,according to Piaget,and to the development of an ethical individuality,according to Steiner.The participation of adults in sessions of creative process,as well as the questions posed after this activity,asking for the relationships between what they created and their life,is evidence of practices favourable to increasing the grasping of consciousness of self and of the process of developing an ethical individuality.展开更多
This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled ...This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled from the Three Gorges Dam.The mechanical properties of the laboratory dam concrete,whether cured in natural or standard environments,continued to improve over time.Furthermore,the laboratory dam concrete exhibited good resistance to diffusion and a refined microstructure after 17 years.However,curing and long-term exposure to the local natural environment reduced the frost resistance.Microstructural analyses of the laboratory concrete samples demonstrated that moderate-heat cement and fine fly ash(FA)particles were almost fully hydrated to form compact micro structures consisting of large quantities of homogeneous calcium(alumino)silicate hydrate(C-(A)-S-H)gels and a few crystals.No obvious interfacial transition zones were observed in the microstructure owing to the longterm pozzolanic reaction.This dense and homogenous microstructure was the crucial reason for the excellent long-term performance of the dam concrete.A high FA volume also played a significant role in the microstructural densification and performance growth of dam concrete at a later age.The concrete drilled from the dam surface exhibited a loose microstructure with higher microporosity,indicating that concrete directly exposed to the actual service environment suffered degradation caused by water and wind attacks.In this study,both macro-performance and microstructural analyses revealed that the application of moderate-heat cement and FA resulted in a dense and homogenous microstructure,which ensured the excellent long-term performance of concrete from the Three Gorges Dam after 17 years.Long-term exposure to an actual service environment may lead to microstructural degradation of the concrete surface.Therefore,the retained long-term dam concrete samples need to be further researched to better understand its microstructural evolution and development of its properties.展开更多
Interest in the dynamics of soil respiration(R_(S))in subalpine forest ecosystems is increasing due to their high soil carbon density and potential sensitivity to environmental changes.However,as a principal silvicult...Interest in the dynamics of soil respiration(R_(S))in subalpine forest ecosystems is increasing due to their high soil carbon density and potential sensitivity to environmental changes.However,as a principal silvicultural practice,the long-term impacts of thinning on R_(S) and its heterotrophic and autotrophic respiration components(R_(h) and Ra,respectively)in subalpine plantations are poorly understood,espe-cially in winter.A 3-year field observation was carried out with consideration of winter CO_(2) efflux in middle-aged sub-alpine spruce plantations in northwestern China.A trench-ing method was used to explore the long-term impacts of thinning on Rs,Rn and R_(a).Seventeen years after thinning,mean annual Rs,Rn and R_(a) increased,while the contribu-tion of R_(h) to R_(s) decreased with thinning intensity.Thinning significantly decreased winter R,because of the reduction in R_(n) but had no significant effect on Ra.The temperature sensitivity(Q_(10))of R_(h) and R_(a) also increased with thinning intensity,with lower Q_(10) values for R_(h)(2.1-2.6)than for Ra(2.4-2.8).The results revealed the explanatory variables and pathways related to R_(n) and R_(a) dynamics.Thinning increased soil moisture and nitrate nitrogen(NO_(3)^(-)-N),and the enhanced nitrogen and water availability promoted R_(h) and R_(a) by improving fine root biomass and microbial activity.Our results highlight the positive roles of NO_(3)^(-)-N in stimulating R_(s) components following long-term thinning.Therefore,applications of nitrogen fertilizer are not recommended while thinning subalpine spruce plantations from the perspective of reducing soil CO_(2) emissions.The increased Q_(10) values of R_(s) components indicate that a large increase in soil CO_(2) emissions would be expected following thinning because of more pronounced climate warming in alpineregions.展开更多
Atmospheric nitrogen(N)deposition is predicted to increase,especially in the subtropics.However,the responses of soil microorganisms to long-term N addition at the molecular level in N-rich subtropical forests have no...Atmospheric nitrogen(N)deposition is predicted to increase,especially in the subtropics.However,the responses of soil microorganisms to long-term N addition at the molecular level in N-rich subtropical forests have not been clarified.A long-term nutrient addition experiment was conducted in a subtropical evergreen old-growth forest in China.The four treatments were:control,low N(50 kg N ha^(-1)a^(-1)),high N(100 kg N ha^(-1)a^(-1)),and combined N and phosphorus(P)(100 kg N ha^(-1)a^(-1)+50 kg P ha^(-1)a^(-1)).Metagenomic sequencing characterized diversity and composition of soil microbial communities and used to construct bacterial/fungal co-occurrence networks.Nutrient-treated soils were more acidic and had higher levels of dissolved organic carbon than controls.There were no significant differences in microbial diversity and community composition across treatments.The addition of nutrients increased the abundance of copiotrophic bacteria and potentially beneficial microorganisms(e.g.,Gemmatimonadetes,Chaetomium,and Aureobasidium).Low N addition increased microbiome network connectivity.Three rare fungi were identified as module hubs under nutrient addition,indicating that low abundance fungi were more sensitive to increased nutrients.The results indicate that the overall composition of microbial communities was stable but not static to long-term N addition.Our findings provide new insights that can aid predictions of the response of soil microbial communities to long-term N addition.展开更多
BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis an...BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.展开更多
Against behaviorism,humanism,and cognitive psychology,this work explores Mocombe’s antihuman psychology as a product of his consciousness field theory.The paper critically assesses Mocombe’s consciousness field theo...Against behaviorism,humanism,and cognitive psychology,this work explores Mocombe’s antihuman psychology as a product of his consciousness field theory.The paper critically assesses Mocombe’s consciousness field theory within the larger body of contemporary ontological debates regarding the nature,origin,and constitution of consciousness,especially human consciousness,vis-à-vis their relations to the psychological theories of behaviorism,humanism,and cognitivism,concluding that consciousness field theory posits an alternative psychological theory of the mind,i.e.,antihuman psychology,to behaviorist,humanist,and cognitivist conceptions of the mind.展开更多
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there hav...BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there have been no specific studies on predicting long-term survival after TIPS placement.AIM To establish a model to predict long-term survival in patients with hepatitis cirrhosis after TIPS.METHODS A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS implantation.Through univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after TIPS.Consequently,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)level.Furthermore,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing models.RESULTS The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS placement.The NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation cohorts.Additionally,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients and guide follow-up management after TIPS implantation.展开更多
Background: Congenital heart disease is a public health issue due to its incidence and mortality rate. The aim of this study was to investigate the long-term mortality of children with congenital heart disease admitte...Background: Congenital heart disease is a public health issue due to its incidence and mortality rate. The aim of this study was to investigate the long-term mortality of children with congenital heart disease admitted to the Departmental University Hospital of Borgou/Alibori (CHUD-B/A) from 2011 to 2022. Methods: This descriptive longitudinal study with analytical aims covered 11 years (April 1, 2011 to December 31, 2022). It consisted of a review of the records of children under 15 years of age with echocardiographically confirmed congenital heart disease. This was followed by an interview with the parents to assess the children’s current condition. Data were entered using Kobocollect software and analyzed using R Studio 4.2.2. software. Results: A total of 143 complete files were retained. The median age at diagnosis was 14 months (IIQ: Q1 = 4;Q3 = 60) with a range of 2 days and 175 months, and the sex-ratio (M/F) was 0.96. Left-to-right shunts were the most frequent cardiopathy group (62.9%). Only 35 children (24.5%) benefited from restorative treatment. The mortality rate was 31.5%. Median survival under the maximum bias assumption was 114 months and 216 months under the assumption of minimum bias. Survival was significantly better in children with right-to-left shunts (p = 0.0049) under the assumption of minimum bias. The death risk factors were: age at diagnosis less than 12 months (aHR = 7.58;95% CI = 3.36 - 17.24;p Conclusion: The long-term mortality of congenital heart disease is high and favoured by the absence of restorative treatment. Local correction of congenital heart disease and medical follow-up will help to reduce this mortality.展开更多
The application of reclaimed asphalt pavement(RAP)and reclaimed asphalt shingles(RAS)on asphalt pavement can reduce the asphalt paving cost,conserve energy and protect the environment.However,the use of high contents ...The application of reclaimed asphalt pavement(RAP)and reclaimed asphalt shingles(RAS)on asphalt pavement can reduce the asphalt paving cost,conserve energy and protect the environment.However,the use of high contents of RAP and RAS in asphalt pavement may lead to durability issues,especially the fatigue cracking and thermal cracking.It is necessary to conduct a series of analyses on asphalt mixtures containing high RAP and RAS,and seek methods to enhance their long-term performance.This paper provides a comprehensive over-view of the long-term performance of recycled asphalt mixtures containing high contents of RAP and RAS.The findings in this research show that rutting resistance of high recycled asphalt mixtures is not a concern,whereas their resistance to fatigue and thermal cracking is not conclusive.Recycling agents can be used to improve the thermal cracking resistance of high recycled asphalt mixtures.An optimum decision on recycling agents will improve the durability properties of high recycled asphalt mixtures.It is recommended that to use a balanced mixture design approach with testing of the blended asphalt binders will provide better understanding of long-term performance of recycled asphalt mixtures containing high RAP and RAS.展开更多
BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric cancer.The analysis of the epidemiological char...BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric cancer.The analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and ESD.AIM To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of ESD.METHODS We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after ESD.We compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with ESD.RESULTS HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN tissues.The disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,respectively.Undifferen-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor prognosis.CONCLUSION Differentiations of gastric mucosal tumors have different epidemiological and endoscopic characteristics,which are closely related to the safety and efficacy of ESD.展开更多
The main purpose of this paper is to respond to the questions what is mind and consciousness and where this resides.The answers are based on the frontline Informational Model of Human Body and Living Structures(IMHBLS...The main purpose of this paper is to respond to the questions what is mind and consciousness and where this resides.The answers are based on the frontline Informational Model of Human Body and Living Structures(IMHBLS),which shows that mind and consciousness can be described by the activity of the Informational System of the Human Body and Living Structures(ISHBLS),consisting of seven informational components,each of them with specific activity and functions,inter-correlated to support the immaterial/informational manifestation of the body expressed by mind and consciousness.The basic concept of matter-related and virtual information results as a consequence of the operability of the physics,chemistry,biologic,or mathematics laws,which actually act as informational operators,such processes are informationally driven and manifested finally as a“media-like functions”of mind and consciousness,on the“screen/display”of prefrontal cortex.The mind is therefore described as the capacity of every individual to access the data field of own life experience,where the thought acts as an informational operator,which can activate the required information from internal/external reality.Consciousness is the result of the info-representation of the explored reality,accumulated by the momentary connection,and compared/combined with the life experience,serving as judgment reference/criteria.The question is discussed in relation with the localization of consciousness,showing that this resides in the brain,as a result of the activity of ISHBLS.The discussion on the experimental evidences concerning the minimal basic components necessary and sufficient to sustain consciousness,compared with the results of the informational model,indicates the cortico-thalamus axis,in a full agreement each other.One of the basic findings is that the activation of consciousness is operated in two steps,one consisting in a feed-forward reception and another in feedback perception for recognition of the info-significance,which is fully supported by the recently reported experimental results.The phenomena of intuition,inspiration,premonition,“deja vue”,retrocausality,and intentionality are discussed.This model unifies the eastern and western concepts/models on consciousness and mind,explaining the energetic Yung/Yin Chinese model by YES/NO-informational Bit-type behavior,the Plato’s ideas/forms by“information”concept as a participating component of reality,Aristotle’s materialist view with matter structuration(assisted by information),and archaic model of the seven“chakras”at human,as vital informational centers connected with the body.展开更多
文摘A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human and living structures,both for their structuration and behavior,explaining consciousness at human as the result of the activity of the Informational System of Human and Living Structures.For this,it is emphasized and discussed the informational structure of the eukaryotic cell,the basic/representative composing unit of the multicellular body of human,animals,and plants,showing that the composition and functions of the informational system are basically similar with that of human.To reveal the driving role of informational mechanisms in human and subhuman organisms,it is introduced the concept of matter-related information,showing that information can be hidden/“embodied”or released/“disembodied”in or from the elemental micro/macro components of the body,during the multiple chain/cascade interactions including transduction processes.It is shown that such interactions are initiated from two main categories of informational sources:implicit(genetic)and explicit(external/internal)sources,the first category leading to structuration of the body and the second the reactive behavior.Consciousness in human and subhuman organisms,expressed by two corresponding informational relations,is the result of the release of information by the mind,acting as an informational operator/device,the development degree of mind and consciousness depending on the complexity degree and adaptation.An analogy of this Informational Model of Human and Living Structures(IMHLS)with the ancient model of chakras is highlighted,showing that these models support each other,applied with beneficial effects in Reiki technique and music-based cognitive multi-task therapy for neuro-rehabilitation.
文摘This work explores the axiology of consciousness in Mocombe’s consciousness field in the material world.The paper critically assesses Mocombe’s consciousness field theory(CFT)within the larger body of contemporary ontological debates regarding the nature,origin,and constitution of consciousness in the universe.The work goes on to highlight the manifestation of Mocombe’s consciousness field in the material resource framework that is the earth,and the nature and origins of ethics and values.
基金The research is granted by Japanese Ministry of Education as a part of Grants-in-Aid for Scientific Research,No.(C)22560533.The author records here warmest appreciation to the Resident Conference for Environment of Tokushima Prefecture for collecting the data in the field of actual travel behavior on the social experiment.
文摘It is the matter for achievement of the low carbon transport system that the excessive use of private vehicles can be controlled appropriately.Not only improvement of service level of modes except private vehicle,but also consciousness for environmental problem of individual trip maker is important for eco-commuting promotion.On the other hand,consciousness for environment would be changed by influence of other person.Accordingly,it is aimed in the study that the structure of decision-making process for modal shift to the eco-commuting mode in the local city is described considering environmental consciousness and social interaction.For the purpose,the consciousness for the environment problem and the travel behavior of the commuter at the suburban area in the local city are investigated by the questionnaire survey.The covariance structure about the eco-consciousness is analyzed with the database of the questionnaire survey by structural equation modeling.As the result,it can be confirmed with the structural equation model that the individual environmental consciousness is strongly related with the intention of self-sacrifice and is influenced with the local interaction of the individual connections.On the other hand,the intention of modal shift for the commuting mode is analyzed with the database of the questionnaire survey.It can be found out that the environmental consciousness is not statistically significant for commuting mode choice with the present poor level of service of public transport.However,the intention of self-sacrifice for the prevention of the global warming is statistically confirmed as the factor of modal shift with the operation of eco-commuting bus service with the RP/SP integrated estimation method.As the result,the multi-agent simulation system with social interaction model for eco consciousness is developed to measure the effect of the eco-commuting promotion.For the purpose,the carbon dioxide emission is estimated based on traffic demand and road network condition in the traffic environment model.On the other hand,the relation between agents is defined based on the small world network.The proposed multi-agent simulation is applied to measure the effect of the eco-commuting promotion such as improvement of level of service on the public transport or education of eco-consciousness.The effect of the promotion plan can be observed with the proposed multi-agent system.Finally,it can be concluded that the proposed multi-agent simulation with social interaction for eco-consciousness is useful for planning of eco-commuting promotion.
基金supported by the National Natural Science Foundation of China No.82074534College Students’Innovative Entrepreneurial Training Plan No.202210063027.
文摘Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI patients.Acupuncture has been used to improve neurological deficits in patients with TBI.This meta-analysis aims to evaluate the effects and safety of acupuncture in improving consciousness in patients with TBI when compared with other therapies.Methods:A systematic search was conducted in electronic databases PubMed,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Allied and Complementary Medicine Database,WHO International Clinical Trials Registry Platform,ClinicalTrials.gov,and Google Scholar for randomized controlled trials that investigated the effect of acupuncture on patients with TBI.From the inception of databases to March 2023.Results:A total of 653 participants were included in nine trials.We found that acupuncture adjunct to routine treatment significantly improved the wakeup rate of patients in TBI when compared with routine treatment alone(relative risk=1.36,95%confidence interval:1.16 to 1.59,I2=4.78%,P=0).Additionally,we found that acupuncture is significantly associated with reduced impaired consciousness after TBI when adjunct to medicine therapy.As a safe intervention,acupuncture can also improve the activities of daily living for people with TBI(mean difference=15.71,95%confidence interval:9.19 to 22.22,I2=0%,P=0).Conclusion:Acupuncture can improve consciousness and braise wakeup of patients with TBI when adjunct to conventional treatment compared with routine treatment alone.Further high-quality studies are needed to confirm these findings and to determine the optimal acupuncture treatment parameter for TBI.
文摘Inspired by Roger Nelson’s Global Consciousness Project (GCP), the Global Earth Healing Project (GEHP) uses a network of several hundred physical noise generators to amplify the combined intentions of their users in order to infuse positive affirmations into the global consciousness. As mentioned in the original study design, it was intended to use the GCP as a reference for the effectiveness of its activities. The data of the GEHP consisting of 21 events from 2013 to 2020 is analyzed and statistically compared to the data of the GCP. An astonishing synchronicity was observed, which suggests an interaction between the brain states of the observers and the physical noise generators of the GCP.
文摘Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industrialization started in the 1800s. World population interconnectedness is enhanced with love and mercy but disrupted with dishonest, lies and wars. Human species has been feeding on animal fat as the finest and prime source of energy for all human history. In 1953 Ancel Keys and collaborates illusionized human kind that their historical source of energy is toxic. Massive health, behavioral as well as economic consequences followed. Human hearts known historically to be the seat of spirit, soul and emotions is proven by our group to orchestrate with global energetic fields. Global consciousness as represented by the planetary electromagnetic fields is in critical need to be feed with awakening merciful information. Documents refuting Ancek Keys dogma and reverting humanity to the truth in their energy source is presented in this review. The harmony we expect is not only physiological but will affect our global planetary environment for the wellbeing of human species in earth.
文摘BACKGROUND Disorders of consciousness including coma in non-trauma patients can be caused by a wide variety of pathologies affecting the central nervous system.They represent a frequent challenge in emergency medicine and are combined with a very high in-hospital mortality.Hence,early treatment of these patients is vital and increases the likelihood of a good outcome.AIM To identify the causes of altered consciousness presentation to the Emergency Department at Suez Canal University Hospital.METHODS This was a descriptive cross-sectional study conducted on 87 patients with acute non-traumatic disturbed level of consciousness(DLOC)at the Emergency Department.RESULTS The mean age of the studied patients was 60.5±13.6 years.Among them,60%were males and 40%were females.The most common cause of acute non-traumatic DLOC was systemic infection,such as sepsis and septic shock(25.3%),followed by respiratory causes(24.1%)and neurological causes(18.4%).CONCLUSION The most common cause of acute non-traumatic DLOC was systemic infections followed by respiratory and neurological causes.
文摘Both consciousness and quantum phenomenon are subjective and indeterministic. In this paper, we propose consciousness is a quantum phenomenon. A quantum theory of consciousness (QTOC) is presented based on a new interpretation of quantum physics. We show that this QTOC can address the mind and body problem, the hard problem of consciousness. It also provides a physics foundation and mathematical formulation to study consciousness and neural network. We demonstrate how to apply it to develop and extend various models of consciousness. We show the predictions from this theory about the existence of a universal quantum vibrational field and the large-scale, nearly instantaneous synchrony of brainwaves among different parts of brain, body, people, and objects. The correlation between Schumann Resonances and some brainwaves is explained. Recent progress in quantum information theory, especially regarding quantum entanglement and quantum error correction code, is applied to study memory and shed new light in neuroscience.
基金the funding of seed money from the Bhopal School of Social Sciences, India。
文摘The persistent environmental problems and the growing difficulty to achieve sustainable development require a re-evaluation of person’ sustainable knowledge, attitude, and behaviour. To go to where we want to go, we must first assess where we are now. The study investigated the level of sustainability consciousness of students in India, and sustainability consciousness was expressed in sustainability knowledge, attitude, and behaviour. Sustainability consciousness was further examined using the three dimensions, such as environment, society, and economy. By drawing the perception map of students and studying the role of the locus of control, the reasons why sustainability knowledge does not appear in sustainability behaviour were analyzed. Quantitative analysis was conducted for a sample of 205 students from higher educational institutions across central India(Madhya Pradesh) from January to March in 2022. The data were analyzed using the SPSS 26 and Smart Partial Least Square(PLS) 3.0. The research revealed that sustainability attitude impacts sustainability behaviour more than sustainability knowledge. The results showed that respondents’ sustainability knowledge is higher than their sustainability attitude and behaviour. Moreover, it was discovered that economic concerns can lead to sustainability behaviour. In order to study respondents’ behaviour regarding sustainability consciousness, the study divided respondents into two groups according to the locus of control: the internal and external locus of control. It was found that most respondents thought whatever happened around them was beyond their control. Further, the locus of control influenced sustainability behaviour in groups with the internal locus of control. The study helps to explain why sustainability knowledge and attitude cannot translate into sustainability behaviour and provides a basis for achieving sustainable development. The conclusions of this study are crucial for governments, educational institutions, and organizations that empower youth to change their behaviour.
文摘This study aims to discuss the possibility of becoming conscious of certain aspects of one’s own existence through creative activity.The discussion involves Piagetian constructivism and Steiner’s ideas about human development and is justified by the contribution of creative activity to the development of autonomy,according to Piaget,and to the development of an ethical individuality,according to Steiner.The participation of adults in sessions of creative process,as well as the questions posed after this activity,asking for the relationships between what they created and their life,is evidence of practices favourable to increasing the grasping of consciousness of self and of the process of developing an ethical individuality.
基金the financial supports provided by the National Natural Science Foundation of China(U2040222,52293431,and 52278259)。
文摘This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled from the Three Gorges Dam.The mechanical properties of the laboratory dam concrete,whether cured in natural or standard environments,continued to improve over time.Furthermore,the laboratory dam concrete exhibited good resistance to diffusion and a refined microstructure after 17 years.However,curing and long-term exposure to the local natural environment reduced the frost resistance.Microstructural analyses of the laboratory concrete samples demonstrated that moderate-heat cement and fine fly ash(FA)particles were almost fully hydrated to form compact micro structures consisting of large quantities of homogeneous calcium(alumino)silicate hydrate(C-(A)-S-H)gels and a few crystals.No obvious interfacial transition zones were observed in the microstructure owing to the longterm pozzolanic reaction.This dense and homogenous microstructure was the crucial reason for the excellent long-term performance of the dam concrete.A high FA volume also played a significant role in the microstructural densification and performance growth of dam concrete at a later age.The concrete drilled from the dam surface exhibited a loose microstructure with higher microporosity,indicating that concrete directly exposed to the actual service environment suffered degradation caused by water and wind attacks.In this study,both macro-performance and microstructural analyses revealed that the application of moderate-heat cement and FA resulted in a dense and homogenous microstructure,which ensured the excellent long-term performance of concrete from the Three Gorges Dam after 17 years.Long-term exposure to an actual service environment may lead to microstructural degradation of the concrete surface.Therefore,the retained long-term dam concrete samples need to be further researched to better understand its microstructural evolution and development of its properties.
基金supported by the National Natural Science Foundation of China (Grant Nos.41701296 and 42277481)the Natural Science Foundation of Gansu Province (GrantNo.22JR5RA058)the Youth Science and Technology Fund Program of Gansu Province (Grant No.22JR5RA087).
文摘Interest in the dynamics of soil respiration(R_(S))in subalpine forest ecosystems is increasing due to their high soil carbon density and potential sensitivity to environmental changes.However,as a principal silvicultural practice,the long-term impacts of thinning on R_(S) and its heterotrophic and autotrophic respiration components(R_(h) and Ra,respectively)in subalpine plantations are poorly understood,espe-cially in winter.A 3-year field observation was carried out with consideration of winter CO_(2) efflux in middle-aged sub-alpine spruce plantations in northwestern China.A trench-ing method was used to explore the long-term impacts of thinning on Rs,Rn and R_(a).Seventeen years after thinning,mean annual Rs,Rn and R_(a) increased,while the contribu-tion of R_(h) to R_(s) decreased with thinning intensity.Thinning significantly decreased winter R,because of the reduction in R_(n) but had no significant effect on Ra.The temperature sensitivity(Q_(10))of R_(h) and R_(a) also increased with thinning intensity,with lower Q_(10) values for R_(h)(2.1-2.6)than for Ra(2.4-2.8).The results revealed the explanatory variables and pathways related to R_(n) and R_(a) dynamics.Thinning increased soil moisture and nitrate nitrogen(NO_(3)^(-)-N),and the enhanced nitrogen and water availability promoted R_(h) and R_(a) by improving fine root biomass and microbial activity.Our results highlight the positive roles of NO_(3)^(-)-N in stimulating R_(s) components following long-term thinning.Therefore,applications of nitrogen fertilizer are not recommended while thinning subalpine spruce plantations from the perspective of reducing soil CO_(2) emissions.The increased Q_(10) values of R_(s) components indicate that a large increase in soil CO_(2) emissions would be expected following thinning because of more pronounced climate warming in alpineregions.
基金supported by the National Science Foundation of China(No.31770672 and 3137062)the National Basic Research Program of China(No.2010CB950602)。
文摘Atmospheric nitrogen(N)deposition is predicted to increase,especially in the subtropics.However,the responses of soil microorganisms to long-term N addition at the molecular level in N-rich subtropical forests have not been clarified.A long-term nutrient addition experiment was conducted in a subtropical evergreen old-growth forest in China.The four treatments were:control,low N(50 kg N ha^(-1)a^(-1)),high N(100 kg N ha^(-1)a^(-1)),and combined N and phosphorus(P)(100 kg N ha^(-1)a^(-1)+50 kg P ha^(-1)a^(-1)).Metagenomic sequencing characterized diversity and composition of soil microbial communities and used to construct bacterial/fungal co-occurrence networks.Nutrient-treated soils were more acidic and had higher levels of dissolved organic carbon than controls.There were no significant differences in microbial diversity and community composition across treatments.The addition of nutrients increased the abundance of copiotrophic bacteria and potentially beneficial microorganisms(e.g.,Gemmatimonadetes,Chaetomium,and Aureobasidium).Low N addition increased microbiome network connectivity.Three rare fungi were identified as module hubs under nutrient addition,indicating that low abundance fungi were more sensitive to increased nutrients.The results indicate that the overall composition of microbial communities was stable but not static to long-term N addition.Our findings provide new insights that can aid predictions of the response of soil microbial communities to long-term N addition.
基金Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-022 and No.2022-PUMCH-D-002CAMS Innovation Fund for Medical Sciences,No.2021-1-I2M-003+1 种基金Undergraduate Innovation Program,No.2023-zglc-06034National Key Clinical Specialty Construction Project,No.ZK108000。
文摘BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.
文摘Against behaviorism,humanism,and cognitive psychology,this work explores Mocombe’s antihuman psychology as a product of his consciousness field theory.The paper critically assesses Mocombe’s consciousness field theory within the larger body of contemporary ontological debates regarding the nature,origin,and constitution of consciousness,especially human consciousness,vis-à-vis their relations to the psychological theories of behaviorism,humanism,and cognitivism,concluding that consciousness field theory posits an alternative psychological theory of the mind,i.e.,antihuman psychology,to behaviorist,humanist,and cognitivist conceptions of the mind.
基金Supported by the Talent Training Plan during the"14th Five-Year Plan"period of Beijing Shijitan Hospital Affiliated to Capital Medical University,No.2023LJRCLFQ.
文摘BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there have been no specific studies on predicting long-term survival after TIPS placement.AIM To establish a model to predict long-term survival in patients with hepatitis cirrhosis after TIPS.METHODS A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS implantation.Through univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after TIPS.Consequently,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)level.Furthermore,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing models.RESULTS The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS placement.The NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation cohorts.Additionally,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients and guide follow-up management after TIPS implantation.
文摘Background: Congenital heart disease is a public health issue due to its incidence and mortality rate. The aim of this study was to investigate the long-term mortality of children with congenital heart disease admitted to the Departmental University Hospital of Borgou/Alibori (CHUD-B/A) from 2011 to 2022. Methods: This descriptive longitudinal study with analytical aims covered 11 years (April 1, 2011 to December 31, 2022). It consisted of a review of the records of children under 15 years of age with echocardiographically confirmed congenital heart disease. This was followed by an interview with the parents to assess the children’s current condition. Data were entered using Kobocollect software and analyzed using R Studio 4.2.2. software. Results: A total of 143 complete files were retained. The median age at diagnosis was 14 months (IIQ: Q1 = 4;Q3 = 60) with a range of 2 days and 175 months, and the sex-ratio (M/F) was 0.96. Left-to-right shunts were the most frequent cardiopathy group (62.9%). Only 35 children (24.5%) benefited from restorative treatment. The mortality rate was 31.5%. Median survival under the maximum bias assumption was 114 months and 216 months under the assumption of minimum bias. Survival was significantly better in children with right-to-left shunts (p = 0.0049) under the assumption of minimum bias. The death risk factors were: age at diagnosis less than 12 months (aHR = 7.58;95% CI = 3.36 - 17.24;p Conclusion: The long-term mortality of congenital heart disease is high and favoured by the absence of restorative treatment. Local correction of congenital heart disease and medical follow-up will help to reduce this mortality.
基金supported by National Natural Science Fund for Excellent Young Scientists Fund Program (Overseas) (Grant No.22FAA02811)Pearl River Talent Plan for the Introduction of High-level Talents (Young Top-notch Talents) (Grant No.2021QN02G744)+1 种基金National Natural Science Foundation of China (Grant No.52178426)the Fundamental Research Funds for the Central Universities (Grant No.SCUT 2022ZYGXZR066 and 2023ZYGXZR001).
文摘The application of reclaimed asphalt pavement(RAP)and reclaimed asphalt shingles(RAS)on asphalt pavement can reduce the asphalt paving cost,conserve energy and protect the environment.However,the use of high contents of RAP and RAS in asphalt pavement may lead to durability issues,especially the fatigue cracking and thermal cracking.It is necessary to conduct a series of analyses on asphalt mixtures containing high RAP and RAS,and seek methods to enhance their long-term performance.This paper provides a comprehensive over-view of the long-term performance of recycled asphalt mixtures containing high contents of RAP and RAS.The findings in this research show that rutting resistance of high recycled asphalt mixtures is not a concern,whereas their resistance to fatigue and thermal cracking is not conclusive.Recycling agents can be used to improve the thermal cracking resistance of high recycled asphalt mixtures.An optimum decision on recycling agents will improve the durability properties of high recycled asphalt mixtures.It is recommended that to use a balanced mixture design approach with testing of the blended asphalt binders will provide better understanding of long-term performance of recycled asphalt mixtures containing high RAP and RAS.
基金Supported by Development Program of Shaanxi Province,No.2021SF-221.
文摘BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric cancer.The analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and ESD.AIM To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of ESD.METHODS We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after ESD.We compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with ESD.RESULTS HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN tissues.The disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,respectively.Undifferen-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor prognosis.CONCLUSION Differentiations of gastric mucosal tumors have different epidemiological and endoscopic characteristics,which are closely related to the safety and efficacy of ESD.
文摘The main purpose of this paper is to respond to the questions what is mind and consciousness and where this resides.The answers are based on the frontline Informational Model of Human Body and Living Structures(IMHBLS),which shows that mind and consciousness can be described by the activity of the Informational System of the Human Body and Living Structures(ISHBLS),consisting of seven informational components,each of them with specific activity and functions,inter-correlated to support the immaterial/informational manifestation of the body expressed by mind and consciousness.The basic concept of matter-related and virtual information results as a consequence of the operability of the physics,chemistry,biologic,or mathematics laws,which actually act as informational operators,such processes are informationally driven and manifested finally as a“media-like functions”of mind and consciousness,on the“screen/display”of prefrontal cortex.The mind is therefore described as the capacity of every individual to access the data field of own life experience,where the thought acts as an informational operator,which can activate the required information from internal/external reality.Consciousness is the result of the info-representation of the explored reality,accumulated by the momentary connection,and compared/combined with the life experience,serving as judgment reference/criteria.The question is discussed in relation with the localization of consciousness,showing that this resides in the brain,as a result of the activity of ISHBLS.The discussion on the experimental evidences concerning the minimal basic components necessary and sufficient to sustain consciousness,compared with the results of the informational model,indicates the cortico-thalamus axis,in a full agreement each other.One of the basic findings is that the activation of consciousness is operated in two steps,one consisting in a feed-forward reception and another in feedback perception for recognition of the info-significance,which is fully supported by the recently reported experimental results.The phenomena of intuition,inspiration,premonition,“deja vue”,retrocausality,and intentionality are discussed.This model unifies the eastern and western concepts/models on consciousness and mind,explaining the energetic Yung/Yin Chinese model by YES/NO-informational Bit-type behavior,the Plato’s ideas/forms by“information”concept as a participating component of reality,Aristotle’s materialist view with matter structuration(assisted by information),and archaic model of the seven“chakras”at human,as vital informational centers connected with the body.