Users face the threat of trajectory privacy leakage when using location-based service applications, especially when their behavior is collected and stored for a long period of time. This accumulated information is exp...Users face the threat of trajectory privacy leakage when using location-based service applications, especially when their behavior is collected and stored for a long period of time. This accumulated information is exploited by opponents, greatly increasing the risk of trajectory privacy leakage. This attack method is called a long-term observation attack. On the premise of ensuring lower time overhead and higher cache contribution rate, the existing methods cannot utilize cache to answer subsequent queries while also resisting long-term observation attacks. So this article proposes a trajectory privacy protection method to resist long-term observation attacks. This method combines caching technology and improves the existing differential privacy mechanism, while incorporating randomization factors that are difficult for attackers to recognize after long-term observation to enhance privacy. Search for locations in the cache of both the mobile client and edge server that can replace the user’s actual location. If there are replacement users in the cache, the query results can be obtained more quickly. Simultaneously obfuscating the spatiotemporal correlation of actual trajectories by generating confusion regions. If it does not exist, the obfuscated location generation method that resists long-term observation attacks is executed to generate the real anonymous area and send it to the service provider. The above steps can comprehensively protect the user’s trajectory privacy. The experimental results show that this method can protect user trajectories from long-term observation attacks while ensuring low time overhead and a high cache contribution rate.展开更多
Objective In order to reduce the interfering noise from the earth surface, scientists have carried out multi-geophysical borehole observations and the related study. This study aims at improving signal-to-noise ratio ...Objective In order to reduce the interfering noise from the earth surface, scientists have carried out multi-geophysical borehole observations and the related study. This study aims at improving signal-to-noise ratio obtained from the observation data to obtain zero noise data, which will be of great help to improve geophysical studies. Insights from this study will be significant for the earthquake disaster reduction, resource exploration and environmental protection.展开更多
Objective In geo-marine science,the generalized bottom boundary layer(BBL)represents a layer between sediments and seawater.The BBL plays an important role in geological,geobiochemical,geophysical and geotechnical r...Objective In geo-marine science,the generalized bottom boundary layer(BBL)represents a layer between sediments and seawater.The BBL plays an important role in geological,geobiochemical,geophysical and geotechnical research because it is the connection region of hydrosphere,展开更多
We experimentally observe the dynamic evolution of atoms in the evaporative cooling, by in-situ imaging the plugged hole of ultracold atoms. Ultracold rubidium atoms confined in a magnetic trap are plugged using a blu...We experimentally observe the dynamic evolution of atoms in the evaporative cooling, by in-situ imaging the plugged hole of ultracold atoms. Ultracold rubidium atoms confined in a magnetic trap are plugged using a blue-detuned laser beam with a waist of 20 m at a wavelength of 767 nm. We probe the variation of the atomic temperature and width versus the radio frequency in the evaporative cooling. Both the behaviors are in good agreement with the calculation of the trapping potential dressed by the rf signal above the threshold temperature,while deviating from the calculation near the phase transition. To accurately obtain the atomic width, we use the plugged hole as the reference to optimize the optical imaging system by precisely minimizing the artificial structures due to the defocus effect.展开更多
During the summer of 2008, the third CHINARE Arctic Expedition was carried out on board of Xuelong Icebreaker in the central Chukchi Sea. A submersible mooring system was deployed and recovered at Station CN-01 (71.4...During the summer of 2008, the third CHINARE Arctic Expedition was carried out on board of Xuelong Icebreaker in the central Chukchi Sea. A submersible mooring system was deployed and recovered at Station CN-01 (71.40.024'N, 167.58.910'W) with 33 days of the current profile records, and continuous observation of temperature and salinity data were collected. This mooring station locates in the blank of similar observation area and it is the first time for our Chinese to finish this kind of long-term mooring work in this area. This mooring system finished integrated hydrological observations with long-term continuous record of the whole profile velocity for the first time. Based on time series analysis of temperature, salinity, velocity and flow direction, we get the following main results. (1) During the observation period, the mean surface current velocity is 70.2 cm/s eastward, and velocity reaches its maximum in average at 3 m level with magnitude 90.0 cm/s, direction 206.. (2) In 9-30 m layers, the semidiurnal period variation is the most obvious, the flow direction is quite stable, and the flow is synchronous and consistent vertically. (3) Besides the semidiurnal period variation, the main variation in the upper layer is in 11-d period, with variations in period 5.5, 5.5, and 3.7 d, which reflect the influences of sea surface wind change and maintenance. (4) Near the bottom the temperature change is correlated and synchronized with the conductivity.展开更多
Discontinuation of antipsychotic therapy has been a significant clinical issue among patients with schizophrenia, since the patients who discontinued antipsychotic treatment showed worse clinical and functional outcom...Discontinuation of antipsychotic therapy has been a significant clinical issue among patients with schizophrenia, since the patients who discontinued antipsychotic treatment showed worse clinical and functional outcomes, and higher risks of relapse of schizophrenia symptoms and hospitalization. We conducted a post-hoc analysis of a post-marketing research with a 12-month follow-up period to identify the predictors for discontinuation of antipsychotic monotherapy in Japan. This is a prospective, naturalistic multicenter observational study, designed to evaluate the discontinuation rates of olanzapine monotherapy and non-olanzapine antipsychotic monotherapy in Japanese adult patients with acute schizophrenia. Patients were treatment-naive, or had switched from other antipsychotics or from poly-pharmacotherapy to oral antipsychotic monotherapy. We analyzed the correlation of discontinuation of antipsychotic monotherapy with baseline characteristics of patients. A total of 1089 patients (578 patients treated with olanzapine and 511 with non-olanzapine antipsychotics) were eligible for analysis. By the end of the 12-month study period, 614 patients (56.4%) discontinued antipsychotic therapy. Multivariate logistic regression analyses indicated significantly lower discontinuation rates in all patients treated with antipsychotics: older age (Odds ratio [OR], 0.871;95% confidence interval [CI], 0.797 to 0.953;p = 0.003), outpatient status (OR, 0.508;95% CI, 0.383 to 0.675;p < 0.001), prior use of antipsychotics (OR, 0.693;95% CI, 0.516 to 0.930;p = 0.015), and olanzapine group showed lower discontinuation rate than that of non-olanzapine group (OR, 1.416;95% CI, 1.086 to 1.846;p = 0.010). The present study indicated that the outpatient status, older age, and prior use of antipsychotics have better adherence to antipsychotic treatment. In addition to these factors, use of anti-parkinson agents showed lower discontinuation rates in the olanzapine monotherapy group.展开更多
The Subantarctic Mode Water(SAMW)forms in the deep mixed layer north of the Antarctic Circumpolar Current and spreads northward into the subtropical gyre.The subtropical South Indian Countercurrent(SICC)flows eastward...The Subantarctic Mode Water(SAMW)forms in the deep mixed layer north of the Antarctic Circumpolar Current and spreads northward into the subtropical gyre.The subtropical South Indian Countercurrent(SICC)flows eastward on the north flank of the thick SAMW layer within 22°-32°S from south of Madagascar at around 25°S,50°E toward western Australia.The dynamical relation of the SAMW and the southern branch of the SICC(30°-32°S)is investigated in this work based on the monthly mean Argo data from 2004 to 2019.The physical properties of the SAMW and its pathway from the formation region are described.Most of the SAMW in the Indian Ocean sector originates from the deep mixed layers of the southeastern Indian Ocean(about 40°S,85°-105°E)and moves along the subtropical gyre.It takes around ten years to arrive east of Madagascar Island preserving its low potential vor-ticity characteristics.As a thick layer with homogeneous vertical properties,the SAMW forces the upper pycnocline to shoal,and the associated eastward shear results in the surface-intensified SICC.The SAMW forms a tongue-shaped thickness pattern,which influ-ences the southern branch of the SICC above the northern flank of the thickest SAMW layer between 24°S and 32°S.The seasonal,interannual,and decade variations of the southern branch of the SICC are closely related to the meridional gradient of the underlying SAMW thickness.The SAMW thickened and strengthened from 2005 to 2015,thereby anchoring a strengthened SICC.The interan-nual covariability of the SAMW and SICC further supports the SAMW’s role in driving SICC variability.展开更多
Health-related quality-of-life (HRQOL) after a radical prostatectomy (RP) or extemal beam radiation therapy (EBRT) has not been studied in conjunction with oncological outcomes in relation to disease risk strati...Health-related quality-of-life (HRQOL) after a radical prostatectomy (RP) or extemal beam radiation therapy (EBRT) has not been studied in conjunction with oncological outcomes in relation to disease risk stratification. Moreover, the long-term outcomes of these treatment approaches have not been studied. We retrospectively analyzed oncological outcomes between consecutive patients receiving RP (n = 86) and EBRT (n = 76) for localized prostate cancer. HRQOL and functional outcomes could be assessed in 62 RP (79%) and 54 EBRT (79%) patients over a 3-year follow-up period (median: 41 months) using the Medical Outcomes Study Short Form-36 (SF-36) and the University of Califomia Los Angeles Prostate Cancer Index (UCLA PCI). The 5-year biochemical progression-free survival did not differ between the RP and EBRT groups for low-risk (74.6% vs. 75.0%, P = 0.931) and intermediate-risk (61.3% vs. 71.1%, P = 0.691) patients. For high-risk patients, progression-free survival was lower in the RP group (45.1%) than in the EBRT group (79.7%) (P = 0.002). The general HRQOL was comparable between the two groups. Regarding functional outcomes, the RP group reported lower scores on urinary function and less urinary bother and sexual bother than the EBRT group (P 〈 0.001, P 〈 0.05 and P 〈 0.001, respectively). With risk stratification, the low- and intermediate-risk patients in the RP group reported poorer urinary function than patients in the EBRT group (P 〈 0.001 for each). The sexual function of the high-risk patients in the EBRT group was better than that of the same risk RP patients (P 〈 0.001). Biochemical recurrence was not associated with the UCLA PCI score in either group. In conclusion, low- to intermediate-risk patients treated with an RP may report relatively decreased urinary function during long-term follow-up. The patient's HRQOL after treatment did not depend on biochemical recurrence.展开更多
WC-Co is used widely in die and mold industries due to its unique combination of hardness, strength and wear-resistance. For machining difficult-to-cut materials, such as tungsten carbide, micro-electrical discharge m...WC-Co is used widely in die and mold industries due to its unique combination of hardness, strength and wear-resistance. For machining difficult-to-cut materials, such as tungsten carbide, micro-electrical discharge machining(EDM) is one of the most effective methods for making holes because the hardness is not a dominant parameter in EDM. This paper describes the characteristics of the discharge conditions for micro-hole EDM of tungsten carbide with a WC grain size of 0.5 μm and Co content of 12%. The EDM process was conducted by varying the condenser and resistance values. A R-C discharge EDM device using arc erosion for micro-hole machining was suggested. Furthermore, the characteristics of the developed micro-EDM were analyzed in terms of the electro-optical observation using an oscilloscope and field emission scanning electron microscope.展开更多
This paper studies the thermodynamic geometry of the Reissner–Nordstr?m-anti-de Sitter(RN-AdS)black hole via detection of the non-local observables in the dual field theory,including the entanglement entropy and equa...This paper studies the thermodynamic geometry of the Reissner–Nordstr?m-anti-de Sitter(RN-AdS)black hole via detection of the non-local observables in the dual field theory,including the entanglement entropy and equal-time two-point correlation function.With the dimensional analysis,we construct the principle of corresponding states of black hole thermodynamics.As a result,our findings can be applied to black holes with different Ad S backgrounds.In this sense,the probe of the thermodynamic geometry of the RN-Ad S black hole though the non-local observables in dual field theory has been confirmed numerically.展开更多
文摘Users face the threat of trajectory privacy leakage when using location-based service applications, especially when their behavior is collected and stored for a long period of time. This accumulated information is exploited by opponents, greatly increasing the risk of trajectory privacy leakage. This attack method is called a long-term observation attack. On the premise of ensuring lower time overhead and higher cache contribution rate, the existing methods cannot utilize cache to answer subsequent queries while also resisting long-term observation attacks. So this article proposes a trajectory privacy protection method to resist long-term observation attacks. This method combines caching technology and improves the existing differential privacy mechanism, while incorporating randomization factors that are difficult for attackers to recognize after long-term observation to enhance privacy. Search for locations in the cache of both the mobile client and edge server that can replace the user’s actual location. If there are replacement users in the cache, the query results can be obtained more quickly. Simultaneously obfuscating the spatiotemporal correlation of actual trajectories by generating confusion regions. If it does not exist, the obfuscated location generation method that resists long-term observation attacks is executed to generate the real anonymous area and send it to the service provider. The above steps can comprehensively protect the user’s trajectory privacy. The experimental results show that this method can protect user trajectories from long-term observation attacks while ensuring low time overhead and a high cache contribution rate.
基金supported by the National Science Foundation of China (grant No.1374052)
文摘Objective In order to reduce the interfering noise from the earth surface, scientists have carried out multi-geophysical borehole observations and the related study. This study aims at improving signal-to-noise ratio obtained from the observation data to obtain zero noise data, which will be of great help to improve geophysical studies. Insights from this study will be significant for the earthquake disaster reduction, resource exploration and environmental protection.
基金supported by the National Natural Science Foundation of China (grants No.41427803 amd 41272316)
文摘Objective In geo-marine science,the generalized bottom boundary layer(BBL)represents a layer between sediments and seawater.The BBL plays an important role in geological,geobiochemical,geophysical and geotechnical research because it is the connection region of hydrosphere,
基金Supported by the National Key Research and Development Program of China under Grant No 2016YFA0301503the National Natural Science Foundation of China under Grant Nos 11674358 and 11434015the Instrument Project of the Chinese Academy of Sciences under Grant No YJKYYQ20170025
文摘We experimentally observe the dynamic evolution of atoms in the evaporative cooling, by in-situ imaging the plugged hole of ultracold atoms. Ultracold rubidium atoms confined in a magnetic trap are plugged using a blue-detuned laser beam with a waist of 20 m at a wavelength of 767 nm. We probe the variation of the atomic temperature and width versus the radio frequency in the evaporative cooling. Both the behaviors are in good agreement with the calculation of the trapping potential dressed by the rf signal above the threshold temperature,while deviating from the calculation near the phase transition. To accurately obtain the atomic width, we use the plugged hole as the reference to optimize the optical imaging system by precisely minimizing the artificial structures due to the defocus effect.
基金The National Key Basic Research and Development Plan under contract No. 2010CB950301:"Sea-ice-air interaction in the Southern Ocean and its influence on the south Indian Ocean",International Polar Year Chinese action plan project:"Chukchi Sea & Beaufort Sea ice anomaly variation and its impact on the winter climate of China"National Science and Technology Support Program under contract No.2006BAB18B02:"Water masses and circulation monitoring technology and its application in the southern ocean"The Basic Research Fund Project under contract No.FIO SOA 2010T01:"Key technology research of polar mooring observation system"
文摘During the summer of 2008, the third CHINARE Arctic Expedition was carried out on board of Xuelong Icebreaker in the central Chukchi Sea. A submersible mooring system was deployed and recovered at Station CN-01 (71.40.024'N, 167.58.910'W) with 33 days of the current profile records, and continuous observation of temperature and salinity data were collected. This mooring station locates in the blank of similar observation area and it is the first time for our Chinese to finish this kind of long-term mooring work in this area. This mooring system finished integrated hydrological observations with long-term continuous record of the whole profile velocity for the first time. Based on time series analysis of temperature, salinity, velocity and flow direction, we get the following main results. (1) During the observation period, the mean surface current velocity is 70.2 cm/s eastward, and velocity reaches its maximum in average at 3 m level with magnitude 90.0 cm/s, direction 206.. (2) In 9-30 m layers, the semidiurnal period variation is the most obvious, the flow direction is quite stable, and the flow is synchronous and consistent vertically. (3) Besides the semidiurnal period variation, the main variation in the upper layer is in 11-d period, with variations in period 5.5, 5.5, and 3.7 d, which reflect the influences of sea surface wind change and maintenance. (4) Near the bottom the temperature change is correlated and synchronized with the conductivity.
文摘Discontinuation of antipsychotic therapy has been a significant clinical issue among patients with schizophrenia, since the patients who discontinued antipsychotic treatment showed worse clinical and functional outcomes, and higher risks of relapse of schizophrenia symptoms and hospitalization. We conducted a post-hoc analysis of a post-marketing research with a 12-month follow-up period to identify the predictors for discontinuation of antipsychotic monotherapy in Japan. This is a prospective, naturalistic multicenter observational study, designed to evaluate the discontinuation rates of olanzapine monotherapy and non-olanzapine antipsychotic monotherapy in Japanese adult patients with acute schizophrenia. Patients were treatment-naive, or had switched from other antipsychotics or from poly-pharmacotherapy to oral antipsychotic monotherapy. We analyzed the correlation of discontinuation of antipsychotic monotherapy with baseline characteristics of patients. A total of 1089 patients (578 patients treated with olanzapine and 511 with non-olanzapine antipsychotics) were eligible for analysis. By the end of the 12-month study period, 614 patients (56.4%) discontinued antipsychotic therapy. Multivariate logistic regression analyses indicated significantly lower discontinuation rates in all patients treated with antipsychotics: older age (Odds ratio [OR], 0.871;95% confidence interval [CI], 0.797 to 0.953;p = 0.003), outpatient status (OR, 0.508;95% CI, 0.383 to 0.675;p < 0.001), prior use of antipsychotics (OR, 0.693;95% CI, 0.516 to 0.930;p = 0.015), and olanzapine group showed lower discontinuation rate than that of non-olanzapine group (OR, 1.416;95% CI, 1.086 to 1.846;p = 0.010). The present study indicated that the outpatient status, older age, and prior use of antipsychotics have better adherence to antipsychotic treatment. In addition to these factors, use of anti-parkinson agents showed lower discontinuation rates in the olanzapine monotherapy group.
基金the National Key R&D Pro-gram of China(Nos.2018YFA0605700,2016YFA0601800)the National Natural Science Foundation of China(No.41876006)。
文摘The Subantarctic Mode Water(SAMW)forms in the deep mixed layer north of the Antarctic Circumpolar Current and spreads northward into the subtropical gyre.The subtropical South Indian Countercurrent(SICC)flows eastward on the north flank of the thick SAMW layer within 22°-32°S from south of Madagascar at around 25°S,50°E toward western Australia.The dynamical relation of the SAMW and the southern branch of the SICC(30°-32°S)is investigated in this work based on the monthly mean Argo data from 2004 to 2019.The physical properties of the SAMW and its pathway from the formation region are described.Most of the SAMW in the Indian Ocean sector originates from the deep mixed layers of the southeastern Indian Ocean(about 40°S,85°-105°E)and moves along the subtropical gyre.It takes around ten years to arrive east of Madagascar Island preserving its low potential vor-ticity characteristics.As a thick layer with homogeneous vertical properties,the SAMW forces the upper pycnocline to shoal,and the associated eastward shear results in the surface-intensified SICC.The SAMW forms a tongue-shaped thickness pattern,which influ-ences the southern branch of the SICC above the northern flank of the thickest SAMW layer between 24°S and 32°S.The seasonal,interannual,and decade variations of the southern branch of the SICC are closely related to the meridional gradient of the underlying SAMW thickness.The SAMW thickened and strengthened from 2005 to 2015,thereby anchoring a strengthened SICC.The interan-nual covariability of the SAMW and SICC further supports the SAMW’s role in driving SICC variability.
文摘Health-related quality-of-life (HRQOL) after a radical prostatectomy (RP) or extemal beam radiation therapy (EBRT) has not been studied in conjunction with oncological outcomes in relation to disease risk stratification. Moreover, the long-term outcomes of these treatment approaches have not been studied. We retrospectively analyzed oncological outcomes between consecutive patients receiving RP (n = 86) and EBRT (n = 76) for localized prostate cancer. HRQOL and functional outcomes could be assessed in 62 RP (79%) and 54 EBRT (79%) patients over a 3-year follow-up period (median: 41 months) using the Medical Outcomes Study Short Form-36 (SF-36) and the University of Califomia Los Angeles Prostate Cancer Index (UCLA PCI). The 5-year biochemical progression-free survival did not differ between the RP and EBRT groups for low-risk (74.6% vs. 75.0%, P = 0.931) and intermediate-risk (61.3% vs. 71.1%, P = 0.691) patients. For high-risk patients, progression-free survival was lower in the RP group (45.1%) than in the EBRT group (79.7%) (P = 0.002). The general HRQOL was comparable between the two groups. Regarding functional outcomes, the RP group reported lower scores on urinary function and less urinary bother and sexual bother than the EBRT group (P 〈 0.001, P 〈 0.05 and P 〈 0.001, respectively). With risk stratification, the low- and intermediate-risk patients in the RP group reported poorer urinary function than patients in the EBRT group (P 〈 0.001 for each). The sexual function of the high-risk patients in the EBRT group was better than that of the same risk RP patients (P 〈 0.001). Biochemical recurrence was not associated with the UCLA PCI score in either group. In conclusion, low- to intermediate-risk patients treated with an RP may report relatively decreased urinary function during long-term follow-up. The patient's HRQOL after treatment did not depend on biochemical recurrence.
基金supported by a Grant-in-aid for the National Core Research Center Program from MOST and KOSEF, Korea (No.R15-2006-022-01001-0)partly supported by Pusan National University Research Grand,2008
文摘WC-Co is used widely in die and mold industries due to its unique combination of hardness, strength and wear-resistance. For machining difficult-to-cut materials, such as tungsten carbide, micro-electrical discharge machining(EDM) is one of the most effective methods for making holes because the hardness is not a dominant parameter in EDM. This paper describes the characteristics of the discharge conditions for micro-hole EDM of tungsten carbide with a WC grain size of 0.5 μm and Co content of 12%. The EDM process was conducted by varying the condenser and resistance values. A R-C discharge EDM device using arc erosion for micro-hole machining was suggested. Furthermore, the characteristics of the developed micro-EDM were analyzed in terms of the electro-optical observation using an oscilloscope and field emission scanning electron microscope.
基金supported by financial support from the National Natural Science Foundation of China(Grant Nos.12275216,12105222,12247103)。
文摘This paper studies the thermodynamic geometry of the Reissner–Nordstr?m-anti-de Sitter(RN-AdS)black hole via detection of the non-local observables in the dual field theory,including the entanglement entropy and equal-time two-point correlation function.With the dimensional analysis,we construct the principle of corresponding states of black hole thermodynamics.As a result,our findings can be applied to black holes with different Ad S backgrounds.In this sense,the probe of the thermodynamic geometry of the RN-Ad S black hole though the non-local observables in dual field theory has been confirmed numerically.