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Process Discovery and Refinement of an Enterprise Management System
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作者 Faizan Ahmed Khan Farooq Ahmad +1 位作者 Arfat Ahmad Khan Chitapong Wechtaisong 《Computer Systems Science & Engineering》 SCIE EI 2023年第3期2019-2032,共14页
The need for the analysis of modern businesses is rapidly increasing as the supporting enterprise systems generate more and more data.This data can be extremely valuable for executing organizations because the data al... The need for the analysis of modern businesses is rapidly increasing as the supporting enterprise systems generate more and more data.This data can be extremely valuable for executing organizations because the data allows constant monitoring,analyzing,and improving the underlying processes,which leads to the reduction of cost and the improvement of the quality.Process mining is a useful technique for analyzing enterprise systems by using an event log that contains behaviours.This research focuses on the process discovery and refinement using real-life event log data collected from a large multinational organization that deals with coatings and paints.By investigating and analyzing their order handling pro-cesses,this study aims at learning a model that gives insight inspection of the processes and performance analysis.Furthermore,the animation is also performed for the better inspection,diagnostics,and compliance-related questions to specify the system.The configuration of the system and the conformance checking for further enhancement is also addressed in this research.To achieve the objectives,this research uses process mining techniques,i.e.process discovery in the form of formal Petri nets models with the help of process maps,and process refinement through conformance checking and enhancement.Initially,the identified executed process is reconstructed by using the process discovery techniques.Following the reconstruction,we perform a deep analysis for the underlying process to ensure the process improvement and redesigning.Finally,some recommendations are made to improve the enterprise management system processes. 展开更多
关键词 process mining enterprise management system business process management process discovery conformance analysis process enhancement
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An Edge-Fog-Cloud Computing-Based Digital Twin Model for Prognostics Health Management of Process Manufacturing Systems
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作者 Jie Ren Chuqiao Xu +3 位作者 Junliang Wang Jie Zhang Xinhua Mao Wei Shen 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第4期599-618,共20页
The prognostics health management(PHM)fromthe systematic viewis critical to the healthy continuous operation of processmanufacturing systems(PMS),with different kinds of dynamic interference events.This paper proposes... The prognostics health management(PHM)fromthe systematic viewis critical to the healthy continuous operation of processmanufacturing systems(PMS),with different kinds of dynamic interference events.This paper proposes a three leveled digital twinmodel for the systematic PHMof PMSs.The unit-leveled digital twinmodel of each basic device unit of PMSs is constructed based on edge computing,which can provide real-time monitoring and analysis of the device status.The station-leveled digital twin models in the PMSs are designed to optimize and control the process parameters,which are deployed for the manufacturing execution on the fog server.The shop-leveled digital twin maintenancemodel is designed for production planning,which gives production instructions fromthe private industrial cloud server.To cope with the dynamic disturbances of a PMS,a big data-driven framework is proposed to control the three-level digital twin models,which contains indicator prediction,influence evaluation,and decisionmaking.Finally,a case study with a real chemical fiber system is introduced to illustrate the effectiveness of the digital twin model with edge-fog-cloud computing for the systematic PHM of PMSs.The result demonstrates that the three-leveled digital twin model for the systematic PHM in PMSs works well in the system’s respects. 展开更多
关键词 process manufacturing system prognostics health management digital twin chemical fiber big data-driven
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How Does Robotics Process Automation (RPA) Affect Project Management Practices
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作者 Mounir El Khatib Amna Almarri +1 位作者 Asma Almemari Aysha Alqassimi 《Advances in Internet of Things》 2023年第2期13-30,共18页
The main purpose of this literature review is to understand the effectiveness and impacts of Robotics Process Automation (RPA) on the practices of Project Management (PM). For attaining the purposes of the research st... The main purpose of this literature review is to understand the effectiveness and impacts of Robotics Process Automation (RPA) on the practices of Project Management (PM). For attaining the purposes of the research study, an extensive literature review was conducted, which helped in gaining a theoretical understanding. These findings were then justified with the help of current and relevant secondary sources in the analysis section. The findings suggested that RPA is quite advantageous for implementing in varied aspects of a business, especially in the field of project management. However, it can pose several challenges, which need to be taken into due consideration by the organizations during execution such as the capabilities of the employees and the abilities of the existing systems to incorporate automation, among others. It was ultimately concluded that RPA is highly advantageous for project management teams but its effective implementation is the key to success. 展开更多
关键词 ROBOTICS Robotics process Automation Project management PLATFORMS
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Formal Modeling and Discovery of Multi-instance Business Processes: A Cloud Resource Management Case Study 被引量:1
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作者 Cong Liu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2022年第12期2151-2160,共10页
Process discovery, as one of the most challenging process analysis techniques, aims to uncover business process models from event logs. Many process discovery approaches were invented in the past twenty years;however,... Process discovery, as one of the most challenging process analysis techniques, aims to uncover business process models from event logs. Many process discovery approaches were invented in the past twenty years;however, most of them have difficulties in handling multi-instance sub-processes. To address this challenge, we first introduce a multi-instance business process model(MBPM) to support the modeling of processes with multiple sub-process instantiations. Formal semantics of MBPMs are precisely defined by using multi-instance Petri nets(MPNs)that are an extension of Petri nets with distinguishable tokens.Then, a novel process discovery technique is developed to support the discovery of MBPMs from event logs with sub-process multi-instantiation information. In addition, we propose to measure the quality of the discovered MBPMs against the input event logs by transforming an MBPM to a classical Petri net such that existing quality metrics, e.g., fitness and precision, can be used.The proposed discovery approach is properly implemented as plugins in the Pro M toolkit. Based on a cloud resource management case study, we compare our approach with the state-of-theart process discovery techniques. The results demonstrate that our approach outperforms existing approaches to discover process models with multi-instance sub-processes. 展开更多
关键词 Cloud resource management process multi-instance Petri nets(MPNs) multi-instance sub-processes process discovery quality evaluation
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Evaluation of process management of postpartum hemorrhage due to uterine atony 被引量:1
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作者 Iris Holzer Rainer Lehner 《Open Journal of Obstetrics and Gynecology》 2013年第7期514-519,共6页
Objective: To evaluate the management process and the guidelines for management of postpartum hemorrhage due to uterine atony at the General Hospital Vienna, Medical University Vienna. Material and Methods: A retrospe... Objective: To evaluate the management process and the guidelines for management of postpartum hemorrhage due to uterine atony at the General Hospital Vienna, Medical University Vienna. Material and Methods: A retrospective analysis was carried out on all 24 cases of postpartum hemorrhage due to uterine atony with an estimated blood loss of more than 800 mL, in which standardized guidelines were obtained. We included all women who gave birth at the General Hospital of Vienna, the Medical University Vienna, during the period from January 1st 2003 and December 31st 2009 and who suffered blood loss 800 mL at minimum due to uterine atony. Results: The guidelines were in use for 14% - 71%. The average blood loss of the 24 cases with uterine atony was 1342 mL. Conclusion: The management process of postpartum hemorrhage due to uterine atony deviates from the hospital’s guidelines in many cases. 展开更多
关键词 POSTPARTUM HEMORRHAGE UTERINE Atony management process
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Reflections on Research and Development Management Innovation in Huawei Enterprises
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作者 ZHAO Yao DING Hui WANG Tingyong 《Chinese Business Review》 2023年第1期31-36,共6页
As an advanced global provider of information and communication technology solutions,Huawei has always maintained a leading position in the ICT field and is committed to achieving a future information society and buil... As an advanced global provider of information and communication technology solutions,Huawei has always maintained a leading position in the ICT field and is committed to achieving a future information society and building a better fully connected world.Looking at the rapid development of Huawei,it is inseparable from its comprehensive and advanced enterprise management innovation concept,which is also one of the main reasons for helping Huawei become a world-class enterprise.“Huawei has not succeeded,it is just growing”is a famous quote from Ren Zhengfei,the main founder and president of Huawei.In the context of the rapid development of the Internet industry and information technology,enterprises must establish the concept of innovative development,implement innovation management,and create a good production and development environment.This paper analyzes the content of Huawei’s enterprise management innovation,including Huawei’s management philosophy,management mode,management status quo,and management innovation suggestions,understands and grasps the choice of enterprise management mode,learns advanced enterprise management experience,and provides reference for other enterprises to practice innovation management. 展开更多
关键词 Huawei R&D management model organizational structure process management
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Risk Management of Clinical Reference Dosimetry of a Large Hospital Network Using Statistical Process Control 被引量:1
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作者 Seng-Boh Lim Thomas LoSasso +2 位作者 Maria Chan Laura Cervino Dale Michael Lovelock 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2021年第3期119-131,共13页
Managing TG-51 reference dosimetry in a large hospital network can be a challenging task. The objectives of this study are to investigate the effectiveness of using Statistical Process Control (SPC) to manage TG-51 wo... Managing TG-51 reference dosimetry in a large hospital network can be a challenging task. The objectives of this study are to investigate the effectiveness of using Statistical Process Control (SPC) to manage TG-51 workflow in such a network. All the sites in the network performed the annual reference dosimetry in water according to TG-51. These data were used to cross-calibrate the same ion chambers in plastic phantoms for monthly QA output measurements. An energy-specific dimensionless beam quality cross-calibration factor, <img src="Edit_6bfb9907-c034-4197-97a7-e8337a7fc21a.png" width="20" height="19" alt="" />, was derived to monitor the process across multiple sites. The SPC analysis was then performed to obtain the mean, <img src="Edit_c630a2dd-f714-4042-a46e-da0ca863cb41.png" width="30" height="20" alt="" /> , standard deviation, <span style="font-size:6.5pt;font-family:;" "=""><span style="white-space:normal;"><span style="font-size:6.5pt;font-family:"">&sigma;</span><span style="white-space:nowrap;"><sub><i>k</i></sub></span></span></span>, the Upper Control Limit (UCL) and Lower Control Limit (LCL) in each beam. This process was first applied to 15 years of historical data at the main campus to assess the effectiveness of the process. A two-year prospective study including all 30 linear accelerators spread over the main campus and seven satellites in the network followed. The ranges of the control limits (±3σ) were found to be in the range of 1.7% - 2.6% and 3.3% - 4.2% for the main campus and the satellite sites respectively. The wider range in the satellite sites was attributed to variations in the workflow. Standardization of workflow was also found to be effective in narrowing the control limits. The SPC is effective in identifying variations in the workflow and was shown to be an effective tool in managing large network reference dosimetry. 展开更多
关键词 TG-51 DOSIMETRY process Control Risk management Large Hospital Network
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A New Fuzzy Clustering-Ranking Algorithm and Its Application in Process Alarm Management 被引量:6
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作者 ZHU Qunxiong(朱群雄) +1 位作者 GENG Zhiqiang(耿志强) 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2005年第4期477-483,共7页
Overmany alarms of modern chemical process give the operators many difficulties to decision and diag- nosis. In order to ensure safe production and process operating, management and optimization of alarm information a... Overmany alarms of modern chemical process give the operators many difficulties to decision and diag- nosis. In order to ensure safe production and process operating, management and optimization of alarm information are challenge work that must be confronted. A new process alarm management method based on fuzzy clustering- ranking algorithm is proposed. The fuzzy clustering algorithm is used to cluster rationally the process variables, and difference driving decision algorithm ranks different clusters and process parameters in every cluster. The alarm signal of higher rank is handled preferentially to manage effectively alarms and avoid blind operation. The validity of proposed algorithm and solution is verified by the practical application of ethylene cracking furnace system. It is an effective and dependable alarm management method to improve operating safety in industrial process. 展开更多
关键词 流程报警管理 模糊聚类-分级算法 化学反应 安全性 生产控制
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Controlling of crustacean zooplankton reproduction in biological activated carbon (BAC) filters by strengthen operation and management of conventional process
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作者 刘丽君 张金松 +1 位作者 李小伟 赫俊国 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2010年第5期661-666,共6页
To counter the mass reproduction and penetration of crustacean zooplankton in Biological Activated Carbon(BAC)filters which may result in the presence of organisms in potable water and water pollution,this paper analy... To counter the mass reproduction and penetration of crustacean zooplankton in Biological Activated Carbon(BAC)filters which may result in the presence of organisms in potable water and water pollution,this paper analyzed the factors affecting organisms' reproduction in BAC filters.A comparative study was performed on the density and composition of crustacean zooplankton of the concerned water treatment units of two advanced water plants(Plant A and B)which with the same raw water and the same treatment technique in southern China.The results obtained show that the crustaceans' density and composition was very different between the sand filtered water of Plant A and Plant B.which Harpacticoida bred sharply in the sediment tanks and penetrated sand filter into BAC filters was the primary reason of crustaceans reproduce in BAC filters of Plant A.For prevention of the organisms reproduction in BAC,some strengthen measures was taken including pre-chlorination,cleaning coagulation tanks and sediment tanks completely,increasing sludge disposal frequency to stop organisms enter BAC filters,and the finished water quality was improved and enhanced. 展开更多
关键词 CRUSTACEAN zooplankton reproduction BAC filter CONVENTIONAL treatment process STRENGTHEN operation and management tap water quality
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Digital Twin-based Quality Management Method for the Assembly Process of Aerospace Products with the Grey-Markov Model and Apriori Algorithm
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作者 Cunbo Zhuang Ziwen Liu +3 位作者 Jianhua Liu Hailong Ma Sikuan Zhai Ying Wu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第5期66-86,共21页
The assembly process of aerospace products such as satellites and rockets has the characteristics of single-or small-batch production,a long development period,high reliability,and frequent disturbances.How to predict... The assembly process of aerospace products such as satellites and rockets has the characteristics of single-or small-batch production,a long development period,high reliability,and frequent disturbances.How to predict and avoid quality abnormalities,quickly locate their causes,and improve product assembly quality and efficiency are urgent engineering issues.As the core technology to realize the integration of virtual and physical space,digital twin(DT)technology can make full use of the low cost,high efficiency,and predictable advantages of digital space to provide a feasible solution to such problems.Hence,a quality management method for the assembly process of aerospace products based on DT is proposed.Given that traditional quality control methods for the assembly process of aerospace products are mostly post-inspection,the Grey-Markov model and T-K control chart are used with a small sample of assembly quality data to predict the value of quality data and the status of an assembly system.The Apriori algorithm is applied to mine the strong association rules related to quality data anomalies and uncontrolled assembly systems so as to solve the issue that the causes of abnormal quality are complicated and difficult to trace.The implementation of the proposed approach is described,taking the collected centroid data of an aerospace product’s cabin,one of the key quality data in the assembly process of aerospace products,as an example.A DT-based quality management system for the assembly process of aerospace products is developed,which can effectively improve the efficiency of quality management for the assembly process of aerospace products and reduce quality abnormalities. 展开更多
关键词 Quality management Digital twin Assembly process Aerospace product Grey Markov model Apriori algorithm
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Process Management in Insurance Companies
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作者 Lech Gasiorkiewicz Marta Kruk 《Management Studies》 2019年第5期486-495,共10页
The importance of insurance activity is constantly growing, generating new problems and setting new challenges. One of these challenges is to meet the growing requirements and expectations of customers. This requires ... The importance of insurance activity is constantly growing, generating new problems and setting new challenges. One of these challenges is to meet the growing requirements and expectations of customers. This requires the efficient management of insurance companies. This means the necessity of applying modern management concepts, first and foremost, the concept of process management and instruments related to this process. This article describes the results of research on process management in insurance companies operating in Poland that was conducted by the Faculty of Management at the Warsaw University of Technology and presents the concept of the identification of processes carried out in insurance companies encompassing management, basic and auxiliary processes, as well as the objectives of the processes and the relationships between the basic processes and other processes carried out in insurance companies. 展开更多
关键词 management of processes process management process identification of insurance activities goals of process implementation relationships between processes
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Enhancing Software Process Management through Control Charts
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作者 Vipul Vashisht 《Journal of Software Engineering and Applications》 2014年第2期87-93,共7页
In software development life cycle, Software Process Management (SPM) acts as a significant part throughout the execution of project. In this study, the application of control chart for analyzing the stability of soft... In software development life cycle, Software Process Management (SPM) acts as a significant part throughout the execution of project. In this study, the application of control chart for analyzing the stability of software process and defects in the software product is discussed. This paper will discuss the analyzing impact or collision of rework effort, defect density, inspection performance and productivity by using control charts. This paper also explains the benefits and challenges of using control charts in software organization. 展开更多
关键词 SOFTWARE process management Control Charts COST of REWORK
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Security Policy Management Process within Six Sigma Framework
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作者 Vijay Anand Jafar Saniie Erdal Oruklu 《Journal of Information Security》 2012年第1期49-58,共10页
This paper presents a management process for creating adaptive, real-time security policies within the Six Sigma (6σ) framework. A key challenge for the creation of a management process is the integration with models... This paper presents a management process for creating adaptive, real-time security policies within the Six Sigma (6σ) framework. A key challenge for the creation of a management process is the integration with models of known Industrial processes. One of the most used industrial process models is Six Sigma which is a business management model wherein customer centric needs are put in perspective with business data to create an efficient system. The security policy creation and management process proposed in this paper is based on the Six Sigma model and presents a method to adapt security goals and risk management of a computing service. By formalizing a security policy management process within an industrial process model, the adaptability of this model to existing industrial tools is seamless and offers a clear risk based policy decision framework. In particular, this paper presents the necessary tools and procedures to map Six Sigma DMAIC (Define-Measure-Analyze-Improve-Control) methodology to security policy management. 展开更多
关键词 SECURITY management SECURITY process POLICY THREAT SIX SIGMA
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Common Management Process Model of New TQM Based on the Situation Analysis
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作者 Kazuhiro Esaki 《Intelligent Information Management》 2016年第6期181-193,共13页
In the previous study, we suggested the concept of new TQM based on the consideration of basic concept of Quality Control. Also, in the previous study, we suggested the target domains and entities of product and proce... In the previous study, we suggested the concept of new TQM based on the consideration of basic concept of Quality Control. Also, in the previous study, we suggested the target domains and entities of product and process based on the TQM Matrix and view point of Three Dimensional Unification Value Models for managing quality of organization systems. Furthermore, in the previous study, we suggest the Common Management Process of organizations. Based on the above suggestion, in this paper, we would like to propose the Common Management Process Model of Total Quality Management based on the consideration of situation analysis and more precise definition of TQM Matrix and Three Dimensional Unification Value Model of “Product and Process”. Improvement of quality and efficiency of organization management can be expected by the integration of conventional different management such as quality assurance, quality improvement, risk management, investment individually from the view point of common management process. 展开更多
关键词 Common management process Model TQM Matrix Three Dimensional Unification Value Model Quality Assurance Quality Improvement Static Risk management Dynamic Risk management Investment management Project management
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Illegal logging in ASEAN:status,cause,impacts and management process
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作者 GUAN Zhi-ji GONG Pei-che 《Ecological Economy》 2016年第4期343-359,共17页
Illegal logging has become a serious problem in forest management in ASEAN. In the paper, the illegal logging status in ASEAN is introduced, and it is sure that Indonesia, Malaysia, Brunei, Laos, Myanmar and Cambodia ... Illegal logging has become a serious problem in forest management in ASEAN. In the paper, the illegal logging status in ASEAN is introduced, and it is sure that Indonesia, Malaysia, Brunei, Laos, Myanmar and Cambodia are production countries, Thailand and Vietnam are the processing countries, and Philippines, Singapore are consumer countries in the whole supply chain of illegal logging. As well, the trade flows of illegal forest products of ASEAN are checked, the cause of illegal logging and its producing impacts are assessed. To tackle illegal logging, one feasible way is to design ecological supply chain to supervise illegal logging process, and under the concept of ecological supply chain, the production countries, processing countries and consumer countries should take actions together. Non-ASEAN countries should improve border control, introduce public procurement policies, promote market-based instruments, and strengthen international cooperation. For ASEAN countries, they should establish cooperation mechanisms within the region, take a unified action, increase governance capacity and promote legality verification or sustainability certification. 展开更多
关键词 illegal logging STATUS management process
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Simulation Based Energy-resource Efficient Manufacturing Integrated with In-process Virtual Management 被引量:2
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作者 KATCHASUWANMANEE Kanet CHENG Kai BATEMAN Richard 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第6期1083-1089,共7页
As energy efficiency is one of the key essentials towards sustainability, the development of an energy-resource efficient manufacturing system is among the great challenges facing the current industry. Meanwhile, the ... As energy efficiency is one of the key essentials towards sustainability, the development of an energy-resource efficient manufacturing system is among the great challenges facing the current industry. Meanwhile, the availability of advanced technological innovation has created more complex manufacturing systems that involve a large variety of processes and machines serving different functions. To extend the limited knowledge on energy-efficient scheduling, the research presented in this paper attempts to model the production schedule at an operation process by considering the balance of energy consumption reduction in production, production work flow(productivity) and quality. An innovative systematic approach to manufacturing energy-resource efficiency is proposed with the virtual simulation as a predictive modelling enabler, which provides real-time manufacturing monitoring, virtual displays and decision-makings and consequentially an analytical and multidimensional correlation analysis on interdependent relationships among energy consumption, work flow and quality errors. The regression analysis results demonstrate positive relationships between the work flow and quality errors and the work flow and energy consumption. When production scheduling is controlled through optimization of work flow, quality errors and overall energy consumption, the energy-resource efficiency can be achieved in the production. Together,this proposed multidimensional modelling and analysis approach provides optimal conditions for the production scheduling at the manufacturing system by taking account of production quality, energy consumption and resource efficiency, which can lead to the key competitive advantages and sustainability of the system operations in the industry. 展开更多
关键词 energy-resource efficient manufacturing virtual manufacturing manufacturing simulation in-process virtual management
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Research on Risk Management of Cross-Sea Bridges Based on Analytic Hierarchy Process—Taking Hangzhou Bay Bridge as an Example
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作者 Wenxing Zhang 《World Journal of Engineering and Technology》 2021年第3期624-636,共13页
Tod</span><span style="white-space:normal;font-family:"">ay, as the process of urbanization is accelerating, the country </span><span style="white-space:normal;font-family... Tod</span><span style="white-space:normal;font-family:"">ay, as the process of urbanization is accelerating, the country </span><span style="white-space:normal;font-family:"">builds an extensive transportation network through bridges and roads, which facilitates the daily travel of the people and greatly promotes the development of the national economy. However, due to the cross-sea bridge spanning the bay, the overall scale, the complex construction environment, and the high technology </span><span style="white-space:normal;font-family:"">content, the objective existence of risk factors in the construction process ca</span><span style="white-space:normal;font-family:"">n</span><span style="white-space:normal;font-family:"">not be completely avoided. In the construction of cross-sea bridges, once a co</span><span style="white-space:normal;font-family:"">n</span><span style="white-space:normal;font-family:"">struction safety accident occurs, it will cause irreparable losses to the constr</span><span style="white-space:normal;font-family:"">uction of the project. Taking Hangzhou Bay Bridge as an actual case, using the </span><span style="white-space:normal;font-family:"">Analytic Hierarchy Process to identify possible risk factors during the life cy</span><span style="white-space:normal;font-family:"">cle of Hangzhou Bay Bridge, establish a corresponding risk evaluation system to </span><span style="white-space:normal;font-family:"">evaluate the importance and probability of risk, and to rank the importance o</span><span style="white-space:normal;font-family:"">f risks, and control the corresponding construction risks by adopting measures such as risk transfer and risk retention. The research example shows that the project risk of the cross-sea bridge project can be combined with the analytic hierarchy process to identify, analyze and evaluate the importance of the various risks faced by the project, so as to adopt corresponding avoidance methods to reduce the project risk loss and achieve the project construction expectations Target. 展开更多
关键词 Sea Bridge Analytic Hierarchy process Risk management
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Paperless, Optimized and Intelligent Business by Using Successful Business Process Management Concepts 被引量:1
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作者 Emir Zunic Almir Djedovic Bahira Zunic 《通讯和计算机(中英文版)》 2016年第5期234-243,共10页
关键词 业务流程管理 管理概念 无纸化 智能化 优化 文档管理系统 支付系统 企业管理
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Analytic Hierarchy Process for Technological Risks in the Process of Innovative Drug Development in China
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作者 Diao Yuanyuan Wu Zhiang 《Asian Journal of Social Pharmacy》 2024年第1期29-42,共14页
Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Method... Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided. 展开更多
关键词 innovative drug drug research and development risk management analytic hierarchy process WEIGHT
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Integration of Knowledge Processes into Management Systems
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作者 Zoltan Pasztory 《Journal of Energy and Power Engineering》 2019年第9期349-353,共5页
Understanding definitions and differences between the processes,knowledge processes and business processes is the first step of the integration of knowledge processes into management systems of an organization.The nex... Understanding definitions and differences between the processes,knowledge processes and business processes is the first step of the integration of knowledge processes into management systems of an organization.The next step is to understand throughout the company why the processes should be introduced and continuously maintained.The knowledge is one of the most valuable assets of the company,relevant part of the intellectual capital.The management of the knowledge and its lifecycle can give a market advantage for the organization.In the nuclear industry this is the vital requirement to maintain the safe and reliable operation of a nuclear facility,or radiation safety activates.Those companies who already implemented an integrated management system were following international standards,or good practices(like ISO 9001,EFQM,Standard Nuclear Performance Model developed by Nuclear Energy Institute(NEI)and others).This article focuses on nuclear industry organizations,approaches and methods,and how to integrate the knowledge processes into management system.This is the last step of the knowledge management implementation in an organization.When it was done,we can say that the knowledge processes are embedded into organization’s day-to-day life and the knowledge managed in the organization as all other resources. 展开更多
关键词 KNOWLEDGE knowledge management knowledge processes Integrated management System(IMS) COMPETENCY nuclear knowledge management nuclear industry
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