Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD pat...Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.展开更多
I returned to China from the United Kingdom in 1953, then worked in Purple Mountain Observatory. It was the early days of new China. The elder generation of astronomers was undertaking an effort of ＂repairing broken ...I returned to China from the United Kingdom in 1953, then worked in Purple Mountain Observatory. It was the early days of new China. The elder generation of astronomers was undertaking an effort of ＂repairing broken and filling defect＂ during those post-war years, and started planning and lay- ing the foundation of modern astronomy. Under their leadership, I started a journey of astronomy whose main task was construction. The journey has been full of twists and turns. As a result of the ＂Great Leap Forward＂ in 1958 and the 1966 launch of the decade-long ＂Cultural Revolution＂ period, the situation of construction in astronomy was similar to that in other sciences, suffering bad effects. Not until the ＂Reform and Opening up＂ period after those events was construction able to continue, and various disciplines and international connections began to open. A ＂passage＂ had gradually developed. In this new circumstance, I kept pursuing the pioneers to explore a forward direction. Looking back today, this journey has been three periods of a four generation relay. This article is divided into three sections that describe my research work in these times that I recall： （1） Looking back at the beginning of the return and tracing the footprints of the founders. （2） Recalling my radio astronomy tour. （3） Retrospection and expectation of LAMOST.展开更多
BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis an...BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.展开更多
Scientific journals usually mirror the development of a country or area in a specific period of time. With the transnational scientific communication model of today＇s world, the internationalization of scientific jou...Scientific journals usually mirror the development of a country or area in a specific period of time. With the transnational scientific communication model of today＇s world, the internationalization of scientific journals not only provides an avenue for researchers to attain their rights to receive and impart information and ideas openly and freely across a global platform, but the increased reach of such publications allows for a broader and stronger voice in regards to academic and scientific debates.展开更多
This paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading.In the model,the formulas that estimate a ship’s added resistance due to waves attacking from different heading ang...This paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading.In the model,the formulas that estimate a ship’s added resistance due to waves attacking from different heading angles have been further developed.A correction factor is proposed to consider the nonlinear effect due to large waves in power estimation.The formulas are developed and verified by model tests of 5 ships in regular waves with various heading angles.The full-scale measurements from three different types of ships,i.e.,a PCTC,a container ship,and a chemical tanker,are used to validate the proposed model for speed loss prediction in irregular waves.The effect of the improved model for speed loss prediction on a ship’s voyage optimization is also investigated.The results indicate that a ship’s voyage optimization solutions can be significantly affected by the prediction accuracy of speed loss caused by waves.展开更多
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there hav...BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there have been no specific studies on predicting long-term survival after TIPS placement.AIM To establish a model to predict long-term survival in patients with hepatitis cirrhosis after TIPS.METHODS A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS implantation.Through univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after TIPS.Consequently,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)level.Furthermore,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing models.RESULTS The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS placement.The NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation cohorts.Additionally,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients and guide follow-up management after TIPS implantation.展开更多
BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is limited.AIM To evaluate long-term outcomes after...BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is limited.AIM To evaluate long-term outcomes after endoscopic removal of malignant colorectal polyps.METHODS A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and 2020.Residual disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were invest-igated.Event rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were performed.Potential risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were enrolled.The proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,respectively.Tumor differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,respectively.Residual tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical resection.Univariate analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance examinations.Adverse outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance only.CONCLUSION Reporting of histological features and adherence to surveillance colonoscopy needs improvement.Long-term adverse outcome rates might be higher than previously reported,irrespective of whether secondary surgery was performed.展开更多
'Asahi Kasei China Fashion Designer Creative awards'2017 S/S collection Show was held in Beijing Hotel to announce the theme of the nineteenth award-winning designer Richard Li’s works show on the evening of ...'Asahi Kasei China Fashion Designer Creative awards'2017 S/S collection Show was held in Beijing Hotel to announce the theme of the nineteenth award-winning designer Richard Li’s works show on the evening of October 29,2016.This event is directly hosted by the China Fashion Week Organizing Committee,Asahi Kasei Corporation and Asahi Kasei Textile Corporation and Hong Kong Fashion Designers Association展开更多
Voyagers,the first and the only mission sent by human beings beyond the end of the solar wind,might be out of service in just several years.In the cosmos beyond 2025,very likely no artificial detector will be flying a...Voyagers,the first and the only mission sent by human beings beyond the end of the solar wind,might be out of service in just several years.In the cosmos beyond 2025,very likely no artificial detector will be flying at the outer brim of the solar system.The Interstellar Express,a mission proposed by CAS scientists,might come timely as a possible successor to fill in the gap.Unlike Voyagers,its detectors are expected to fly not only to the nose part of the heliosphere,but also the tail part and the altitude dimension.As planned in the shortterm stage of its three-step layout,the first two detectors will be launched by the end of 2025,if everything goes well.展开更多
文摘Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.
文摘I returned to China from the United Kingdom in 1953, then worked in Purple Mountain Observatory. It was the early days of new China. The elder generation of astronomers was undertaking an effort of ＂repairing broken and filling defect＂ during those post-war years, and started planning and lay- ing the foundation of modern astronomy. Under their leadership, I started a journey of astronomy whose main task was construction. The journey has been full of twists and turns. As a result of the ＂Great Leap Forward＂ in 1958 and the 1966 launch of the decade-long ＂Cultural Revolution＂ period, the situation of construction in astronomy was similar to that in other sciences, suffering bad effects. Not until the ＂Reform and Opening up＂ period after those events was construction able to continue, and various disciplines and international connections began to open. A ＂passage＂ had gradually developed. In this new circumstance, I kept pursuing the pioneers to explore a forward direction. Looking back today, this journey has been three periods of a four generation relay. This article is divided into three sections that describe my research work in these times that I recall： （1） Looking back at the beginning of the return and tracing the footprints of the founders. （2） Recalling my radio astronomy tour. （3） Retrospection and expectation of LAMOST.
基金Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-022 and No.2022-PUMCH-D-002CAMS Innovation Fund for Medical Sciences,No.2021-1-I2M-003+1 种基金Undergraduate Innovation Program,No.2023-zglc-06034National Key Clinical Specialty Construction Project,No.ZK108000。
文摘BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.
文摘Scientific journals usually mirror the development of a country or area in a specific period of time. With the transnational scientific communication model of today＇s world, the internationalization of scientific journals not only provides an avenue for researchers to attain their rights to receive and impart information and ideas openly and freely across a global platform, but the increased reach of such publications allows for a broader and stronger voice in regards to academic and scientific debates.
基金Open access funding provided by Chalmers University of Technology.The authors acknowledge the financial support from the European Commission(Horizon 2020)project EcoSail(Grant Number 820593)We are also grateful to the support from the Swedish Foundation for International Cooperation in Research and Higher Education(CH2016-6673)+1 种基金National Natural Science Foundation of China(NSFC-51779202)The second author thanks the funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie(Grant Number 754412)and VGR MoRE2020.
文摘This paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading.In the model,the formulas that estimate a ship’s added resistance due to waves attacking from different heading angles have been further developed.A correction factor is proposed to consider the nonlinear effect due to large waves in power estimation.The formulas are developed and verified by model tests of 5 ships in regular waves with various heading angles.The full-scale measurements from three different types of ships,i.e.,a PCTC,a container ship,and a chemical tanker,are used to validate the proposed model for speed loss prediction in irregular waves.The effect of the improved model for speed loss prediction on a ship’s voyage optimization is also investigated.The results indicate that a ship’s voyage optimization solutions can be significantly affected by the prediction accuracy of speed loss caused by waves.
基金Supported by the Talent Training Plan during the"14th Five-Year Plan"period of Beijing Shijitan Hospital Affiliated to Capital Medical University,No.2023LJRCLFQ.
文摘BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ascites.However,there have been no specific studies on predicting long-term survival after TIPS placement.AIM To establish a model to predict long-term survival in patients with hepatitis cirrhosis after TIPS.METHODS A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS implantation.Through univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after TIPS.Consequently,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)level.Furthermore,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing models.RESULTS The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS placement.The NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation cohorts.Additionally,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients and guide follow-up management after TIPS implantation.
基金Supported by the New National Excellence Program of the Ministry for Innovation and Technology From the Source of the National Research,Development and Innovation Fund,No.ÚNKP-22-4-SZTE-296,No.ÚNKP-23-3-SZTE-268,and No.ÚNKP-23-5-SZTE-719the EU’s Horizon 2020 Research and Innovation Program under Grant Agreement,No.739593.
文摘BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is limited.AIM To evaluate long-term outcomes after endoscopic removal of malignant colorectal polyps.METHODS A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and 2020.Residual disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were invest-igated.Event rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were performed.Potential risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were enrolled.The proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,respectively.Tumor differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,respectively.Residual tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical resection.Univariate analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance examinations.Adverse outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance only.CONCLUSION Reporting of histological features and adherence to surveillance colonoscopy needs improvement.Long-term adverse outcome rates might be higher than previously reported,irrespective of whether secondary surgery was performed.
文摘'Asahi Kasei China Fashion Designer Creative awards'2017 S/S collection Show was held in Beijing Hotel to announce the theme of the nineteenth award-winning designer Richard Li’s works show on the evening of October 29,2016.This event is directly hosted by the China Fashion Week Organizing Committee,Asahi Kasei Corporation and Asahi Kasei Textile Corporation and Hong Kong Fashion Designers Association
文摘Voyagers,the first and the only mission sent by human beings beyond the end of the solar wind,might be out of service in just several years.In the cosmos beyond 2025,very likely no artificial detector will be flying at the outer brim of the solar system.The Interstellar Express,a mission proposed by CAS scientists,might come timely as a possible successor to fill in the gap.Unlike Voyagers,its detectors are expected to fly not only to the nose part of the heliosphere,but also the tail part and the altitude dimension.As planned in the shortterm stage of its three-step layout,the first two detectors will be launched by the end of 2025,if everything goes well.
