A novel EVA/unmodified nano-magnesium hydroxide （NMH）/silicone rubber ternary nanocomposite was prepared by using a special compound flame retardant of NMH and silicone rubber （CFR）. The flammability of the ternar...A novel EVA/unmodified nano-magnesium hydroxide （NMH）/silicone rubber ternary nanocomposite was prepared by using a special compound flame retardant of NMH and silicone rubber （CFR）. The flammability of the ternary composite was studied by cone calorimeter test （CCT）. Synergistic effect on flame retardancy was found between silicone rubber and NMH. EVA/CFR ternary nanocomposite showed the lowest peak heat release rate （PHRR） and mass loss rate （MLR） among the samples of virgin EVA, EVA composites. The synergistic flame retardancy of silicone rubber and NMH in EVA system is attributed to the enhanced char layers in the condensed phase that prevents the heat and mass transfer in the fire.展开更多
Macrophages play a vital role for guiding the fate of osteogenesisrelated cells.It is well known that nano-topography and bioactive ions can directly enhance osteogenic behavior.However,the effects of nano-structure c...Macrophages play a vital role for guiding the fate of osteogenesisrelated cells.It is well known that nano-topography and bioactive ions can directly enhance osteogenic behavior.However,the effects of nano-structure combined with bioactive ions release on macrophage polarization and the following osteogenesis and angiogenesis are rarely reported.Herein,Mg(OH)_(2)films with nano-sheet structures were constructed on the surface of Ti using hydrothermal treatment.The film presented nanosheet topography and sustained release of Mg ions.The results of in vitro culture of bone marrow-derived macrophages(BMDMs),including PCR,western blot and flow cytometry suggested that the nano-Mg(OH)_(2)films were more favorable for macrophages polarizing to tissue healing M2 phenotype.Moreover,air-pouch model confirmed that the nano-Mg(OH)_(2)film coated Ti would induce milder inflammation and thinner fibrous layer in vivo,compared with untreated Ti.Furthermore,macrophages-conditioned culture mediums were collected from nano-Mg(OH)_(2)coated Ti group was superior for the osteogenic behaviors of mice bone marrow stem cells and the angiogenic behaviors of human umbilical vein endothelial cells.With harmonious early inflammatory response and subsequently improved osteogenesis and angiogenesis,the nano-Mg(OH)_(2)coated Ti is promising for orthopedic applications.展开更多
基金This work was subsidized by the Special Funds for Major State Basic Research Projects(No.2005CB623800).
文摘A novel EVA/unmodified nano-magnesium hydroxide （NMH）/silicone rubber ternary nanocomposite was prepared by using a special compound flame retardant of NMH and silicone rubber （CFR）. The flammability of the ternary composite was studied by cone calorimeter test （CCT）. Synergistic effect on flame retardancy was found between silicone rubber and NMH. EVA/CFR ternary nanocomposite showed the lowest peak heat release rate （PHRR） and mass loss rate （MLR） among the samples of virgin EVA, EVA composites. The synergistic flame retardancy of silicone rubber and NMH in EVA system is attributed to the enhanced char layers in the condensed phase that prevents the heat and mass transfer in the fire.
基金supported by the National Natural Science Foundation of China(52001076)the Scientific and Technological Projects of Guangzhou,China(202102020431)+1 种基金the NSFC Incubation Project of Guangdong Provincial People’s Hospital(KY0120220044)the Guangdong Basic and Applied Basic Research Foundation(2021A1515110135).
文摘Macrophages play a vital role for guiding the fate of osteogenesisrelated cells.It is well known that nano-topography and bioactive ions can directly enhance osteogenic behavior.However,the effects of nano-structure combined with bioactive ions release on macrophage polarization and the following osteogenesis and angiogenesis are rarely reported.Herein,Mg(OH)_(2)films with nano-sheet structures were constructed on the surface of Ti using hydrothermal treatment.The film presented nanosheet topography and sustained release of Mg ions.The results of in vitro culture of bone marrow-derived macrophages(BMDMs),including PCR,western blot and flow cytometry suggested that the nano-Mg(OH)_(2)films were more favorable for macrophages polarizing to tissue healing M2 phenotype.Moreover,air-pouch model confirmed that the nano-Mg(OH)_(2)film coated Ti would induce milder inflammation and thinner fibrous layer in vivo,compared with untreated Ti.Furthermore,macrophages-conditioned culture mediums were collected from nano-Mg(OH)_(2)coated Ti group was superior for the osteogenic behaviors of mice bone marrow stem cells and the angiogenic behaviors of human umbilical vein endothelial cells.With harmonious early inflammatory response and subsequently improved osteogenesis and angiogenesis,the nano-Mg(OH)_(2)coated Ti is promising for orthopedic applications.
