This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the...This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the MCNPX code for analysing neutron behavior and the PARET/ANL code for understanding power variations, to get a clearer picture of the reactor’s performance. The analysis covers the initial six years of GHARR-1’s operation and includes projections for its whole 60-year lifespan. We closely observed the patterns of both the highest and average PPFs at 21 axial nodes, with measurements taken every ten years. The findings of this study reveal important patterns in power distribution within the core, which are essential for improving the safety regulations and fuel management techniques of the reactor. We provide a meticulous approach, extensive data, and an analysis of the findings, highlighting the significance of continuous monitoring and analysis for proactive management of nuclear reactors. The findings of this study not only enhance our comprehension of nuclear reactor safety but also carry significant ramifications for sustainable energy progress in Ghana and the wider global context. Nuclear engineering is essential in tackling global concerns, such as the demand for clean and dependable energy sources. Research on optimising nuclear reactors, particularly in terms of safety and efficiency, is crucial for the ongoing advancement and acceptance of nuclear energy.展开更多
Oral submucous fibrosis （OSF） is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major ae...Oral submucous fibrosis （OSF） is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation （LPLI） has been reported to be beneficial in fibrosis prevention in different damaged organs. The aim of this study was to investigate the potential therapeutic effects of LPLI on arecoline-induced fibrosis. Arecoline- stimulated human gingival fibroblasts （HGFs） were treated with or without LPLI. The expression levels of the fibrotic marker genes alpha-smooth muscle actin （a-SMA） and connective tissue growth factor （CTGF/CCN2） were analysed by quantitative real- time reverse transcription polymerase chain reaction （RT-PCR） and western blots. In addition, the transcriptional activity of CCN2 was further determined by a reporter assay. The results indicated that arecoline increased the messenger RNA and protein expression of CCN2 and a-SMA in HGF. Interestingly, both LPLI and forskolin, an adenylyl cyclase activator, reduced the expression of arecoline-mediated fibrotic marker genes and inhibited the transcriptional activity of CCN2. Moreover, pretreatment with SQ22536, an adenylyl cyclase inhibitor, blocked LPLI＇s inhibition of the expression of arecoline-mediated fibrotic marker genes. Our data suggest that LPLI may inhibit the expression of arecoline-mediated fibrotic marker genes via the cAMP signalling pathway.展开更多
LoRa(Long Range radio)系统在当前不断发展的低功率广域网(LPWAN)中处于相对领先地位。它的MAC层采用的是基于ALOHA的接入协议。该接入机制虽然简单易实现,但同时也容易加剧冲突和碰撞的发生,降低整个系统的通信性能。因此,需要研究多...LoRa(Long Range radio)系统在当前不断发展的低功率广域网(LPWAN)中处于相对领先地位。它的MAC层采用的是基于ALOHA的接入协议。该接入机制虽然简单易实现,但同时也容易加剧冲突和碰撞的发生,降低整个系统的通信性能。因此,需要研究多个终端同时占用信道资源时的相互干扰情况,而LoRa信号的扩频因子(SF)将决定信号的通信覆盖范围。因此,分析了干扰信号的SF与发送信号的SF相同以及不同时,干扰信号对发送信号解调性能的影响。实验结果表明,相同SF信号间的干扰影响相对较大,而干扰信号使用的SF与发送信号不同时,干扰的影响相对较小。通过理论分析,获得了接收端正确解调时所要求的信干比(SIR)。可见,不同SF的LoRa信号可看作伪正交。展开更多
文摘This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the MCNPX code for analysing neutron behavior and the PARET/ANL code for understanding power variations, to get a clearer picture of the reactor’s performance. The analysis covers the initial six years of GHARR-1’s operation and includes projections for its whole 60-year lifespan. We closely observed the patterns of both the highest and average PPFs at 21 axial nodes, with measurements taken every ten years. The findings of this study reveal important patterns in power distribution within the core, which are essential for improving the safety regulations and fuel management techniques of the reactor. We provide a meticulous approach, extensive data, and an analysis of the findings, highlighting the significance of continuous monitoring and analysis for proactive management of nuclear reactors. The findings of this study not only enhance our comprehension of nuclear reactor safety but also carry significant ramifications for sustainable energy progress in Ghana and the wider global context. Nuclear engineering is essential in tackling global concerns, such as the demand for clean and dependable energy sources. Research on optimising nuclear reactors, particularly in terms of safety and efficiency, is crucial for the ongoing advancement and acceptance of nuclear energy.
基金supported by the Kaohsiung Municipal Ta-Tung Hospital(grant kmtth-102-010)the Kaohsiung Medical University in Taiwan under the grant“Aim for the Top Universities Grant”(KMU-TP103B08)
文摘Oral submucous fibrosis （OSF） is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation （LPLI） has been reported to be beneficial in fibrosis prevention in different damaged organs. The aim of this study was to investigate the potential therapeutic effects of LPLI on arecoline-induced fibrosis. Arecoline- stimulated human gingival fibroblasts （HGFs） were treated with or without LPLI. The expression levels of the fibrotic marker genes alpha-smooth muscle actin （a-SMA） and connective tissue growth factor （CTGF/CCN2） were analysed by quantitative real- time reverse transcription polymerase chain reaction （RT-PCR） and western blots. In addition, the transcriptional activity of CCN2 was further determined by a reporter assay. The results indicated that arecoline increased the messenger RNA and protein expression of CCN2 and a-SMA in HGF. Interestingly, both LPLI and forskolin, an adenylyl cyclase activator, reduced the expression of arecoline-mediated fibrotic marker genes and inhibited the transcriptional activity of CCN2. Moreover, pretreatment with SQ22536, an adenylyl cyclase inhibitor, blocked LPLI＇s inhibition of the expression of arecoline-mediated fibrotic marker genes. Our data suggest that LPLI may inhibit the expression of arecoline-mediated fibrotic marker genes via the cAMP signalling pathway.
文摘LoRa(Long Range radio)系统在当前不断发展的低功率广域网(LPWAN)中处于相对领先地位。它的MAC层采用的是基于ALOHA的接入协议。该接入机制虽然简单易实现,但同时也容易加剧冲突和碰撞的发生,降低整个系统的通信性能。因此,需要研究多个终端同时占用信道资源时的相互干扰情况,而LoRa信号的扩频因子(SF)将决定信号的通信覆盖范围。因此,分析了干扰信号的SF与发送信号的SF相同以及不同时,干扰信号对发送信号解调性能的影响。实验结果表明,相同SF信号间的干扰影响相对较大,而干扰信号使用的SF与发送信号不同时,干扰的影响相对较小。通过理论分析,获得了接收端正确解调时所要求的信干比(SIR)。可见,不同SF的LoRa信号可看作伪正交。
