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China's low-carbon competitiveness and its effect decomposition from the perspective of wellbeing performance of ecological input
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作者 LIU Guo-ping NIE Feng 《Ecological Economy》 2023年第3期202-216,共15页
From the perspective of wellbeing performance of ecological input,this paper constructs a low-carbon competitiveness evaluation model with wellbeing performance of carbon emissions as the measurement standard,and uses... From the perspective of wellbeing performance of ecological input,this paper constructs a low-carbon competitiveness evaluation model with wellbeing performance of carbon emissions as the measurement standard,and uses the LMDI factor decomposition method to decompose the total effect of low-carbon competitiveness changes into technology effect and service effect.And then it conducts positive analysis and comparison of the low-carbon competitiveness and its effect contribution of G20 countries from1990 to 2018.The results are as follows:Firstly,in 2018,the UK,France,Argentina,Brazil,and Germany had higher low-carbon competitiveness.From 1990 to 2018,the low-carbon competitiveness of the UK,Turkey,Germany,Italy,and Brazil increase rapidly.Secondly,from 1990 to 2018,the total effect of low-carbon competitiveness of G20 member states was all positive,that is to say,the overall wellbeing performance of carbon emissions increased,technology effect and service effect are positive in 17 countries and negative in 2 countries respectively.Thirdly,China's low-carbon competitiveness is low,lacking static and dynamic advantages,although the technology effect is the highest,but the service effect is the lowest,resulting in a low total effect,which indicates that the wellbeing performance of economic growth is the main bottleneck of China's low-carbon development.Finally,the policy recommendations for China's future low-carbon transition and sustainable development are put forward. 展开更多
关键词 wellbeing performance of ecological input low-carbon competitiveness factor decomposition
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Enhancement of Competitiveness of Border Trade Entrepreneurs: Case Study of Su-Ngai Kolok Checkpoint, Narathiwat Province
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作者 Sumalee Grodgangunt Roihan Saaree +2 位作者 Chonlakan Satabodee Rungsiri Padungrat Mathurose Tongintharach 《Management Studies》 2024年第4期225-244,共20页
This research aimed to analyze the enhancement of competitiveness among fruit and vegetable export entrepreneurs,with the case study of the Su-ngai Kolok checkpoint in Narathiwat Province.This research focused on thre... This research aimed to analyze the enhancement of competitiveness among fruit and vegetable export entrepreneurs,with the case study of the Su-ngai Kolok checkpoint in Narathiwat Province.This research focused on three objectives:(1)examining how competitiveness is enhanced through government support and the development of border trade zones,(2)studying the supply chain dynamics,including strategic factors and opportunities in agricultural product management,and(3)developing a model for border trade to strengthen exporters’capabilities.The research employed qualitative methods,with data collected from 25 informants through interviews and employed descriptive methods.The research results revealed that:(1)government agencies play a crucial role in improving competitiveness by developing border economic zones and trade policies;additionally,(2)the research highlighted the importance of strategic partnerships,network building,and efficient logistics along the value chain;(3)the proposed Border Trade Model includes elements for instance government policy,partnerships,entrepreneurial potential,and transportation channels,aiming to enhance the overall efficiency and effectiveness of vegetable and fruit exporters in the region. 展开更多
关键词 ENHANCEMENT competitiveness border trade entrepreneurs
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Impact of coupling coordination development of port and city environments on urban economic competitiveness:Evidence from the coastal port cities in eastern China
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作者 LI Zhen-qiang YI Ying +2 位作者 LI Jia-li YOU Xiao-yue ZHOU Qiu-yang 《Ecological Economy》 2024年第1期53-71,共19页
Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern Ch... Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern China from 2000 to 2018,this study explores the coupling coordination development of port and city environments and its impact on urban economic competitiveness by constructing the coupling coordination degree model and the panel threshold model.The research results show that:(1)In terms of the coupling coordination development of port and city environments,most coastal ports and their hinterland cities are in a state of moderate or serious disorder.Overall,the degree of coupling coordination of port and city environments needs to be further improved;(2)The coupling coordination degree of port and city environments has a significant impact on urban economic competitiveness,and this effect gradually increases with the development of the ports and the urban economy.Among the variables that impact the urban economic competitiveness,fixed assets investment and foreign trade are significant factors that can enhance urban economic competitiveness.(3)At present,there is a“U-shaped”relationship between the coupling coordination degree of port-city environments and the urban economic competitiveness.This relationship lies on the right side of the inflection point of the“U-shaped”curve.Therefore,following the concept of assigning priority to ecological development,expanding fixed assets investment and actively developing foreign trade can further enhance the urban economic competitiveness. 展开更多
关键词 coastal ports city environments coupling coordination degree urban economic competitiveness threshold effect
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Export Competitiveness and Sustainable Development of the Ukrainian Timber Industry
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作者 Anastasiia Shapiro 《Open Journal of Applied Sciences》 2024年第10期2777-2789,共13页
This paper conducts a comprehensive analysis of the export dynamics within the Ukrainian timber industry, emphasizing its pivotal role in the national economy. The study begins by outlining the research objectives, co... This paper conducts a comprehensive analysis of the export dynamics within the Ukrainian timber industry, emphasizing its pivotal role in the national economy. The study begins by outlining the research objectives, context, and innovative methodologies, setting the stage for a deep dive into the theoretical underpinnings of sustainable and competitive trade. It explores Ukraine’s rich forest biodiversity across varied vegetation zones and its geopolitical significance. Detailed evaluations of forest resource management, policy frameworks, and institutional support form the core of the analysis. Challenges such as imbalanced export structures and legal inconsistencies are critically examined. The research employs trade gravity models and competitive indicators like the Revealed Comparative Advantage (RCA) and Market Share (MS) to assess factors influencing exports and to forecast potential growth areas. The findings inform strategic recommendations aimed at enhancing export capacity through market diversification, brand development, and legal stability. The conclusion highlights the need for strategic interventions to harness Ukraine’s timber resources sustainably, balancing economic gains with environmental stewardship. 展开更多
关键词 Ukrainian Timber Industry Export Dynamics Export competitiveness Sustainable Trade Forest Resource Management
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Core Competitiveness Construction of Clothing Brands in Low-Carbon Economy
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作者 金玲 刘晓刚 《Journal of Donghua University(English Edition)》 CAS 2023年第3期319-325,共7页
The climate issue has become an environmental concern for all sectors of the world and the low-carbon economy has thus become a new economic development model to combat climate change.With the development of low-carbo... The climate issue has become an environmental concern for all sectors of the world and the low-carbon economy has thus become a new economic development model to combat climate change.With the development of low-carbon economy era,the textile and clothing industry plays an important role in stabilizing the development of low-carbon economy and society,and China has put forward the development requirements of low-carbon transformation for the textile and clothing industry,and also it has an important strategic value to promote the high-quality development of low-carbon economy and society,and the construction of brands’ core competitiveness is an inevitable choice for clothing brands in the face of the new form of international competition.As a result,the evaluation indicator of clothing brands’ core competitiveness in the low-carbon economy is used to measure the core competitiveness of clothing brands.Based on the corresponding verification results obtained by analytic hierarchy process(AHP) analysis,it can guide the low-carbon development of the clothing industry,thus proposing a more reasonable way to build the core competitiveness of clothing brands.It can promote the low-carbon transformation and upgrading of the clothing industry,effectively increase the market share of clothing brands,and promote the high-quality development of clothing brands. 展开更多
关键词 low-carbon clothing brand competitiveness CONSTRUCTION
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Competitive oxidation behavior of Ni-based superalloy GH4738 at extreme temperature 被引量:3
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作者 Hui Xu Shufeng Yang +4 位作者 Enhui Wang Yunsong Liu Chunyu Guo Xinmei Hou Yanling Zhang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CSCD 2024年第1期138-145,共8页
A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isotherm... A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted. 展开更多
关键词 Ni-based superalloy GH4738 extreme temperature competitive oxidation oxidation mechanism oxidation kinetics
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Forge ahead and improve the core competitiveness of Animal Models and Experimental Medicine(AMEM)
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作者 Jian-Dong Jiang 《Animal Models and Experimental Medicine》 CAS CSCD 2023年第1期2-2,共1页
After 5 years of accumulation, Animal Models and Experimental Medicine(AMEM) has received 396 manuscripts from 46 countries and regions, including Chinese mainland, Iran, the United States, India, Israel, Nigeria, Bra... After 5 years of accumulation, Animal Models and Experimental Medicine(AMEM) has received 396 manuscripts from 46 countries and regions, including Chinese mainland, Iran, the United States, India, Israel, Nigeria, Brazil, Bangladesh, Sri Lanka, the Netherlands, Denmark, Australia, Japan, and Spain. It has become an important international exchange and display platform for innovative research results in the field of laboratory animal science and basic medicine. 展开更多
关键词 competitiveness MAINLAND Israel
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Effect of Bt traits on transgenic rice's growth and weed competitiveness
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作者 WANG Kang-xu ZHANG Ke-rou +1 位作者 CAO Cou-gui JIANG Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第8期2346-2358,共13页
Transgene escape could lead to genetically modified rice establishing wild populations in the natural environment and competing for survival space with weeds.However,whether the expression of the Bacillus thuringiensi... Transgene escape could lead to genetically modified rice establishing wild populations in the natural environment and competing for survival space with weeds.However,whether the expression of the Bacillus thuringiensis(Bt)gene in rice will alter the relationship between transgene plants and weeds and induce undesirable environmental consequences are poorly understood.Thus,field experiments were conducted to investigate the weed competitiveness and assess the ecological risk of transgenic Bt rice under herbicide-free and lepidopterous pest-controlled environments.Results showed that weed–rice competition in the direct-sowing(DS)field was earlier and more severe than that in the transplanting(TP)field,which resulted in a significant decrease in biomass and yield in DS.However,conventional Bt and non-Bt rice yield was not significantly different.The weed number,weed coverage ratio,and weed diversity of conventional Bt rice were significantly higher than those of non-Bt rice at the early growth and mature stages,especially in DS plots,suggesting that Bt traits did not increase the weed competitiveness of transgenic rice and had no negative effect on weed diversity.Grain yield and weed number varied between different hybrid rice lines,but those differences were insignificant between Bt and non-Bt rice.The number of insects increased with the increase of weeds in hybrid rice plots,whereas the insect number and diversity did not display a significant difference between Bt and non-Bt rice.Therefore,the ecological risk of transgenic Bt rice is comparable to non-Bt rice. 展开更多
关键词 BIOSAFETY field evaluation genetically modified crops Oryza sativa weed competitiveness
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Comparative Analysis of Rice Export Competitiveness in Heilongjiang Province of China Based on Index Method
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作者 Min LU Yafei GUO 《Asian Agricultural Research》 2023年第6期14-20,共7页
Based on the analysis of rice planting and export development in Heilongjiang Province in 2013-2021,this paper comprehensively used three export competitiveness analysis methods,namely,trade competitiveness index,reve... Based on the analysis of rice planting and export development in Heilongjiang Province in 2013-2021,this paper comprehensively used three export competitiveness analysis methods,namely,trade competitiveness index,revealed comparative advantage(RCA)analysis and international market share analysis,to compare the four major rice exporters in the world and the three major rice export provinces and cities in China.Besides,it evaluated the rice export competitiveness of Heilongjiang Province from multiple perspectives.It analyzed the reasons for low competitiveness in terms of export product structure,export market structure,production and processing technology,and brand building.Finally,it is recommended to clarify the positioning of rice export quality and take more measures to ensure product quality;improve the level of industrialization of rice production and processing,and extend the rice industry chain;develop diversified rice export markets and improve export flexibility;adhere to the principle of"opening the door and going out",expand the international popularity of high-quality brands,so as to enhance the rice export competitiveness of Heilongjiang Province. 展开更多
关键词 RICE Export competitiveness Trade competitiveness index Revealed comparative advantage(RCA)analysis International market share analysis
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Determinates of the competitiveness of provincial forest health care industry in China
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作者 LIU Fang ZOU Zai-jin 《Ecological Economy》 2023年第4期344-358,共15页
Due to the late start of China’s forest health industry,related research is lagging behind,which results in the inability to propose a corresponding path to enhance competitiveness.Based on this,the evaluation index ... Due to the late start of China’s forest health industry,related research is lagging behind,which results in the inability to propose a corresponding path to enhance competitiveness.Based on this,the evaluation index system of provincial forest health industry competitiveness was constructed by using the Porter diamond model,and the Entropy-TOPSIS model is used to evaluate the competitiveness of China’s provincial forest health industry,and the key influencing factors of the forest health industry competitiveness are identified by using the grey correlation analysis method,and the specific promotion path was designed.The empirical results show that the grey correlation degree between related and supporting industries and the competitiveness score of the forest health industry is the highest,which confirms that it is the key influencing factor of the competitiveness of the forest health industry.Therefore,government departments should vigorously promote the integration of cultural tourism,medical care,pension and other related industries with the forest health care industry;enterprises should strengthen the construction of forest health infrastr ucture and supporting facilities to improve the level of forest health services. 展开更多
关键词 industrial competitiveness forest health influencing factors promotion path
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Competitive effect, but not competitive response, varies along a climatic gradient depending on tree species identity
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作者 Teresa Valor Lluís Coll +9 位作者 David I.Forrester Hans Pretzsch Miren del Río Kamil Bielak Bogdan Brzeziecki Franz Binder Torben Hilmers Zuzana Sitková Roberto Tognetti Aitor Ameztegui 《Forest Ecosystems》 SCIE CSCD 2024年第2期142-151,共10页
Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerni... Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic gradient.Methods: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to climate.Likelihood methods and information theory were used to select the best model.Results: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their maximum.Conclusions: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of the target tree to competition. The modelling approach should be useful in future research to expand our knowledge of how competition modulates forest communities across environmental gradients. 展开更多
关键词 competition coefficient competition reduction Interspecific competition Intraspecific competition Mixing effects Mixed species forest Neighbourhood models Plant-plant interactions
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Feasibility of Scaling up the Cost-Competitive and Clean Electrolytic Hydrogen Supply in China
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作者 Guangsheng Pan Wei Gu +4 位作者 Zhongfan Gu Jin Lin Suyang Zhou Zhi Wu Shuai Lu 《Engineering》 SCIE EI CAS CSCD 2024年第8期154-165,共12页
Scaling up clean hydrogen supply in the near future is critical to achieving China’s hydrogen development target.This study established an electrolytic hydrogen development mechanism considering the generation mix an... Scaling up clean hydrogen supply in the near future is critical to achieving China’s hydrogen development target.This study established an electrolytic hydrogen development mechanism considering the generation mix and operation optimization of power systems with access to hydrogen.Based on the incremental cost principle,we quantified the provincial and national clean hydrogen production cost performance levels in 2030.The results indicated that this mechanism could effectively reduce the production cost of clean hydrogen in most provinces,with a national average value of less than 2 USD·kg^(-1) at the 40-megaton hydrogen supply scale.Provincial cooperation via power transmission lines could further reduce the production cost to 1.72 USD·kg^(-1).However,performance is affected by the potential distribution of hydrogen demand.From the supply side,competitiveness of the mechanism is limited to clean hydrogen production,while from the demand side,it could help electrolytic hydrogen fulfil a more significant role.This study could provide a solution for the ambitious development of renewables and the hydrogen economy in China. 展开更多
关键词 low-carbon energy system Electrolytic hydrogen RENEWABLES Cost optimization and analysis
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Live-streaming selling strategies for competitive firms
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作者 Quan Du Zhixin Chen +1 位作者 Jie Wu Xiang Ji 《中国科学技术大学学报》 CAS CSCD 北大核心 2024年第5期22-35,I0006,I0007,共16页
The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have appli... The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have applied analytical models to explore live-streaming strategies for firms in different scenarios.However,the previous literature mainly considers monopolists,while in the real world,competition is not rare.To fill this gap between the literature and practical observations,this paper applies a game theoretical model to study live-streaming adoption and pricing strategy for firms under competitive environments.The results show that,for competitive firms,the equilibrium strategy depends on the relation between the commission rate and the intensity of the market expansion effect.Additionally,compared to the case in which no firm adopts live-streaming,competitive firms do not always benefit from the adoption of live-streaming selling.The paper also shows that competition plays a negative role in inducing a firm to adopt live-streaming. 展开更多
关键词 live-streaming commerce live-streaming strategy game competitION
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Optimal Control for Age Distribution and Weighted Size Competitive Species in a Polluted Environment
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作者 WANG Zhanping 《应用数学》 北大核心 2024年第4期1014-1026,共13页
In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to ob... In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to obtain the existence and uniqueness exhibited by a non-negative solution of above mentioned model.A maximum principle helps to carefully verify the existence of the optimal control policy,and tangent-normal cone techniques help to obtain the optimal condition specific to control issue. 展开更多
关键词 Optimal control competitive species POLLUTION Maximum principle
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Countermeasures to Improve the Competitiveness of Medicine Circulation Enterprises in China under the New Situation
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作者 Chen Huasheng Dong Li 《Asian Journal of Social Pharmacy》 2023年第1期71-77,共7页
Objective To analyze the current situation of medicine circulation enterprises and summarize the influence of frequently introduced industry policies on the pharmaceutical field,so as to provide suggestions on improvi... Objective To analyze the current situation of medicine circulation enterprises and summarize the influence of frequently introduced industry policies on the pharmaceutical field,so as to provide suggestions on improving the competitiveness and maintaining sustainable development of medicine circulation enterprises in China.Methods Industry policy analysis,literature inquiry,expert interview and questionnaire survey were used to study the challenges that medicine circulation faced under the new situation.Then,the key indexes were found out to improve its competitiveness.Results and Conclusion Through the analysis of the current situation of the industry,policy orientation and market demand,some suggestions are put forward for related enterprises to improve their competitiveness. 展开更多
关键词 medicine circulation competitiveness POLICY key evaluation index
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Weight Analysis of the Influencing Factors of Homestay Competitiveness in Rural Guangzhou,China
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作者 Yujia Niu Cheok Mui Yee Benjamin Chan Yin-Fah 《Journal of Architectural Research and Development》 2023年第2期40-52,共13页
At present,Guangzhou homestay industry is facing a bottleneck.Therefore,it is particularly important to analyze the factors that influence the competitiveness of rural homestays in Guangzhou,determine the evaluation s... At present,Guangzhou homestay industry is facing a bottleneck.Therefore,it is particularly important to analyze the factors that influence the competitiveness of rural homestays in Guangzhou,determine the evaluation system of competitiveness,and determine the weight of each factor.Based on Porter’s diamond theory,this paper analyzes and summarizes the influencing factors of homestay competitiveness,and divides the influencing factors into 5 primary factors and 34 secondary factors.The analytic hierarchy process(AHP)was used to determine the judgment matrix to form the weight results of each factor,and the results show that product characteristics account for the largest proportion among first level factors.Secondary factors such as theme creativity,personalized brand and the overall score account for a large proportion.The research results can act as a reference for the construction of competitiveness evaluation mechanism and model of local rural quality homestays. 展开更多
关键词 Homestay competitiveness Influencing factors Weight analysis
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CRB:A new rumor blocking algorithm in online social networks based on competitive spreading model and influence maximization
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作者 董晨 徐桂琼 孟蕾 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期588-604,共17页
The virtuality and openness of online social platforms make networks a hotbed for the rapid propagation of various rumors.In order to block the outbreak of rumor,one of the most effective containment measures is sprea... The virtuality and openness of online social platforms make networks a hotbed for the rapid propagation of various rumors.In order to block the outbreak of rumor,one of the most effective containment measures is spreading positive information to counterbalance the diffusion of rumor.The spreading mechanism of rumors and effective suppression strategies are significant and challenging research issues.Firstly,in order to simulate the dissemination of multiple types of information,we propose a competitive linear threshold model with state transition(CLTST)to describe the spreading process of rumor and anti-rumor in the same network.Subsequently,we put forward a community-based rumor blocking(CRB)algorithm based on influence maximization theory in social networks.Its crucial step is to identify a set of influential seeds that propagate anti-rumor information to other nodes,which includes community detection,selection of candidate anti-rumor seeds and generation of anti-rumor seed set.Under the CLTST model,the CRB algorithm has been compared with six state-of-the-art algorithms on nine online social networks to verify the performance.Experimental results show that the proposed model can better reflect the process of rumor propagation,and review the propagation mechanism of rumor and anti-rumor in online social networks.Moreover,the proposed CRB algorithm has better performance in weakening the rumor dissemination ability,which can select anti-rumor seeds in networks more accurately and achieve better performance in influence spread,sensitivity analysis,seeds distribution and running time. 展开更多
关键词 online social networks rumor blocking competitive linear threshold model influence maximization
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Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma
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作者 Yong Pan Yi-Ru Zhang +4 位作者 Ling-Yun Wang Li-Na Wu Ying-Qiu Ma Zhou Fang Shi-Bo Li 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1514-1531,共18页
BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepat... BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC. 展开更多
关键词 Hepatocellular carcinoma competitive endogenous RNA Molecular mechanism Prognosis Biomarker
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A Cooperated Imperialist Competitive Algorithm for Unrelated Parallel Batch Machine Scheduling Problem
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作者 Deming Lei Heen Li 《Computers, Materials & Continua》 SCIE EI 2024年第5期1855-1874,共20页
This study focuses on the scheduling problem of unrelated parallel batch processing machines(BPM)with release times,a scenario derived from the moulding process in a foundry.In this process,a batch is initially formed... This study focuses on the scheduling problem of unrelated parallel batch processing machines(BPM)with release times,a scenario derived from the moulding process in a foundry.In this process,a batch is initially formed,placed in a sandbox,and then the sandbox is positioned on a BPM formoulding.The complexity of the scheduling problem increases due to the consideration of BPM capacity and sandbox volume.To minimize the makespan,a new cooperated imperialist competitive algorithm(CICA)is introduced.In CICA,the number of empires is not a parameter,and four empires aremaintained throughout the search process.Two types of assimilations are achieved:The strongest and weakest empires cooperate in their assimilation,while the remaining two empires,having a close normalization total cost,combine in their assimilation.A new form of imperialist competition is proposed to prevent insufficient competition,and the unique features of the problem are effectively utilized.Computational experiments are conducted across several instances,and a significant amount of experimental results show that the newstrategies of CICAare effective,indicating promising advantages for the considered BPMscheduling problems. 展开更多
关键词 Release time ASSIMILATION imperialist competitive algorithm batch processing machines scheduling
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Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis
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作者 Joseph Edwin Kanu Jonathan Soldera 《World Journal of Gastroenterology》 SCIE CAS 2024年第9期1213-1223,共11页
BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating... BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating H.pylori is crucial for treating and preventing these conditions.While conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression therapies.Potassium competitive acid blocker(P-CAB)triple and dual therapy are new regimens for H.pylori eradication.Initially used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for H.pylori eradication.AIM To assess the efficacy of regimens containing P-CABs in eradicating H.pylori infection.METHODS This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating H.pylori were included.Exclusion criteria included case reports,case series,unpublished trials,or conference abstracts.Data variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and H.pylori eradication method were gathered by two independent reviewers.Meta-analysis was performed in R software,and forest plots were generated.RESULTS A total of 256 references were initially retrieved through the search command.Ultimately,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple therapy.The intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention group and 3578 in the PPI control group across these studies.The analysis revealed a significant difference in H.pylori eradication between VPZ triple therapy and PPI triple therapy in both RCTs and observational studies[risk ratio(RR)=1.17,95%confidence interval(CI):1.11-1.22,P<0.0001]and(RR=1.13,95%CI:1.09-1.17,P<0.0001],respectively.However,no significant difference was found between tegoprazan(TPZ)triple therapy and PPI triple therapy in both RCTs and observational studies(RR=1.04,95%CI:0.93-1.16,P=0.5)and(RR=1.03,95%CI:0.97-1.10,P=0.3),respectively.CONCLUSION VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H.pylori,positioning it as a highly effective first-line regimen.Additionally,TPZ-based triple therapy was non-inferior to classical PPI triple therapy. 展开更多
关键词 Helicobacter pylori infection Potassium competitive acid blockers Proton pump inhibitors Vonoprazan AMOXICILLIN
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