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Effect of low-speed waterjet pressure on the rock-breaking performance of unsubmerged cavitating abrasive waterjet
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作者 Chen-Xing Fan Deng Li +1 位作者 Yong Kang Hai-Tao Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2638-2649,共12页
Unsubmerged cavitating abrasive waterjet(UCAWJ)has been shown to artificially create a submerged environment that produces shear cavitation,which effectively enhances rock-breaking performance.The shear cavitation gen... Unsubmerged cavitating abrasive waterjet(UCAWJ)has been shown to artificially create a submerged environment that produces shear cavitation,which effectively enhances rock-breaking performance.The shear cavitation generation and collapse intensity depend on the pressure difference between the intermediate high-speed abrasive waterjet and the coaxial low-speed waterjet.However,the effect of the pressure of the coaxial low-speed waterjet is pending.For this purpose,the effect of low-speed waterjet pressure on rock-breaking performance at different standoff distances was experimentally investigated,and the effects of erosion time and ruby nozzle diameter on erosion performance were discussed.Finally,the micromorphology of the sandstone was observed at different locations.The results show that increased erosion time and ruby nozzle diameter can significantly improve the rock-breaking performance.At different standoff distances,the mass loss increases first and then decreases with the increase of low-speed waterjet pressure,the maximum mass loss is 10.4 g at a low-speed waterjet pressure of0.09 MPa.The surface morphology of cavitation erosion was measured using a 3D profiler,the increase in both erosion depth and surface roughness indicated a significant increase in the intensity of the shear cavitation collapse.At a low-speed waterjet pressure of 0.18 MPa,the cavitation erosion surface depth can reach 600μm with a roughness of 127μm. 展开更多
关键词 Rock-breaking Coaxial low-speed waterjet pressure Abrasive waterjet CAVITATION Unsubmerged environment
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Numerical Simulation-Based Analysis of the Impact of Overloading on Segmentally Assembled Bridges
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作者 Donghui Ma Wenqi Wu +4 位作者 Yuan Li Lun Zhao Yingchun Cai Pan Guo Shaolin Yang 《Structural Durability & Health Monitoring》 EI 2024年第5期663-681,共19页
Segmentally assembled bridges are increasinglyfinding engineering applications in recent years due to their unique advantages,especially as urban viaducts.Vehicle loads are one of the most important variable loads acti... Segmentally assembled bridges are increasinglyfinding engineering applications in recent years due to their unique advantages,especially as urban viaducts.Vehicle loads are one of the most important variable loads acting on bridge structures.Accordingly,the influence of overloaded vehicles on existing assembled bridge structures is an urgent concern at present.This paper establishes thefinite element model of the segmentally assembled bridge based on ABAQUS software and analyzes the influence of vehicle overload on an assembled girder bridge struc-ture.First,afinite element model corresponding to the target bridge is established based on ABAQUS software,and the load is controlled to simulate vehicle movement in each area of the traveling zone at different times.Sec-ond,the key cross-sections of segmental girder bridges are monitored in real time based on the force character-istics of continuous girder bridges,and they are compared with the simulation results.Finally,a material damage ontology model is introduced,and the structural damage caused by different overloading rates is compared and analyzed.Results show that thefinite element modeling method is accurate by comparing with on-site measured data,and it is suitable for the numerical simulation of segmental girder bridges;Dynamic sensors installed at 1/4L,1/2L,and 3/4L of the segmental girder main beams could be used to identify the dynamic response of segmental girder bridges;The bottom plate of the segmental girder bridge is mostly damaged at the position where the length of the precast beam section changes and the midspan position.With the increase in load,damage in the direction of the bridge develops faster than that in the direction of the transverse bridge.Thefindings of this study can guide maintenance departments in the management and maintenance of bridges and vehicles. 展开更多
关键词 Segmentally assembled bridge dynamic response moving loads overloading structural damage finite element analysis
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Overloading of Landing Based on the Deformation of the Lunar Lander 被引量:16
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作者 陈金宝 聂宏 +1 位作者 张明 汪岸柳 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第1期43-47,共5页
Along with the progress of sciences and technologies, a lot of explorations are taken in many countries or organizations in succession. Lunar, the natural satellite of the earth, become a focus of the space discovery ... Along with the progress of sciences and technologies, a lot of explorations are taken in many countries or organizations in succession. Lunar, the natural satellite of the earth, become a focus of the space discovery again recently because of its abundant resource and high value in use. Lunar exploration is also one of the most important projects in China. A primary objective of the probe in lunar is to soft-land a manned spacecraft on the lunar surface. The soft-landing system is the key composition of the lunar lander. In the overall design of lunar lander, the analysis of touchdown dynamics during landing stage is an important work. The rigid-flexible coupling dynamics of a system with flexible cantilevers attached to the main lander is analyzed. The equations are derived from the subsystem method. Results show that the deformations of cantilevers have considerable effect on the overloading of the lunar lander system. 展开更多
关键词 lunar lander rigid-flexible coupling DEFORMATION overloading
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SOME CHARACTERISTICS OF LOW-SPEED STREAKS UNDER SHEARED AIR-WATER INTERFACES 被引量:2
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作者 王双峰 贾复 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2001年第2期115-124,共10页
The characteristics of low-speed fluid streaks occurring under sheared air-water interfaces were examined by means of hydrogen bubble visualization technique. A critical shear condition under which the streaky structu... The characteristics of low-speed fluid streaks occurring under sheared air-water interfaces were examined by means of hydrogen bubble visualization technique. A critical shear condition under which the streaky structure first appears was determined to be u(tau) approximate to 0.19 cm/s. The mean spanwise streak spacing increases with distance from the water surface owing to merging and bursting processes, and a linear relationship describing variation of non-dimensional spacing <(<lambda>+)over bar> versus y(+) was found essentially independent of shear stress on the interface. Values of <(<lambda>+)over bar>, however, are remarkably smaller than their counterparts in the near-wall region of turbulent boundary layers. Though low-speed streaks occur randomly in time and space, the streak spacing exhibits a lognormal probability distribution behavior. A tentative explanation concerning the formation of streaky structure is suggested, and the fact that <(<lambda>+)over bar> takes rather smaller values than that in wall turbulence is briefly discussed. 展开更多
关键词 air-water interface low-speed streak turbulent coherent structure flow visualization
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POD analysis of the instability mode of a low-speed streak in a laminar boundary layer 被引量:2
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作者 Si-Chao Deng Chong Pan +1 位作者 Jin-Jun Wang Akira Rinoshika 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2017年第6期981-991,共11页
The instability of one single low-speed streak in a zero-pressure-gradient laminar boundary layer is investigated experimentally via both hydrogen bubble visualization and planar particle image velocimetry(PIV) measur... The instability of one single low-speed streak in a zero-pressure-gradient laminar boundary layer is investigated experimentally via both hydrogen bubble visualization and planar particle image velocimetry(PIV) measurement. A single low-speed streak is generated and destabilized by the wake of an interference wire positioned normal to the wall and in the upstream. The downstream development of the streak includes secondary instability and self-reproduction process, which leads to the generation of two additional streaks appearing on either side of the primary one. A proper orthogonal decomposition(POD) analysis of PIV measured velocity field is used to identify the components of the streak instability in the POD mode space: for a sinuous/varicose type of POD mode, its basis functions present anti-symmetric/symmetric distributions about the streak centerline in the streamwise component, and the symmetry condition reverses in the spanwise component. It is further shown that sinuous mode dominates the turbulent kinematic energy(TKE) through the whole streak evolution process, the TKE content first increases along the streamwise direction to a saturation value and then decays slowly. In contrast, varicose mode exhibits a sustained growth of the TKE content,suggesting an increasing competition of varicose instability against sinuous instability. 展开更多
关键词 low-speed streak Boundary layer transition Streak instability
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Experimental investigation on vibration characteristics of the medium-low-speed maglev vehicle-turnout coupled system 被引量:3
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作者 Miao Li Dinggang Gao +3 位作者 Tie Li Shihui Luo Weihua Ma Xiaohao Chen 《Railway Engineering Science》 2022年第2期242-261,共20页
The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify t... The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify the vibration characteristics of this coupled system through field tests.To this end,dynamic performance tests were conducted on a vehicle–turnout coupled system in a medium–low-speed maglev test line.Firstly,the dynamic response data of the coupled system under various operating conditions were obtained.Then,the natural vibration characteristics of the turnout were analysed using the free attenuation method and the finite element method,indicating a good agreement between the simulation results and the measured results;the acceleration response characteristics of the coupled system were analysed in detail,and the ride quality of the vehicle was assessed by Sperling index.Finally,the frequency distribution characteristics of the coupled system were discussed.All these test results could provide references for model validation and optimized design of medium–low-speed maglev transport systems. 展开更多
关键词 Medium–low-speed maglev Vehicle–turnout coupled system Field test Vibration characteristics Ride quality
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Numerical study on evolution of subharmonic varicose low-speed streaks in turbulent channel flow 被引量:2
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作者 Jian LI Gang DONG Jianlei ZHANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2016年第3期325-340,共16页
The evolution of two spanwise-aligned low-speed streaks in a wall turbulent flow, triggered by the instability of the subharmonic varicose (SV) mode, is studied by a direct numerical simulation (DNS) method in a s... The evolution of two spanwise-aligned low-speed streaks in a wall turbulent flow, triggered by the instability of the subharmonic varicose (SV) mode, is studied by a direct numerical simulation (DNS) method in a small spatial-periodic channel. The results show that the SV low-speed streaks are self-sustained at the early stage, and then transform into subharmonic sinuous (SS) low-speed streaks. Initially, the streamwise vortex sheets are formed by shearing, and then evolve into zigzag vortex sheets due to the mutual induction. As the intensification of the SV low-speed streaks becomes prominent, the tilted streamwise vortex tubes and the V-like streamwise vortex tubes can be formed simultaneously by increasing +~. When the SV low-speed streaks break down, new zigzag streamwise vortices will be generated, thus giving birth to the next sustaining cycle of the SV low-speed streaks. When the second breakdown happens, new secondary V-like streamwise vortices instead of zigzag streamwise vortices will be generated. Because of the sweep motion of the fluid induced by the secondary V-like streamwise vortices, each decayed low-speed streak can be divided into two parts, and each part combines with the part of another streak, finally leading to the formation of SS low-speed streaks. 展开更多
关键词 low-speed streak subharmonic varicose mode turbulent boundary layer direct numerical simulation
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High-frequency characterization of high-speed modulators and photodetectors in a link with low-speed photonic sampling 被引量:1
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作者 Mengke Wang Shangjian Zhang +6 位作者 Zhao Liu Xuyan Zhang Yutong He Yangxue Ma Yali Zhang Zhiyao Zhang Yong Liu 《Journal of Semiconductors》 EI CAS CSCD 2021年第4期111-117,共7页
We propose a low-speed photonic sampling for independent high-frequency characterization of a Mach–Zehnder modulator(MZM)and a photodetector(PD)in an optical link.A low-speed mode-locked laser diode(MLLD)provides an ... We propose a low-speed photonic sampling for independent high-frequency characterization of a Mach–Zehnder modulator(MZM)and a photodetector(PD)in an optical link.A low-speed mode-locked laser diode(MLLD)provides an ultrawideband optical stimulus with scalable frequency range,working as the photonic sampling source of the link.The uneven spectrum lines of the MLLD are firstly characterized with symmetric modulation within the interesting frequency range.Then,the electro-optic modulated signals are down-converted to the first Nyquist frequency range,yielding the self-referenced extraction of modulation depth and half-wave voltage of the MZM without correcting the responsivity fluctuation of the PD in the link.Finally,the frequency responsivity of the PD is self-referenced measured under null modulation of the MZM.As frequency responses of the MZM and the PD can be independently obtained,our method allows self-referenced high-frequency measurement for a high-speed optical link.In the proof-of-concept experiment,a 96.9 MS/s MLLD is used for measuring a MZM and a PD within the frequency range up to 50 GHz.The consistency between our method and the conventional method verifies that the ultra-wideband and self-referenced high-frequency characterization of high-speed MZMs and PDs. 展开更多
关键词 frequency response modulators PHOTODETECTORS low-speed photonic sampling microwave photonics
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Numerical simulation on evolution of subharmonic low-speed streaks in minimal channel turbulent flow 被引量:1
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作者 李健 董刚 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2013年第9期1069-1082,共14页
The evolution of low-speed streaks in the turbulent boundary layer of the minimum channel flow unit at a low Reynolds number is simulated by the direct numer- ical simulation (DNS) based on the standard Fourier-Cheb... The evolution of low-speed streaks in the turbulent boundary layer of the minimum channel flow unit at a low Reynolds number is simulated by the direct numer- ical simulation (DNS) based on the standard Fourier-Chebyshev spectral method. The subharmonic sinuous (SS) mode for two spanwise-aligned low-speed streaks is excited by imposing the initial perturbations. The possibilities and the physical realities of the turbulent sustaining in the minimal channel unit are examined. Based on such a flow field environment, the evolution of the low-speed streaks during a cycle of turbulent sus- taining, including lift-up, oscillation, and breakdown, is investigated. The development of streamwise vortices and the dynamics of vortex structures are examined. The results show that the vortices generated from the same streak are staggered along the streamwise direction, while the vortices induced by different streaks tilt toward the normal direction due to the mutual induction effect. It is the spatial variations of the streamwise vortices that cause the lift-up of the streaks. By resolving the transport dynamics of enstrophy, the strength of the vortices is found to continuously grow in the logarithmic layer through the vortex stretching mechanism during the evolution of streaks. The enhancement of the vortices contributes to the spanwise oscillation and the following breakdown of the low-speed streaks. 展开更多
关键词 low-speed streak streamwise vortice instability ENSTROPHY directnumerical simulation (DNS)
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Optimizing the Exhaust System of Marine Diesel Engines to Improve Low-speed Performances and Cylinder Working Conditions 被引量:1
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作者 Sheng Liu Ling Leng +1 位作者 Wenjie Zhou Lei Shi 《Fluid Dynamics & Materials Processing》 EI 2021年第4期683-695,共13页
Proper design of exhaust systems in marine high-power turbocharged diesel engines can contribute to improve the low-speed performance of these engines and make the working conditions of the cylinders more uniform.Here... Proper design of exhaust systems in marine high-power turbocharged diesel engines can contribute to improve the low-speed performance of these engines and make the working conditions of the cylinders more uniform.Here a high-power marine 16-cylinder V-type turbocharged diesel engine is simulated using the GT-Power software.The results reveal the differences induced by different exhaust system structures,such as an 8-cylinder-inpipe exhaust system with single/double superchargers and a 4-cylinder-in-pipe exhaust system with a single supercharger.After a comparative analysis,the 8-cylinder type with double superchargers is determined to be the optimal solution,and the structure of the exhaust system is further optimized.The simulations show that the optimized maximum exhaust temperature difference among cylinders is reduced by 66%.Finally,the simulation results and the optimized performance of the designed exhaust system are verified through experiments. 展开更多
关键词 Exhaust system low-speed performance cylinder uniformity diesel engine
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Evaluation of the Impact of Truck Overloading on Flexible Compacted Gravel Lateritic Soil’s Pavements by FEM with Cast3M<sup>&copy;</sup> 被引量:1
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作者 Fatou Samb Meissa Fall +1 位作者 Yves Berthaud Farid Bendboudjema 《Geomaterials》 2015年第1期19-24,共6页
Within the framework of a FEM of the nonlinear behavior of lateritic pavement of Senegal, the effect of truck overloading is studied to estimate its impact on the deformability of road pavement on compacted gravel lat... Within the framework of a FEM of the nonlinear behavior of lateritic pavement of Senegal, the effect of truck overloading is studied to estimate its impact on the deformability of road pavement on compacted gravel lateritic soils. For that purpose, various loading conditions were tested to measure the impact on the critical response parameters of road pavement design. The implementation of the models was realized with Cast3M&copy;. This study allowed us to point out that the observed variations are linear and would help to plan in advance the impact of axle overloads for a better evaluation within the framework of the mechanistic (M. E.) design of pavements. 展开更多
关键词 FEM AXLE overload Nonlinear Behavior GRAVEL Lateritic Soil
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Dynamics of low-speed streak evolution and interaction in laminar boundary layer 被引量:1
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作者 Si-Chao Deng Chong Pan Jin-Jun Wang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2014年第5期636-645,共10页
The present paper presents an experimental effort on the regeneration process of two low-speed laminar streaks in a zero-pressure-gradient laminar boundary layer. Two vertical thin wires separated by a spanwise distan... The present paper presents an experimental effort on the regeneration process of two low-speed laminar streaks in a zero-pressure-gradient laminar boundary layer. Two vertical thin wires separated by a spanwise distance of 30 mm are used to introduce disturbances of two rolls of transitional Karmain vortex street to the downstream boundary layer. Both hydrogen bubble visualization and particle image velocimetry (PIV) measurement show that two lowspeed streaks are induced through leading-edge receptivity process. As these streaks develop in the downstream, two additional low-speed streaks begin to appear outboard of the flank of the original two, together with complex dynamics of streak splitting and merging. A flow pattern of four streaks aligned along the spanwise direction occurs finally in the far downstream. It is found that besides the mechanisms of streak breakdown, the streak interaction is also an important factor characterizing the instability of low speed streaks and their regeneration process. 展开更多
关键词 low-speed streak - Boundary layer transition Streak reproduction
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Study of the structure and architecture of aortic smooth muscle cells under pressure overloading in rats
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作者 张放鸣 何光篪 +1 位作者 刘正津 陈海平 《Journal of Medical Colleges of PLA(China)》 CAS 1995年第2期87-92,共6页
Male Wistar rats were used to study the changes of the structure and architecture of the smooth muscle cells(SMCs) of the aorta under pressure overloading(PO).The aorta was cut open longitudinally and the tunica media... Male Wistar rats were used to study the changes of the structure and architecture of the smooth muscle cells(SMCs) of the aorta under pressure overloading(PO).The aorta was cut open longitudinally and the tunica media was examined with a histological tech 展开更多
关键词 AORTA SMOOTH MUSCLE cell ARCHITECTURE strucrture PRESSURE overloading rat
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EFFECT OF NON-PROPORTIONAL OVERLOADING ON FATIGUE CRACK GROWTH
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作者 GAO Hua CHEN Youxuan LI Ming Shanghai University of Engineering Science,Shanghai,ChinaCHEN Dehai Shanghai Dalong Machinery,Shanghai,China Associate Professor,Dept.of Materials,Shanghai University of Engineering Science,Shanghai 200051,China 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 1991年第1期59-64,共6页
The effect of proportional and non-proportional overloading on mode l fatigue crack growth have been studied,and the influences of crack tip plastic zone,crack tip blunting as well as crack closure were discussed.Prop... The effect of proportional and non-proportional overloading on mode l fatigue crack growth have been studied,and the influences of crack tip plastic zone,crack tip blunting as well as crack closure were discussed.Proportional(model I)overloading may cause more serious crack growth retardation than non-proportional(mixed mode)overloading.Therefore,for estimating the fatigue life of engineering structures to simplify a real overload which may of- ten be non-proportional as a proportional one is not always safe. 展开更多
关键词 non-proportional overloading fatigue crack growth mixed mode loading
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Overloading and Pavement Service Life <br/>—A Case Study on Narayanghat-Mugling Road, Nepal
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作者 Krishna Nath Ojha 《Journal of Transportation Technologies》 2018年第4期343-356,共14页
The ability of a pavement structure in carrying out its function reduces in line with the increase of traffic load, especially if there are overloaded heavy vehicle passing through the road. This study was done to kno... The ability of a pavement structure in carrying out its function reduces in line with the increase of traffic load, especially if there are overloaded heavy vehicle passing through the road. This study was done to know the effect of overloading vehicles on the road pavement and remaining service life of the pavement. In this study, the service life of pavement due to overloaded vehicles was analyzed using the AASHTO 1993. In Narayanghat-Mugling road the composition of traffic seems to be 83.76% heavy vehicles, 9.18% medium vehicle and 7.05% light vehicle. For the direction of Narayanghat-Mugling, the pavement service life might be reduced by 59.90% due to overloading condition, while for the opposite direction, the service life would not reduced caused by the same factor. The impact of overload conditions on the road pavement showed premature failure;that is, a condition which the damage reduced the life of roads before the design life of the road is reached. From the results, it can be concluded that overloaded vehicles on the road are very influential to the reduction in pavement service life. Therefore, it is expected that road users to comply with existing regulations in the conduct of transportation. As overloading is increasing, it has to be controlled by rules and regulations with penalty to control the overloading. So fines must be associated with intensified enforcement when considered in further strategy. Regular monitoring, inspection and enforcement are the effective ways to control overloading. Use of technology (Automatic overloading information system) may be the effective way to control the overloading. 展开更多
关键词 STANDARD VEHICLE overloaded VEHICLE STANDARD Loading overloading PAVEMENT Service Life
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OCDMA/OCDMA Overloading Scheme for Cellular DS-CDMA Using Orthogonal Gold Codes and Complex Scrambling
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作者 Preetam KUMAR Saswat CHAKRABARTI 《International Journal of Communications, Network and System Sciences》 2008年第3期207-214,共8页
Overloading is a method to extend capacity limitation of multiple access techniques. The system becomes overloaded, when the number of users exceeds the signal dimensions. One of the efficient schemes to overload a CD... Overloading is a method to extend capacity limitation of multiple access techniques. The system becomes overloaded, when the number of users exceeds the signal dimensions. One of the efficient schemes to overload a CDMA system is to use two sets of orthogonal signal waveforms (O/O). In this paper, the BER performance of a new overloading scheme using scrambled orthogonal Gold code (OG/OG) sets is evaluated with soft decision interference cancellation (SDIC) receiver. When complex scrambling is not used, it is shown that OG/OG scheme provides 25% (16 extra users) channel overloading for synchronous DS-CDMA system in an AWGN channel, with an SNR degradation of about 0.35 dB as compared to single user bound at a BER of 1e-5. We have evaluated the overloading performance, when two set are scrambled with set specific deterministic or random complex scrambling sequence. It is shown that the amount of overloading increases significantly from 25% to 63% (40 extra users) by using random complex scrambling for N=64. For deterministic (periodic) scrambling, the overloading percentage increases considerably to 78. On a Rayleigh fading channel, an overloading of 40% is obtained without scrambling at a BER of 5e-4 with near single user performance. With complex scrambling overloading % increases considerably to 100%. 展开更多
关键词 DS-CDMA ORTHOGONAL Codes overloading Interfernce CANCELLATION
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Evolution of the Deflection According to Truck Overloading—Comparison between Benkelman Beam Method and FEM of Lateritic Pavements
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作者 Fatou Samb Ndiassé Diop +1 位作者 Baye Birane Thiam Makhaly Ba 《Open Journal of Civil Engineering》 2018年第4期478-488,共11页
The study of the deflection due to the passage of an axle on a pavement structure has the advantage to make possible to pronounce on the portance, the rigidity and the homogeneity of this one. In the case where the al... The study of the deflection due to the passage of an axle on a pavement structure has the advantage to make possible to pronounce on the portance, the rigidity and the homogeneity of this one. In the case where the allowed axle load is not respected, surface deflection leads to premature deterioration of the roadway. In order to study the evolution of these deformations, deflection measurements were made by using the Benkelman method in the Fatick-Kaolack road in Senegal by varying the axle load with the following values: 10, 13 and 16 tons on three different zones. The results show a linear evolution of the deflection as a function of the axle load. Also, the impact of truck overloading was studied by considering different values of the axle load with comparison to the allowed axle load by using frequent types of vehicle. A numerical simulation of the Cast3M pavement was done first, in the case of an isolated single wheel with a radius of 12.5 cm, then in the case of an equivalent dual wheel with a radius of 18.1 cm for loads of 10 to 19 tons. In the same way, the pavement design software (ALIZE) is used to analyse the variation of the axle load. The results show a linear evolution of the deflection, which corroborates the measurements made in the field and those obtained by Samb (2014) with a slope coefficient equal to 1.7. Nevertheless, the case of an isolated single wheel of 12.5 cm radius is closest to the measurements with a straight line of slope coefficient equal to 1.9. 展开更多
关键词 DEFLECTION Axle overload TRUCK overloading Cast3M ALIZE FEM Lateritic GRAVEL
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Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis 被引量:4
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作者 Xiuling Tang Tao Yan +8 位作者 Saiying Wang Qingqing Liu Qi Yang Yongqiang Zhang Yujiao Li Yumei Wu Shuibing Liu Yulong Ma Le Yang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期642-649,共8页
β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unkno... β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways. 展开更多
关键词 APOPTOSIS blood-brain barrier Β-SITOSTEROL cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1L1
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Study on Crack Closure Considering Welding Residual Stress Under Constant Amplitude Loading and Overloading
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作者 Ziya Peng Ping Yang +1 位作者 Kang Hu Yueling Song 《Journal of Marine Science and Application》 CSCD 2020年第2期195-207,共13页
Welding residual stress in the engineering structure has a non-negligible influence on crack propagation,and crack closure is a significant factor affecting the crack propagation.Based on the elastoplastic finite elem... Welding residual stress in the engineering structure has a non-negligible influence on crack propagation,and crack closure is a significant factor affecting the crack propagation.Based on the elastoplastic finite element method and crack closure theory,we studied crack closure and residual compressive stress field of butt-welded plates under constant amplitude loading and overloading regarding the stress ratio,maximum load,overload ratio,and number of overloads.The results show that the welding residual tensile stress can decrease the crack closure because of a decrease in the residual compressive stress in the wake zone,but the effect is gradually reduced with increased stress ratio or maximum load.And the combined effect of welding residual tensile stress and overload can produce a stronger retardation effect on crack propagation. 展开更多
关键词 Welding residual stress Crack closure overloading Crack propagation Butt-welded plate
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PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function
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作者 Yan Shao Hongbo Zhang +13 位作者 Hong Guan Chunyu Wu Weizhong Qi Lingfeng Yang Jianbin Yin Haiyan Zhang Liangliang Liu Yuheng Lu Yitao Zhao Sheng Zhang Chun Zeng Guiqing Wang Xiaochun Bai Daozhang Cai 《Bone Research》 SCIE CAS CSCD 2024年第3期621-633,共13页
Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte ... Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology,but their roles and the associated mechanisms in mechanical stress-associated chondrocyte senescence and OA have not been elucidated. 展开更多
关键词 overload aging stress
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