This paper proposes a new primary lazy update protocol, PTCS （Primary Transaction Commit Schedule）. In the PTCS protocol, a serializable primary transaction schedule is generated firstly and then the secondary trans...This paper proposes a new primary lazy update protocol, PTCS （Primary Transaction Commit Schedule）. In the PTCS protocol, a serializable primary transaction schedule is generated firstly and then the secondary transactions are committed according to the serializable primary transaction schedule. PTCS protocol can guarantee serializability if the data copy graph contains no directed circles. It can also be ex tended to eliminate all requirements on the data copy graph. Compared to earlier works, PTCS protocol not only imposes a much weaker requirement on the data placement, but also avoids the deadlock caused by transaction waits and extra message overhead. The performance experiments show that the degradation of the performance caused by the replica man- agement of the PTCS protocol is tolerable.展开更多
Colorectal cancers(CRCs) display a wide variety of genomic aberrations that may be either causally linked to their development and progression, or might serve as biomarkers for their presence. Recent advances in rapid...Colorectal cancers(CRCs) display a wide variety of genomic aberrations that may be either causally linked to their development and progression, or might serve as biomarkers for their presence. Recent advances in rapid high-throughput genetic and genomic analysis have helped to identify a plethora of alterations that can potentially serve as new cancer biomarkers, and thus help to improve CRC diagnosis, prognosis, and treatment. Each distinct data type(copy number variations, gene and micro RNAs expression, Cp G island methylation) provides an investigator with a different, partially independent, and complementary view of the entire genome. However, elucidation of gene function will require more information than can be provided by analyzing a single type of data. The integration of knowledge obtained from different sources is becoming increasingly essential for obtaining an interdisciplinary view of large amounts of information, and also for cross-validating experimental results. The integration of numerous types of genetic and genomic data derived from public sources, and via the use of ad-hoc bioinformatics tools and statistical methods facilitates the discovery and validation of novel, informative biomarkers. This combinatory approach will also enable researchers to more accurately and comprehensively understand the associations between different biologic pathways, mechanisms, and phenomena, and gain new insights into the etiology of CRC.展开更多
内存错误漏洞仍是当前网络攻击中造成危害最严重的漏洞之一.内存错误漏洞的产生往往与对内存拷贝类函数的误用有关.目前针对内存拷贝类函数的识别主要借助于符号表和代码特征模式匹配,具有较高的误报率和漏报率,并且适用性较差.提出了...内存错误漏洞仍是当前网络攻击中造成危害最严重的漏洞之一.内存错误漏洞的产生往往与对内存拷贝类函数的误用有关.目前针对内存拷贝类函数的识别主要借助于符号表和代码特征模式匹配,具有较高的误报率和漏报率,并且适用性较差.提出了一种内存拷贝类函数识别技术CPYFinder(copy function finder).该技术在内存拷贝类函数控制流特征的基础上,将二进制代码转换为中间语言表示VEX IR(intermediate representation)进行数据流的构建和分析,根据内存拷贝类函数在数据流上的特征进行识别.该技术能够在较低的运行时间下对多种指令集架构(x86,ARM,MIPS,PowerPC)的二进制程序中的内存拷贝类函数进行识别.实验结果表明,相比于最新的工作BootStomp和SaTC,CPYFinder在对内存拷贝类函数识别上具有更好的表现,在精准率和召回率上得到更好的平衡,并且运行时间与SaTC几乎相等,仅相当于BootStomp耗时的19%.此外,CPYFinder在漏洞函数识别上也具有更好的表现.展开更多
旨在鉴别与鸭重要经济性状潜在相关的拷贝数变异(copy number variations,CNVs),为解析CNVs对鸭经济性状的影响提供前期研究基础。本研究利用从美国国家生物技术信息中心(National Center for Biotechnology Information,NCBI)公共数据...旨在鉴别与鸭重要经济性状潜在相关的拷贝数变异(copy number variations,CNVs),为解析CNVs对鸭经济性状的影响提供前期研究基础。本研究利用从美国国家生物技术信息中心(National Center for Biotechnology Information,NCBI)公共数据库中下载的8个鸭品种共78个个体的全基因组重测序数据,采用CNVnator和CNVcaller软件进行全基因组CNVs检测,同时只保留两个软件检测结果中存在至少1 bp重叠的同类型CNVRs,以消除假阳性对试验结果的影响。结果显示,8个鸭品种的CNVs合并后共检测出7550个CNV regions(CNVRs),其中包括7098个duplications和452个deletions。这些CNVRs在鸭29条常染色体上呈不均匀分布,总长度为16111.2 kb,平均长度为2134 bp,约占鸭基因组的1.51%。此外,本研究在8个鸭品种共筛选到4304个潜在的品种特异性CNVRs,覆盖1230个注释基因。通过基因功能Gene Ontology(GO)富集分析,鉴别到38个可能与生长和繁殖相关的CNVRs。本研究共发现7550个CNVRs,筛选出4304个潜在的品种特异性CNVRs,并鉴别到38个与鸭生长和繁殖潜在相关的CNVRs,为深入探究CNVs对鸭重要经济性状的影响提供了必要的研究基础。展开更多
基金Supported by Visiting Scholar Foundation of KeyLabin University and National Lab of Switching Technology and Tele-communication Networks ([2000]123)
文摘This paper proposes a new primary lazy update protocol, PTCS （Primary Transaction Commit Schedule）. In the PTCS protocol, a serializable primary transaction schedule is generated firstly and then the secondary transactions are committed according to the serializable primary transaction schedule. PTCS protocol can guarantee serializability if the data copy graph contains no directed circles. It can also be ex tended to eliminate all requirements on the data copy graph. Compared to earlier works, PTCS protocol not only imposes a much weaker requirement on the data placement, but also avoids the deadlock caused by transaction waits and extra message overhead. The performance experiments show that the degradation of the performance caused by the replica man- agement of the PTCS protocol is tolerable.
基金Supported by Associazione Italiana per la Ricerca sul CancroGrants No.10529 and No.12162funds obtained throughan Italian law that allows taxpayers to allocate 0.5%share of theirincome tax contribution to a research institution of their choice
文摘Colorectal cancers(CRCs) display a wide variety of genomic aberrations that may be either causally linked to their development and progression, or might serve as biomarkers for their presence. Recent advances in rapid high-throughput genetic and genomic analysis have helped to identify a plethora of alterations that can potentially serve as new cancer biomarkers, and thus help to improve CRC diagnosis, prognosis, and treatment. Each distinct data type(copy number variations, gene and micro RNAs expression, Cp G island methylation) provides an investigator with a different, partially independent, and complementary view of the entire genome. However, elucidation of gene function will require more information than can be provided by analyzing a single type of data. The integration of knowledge obtained from different sources is becoming increasingly essential for obtaining an interdisciplinary view of large amounts of information, and also for cross-validating experimental results. The integration of numerous types of genetic and genomic data derived from public sources, and via the use of ad-hoc bioinformatics tools and statistical methods facilitates the discovery and validation of novel, informative biomarkers. This combinatory approach will also enable researchers to more accurately and comprehensively understand the associations between different biologic pathways, mechanisms, and phenomena, and gain new insights into the etiology of CRC.
文摘内存错误漏洞仍是当前网络攻击中造成危害最严重的漏洞之一.内存错误漏洞的产生往往与对内存拷贝类函数的误用有关.目前针对内存拷贝类函数的识别主要借助于符号表和代码特征模式匹配,具有较高的误报率和漏报率,并且适用性较差.提出了一种内存拷贝类函数识别技术CPYFinder(copy function finder).该技术在内存拷贝类函数控制流特征的基础上,将二进制代码转换为中间语言表示VEX IR(intermediate representation)进行数据流的构建和分析,根据内存拷贝类函数在数据流上的特征进行识别.该技术能够在较低的运行时间下对多种指令集架构(x86,ARM,MIPS,PowerPC)的二进制程序中的内存拷贝类函数进行识别.实验结果表明,相比于最新的工作BootStomp和SaTC,CPYFinder在对内存拷贝类函数识别上具有更好的表现,在精准率和召回率上得到更好的平衡,并且运行时间与SaTC几乎相等,仅相当于BootStomp耗时的19%.此外,CPYFinder在漏洞函数识别上也具有更好的表现.
文摘旨在鉴别与鸭重要经济性状潜在相关的拷贝数变异(copy number variations,CNVs),为解析CNVs对鸭经济性状的影响提供前期研究基础。本研究利用从美国国家生物技术信息中心(National Center for Biotechnology Information,NCBI)公共数据库中下载的8个鸭品种共78个个体的全基因组重测序数据,采用CNVnator和CNVcaller软件进行全基因组CNVs检测,同时只保留两个软件检测结果中存在至少1 bp重叠的同类型CNVRs,以消除假阳性对试验结果的影响。结果显示,8个鸭品种的CNVs合并后共检测出7550个CNV regions(CNVRs),其中包括7098个duplications和452个deletions。这些CNVRs在鸭29条常染色体上呈不均匀分布,总长度为16111.2 kb,平均长度为2134 bp,约占鸭基因组的1.51%。此外,本研究在8个鸭品种共筛选到4304个潜在的品种特异性CNVRs,覆盖1230个注释基因。通过基因功能Gene Ontology(GO)富集分析,鉴别到38个可能与生长和繁殖相关的CNVRs。本研究共发现7550个CNVRs,筛选出4304个潜在的品种特异性CNVRs,并鉴别到38个与鸭生长和繁殖潜在相关的CNVRs,为深入探究CNVs对鸭重要经济性状的影响提供了必要的研究基础。
