^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-...^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。展开更多
由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解...由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解线性代数方程组(information-theoretically secure outsourcing of linear algebraic equations,ITS-OutsLAE)方法 .与之前的研究相比,在保持计算和通信复杂度与现有最优方案保持一致的同时,首次将方程组唯一解的安全性提升至信息论安全(完美保密).给出了形式化的安全性证明,并通过理论分析和实验证明了所提方法的实用性.展开更多
Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber developme...Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield.展开更多
Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LU...Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LUS) in resource-rich ICUs is still under investigation. The present study compares the utility of LUS to that of CXR in identifying pulmonary edema and pleural effusion in ICU patients. In addition, consolidation and pneumothorax were analyzed as secondary outcome measures. Material and Methods This is a prospective, single centric, observational study. Patients admitted in ICU were examined for lung pathologies, using LUS by a trained intensivist;and CXR done within 4 hours of each other. The final diagnosis was ascertained by an independent senior radiologist, based on the complete medical chart including clinical findings and the results of thoracic CT, if available. The results were compared and analyzed. Results Sensitivity, specificity and diagnostic accuracy of LUS was 95%, 94.4%, 94.67% for pleural effusion;and 98.33%, 97.78%, 98.00% for pulmonary edema respectively. Corresponding values with CXR were 48.33%, 76.67%, 65.33% for pleural effusion;and 36.67%, 82.22% and 64.00% for pulmonary edema respectively. Sensitivity, specificity and diagnostic accuracy of LUS was 91.30%, 96.85%, 96.00% for consolidation;and 100.00%, 79.02%, 80.00% for pneumothorax respectively. Corresponding values with CXR were 60.87%, 81.10%, 78.00% for consolidation;and 71.3%, 97.20%, 96.00% for pneumothorax respectively. Conclusion LUS has better diagnostic accuracy in diagnosis of pleural effusion and pulmonary edema when compared with CXR and is thus recommended as an effective alternative for diagnosis of these conditions in acute care settings. Our study recommends that a thoracic CT scan can be avoided in most of such cases.展开更多
实现高发光效率、高亮度和良好的热稳定性是固态照明的迫切要求。因此,用于高功率发光二极管或激光二极管(LED/LD)的高性能荧光转换材料具有重要的研究意义。在这项工作中,通过将Lu^(3+)离子引入YAG∶Ce荧光陶瓷中方法作为有效策略来改...实现高发光效率、高亮度和良好的热稳定性是固态照明的迫切要求。因此,用于高功率发光二极管或激光二极管(LED/LD)的高性能荧光转换材料具有重要的研究意义。在这项工作中,通过将Lu^(3+)离子引入YAG∶Ce荧光陶瓷中方法作为有效策略来改善YAG∶Ce荧光材料的发光性能。采用固相反应和真空烧结法制Article ID:1000-7032(2023)06-0964^(-1)1收稿日期:2022^(-1)2-31;修订日期:2023-01-30基金项目:中国科学院战略性先导科技专项(XDA22010301)Supported by The Strategic Priority Research Program of The Chinese Academy of Sciences(XDA22010301)第6 HUANG Xinyou期,et al.:LuYAG∶Ce Transparent Ceramic Phosphors for High-brightness Solid-state…备了不同Lu^(3+)含量的(Lu,Y)_(3)Al_(5)O_(12)∶Ce荧光陶瓷(LuYAG∶Ce荧光陶瓷)。随着Lu^(3+)含量的增加,LuYAG∶Ce荧光陶瓷中的Y^(3+)位点被Lu^(3+)位点取代,Ce^(3+)的发射峰呈现从573 nm到563 nm的蓝移现象。当Lu^(3+)含量为60%时,通过将LuYAG∶Ce荧光陶瓷与蓝光LED组合,其发光强度达到最大值,流明效率达到114 lm∙W^(-1)。使用450 nm激光源与LuYAG∶Ce荧光陶瓷构建了透射模式下的激光驱动照明装置。随着功率密度从2.2 W·mm^(-2)增加到39 W·mm^(-2),Lu^(3+)含量为60%的荧光陶瓷光通量从128 lm增加到1874 lm,且没有发光饱和的迹象,最佳发光效率达到128 lm·W^(-1)。因此,LuYAG∶Ce荧光陶瓷有望成为高功率LED/LD照明的潜在荧光转换材料。展开更多
The Spanish Central System(SCS)contains several suites of Palaeozoic mafic igneous intrusions with contrasting geochemical affinity:Ordovician tholeiitic metabasites,Variscan calc-alkaline gabbros(Gb1)and microdiorite...The Spanish Central System(SCS)contains several suites of Palaeozoic mafic igneous intrusions with contrasting geochemical affinity:Ordovician tholeiitic metabasites,Variscan calc-alkaline gabbros(Gb1)and microdiorites(Gb2),shoshonitic monzogabbros(Gb3)and alkaline diabases and lamprophyres(Gb4).Not all of these rocks are accurately dated,and several aspects of their genesis are still poorly understood.We present new whole-rock geochemical data(major and trace elements,and Sr-Nd isotopes),U-Pb and Lu-Hf isotopic ratios on magmatic zircons and 40 Ar/39Ar amphibole geochronology results in order to establish a precise chronology for the successive events of magmatism in the SCS,and discuss the nature of their mantle sources.Accurate ages have been determined for the Variscan gabbros(305-294 Ma),the microdiorites(299 Ma)and the accompanying felsic porphyries(292 Ma),the shoshonitic monzogabbros(285 Ma),and the alkaline diabases(274 Ma)and monzosyenites(271-264 Ma).According to this information,the Variscan mafic magmatism would be mainly concentrated in the range of 305-294 Ma,with a final manifestation represented by the minor shoshonitic dykes.The alkaline magmatism proved to be slightly older than previously thought and yielded at least two distinct pulses:diabases and lamprophyres-monzosyenites.Zircon Hf isotopes evidence the involvement of depleted and slightly enriched mantle sources.The bulk of the eHf values are in the broad range of-8 to+11,indicative of melting both depleted and enriched mantle regions.The high within-sample Hf isotope variation(up to-11 epsilon units)shown by samples from the Variscan series(gabbros,microdiorites and monzogabbros)could be explained mainly by hybridisation of magmas derived from heterogeneous lithospheric mantle sources.Pressure estimates indicate that the Variscan mafic magmas were extracted from the lithosphere.The Nd-Hf isotopic composition of these suites of rocks suggests the recycling of pelitic sediments during the Cadomian orogeny.Deeper(asthenospheric)mantle levels were involved in the generation of the alkaline suite,whose anomalous negative eHf values(moderately decoupled with respect to radiogenic Nd)could be associated with subducted oceanic components raised by mantle upwelling associated with lithosphere thinning and extension during the Permian.展开更多
文摘^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。
文摘由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解线性代数方程组(information-theoretically secure outsourcing of linear algebraic equations,ITS-OutsLAE)方法 .与之前的研究相比,在保持计算和通信复杂度与现有最优方案保持一致的同时,首次将方程组唯一解的安全性提升至信息论安全(完美保密).给出了形式化的安全性证明,并通过理论分析和实验证明了所提方法的实用性.
基金supported by the National Natural Science Foundation of China(31801409)the Safe Preservation and Accurate Identification of Flax Germplasm Resources in South,China(23ZH174)+2 种基金the Construction of Modern Agricultural Industrial Technology System,China(CARS-16-E01)the Protection and Utilization of Crop Germplasm Resources,China(2016NWB044)the National Science and Technology Resource Sharing Service Platform Project,China(NCGRC-2020-15)。
文摘Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield.
文摘Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LUS) in resource-rich ICUs is still under investigation. The present study compares the utility of LUS to that of CXR in identifying pulmonary edema and pleural effusion in ICU patients. In addition, consolidation and pneumothorax were analyzed as secondary outcome measures. Material and Methods This is a prospective, single centric, observational study. Patients admitted in ICU were examined for lung pathologies, using LUS by a trained intensivist;and CXR done within 4 hours of each other. The final diagnosis was ascertained by an independent senior radiologist, based on the complete medical chart including clinical findings and the results of thoracic CT, if available. The results were compared and analyzed. Results Sensitivity, specificity and diagnostic accuracy of LUS was 95%, 94.4%, 94.67% for pleural effusion;and 98.33%, 97.78%, 98.00% for pulmonary edema respectively. Corresponding values with CXR were 48.33%, 76.67%, 65.33% for pleural effusion;and 36.67%, 82.22% and 64.00% for pulmonary edema respectively. Sensitivity, specificity and diagnostic accuracy of LUS was 91.30%, 96.85%, 96.00% for consolidation;and 100.00%, 79.02%, 80.00% for pneumothorax respectively. Corresponding values with CXR were 60.87%, 81.10%, 78.00% for consolidation;and 71.3%, 97.20%, 96.00% for pneumothorax respectively. Conclusion LUS has better diagnostic accuracy in diagnosis of pleural effusion and pulmonary edema when compared with CXR and is thus recommended as an effective alternative for diagnosis of these conditions in acute care settings. Our study recommends that a thoracic CT scan can be avoided in most of such cases.
文摘实现高发光效率、高亮度和良好的热稳定性是固态照明的迫切要求。因此,用于高功率发光二极管或激光二极管(LED/LD)的高性能荧光转换材料具有重要的研究意义。在这项工作中,通过将Lu^(3+)离子引入YAG∶Ce荧光陶瓷中方法作为有效策略来改善YAG∶Ce荧光材料的发光性能。采用固相反应和真空烧结法制Article ID:1000-7032(2023)06-0964^(-1)1收稿日期:2022^(-1)2-31;修订日期:2023-01-30基金项目:中国科学院战略性先导科技专项(XDA22010301)Supported by The Strategic Priority Research Program of The Chinese Academy of Sciences(XDA22010301)第6 HUANG Xinyou期,et al.:LuYAG∶Ce Transparent Ceramic Phosphors for High-brightness Solid-state…备了不同Lu^(3+)含量的(Lu,Y)_(3)Al_(5)O_(12)∶Ce荧光陶瓷(LuYAG∶Ce荧光陶瓷)。随着Lu^(3+)含量的增加,LuYAG∶Ce荧光陶瓷中的Y^(3+)位点被Lu^(3+)位点取代,Ce^(3+)的发射峰呈现从573 nm到563 nm的蓝移现象。当Lu^(3+)含量为60%时,通过将LuYAG∶Ce荧光陶瓷与蓝光LED组合,其发光强度达到最大值,流明效率达到114 lm∙W^(-1)。使用450 nm激光源与LuYAG∶Ce荧光陶瓷构建了透射模式下的激光驱动照明装置。随着功率密度从2.2 W·mm^(-2)增加到39 W·mm^(-2),Lu^(3+)含量为60%的荧光陶瓷光通量从128 lm增加到1874 lm,且没有发光饱和的迹象,最佳发光效率达到128 lm·W^(-1)。因此,LuYAG∶Ce荧光陶瓷有望成为高功率LED/LD照明的潜在荧光转换材料。
基金supported by the CGL2016-78796 project of the Ministerio de Economiay Competitividad of Spain and the UCM Research Group 2018/19 n°910492。
文摘The Spanish Central System(SCS)contains several suites of Palaeozoic mafic igneous intrusions with contrasting geochemical affinity:Ordovician tholeiitic metabasites,Variscan calc-alkaline gabbros(Gb1)and microdiorites(Gb2),shoshonitic monzogabbros(Gb3)and alkaline diabases and lamprophyres(Gb4).Not all of these rocks are accurately dated,and several aspects of their genesis are still poorly understood.We present new whole-rock geochemical data(major and trace elements,and Sr-Nd isotopes),U-Pb and Lu-Hf isotopic ratios on magmatic zircons and 40 Ar/39Ar amphibole geochronology results in order to establish a precise chronology for the successive events of magmatism in the SCS,and discuss the nature of their mantle sources.Accurate ages have been determined for the Variscan gabbros(305-294 Ma),the microdiorites(299 Ma)and the accompanying felsic porphyries(292 Ma),the shoshonitic monzogabbros(285 Ma),and the alkaline diabases(274 Ma)and monzosyenites(271-264 Ma).According to this information,the Variscan mafic magmatism would be mainly concentrated in the range of 305-294 Ma,with a final manifestation represented by the minor shoshonitic dykes.The alkaline magmatism proved to be slightly older than previously thought and yielded at least two distinct pulses:diabases and lamprophyres-monzosyenites.Zircon Hf isotopes evidence the involvement of depleted and slightly enriched mantle sources.The bulk of the eHf values are in the broad range of-8 to+11,indicative of melting both depleted and enriched mantle regions.The high within-sample Hf isotope variation(up to-11 epsilon units)shown by samples from the Variscan series(gabbros,microdiorites and monzogabbros)could be explained mainly by hybridisation of magmas derived from heterogeneous lithospheric mantle sources.Pressure estimates indicate that the Variscan mafic magmas were extracted from the lithosphere.The Nd-Hf isotopic composition of these suites of rocks suggests the recycling of pelitic sediments during the Cadomian orogeny.Deeper(asthenospheric)mantle levels were involved in the generation of the alkaline suite,whose anomalous negative eHf values(moderately decoupled with respect to radiogenic Nd)could be associated with subducted oceanic components raised by mantle upwelling associated with lithosphere thinning and extension during the Permian.
