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Introduction to Mesh Based Generated Lumped Parameter Models for Electromagnetic Problems using Triangular Elements
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作者 Haidar Y.Diab Salim Asfirane +2 位作者 Nicolas Bracikowski Frédéric Gillon Yacine Amara 《CES Transactions on Electrical Machines and Systems》 CSCD 2023年第1期21-34,共14页
This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been pu... This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been published,but very few on those generated from a mesh using triangular elements.The use of triangular elements is aimed at extending the application of the approach to any shape of modeled devices.Basic concepts of the approach are presented in the case of electromagnetic devices.The procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB environment are also included. 展开更多
关键词 lumped parameter modeling Finite element method MESH Triangular elements Electromagnetic devices MODELING
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A modified lumped parameter model of distribution transformer winding 被引量:5
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作者 Qingqing Ding Yao Yao +5 位作者 Bingqian Wang Jingwei Fu Wei Zhang Chao Zeng Xiaoping Li Stanimir Valtchev 《Global Energy Interconnection》 2020年第2期158-165,共8页
The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed paramete... The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed parameters model can depict the winding characteristics accurately,but it requires complex calculations.Lumped parameter model requires less calculations,but its applicable frequency range is not wide.This paper studies the amplitude-frequency characteristics of the lightning wave,compares the transformer modelling methods and finally proposes a modified lumped parameter model,based on the above comparison.The proposed model minimizes the errors provoked by the lumped parameter approximation,and the hyperbolic functions of the distributed parameter model.By this modification it becomes possible to accurately describe the winding characteristics and rapidly obtain the node voltage response.The proposed model can provide theoretical and experimental support to lightning protection of the distribution transformer. 展开更多
关键词 Wide band frequency response Distributed parameter model lumped parameter model Distribution transformer Lightning protection
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Introduction to Mesh Based Generated Lumped Parameter Models for Electromagnetic Problems 被引量:2
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作者 Shuo Yang Salim Asfirane +6 位作者 Sami Hlioui Smail Mezani Guillaume Krebs Yacine Amara Georges Barakat Mohamed Gabsi Wei Hua 《CES Transactions on Electrical Machines and Systems》 CSCD 2021年第2期152-162,共11页
This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are the... This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are then presented in the case of electromagnetic devices.A step-by-step procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB and Scilab environments are also included. 展开更多
关键词 lumped parameter modeling finite element method MESH electromagnetic devices MODELING
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High Purity Hydrogen Production by Metal Hydride System:A Parametric Study Based on the Lumped Parameter Model
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作者 KOUA Koua Alain Jesus TONG Liang +1 位作者 YANG Tianqi XIAO Jinsheng 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2021年第1期127-135,共9页
The simulation of hydrogen purification in a mixture gas of hydrogen/carbon dioxide (H2/CO2) by metal hydride system was reported.The lumped parameter model was developed and validated.The validated model was implemen... The simulation of hydrogen purification in a mixture gas of hydrogen/carbon dioxide (H2/CO2) by metal hydride system was reported.The lumped parameter model was developed and validated.The validated model was implemented on the software Matlab/Simulink to simulate the present investigation.The simulation results demonstrate that the purification efficiency depends on the external pressure and the venting time.An increase in the external pressure and enough venting time makes it possible to effectively remove the impurities from the tank during the venting process and allows to desorb pure hydrogen.The impurities are partially removed from the tank for low external pressure and venting time during the venting process and the desorbed hydrogen is contaminated.Other parameters such as the overall heat transfer coefficient,solid material mass,supply pressure,and the ambient temperature influence the purification system in terms of the hydrogen recovery rate.An increase in the overall heat transfer coefficient,solid material mass,and supply pressure improves the hydrogen recovery rate while a decrease in the ambient temperature enhances the recovery rate. 展开更多
关键词 hydrogen production hydrogen purification carbon dioxide metal hydride lumped parameter parametric study
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An improved lumped parameter model predicting attenuation of earmuff with air leakage
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作者 Xu Zhong Zhe Chen Dong Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第11期364-370,共7页
Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air l... Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air leakage,under controlled air leakage is introduced to earmuff to achieve adjustable attenuations in different signal-to-noise ratios(SNRs)and balance between attenuation and speech intelligibility.This work is to develop an improved lumped parameter model(LPM)to predict earmuff attenuation with consideration of air leakage.Air leakage paths are introduced into conventional LPM without air leakage,and air leakage path impedance is analytically described by Maa’s microperforated tube impedance.Earmuff passive attenuation behavior can be analytically described and analyzed with the improved LPM.Finally,the validity of improved LPM is verified experimentally.The results indicate that the improved LPM can predict earmuff attenuation with air leakage,and air leakage deteriorates earmuff attenuation and turns resonance frequency higher. 展开更多
关键词 earmuff lumped parameter model air leakage ATTENUATION
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Lumped Parameter Mass Flow Rate and Pressure Control Characteristics Model for High-Speed Pneumatic PWM on/off Valve
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作者 向忠 胡旭东 +1 位作者 刘昊 汝晶炜 《Journal of Donghua University(English Edition)》 EI CAS 2014年第3期293-303,共11页
Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the val... Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the valves time periods was well developed. With this model,the mass flow rate and dynamic pressure characteristics of constant volumes controlled by high-speed pneumatic PWM on /off valves was well described. A variable flow rate coefficient model was proposed to substitute for the constant one used in most of the prior works to investigate PWM on /off valves' dynamical pressure response, and a formula for disclosing the inherent relationship among the PWM command signal,static mass flow rate,and sonic conductance of the valve was newly derived.Finally,an extensive set of analytical experimental comparisons were implemented to verify the validity of the proposed mathematica model. With the proposed model, PWM on /off valves' characteristics,such as mass flow rate,step pressure response of the valve control system,mean pressure and ripple amplitude,not only in the linear range,but also in the nonlinear range can be wel predicted; Good agreement between measured and calculated results was obtained,which proved that the model is helpful for designing a control strategy in a closed loop control system. 展开更多
关键词 lumped parameter model pneumatic on/off valve pulse width modulation(PWM) mass flow rate pressure characteristic
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An Efficient Approach for the Numerical Identification of R and L Parameters of High Frequency Multi-winding Transformers
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作者 Z. De Greve O. Deblecker J. Lobry 《Journal of Energy and Power Engineering》 2011年第7期641-650,共10页
In this paper, equivalent circuits for high frequency multi-winding magnetic components are derived from finite element (FE) computations. Lumped parameter models are first presented, based on previously published w... In this paper, equivalent circuits for high frequency multi-winding magnetic components are derived from finite element (FE) computations. Lumped parameter models are first presented, based on previously published work. All parameters of these circuits can be interpreted as the results of open and short-circuit tests on the transformer. Based on this consideration, numerical procedures are then proposed to derive frequency-dependent lumped parameters from FE simulations. By using an adequate formulation, parameters are directly obtained from the FE model degrees of freedom, without performing any volume integration in post-processing, which can be source of numerical errors. In this contribution, attention is paid on the modeling of magnetic coupling using inductances, and dissipative effects (winding and core losses) using resistances. The impact of conductor eddy currents on the circuit parameters is moreover studied in details. Instead of an analysis of the impact conductor eddy currents may have on the circuit parameters is moreover carried through. 展开更多
关键词 Multi-winding transformer finite elements lumped parameter circuits.
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Time-domain identification of dynamic properties of layered soil by using extended Kalman filter and recorded seismic data 被引量:3
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作者 郑亦斌 王满生 +2 位作者 刘荷 姚英 周锡元 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2004年第2期237-247,共11页
A novel time-domain identification technique is developed for the seismic response analysis of soil-structure interaction.A two-degree-of-freedom (2DOF) model with eight lumped parameters is adopted to model the frequ... A novel time-domain identification technique is developed for the seismic response analysis of soil-structure interaction.A two-degree-of-freedom (2DOF) model with eight lumped parameters is adopted to model the frequency- dependent behavior of soils.For layered soil,the equivalent eight parameters of the 2DOF model are identified by the extended Kalman filter (EKF) method using recorded seismic data.The polynomial approximations for derivation of state estimators are applied in the EKF procedure.A realistic identification example is given for the layered-soil of a building site in Anchorage,Alaska in the United States.Results of the example demonstrate the feasibility and practicality of the proposed identification technique.The 2DOF soil model and the identification technique can be used for nonlinear response analysis of soil-structure interaction in the time-domain for layered or complex soil conditions.The identified parameters can be stored in a database tor use in other similar soil conditions,lfa universal database that covers information related to most soil conditions is developed in the thture,engineers could conveniently perform time history analyses of soil-structural interaction. 展开更多
关键词 soil-structure interaction IDENTIFICATION extended Kalman filter 2DOF model equivalent lumped parameters polynomial approximation seismic data
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GEOTHERMAL RESOURCES ASSESSMENT AND NUMERICAL SIMULATION IN TUANBO REGION
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作者 朱家玲 李春华 高天真 《Transactions of Tianjin University》 EI CAS 2001年第4期251-254,共4页
This paper mainly deals with the reservoir on the heat and mass transfer and mass and energy balance in a geothermal field.On the basis of briefing the general characteristics of the reservoir and the supposition of t... This paper mainly deals with the reservoir on the heat and mass transfer and mass and energy balance in a geothermal field.On the basis of briefing the general characteristics of the reservoir and the supposition of the reservoir modeling,the paper emphasizes the mathematical descriptions of hydra thermal transportation and convection by two methods according to the different models,such as lumped parameter model and distributed parameter model.It is effective to use these models in simulating the heterogeneous,and anisotropical fracture reservoir for the designed lifetime of 15 years. 展开更多
关键词 assessment of geothermal resources mass and energy balance lumped parameter model distributed parameter model
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Modeling and Simulation of Hydraulic Long Transmission Line by Bond Graph
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作者 Dragan Prsie Novak Nedie Ljubisa Dubonjie 《Journal of Mechanics Engineering and Automation》 2013年第4期257-262,共6页
This paper addresses the issue of modeling of the hydraulic long transmission line. In its base, such model is nonlinear with distributed parameters. Since general solution in closed-form for such model in time-domain... This paper addresses the issue of modeling of the hydraulic long transmission line. In its base, such model is nonlinear with distributed parameters. Since general solution in closed-form for such model in time-domain is not available, certain simplifications have to be introduced. The pipeline in the paper has been divided to a cascaded network of n segments so that a model with lumped parameters could be reached. For segment modeling, a standard library of bond graphs element has been used. On the basis of models with lumped parameters, the effect of the number of segments, pipeline length and effective bulk modulus on the dynamics of long transmission line have been analyzed. 展开更多
关键词 Long transmission line lumped parameters n segments bond graph
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Design of a Hydraulic System for Liquid Packaging
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作者 Claudio Angeloni Franzoni Federica Massimo Milani Fabrizio Paltrinieri 《Journal of Energy and Power Engineering》 2012年第8期1233-1241,共9页
The paper analyzes the dynamic behaviour of an industrial system devoted to the automated hydraulic packaging of beverages. More in detail, a lumped and distributed numerical approach is used to model both the filling... The paper analyzes the dynamic behaviour of an industrial system devoted to the automated hydraulic packaging of beverages. More in detail, a lumped and distributed numerical approach is used to model both the filling system and the multi-actuators hydraulic circuit needed to shape and separate the packages. The model reliability and accuracy are addressed by means of a numerical vs. experimental comparison of the main hydraulic and mechanical quantities for an actual production rate. Afterwards, the system architecture is redesigned in order to obtain higher production rates, and the effects of the hydraulic behaviour variation on the hydraulic efficiency are highlighted. Finally, a sensitivity analysis with respect to the main design parameters is carried out, in order to determine the circuit layout that maximizes the system efficiency in the whole production-rate range. 展开更多
关键词 Automated liquid packaging lumped parameters approach efficiency.
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Calculation and experimental study on heating temperature field of super-high strength aluminum alloy thick plate 被引量:5
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作者 Shi-tong FAN Yun-lai DENG +1 位作者 Jin ZHANG Xiao-bin GUO 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2017年第11期2415-2422,共8页
Stepped heating treatment has been applied to aluminum alloy thick plate to improve the mechanical performance and corrosion resistance.Accurate temperature control of the plate is the difficulty in engineering applic... Stepped heating treatment has been applied to aluminum alloy thick plate to improve the mechanical performance and corrosion resistance.Accurate temperature control of the plate is the difficulty in engineering application.The heating process,the calculation of surface heat transfer coefficient and the accurate temperature control method were studied based on measured heating temperature for the large-size thick plate.The results show that,the temperature difference between the surface and center of the thick plate is small.Based on the temperature uniformity,the surface heat transfer coefficient was calculated,and it is constant below300°C,but grows greatly over300°C.Consequently,a lumped parameter method(LPM)was developed to predict the plate temperature.A stepped solution treatment was designed by using LPM,and verified by finite element method(FEM)and experiments.Temperature curves calculated by LPM and FEM agree well with the experimental data,and the LPM is more convenient in engineering application. 展开更多
关键词 lumped parameter method surface heat transfer coefficient temperature field aluminum alloy thick plate
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Acceleration-Dependent Analysis of Vertical Ball Screw Feed System without Counterweight 被引量:1
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作者 Cunfan Zou Huijie Zhang +3 位作者 Jun Zhang Dongdong Song Hui Liu Wanhua Zhao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2021年第3期243-255,共13页
The distinguishing feature of a vertical ball screw feed system without counterweight is that the spindle system weight directly acts on the kinematic joints.Research into the dynamic characteristics under acceleratio... The distinguishing feature of a vertical ball screw feed system without counterweight is that the spindle system weight directly acts on the kinematic joints.Research into the dynamic characteristics under acceleration and deceleration is an important step in improving the structural performance of vertical milling machines.The magnitude and direction of the inertial force change significantly when the spindle system accelerates and decelerates.Therefore,the kinematic joint contact stiffness changes under the action of the inertial force and the spindle system weight.Thus,the system transmission stiffness also varies and affects the dynamics.In this study,a variable-coefficient lumped parameter dynamic model that considers the changes in the spindle system weight and the magnitude and direction of the inertial force is established for a ball screw feed system without counterweight.In addition,a calculation method for the system stiffness is provided.Experiments on a vertical ball screw feed system under acceleration and deceleration with different accelerations are also performed to verify the proposed dynamic model.Finally,the influence of the spindle system position,the rated dynamic load of the screw-nut joint,and the screw tension force on the natural frequency of the vertical ball screw feed system under acceleration and deceleration are studied.The results show that the vertical ball screw feed system has obviously different variable dynamics under acceleration and deceleration.The influence of the rated dynamic load and the spindle system position on the natural frequency under acceleration and deceleration is much greater than that of the screw tension force. 展开更多
关键词 Vertical ball screw feed system Acceleration and deceleration Joints stiffness Variable-coefficient lumped parameter model Power spectral density Natural frequency
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MODELING AND EXPERIMENTAL STUDY OF A PASSIVE HYDRAULIC ENGINE MOUNT WITH INERTIA AND DIRECT-DECOUPLER 被引量:1
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作者 ZHANG Yunxia ZHANG Jianwu +1 位作者 SHANGGUAN Wenbin FENG Qishan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2008年第3期31-35,共5页
To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compl... To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compliance of the decoupler chamber, effective piston area, fluid inertia and resistance of inertia track and direct-decoupler, are identified by means of experiments and finite element method (FEM). Dynamic behaviors are tested with elastomer test system for purpose of validating PHEM. With incorporation of inertia track and direct-decoupler, PHEM behaves effective and efficient vibration isolation in range of both low and high frequencies. The comparison of the numerical results with the experimental observations shows that the present PHEM achieves fairly good performance for the engine vibration isolation. 展开更多
关键词 Passive hydraulic engine mount lumped parameter model Parameter identification Dynamic response
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A DYNAMIC MATHEMATICAL MODEL STUDY OFTHE PLATE-FIN HUMID HEAT EXCHANGER
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作者 LiuBoqiang YuanXiugan LiMin(Faculty 505, Beijing University of Aeronautics and Astronautics,Beijing,China,100083) 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 1995年第3期179-184,共6页
ADYNAMICMATHEMATICALMODELSTUDYOFTHEPLATE-FINHUMIDHEATEXCHANGERLiuBoqiang;YuanXiugan;LiMin(Faculty505,Beijing... ADYNAMICMATHEMATICALMODELSTUDYOFTHEPLATE-FINHUMIDHEATEXCHANGERLiuBoqiang;YuanXiugan;LiMin(Faculty505,BeijingUniversityofAeron... 展开更多
关键词 exchangrrs lumped parameter systems dynamic models numerical ana-lysis
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Comprehensive lumped parameter and multibody approach for the dynamic simulation of agricultural tractors with tyre–soil interaction
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作者 Massimo Martelli Damiano Chiarabelli +3 位作者 Silvia Gessi Pietro Marani Emiliano Mucchi Marco Polastri 《IET Cyber-Systems and Robotics》 EI 2023年第3期1-23,共23页
Modern agricultural tractors are complex systems,in which multiple physical(and technological)domains interact to reach a wide set of competing goals,including work operational performance and energy efficiency.This c... Modern agricultural tractors are complex systems,in which multiple physical(and technological)domains interact to reach a wide set of competing goals,including work operational performance and energy efficiency.This complexity translates to the dynamic,multi‐domain simulation models implemented to serve as digital twins,for rapid prototyping and effective pre‐tuning,prior to bench and on‐field testing.Consequently,a suitable simulation framework should have the capability to focus both on the vehicle as a whole and on individual subsystems.For each of the latter,multiple options should be available,with different levels of detail,to properly address the relevant phenomena,depending on the specific focus,for an optimal balance between accuracy and computation time.The methodology proposed here by the authors is based on the lumped parameter approach and integrates the models for the following subsystems in a modular context:internal combustion engine,hydromechanical transmission,vehicle body,and tyre–soil interaction.The model is completed by a load cycle module that generates stimulus time histories to reproduce the work load under real operating conditions.Traction capability is affected by vertical load on the wheels,which is even more relevant if the vehicle is travelling on an uncompacted soil and subject to a variable drawbar pull force as it is when ploughing.The vertical load is,in turn,heavily affected by vehicle dynamics,which can be accurately modelled via a full multibody implementation.The presented lumped parameter model is intended as a powerful simulation tool to evaluate tractor performance,both in terms of fuel consumption and traction dynamics,by considering the cascade phenomena from the wheel–ground interaction to the engine,passing through the dynamics of vehicle bodies and their mass transfer.Its capabilities and numerical results are presented for the simulation of a realistic ploughing operation. 展开更多
关键词 agricultural tractor digital twin lumped parameter simulation multibody POWERTRAIN tyre-soil interaction
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Improving the Performance of an Electro-Hydraulic Load-Sensing Proportional Control Valve
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作者 Raffaele Babbone Massimo Milani Luca Montorsi Fabrizio Paltrinieri 《Journal of Energy and Power Engineering》 2013年第12期2336-2346,共11页
The paper deals with the simulation and the experimental verification of the hydraulic behavior of an electro-hydraulic load-sensing proportional control valve. An innovative CAE (computer aided engineering) methodo... The paper deals with the simulation and the experimental verification of the hydraulic behavior of an electro-hydraulic load-sensing proportional control valve. An innovative CAE (computer aided engineering) methodology, developed combining CFD (computational fluid dynamics) simulations with lumped and distributed numerical modeling, is firstly introduced and tailored by comparing the numerical results with measurements coming from an experimental campaign performed for a wide range of pressure loads and metered flow rates. Then, both the reliability and the limits of the numerical approach are highlighted through a detailed numerical vs. experimental comparison, involving the pressure of the main hydraulic lines, the flow rate through the first section and the local compensator displacement. Finally, the CAE methodology has been applied for assessing the internal ducts hydraulic permeability and the local compensator spring pre-load influence on the control valve metering curves. At the end of this analysis, an optimized design configuration, featuring a maximum controlled volumetric flow rate increased of more than 25%, has been proposed. 展开更多
关键词 Proportional control valve load-sensing CFD lumped and distributed parameters modeling.
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Accurate 3D Thermal Network Development for Direct-drive Outer-rotor Hybrid-PM Flux-switching Generator
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作者 Ali Zarghani Mohammad Farahzadi +1 位作者 Aghil Ghaheri Karim Abbaszadeh 《Chinese Journal of Electrical Engineering》 EI CSCD 2024年第2期80-92,共13页
Heat and thermal problems are major obstacles to achieving high power density in compact permanent magnet(PM)topologies.Consequently,a comprehensive,accurate,and rapid temperature rise estimation method is required fo... Heat and thermal problems are major obstacles to achieving high power density in compact permanent magnet(PM)topologies.Consequently,a comprehensive,accurate,and rapid temperature rise estimation method is required for novel electric machines to ensure safe and reliable operations.A unique three-dimensional(3D)lumped parameter thermal network(LPTN)is presented for accurate thermal modeling of a newly developed outer-rotor hybrid-PM flux switching generator(OR-HPMFSG)for direct-drive applications.First,the losses of the OR-HPMFSG are calculated using 3D finite element analysis(FEA).Subsequently,all machine components considering the thermal contact resistance,anisotropic thermal conductivity of materials,and various heat flow paths are comprehensively modeled based on the thermal resistances.In the proposed 3-D LPTN,internal nodes are considered to predict the average temperature as well as the hot spots of all active and passive components.Experimental measurements are performed on a prototype OR-HPMFSG to validate the efficiency of the 3-D LPTN.A comparison of the results at various operating points between the developed 3-D LPTN,experimental test,and FEA indicates that the 3-D LPTN quickly approximates the hotspot and mean temperature of all components under both transient and steady states with high accuracy. 展开更多
关键词 Direct-drive wind turbine hybrid-PM flux switching generator lumped parameter thermal network temperature estimation 3D thermal modeling
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Lumped Parameter Outflow Models for 1-D Blood Flow Simulations:Effect on Pulse Waves and Parameter Estimation 被引量:1
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作者 J.Alastruey K.H.Parker +1 位作者 J.Peiro S.J.Sherwin 《Communications in Computational Physics》 SCIE 2008年第7期317-336,共20页
Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the c... Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%. 展开更多
关键词 Pulse wave propagation one-dimensional modelling lumped parameter outflow models time-domain coupling arterial compliance peripheral compliance peripheral resistance multiscale modelling.
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INVESTIGATION ON EFFECT OF DRUG DOSING REGIMENTS ON DRUG DELIVERY IN SOLID TUMOR VIA LUMPED PARAMETER MODELING AND ANIMAL EXPERIMENTS
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作者 GAO Ci-xiu XU Shi-xiong +1 位作者 JIANG Yu-ping TU Jiang-long 《Journal of Hydrodynamics》 SCIE EI CSCD 2009年第1期20-25,共6页
This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tum... This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (Ct) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (HCPT), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor. 展开更多
关键词 solid tumor dosing regiments lumped parameter model experiment on rats
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