We hypothesized that liquid menisci occlusions may form inside small airways, travel along the airway while losing mass and finally may disintegrate into bioaerosols. Spreading of the COVID-19 virus is strongly relate...We hypothesized that liquid menisci occlusions may form inside small airways, travel along the airway while losing mass and finally may disintegrate into bioaerosols. Spreading of the COVID-19 virus is strongly related to the number of such bioaerosols exhaled by “super-spreaders”. We show, employing numerical methods, that this number can be diminished by administering surfactants which lower the surface-tension of the mucus which covers the airways.展开更多
A 56-year-old man presented spontaneously to the Emergency Department complaining of facial and neck oedema after assumption of nonsteroidal anti-inflammatory drugs(NSAIDS).The triage nurse assigned the patient to Acc...A 56-year-old man presented spontaneously to the Emergency Department complaining of facial and neck oedema after assumption of nonsteroidal anti-inflammatory drugs(NSAIDS).The triage nurse assigned the patient to Accident&Emergency(A&E)doctor as probable allergic reaction to NSAIDS.Chest X-ray(CXR),ordered after 24 hours,revealed a huge subcutaneous chest and neck emphysema without clearly visible pneumothorax.Subsequent chest CT scan showed a small left pneumothorax and a large amount of air in the mediastinum.The patient was conservatively treated since he was eupnoeic and hemodynamically stable.The pathophysiology of pneumomediastinum was first described by Macklin in 1939.The Macklin effect involves alveolar ruptures with air dissection along bronchovascular sheaths to the mediastinum.In this case the patient did not report in his history a recent blunt thoracic trauma and the initial suspicion of an allergic reaction has prevented physicians to immediately achieve the correct diagnosis.展开更多
文摘We hypothesized that liquid menisci occlusions may form inside small airways, travel along the airway while losing mass and finally may disintegrate into bioaerosols. Spreading of the COVID-19 virus is strongly related to the number of such bioaerosols exhaled by “super-spreaders”. We show, employing numerical methods, that this number can be diminished by administering surfactants which lower the surface-tension of the mucus which covers the airways.
文摘A 56-year-old man presented spontaneously to the Emergency Department complaining of facial and neck oedema after assumption of nonsteroidal anti-inflammatory drugs(NSAIDS).The triage nurse assigned the patient to Accident&Emergency(A&E)doctor as probable allergic reaction to NSAIDS.Chest X-ray(CXR),ordered after 24 hours,revealed a huge subcutaneous chest and neck emphysema without clearly visible pneumothorax.Subsequent chest CT scan showed a small left pneumothorax and a large amount of air in the mediastinum.The patient was conservatively treated since he was eupnoeic and hemodynamically stable.The pathophysiology of pneumomediastinum was first described by Macklin in 1939.The Macklin effect involves alveolar ruptures with air dissection along bronchovascular sheaths to the mediastinum.In this case the patient did not report in his history a recent blunt thoracic trauma and the initial suspicion of an allergic reaction has prevented physicians to immediately achieve the correct diagnosis.
