One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-...One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-butyl ester] which showed mod- erate antitumor activities against the A2780 cells and OVCAR-3 cells. Its structure was established by means of spectral data, particularly NMR, including HSQC and HMBC techniques.展开更多
A new kind of second order nonlinear optical(NLO) material m hydroxybenzoic acid(HBA) was reported in this paper. Primary study results revealed that it had a relatively strong nonlinearity, its powder SHG effect was ...A new kind of second order nonlinear optical(NLO) material m hydroxybenzoic acid(HBA) was reported in this paper. Primary study results revealed that it had a relatively strong nonlinearity, its powder SHG effect was 12 times that of KDP. The solid cut off wavelength λ cut off (350 nm) is very short compared to other organic second order NLO materials. The experimental results also showed that HBA had a high laser damage threshold and good characteristic thermal stability. Furthermore, We calculated its second order nonlinear hyperpolarizability β and analyzed the microscopic nonlinear properties, and found that the hydroxyl group could improve β obviously while the hydroxyl multisubstitution could hardly contribute to β values. [WT5HZ]展开更多
目前2-羟基对苯二甲酸(2-HTA)的生产主要以间羟基苯甲酸、甲酸钾、二氧化碳为原料实验室制备,未见放大生产的报导。为满足市场需求,以间羟基苯甲酸、碳酸氢钾、碳酸钾和氢氧化钾为原料,加入一定量高沸点溶剂,用改进的Koble-Schmi t t法...目前2-羟基对苯二甲酸(2-HTA)的生产主要以间羟基苯甲酸、甲酸钾、二氧化碳为原料实验室制备,未见放大生产的报导。为满足市场需求,以间羟基苯甲酸、碳酸氢钾、碳酸钾和氢氧化钾为原料,加入一定量高沸点溶剂,用改进的Koble-Schmi t t法放大生产制备2-羟基对苯二甲酸。考察原料配比、反应温度、反应压力和反应时间对产物收率的影响,用高效液相色谱法(HPLC)分析产物纯度,用DSC测定产物的熔点,用FTIR和1H NMR对产物的结构进行表征。在间羟基苯甲酸与碳酸氢钾、碳酸钾和氢氧化钾物质的量比为2.67∶3.77∶1.3∶1,反应温度180℃,反应压力2.0 MPa,反应时间8 h时,粗产品经混合溶剂一次精制,2-羟基对苯二甲酸的收率达74.87%,纯度99.7%,钾金属离子含量19 mg/kg。结果表明改进的Koble-Schmi t t法放大工艺,成本低、步骤少、环境污染小,适合放大生产。展开更多
基金financially supported by Chinese Academy of Nutritional Sciences,Shanghai Institutes for Biological Sciences
文摘One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-butyl ester] which showed mod- erate antitumor activities against the A2780 cells and OVCAR-3 cells. Its structure was established by means of spectral data, particularly NMR, including HSQC and HMBC techniques.
文摘A new kind of second order nonlinear optical(NLO) material m hydroxybenzoic acid(HBA) was reported in this paper. Primary study results revealed that it had a relatively strong nonlinearity, its powder SHG effect was 12 times that of KDP. The solid cut off wavelength λ cut off (350 nm) is very short compared to other organic second order NLO materials. The experimental results also showed that HBA had a high laser damage threshold and good characteristic thermal stability. Furthermore, We calculated its second order nonlinear hyperpolarizability β and analyzed the microscopic nonlinear properties, and found that the hydroxyl group could improve β obviously while the hydroxyl multisubstitution could hardly contribute to β values. [WT5HZ]
文摘目前2-羟基对苯二甲酸(2-HTA)的生产主要以间羟基苯甲酸、甲酸钾、二氧化碳为原料实验室制备,未见放大生产的报导。为满足市场需求,以间羟基苯甲酸、碳酸氢钾、碳酸钾和氢氧化钾为原料,加入一定量高沸点溶剂,用改进的Koble-Schmi t t法放大生产制备2-羟基对苯二甲酸。考察原料配比、反应温度、反应压力和反应时间对产物收率的影响,用高效液相色谱法(HPLC)分析产物纯度,用DSC测定产物的熔点,用FTIR和1H NMR对产物的结构进行表征。在间羟基苯甲酸与碳酸氢钾、碳酸钾和氢氧化钾物质的量比为2.67∶3.77∶1.3∶1,反应温度180℃,反应压力2.0 MPa,反应时间8 h时,粗产品经混合溶剂一次精制,2-羟基对苯二甲酸的收率达74.87%,纯度99.7%,钾金属离子含量19 mg/kg。结果表明改进的Koble-Schmi t t法放大工艺,成本低、步骤少、环境污染小,适合放大生产。
