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气象观测场在汽车试验场中的应用研究
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作者 陈海建 《时代汽车》 2024年第14期172-174,178,共4页
汽车试验场作为汽车开展道路测试的重要场所,用于验证汽车产品的品质以及可靠性。除了场地道路外,气象条件作为汽车道路测试的重要一环,在《GB/T12534-1990汽车道路试验方法通则》中也有明确要求,如:试验时应是无雨无雾天气,相对湿度小... 汽车试验场作为汽车开展道路测试的重要场所,用于验证汽车产品的品质以及可靠性。除了场地道路外,气象条件作为汽车道路测试的重要一环,在《GB/T12534-1990汽车道路试验方法通则》中也有明确要求,如:试验时应是无雨无雾天气,相对湿度小于95%,气温0-40℃,风速不大于3m/s。同时气象条件也作为试验场道路管控的重要依据,实时风速、雨量、能见度等信息为场地管理者发布限速、限行、封场等通知提供必要参考依据,直接影响道路测试安全管控的及时性。因此,文章从气象观测场的建设、气象服务、异常天气道路管控等方面开展气象观测场在汽车试验场中的应用研究。 展开更多
关键词 products. In addition to the SITE roads mETEOROLOGICAL conditions are an important part of AUTOmOTIVE ROAD testing and there are also clear requirements in the GB/T12534-1990 General Rules for AUTOmOTIVE ROAD Test methods. For example the test should be conducted in rain and fog free weather with a relative humidity of less than 95% a temperature of 0-40 and a wind SPEED of no more than 3m/s. At the same time mETEOROLOGICAL conditions also serve as an important basis for ROAD control in the test site. Real time information such as wind SPEED rainfall and visibility provides necessary reference for SITE managers to issue notices on SPEED limits SITE closures and trac restrictions directly aecting the timeliness of ROAD testing safety control. Therefore this article conducts research on the application of mETEOROLOGICAL observation SITES in AUTOmOTIVE testing SITES from the construction of mETEOROLOGICAL observation SITES mETEOROLOGICAL services and abnormal weather ROAD control.
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Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR 被引量:13
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作者 Kenneth Maiese 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第3期372-385,共14页
Throughout the globe,diabetes mellitus(DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and af... Throughout the globe,diabetes mellitus(DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin(m TOR) is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1(m TORC1) and m TOR Complex 2(m TORC2) and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase(PI 3-K),protein kinase B(Akt),AMP activated protein kinase(AMPK),silent mating type information regulation 2 homolog 1(Saccharomyces cerevisiae)(SIRT1),Wnt1 inducible signaling pathway protein 1(WISP1),and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM. 展开更多
关键词 Akt AmP activated protein kinase(AmPK) apoptosis Alzheimer’s disease autophagy β-cell cancer cardiovascular disease caspase CCN family diabetes mellitus epidermal growth factor erythropoietin fibroblast growth factor forkhead transcription factors Fox O FRAP1 hamartin(tuberous sclerosis 1)/tuberin(tuberous sclerosis 2)(TSC1/TSC2) insulin mechanistic target of rapamycin(mTOR) m TOR Complex 1(m T ORC1) m TOR Complex 2(m TORC2) nicotinamide nicotinamide adenine dinucleotide(NAD%PLUS%) non-communicable diseases oxidative stress phosphoinositide 3-kinase(PI 3-K) programmed cell death silent mating type information regulation 2 homolog 1(Saccharomyces cerevisiae)(SIRT1) sirtuin stem cells wingless Wnt Wnt1 inducible signaling pathway protein 1(WISP1)
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Fast and Accurate Identification of <i>M. tuberculosis</i>Complex Using an Immunochromatographic MPT64 Antigen Detection Test 被引量:2
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作者 Anto Jesuraj Uday Kumar Hiresave Srinivasa 《Journal of Tuberculosis Research》 2015年第4期149-156,共8页
Background: A new rapid Immunochromatographic test (ICT) kit (MPT64 TB Ag Kit) for detection of MPT64 Antigen in M. tuberculosis (MTB) isolates used for rapid identification of MTB isolates developed by SD (Standard D... Background: A new rapid Immunochromatographic test (ICT) kit (MPT64 TB Ag Kit) for detection of MPT64 Antigen in M. tuberculosis (MTB) isolates used for rapid identification of MTB isolates developed by SD (Standard Diagnostics) Bio line, South Korea was evaluated. The ICT is a rapid, reliable and cheaper method that can be used instead of conventional biochemical tests for confirming MTB in culture isolates in resource limited laboratories. The study also evaluated the ability of ICT to detect MPT64-Antigen before the micro MGIT could signal positive. Material/Methods: A total of 450 sputum samples of individual patients were used for the study. 152 isolates of Mycobacteria were recovered from solid and liquid media. These strains were tested for the detection of MPT64-antigen. H37Rv strain was served as the positive reference control and also used for early detection of Antigen experiment. Findings: The development of bands on both test and sample region when H37Rv strain was tested were seen (MPT64 antigen positive). When 138 MTB isolates were tested, it showed a similar banding pattern indicating 100% sensitivity. MPT64 band formation was not detected in any of the 14 isolates indicating 100% specificity. Both PPV & NPV were 100%. All the isolates negative for MPT64 Ag were confirmed as MOTT by conventional bio-chemical PNBA. The H37Rv strain showed a faint band from the 2nd day onwards from inoculation till 3rd day in the earlier Antigen detection experiment. Conclusion: Rapid identification of MTB culture isolate is a pressing need for diagnosis and proceeding to perform drug susceptibility testing. MPT64 TB Ag detection ICT kit is a rapid, reliable method, good substitute for molecular identification methods, and conventional biochemical test which is time-consuming and technically demanding. The early detection of Antigen can be used as an effective tool in diagnosis. 展开更多
关键词 mTB (m. tuberculosis) mOTT (mycobacteria Other than m. tuberculosis) PNBA (Para Nitro Benzoic Assay) mPT64 Antigen ICT (Immunochromatography Test) mGIT (mycobacterium Growth Indicator Tube) SD TB Ag mPT64 Rapid (Standard Diagnostics Seoul South Korea)
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Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats 被引量:4
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作者 HelenaFWrzos TarunTandon AnnOuyang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第22期3292-3298,共7页
AIM:To investigate the pathway(s)mediating rat antral circular smooth muscle contractile responses to the cholinomimetic agent,bethanechol and the subtypes of muscarinic receptors mediating the cholinergic contraction... AIM:To investigate the pathway(s)mediating rat antral circular smooth muscle contractile responses to the cholinomimetic agent,bethanechol and the subtypes of muscarinic receptors mediating the cholinergic contraction. METHODS:Circular smooth muscle strips from the antrum of Sprague-Dawley rats were mounted in muscle baths in Krebs buffer.Isometric tension was recorded.Cumulative concentration-response curves were obtained for(+)-cis- dioxolane(cD),a nonspecific muscarinic agonist,at 10^(-8)- 10^(-4)mol/L,in the presence of tetrodotoxin(TTX,10^(-7)mol/L). Results were normalized to cross sectional area.A repeat concentration-response curve was obtained after incubation of the muscle for 90 min with antagonists for M1(pirenzepine), M2(methoctramine)and M3(darifenadn)muscarinic receptor subtypes.The sensitivity to PTX was tested by the ip injection of 100 mg/kg of PTX 5 d before the experiment.The antral circular smooth muscles were removed from PTX-treated and non-treated rats as strips and dispersed smooth muscle cells to identify whether PTX-linked pathway mediated the contractility to bethanechol. RESULTS:A dose-dependent contractile response observed with bethanechol,was not affected by TTx.The pretreatment of rats with pertussis toxin decreased the contraction induced by bethanechol.Lack of calcium as well as the presence of the L-type calcium channel blocker,nifedipine,also inhibited the cholinergic contraction,with a reduction in response from 2.5±0.4 g/mm^2 to 1.2±0.4 g/mm^2(P<0.05).The dose- response curves were shifted to the right by muscarinic antagonists in the following order of affinity:darifenacin (M_3)>methocramine(M_2)>pirenzepine(M_1). CONCLUSION:The muscarinic receptors-dependent contraction of rat antral circular smooth muscles was linked to the signal transduction pathway(s)involving pertussis-toxin sensitive GTP-binding proteins and to extracellular calcium via L-type voltage gated calcium channels.The presence of the residual contractile response after the treatment with nifedipine,suggests that an additional pathway could mediate the cholinergic contraction.The involvement of more than one muscarinic receptor(functionally predominant type 3 over type 2)also suggests more than one pathway mediating the cholinergic contraction in rat antrum. 展开更多
关键词 Anesthetics Local Animals BENZOFURANS BETHANECHOL Calcium Calcium Channel Blockers Cholinergic Agonists Dose-Response Relationship Drug GTP-Binding Proteins In Vitro male muscarinic Antagonists muscle Contraction muscle Smooth Nifedipine Pertussis Toxin Pirenzepine Pyloric Antrum PYRROLIDINES RATS Rats Sprague-Dawley Receptor muscarinic m1 inhibitors Receptor muscarinic m2 Receptor muscarinic m3 Signal Transduction Tetrodotoxin
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Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage:an intrinsic review of a hematoma resolving pathway 被引量:2
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作者 Jerry Flores Jiping Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期350-354,共5页
Germinal matrix hemorrhage is one of the leading causes of morbidity,mortality,and acquired infantile hydrocephalus in preterm infants in the United States,with little progress made in its clinical management.Blood cl... Germinal matrix hemorrhage is one of the leading causes of morbidity,mortality,and acquired infantile hydrocephalus in preterm infants in the United States,with little progress made in its clinical management.Blood clots have been shown to elicit secondary brain injury after germinal matrix hemorrhage,by disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage causing post-hemorrhagic hydrocephalus development.Current evidence suggests that rapid hematoma resolution is necessary to improve neurological outcomes after hemorrhagic stroke.Various articles have demonstrated the beneficial effects of stimulating the polarization of microglia cells into the M2 phenotype,as it has been suggested that they play an essential role in the rapid phagocytosis of the blood clot after hemorrhagic models of stroke.N-formyl peptide receptor 2(FPR2),a G-protein-coupled receptor,has been shown to be neuroprotective after stroke.FPR2 activation has been associated with the upregulation of phagocytic macrophage clearance,yet its mechanism has not been fully explored.Recent literature suggests that FPR2 may play a role in the stimulation of scavenger receptor CD36.Scavenger receptor CD36 plays a vital role in microglia phagocytic blood clot clearance after germinal matrix hemorrhage.FPR2 has been shown to phosphorylate extracellular-signal-regulated kinase 1/2(ERK1/2),which then promotes the transcription of the dual-specificity protein phosphatase 1(DUSP1)gene.In this review,we present an intrinsic outline of the main components involved in FPR2 stimulation and hematoma resolution after germinal matrix hemorrhage. 展开更多
关键词 AnxA1 FPR2 GmH hematoma resolution hemorrhagic stroke m1 m2 microglia polarization mICROGLIA PHAGOCYTOSIS
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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future
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作者 Zhiyuan Yin Jiahui Kang +3 位作者 Xuan Cheng Hui Gao Shujia Huo Haiwei Xu 《Neural Regeneration Research》 SCIE CAS 2025年第4期946-959,共14页
Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume respon... Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored functionality.Conversely,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various technologies.Advancements in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in mice.Nevertheless,there remain issues that hinder improving reprogramming efficiency and maturity.Thus,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming strategies.This review describes recent progress in relatively successful Müller glia reprogramming strategies.It also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice. 展开更多
关键词 cell fusion chemical small-molecules EPIGENETIC extracellular matrix immune metabolic mICE müller glia neurodegenerative diseases REPROGRAmmING retina regeneration
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Correlation of tumor-associated macrophage density and proportion of M2 subtypes with the pathological stage of colorectal cancer
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作者 Fouzia Fazal Muhammad Arsalan Khan +2 位作者 Sumayya Shawana Rahma Rashid Muhammed Mubarak 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期1878-1889,共12页
BACKGROUND Colorectal cancer(CRC)is a prevalent global malignancy with complex prognostic factors.Tumor-associated macrophages(TAMs)have shown paradoxical associations with CRC survival,particularly concerning the M2 ... BACKGROUND Colorectal cancer(CRC)is a prevalent global malignancy with complex prognostic factors.Tumor-associated macrophages(TAMs)have shown paradoxical associations with CRC survival,particularly concerning the M2 subset.AIM We aimed to establish a simplified protocol for quantifying M2-like TAMs and explore their correlation with clinicopathological factors.METHODS A cross-sectional study included histopathological assessment of paraffinembedded tissue blocks obtained from 43 CRC patients.Using CD68 and CD163 immunohistochemistry,we quantified TAMs in tumor stroma and front,focusing on M2 proportion.Demographic,histopathological,and clinical parameters were collected.RESULTS TAM density was significantly higher at the tumor front,with the M2 proportion three times greater in both zones.The tumor front had a higher M2 proportion,which correlated significantly with advanced tumor stage(P=0.04),pathological nodal involvement(P=0.04),and lymphovascular invasion(LVI,P=0.01).However,no significant association was found between the M2 proportion in the tumor stroma and clinicopathological factors.CONCLUSION Our study introduces a simplified protocol for quantifying M2-like TAMs in CRC tissue samples.We demonstrated a significant correlation between an increased M2 proportion at the tumor front and advanced tumor stage,nodal involvement,and LVI.This suggests that M2-like TAMs might serve as potential indicators of disease progression in CRC,warranting further investigation and potential clinical application. 展开更多
关键词 Colorectal cancer mACROPHAGES Tumor stroma m2 subset Tumor front Tumor stage Lymphovascular invasion Prognosis Tumor-associated macrophages Immunohistochemistry
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人脑初级体感皮质M_(20)反应的性别差异-脑磁图研究
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作者 孙吉林 李素敏 +3 位作者 吴杰 吴晶 赵华东 尹岭 《现代电生理学杂志》 2005年第2期68-71,共4页
目的:应用脑磁图(MEG)研究健康受试者初级体感皮质反应M20的潜伏期、波幅及位置的性别差异。方法:对40例受试者给予双侧腕部正中神经电刺激,固定电流脉冲0.3ms,刺激间期0.5s,诱发初级体感皮质兴奋。脑磁图检查后进行MR扫描,层厚1.5mm。... 目的:应用脑磁图(MEG)研究健康受试者初级体感皮质反应M20的潜伏期、波幅及位置的性别差异。方法:对40例受试者给予双侧腕部正中神经电刺激,固定电流脉冲0.3ms,刺激间期0.5s,诱发初级体感皮质兴奋。脑磁图检查后进行MR扫描,层厚1.5mm。大脑初级体感皮质反应由等电流偶极(ECD)评价。将脑磁图所获得的M20反应叠加到MRI上,形成磁源性影像(MSI)。结果:依照给予电刺激后反应潜伏期不同分别称为M20、M35及M60,因M35及M60易受刺激间期(ISI)的影响,只对M20的潜伏期、波幅及反应位置的性别差异进行分析。结果为(1)M20左、右半球潜伏期男性20.6±1.0ms和20.7±1.2ms,女性20.1±0.9ms和20.2±0.9ms,男女性同侧半球潜伏期无显著性差异(P>0.05);(2)M20左、右半球波幅男性23.6±11.2nAm和25.4±11.2nAm,女性25.8±10.5nAm和27.6±7.8nAm,男女性同侧半球波幅无显著性差异(P>0.05);(3)左半球男女性M20偶极位置在X轴位存在显著性差异(P<0.05),显示男性X轴上与女性相比稍偏外侧,右半球男女性M20偶极位置在X轴位无显著性差异(P>0.05),Y,Z轴无显著性差异(P>0.05);(4)磁源性影像显示所有受试者M20反应峰值均位于中央后回。结论:脑磁图可明确不同性别的大脑初级体感皮质反应M20潜伏期、波幅及位置。磁源性影像显示M20峰值位于? 展开更多
关键词 mR扫描 m35 mRI
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Microglia:a promising therapeutic target in spinal cord injury
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作者 Xiaowei Zha Guoli Zheng +3 位作者 Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi 《Neural Regeneration Research》 SCIE CAS 2025年第2期454-463,共10页
Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accou... Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal regeneration.In this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor cells.Despite a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive research.This review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target. 展开更多
关键词 ASTROCYTES CYTOKINES functional recovery immune regulation m1/m2 activation mACROPHAGES mICROGLIA NEUROINFLAmmATION spinal cord injury therapy
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On a Grouping Method for Constructing Mixed Orthogonal Arrays 被引量:1
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作者 Chung-Yi Suen 《Open Journal of Statistics》 2012年第2期188-197,共10页
Mixed orthogonal arrays of strength two and size smn are constructed by grouping points in the finite projective geometry PG(mn-1, s). PG(mn-1, s) can be partitioned into [(smn-1)/(sn-1)](n-1)-flats such that each (n-... Mixed orthogonal arrays of strength two and size smn are constructed by grouping points in the finite projective geometry PG(mn-1, s). PG(mn-1, s) can be partitioned into [(smn-1)/(sn-1)](n-1)-flats such that each (n-1)-flat is associated with a point in PG(m-1, sn). An orthogonal array Lsmn((sn)(smn-)(sn-1) can be constructed by using (smn-1)/( sn-1) points in PG(m-1, sn). A set of (st-1)/(s-1) points in PG(m-1, sn) is called a (t-1)-flat over GF(s) if it is isomorphic to PG(t-1, s). If there exists a (t-1)-flat over GF(s) in PG(m-1, sn), then we can replace the corresponding [(st-1)/(s-1)] sn-level columns in Lsmn((sn)(smn-)(sn-1) by (smn-1)/( sn-1) st -level columns and obtain a mixed orthogonal array. Many new mixed orthogonal arrays can be obtained by this procedure. In this paper, we study methods for finding disjoint (t-1)-flats over GF(s) in PG(m-1, sn) in order to construct more mixed orthogonal arrays of strength two. In particular, if m and n are relatively prime then we can construct an Lsmn((sm)smn-1/sm-1-i(sn-1)/ (s-1)( sn) i(sm-1)/ s-1) for any 0i(smn-1)(s-1)/( sm-1)( sn-1) New orthogonal arrays of sizes 256, 512, and 1024 are obtained by using PG(7,2), PG(8,2), and PG(9,2) respectively. 展开更多
关键词 FINITE field FINITE PROJECTIVE geometry (t-1)-flat over GF(s) in PG(m-1 sn ) Geometric ORTHOGONAL array matrix representation minimal polynomial ORTHOGONAL main-effect plan PRImITIVE element Tight.
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半边旗提取物5F对人高转移卵巢癌细胞HO-8910PMETS-1mRNA和VEGF蛋白表达的影响 被引量:9
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作者 何太平 莫丽儿 梁念慈 《中药材》 CAS CSCD 北大核心 2005年第4期307-309,共3页
目的:研究半边旗提取物5F(以下简称5F)对HO-8910PM细胞内VEGF蛋白及ETS-1mRNA表达的影响,探讨其抗肿瘤侵袭转移的作用机制.方法:RT-PCR分析ETS-1mRNA的表达;Western blot分析VEGF蛋白的表达.结果:25~100 μmol/L 5F作用HO-8910PM细胞2... 目的:研究半边旗提取物5F(以下简称5F)对HO-8910PM细胞内VEGF蛋白及ETS-1mRNA表达的影响,探讨其抗肿瘤侵袭转移的作用机制.方法:RT-PCR分析ETS-1mRNA的表达;Western blot分析VEGF蛋白的表达.结果:25~100 μmol/L 5F作用HO-8910PM细胞24 h后,明显下调ETS-1mRNA的表达;5F明显下调VEGF蛋白表达水平.结论:5F抗肿瘤侵袭转移能力与ETS-1mRNA和VEGF蛋白的表达有关. 展开更多
关键词 5F HO-8910Pm VEGF mRNA表达 WESTEm ETS-1 PCR mol/L blot RT- 24h m细胞
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Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury 被引量:1
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作者 Yanan Dou Xiaowei Fei +7 位作者 Xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao Lyu Zhou Fei Xia Li Fei Fei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1608-1617,共10页
Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in ... Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in neuroinflammation in the cerebrum.However,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown.In our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion injury.For in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller cells.We found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion injury.Furthermore,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte rleukin-18.The opposite results we re observed with Homerla ove rexpression.Finally,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion injury.Taken together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury. 展开更多
关键词 CASPASE-8 Homer1a INTERLEUKIN-18 INTERLEUKIN-1Β intraocular pressure ischemia/reperfusion injury JSH-23 müller cells NLRP3 nuclear factor-kB p65 RETINA
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Polysurfacic Tori or Kideas Inspired by the Möbius Strip Topology
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作者 Emmanuel Cadier Anaxhaoza 《Advances in Pure Mathematics》 2023年第9期543-551,共9页
Polysurfacic tori or kideas are three-dimensional objects formed by rotating a regular polygon around a central axis. These toric shapes are referred to as “polysurfacic” because their characteristics, such as the n... Polysurfacic tori or kideas are three-dimensional objects formed by rotating a regular polygon around a central axis. These toric shapes are referred to as “polysurfacic” because their characteristics, such as the number of sides or surfaces separated by edges, can vary in a non-trivial manner depending on the degree of twisting during the revolution. We use the term “Kideas” to specifically denote these polysurfacic tori, and we represent the number of sides (referred to as “facets”) of the original polygon followed by a point, while the number of facets from which the torus is twisted during its revolution is indicated. We then explore the use of concave regular polygons to generate Kideas. We finally give acceleration for the algorithm for calculating the set of prime numbers. 展开更多
关键词 Heavenly Things Topology Euclidian Geometry möbius Strip Emmanuel’s Tori YiBoLongs Tori Cadiers Tori möbius Tori Polysurfacic Tori Kideas The Keys KideaCross KideaStar Churros Algorithm for Calculating the Set of Prime Numbers P The Last Found Element of P
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Einstein’s General Relativity and Pure Gravity in a Cosserat and De Sitter-Witten Spacetime Setting as the Explanation of Dark Energy and Cosmic Accelerated Expansion
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作者 Mohamed S. El Naschie 《International Journal of Astronomy and Astrophysics》 2014年第2期332-339,共8页
Ordinary energy and dark energy density are determined using a Cosserat-Cartan and killing-Yano reinterpretation of Einstein’s special and general relativity. Thus starting from a maximally symmetric space with 528 k... Ordinary energy and dark energy density are determined using a Cosserat-Cartan and killing-Yano reinterpretation of Einstein’s special and general relativity. Thus starting from a maximally symmetric space with 528 killing vector fields corresponding to Witten’s five Branes model in eleven dimensional M-theory we reason that 504 of the 528 are essentially the components of the relevant killing-Yano tensor. In turn this tensor is related to hidden symmetries and torsional coupled stresses of the Cosserat micro-polar space as well as the Einstein-Cartan connection. Proceeding in this way the dark energy density is found to be that of Einstein’s maximal energy mc2 where m is the mass and c is the speed of light multiplied with a Lorentz factor equal to the ratio of the 504 killing-Yano tensor and the 528 states maximally symmetric space. Thus we have E (dark) = mc2 (504/528) = mc2 (21/22) which is about 95.5% of the total maximal energy density in astounding agreement with COBE, WMAP and Planck cosmological measurements as well as the type 1a supernova analysis. Finally theory and results are validated via a related theory based on the degrees of freedom of pure gravity, the theory of nonlocal elasticity as well as ‘t Hooft-Veltman renormalization method. 展开更多
关键词 General RELATIVITY COSSERAT micro-Polar Space Dark Energy Teleparellelism Wittens m-THEORY De Sitter SPACETImE Killing-Yano Tensor Einstein-Cartan RELATIVITY PURE GRAVITY Kaluza-Klein Theory Nonlocal Elasticity 't Hooft-Veltman Renormalization
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Quantum Coherent Entangled Hydrogen Atom Non-Locality
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作者 Mark Moody 《Journal of Applied Mathematics and Physics》 2020年第5期737-752,共16页
The discovery of a data based informational wave pattern infuses coherent entanglement into the system. This discovery of how to add coherent entanglement into the model provides the missing key, that has opened the d... The discovery of a data based informational wave pattern infuses coherent entanglement into the system. This discovery of how to add coherent entanglement into the model provides the missing key, that has opened the door to understanding the universe. It is found that the inclusion of coherence and entanglement at the start of the system is extremely simple and in fact it is so simple that it has simply been overlooked. Entanglement and coherence are the most fundamental aspects of our universe. It is demonstrated that the basic model of the hydrogen atom is made from the CMB. If we add entanglement into this basic model of the hydrogen atom a math system called Wave Pattern Entangled Math is unveiled. This system of wave interference mathematics creates a data system in which entanglement and coherence can easily be understood. The final outcome is an unbreakable pattern of information, including entangled energy, entropy, spin, universal expansion, compression, velocity of light, C2, and Quantum Coherence. 展开更多
关键词 Entropy Function Entanglement ENTANGLED Universal matrix WAVE Pattern ENTANGLED mATH WPEm Complementarity CAUSALITY Wave-Particle Duality Hydrogen Atom C.m.B. Cosmic microwave Background WAVE Frequency
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Risk of connective—tissue disease in men with testicular or penile prostheses:a preliminary study
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作者 KuJH SongYS 《Asian Journal of Andrology》 SCIE CAS CSCD 2002年第1期67-72,共6页
AIM: To help clarifying the possibility of connective-tissue diseases in men with penile or testicular prostheses. METHODS: Eight patients underwent inflatable penile prostheses and 15, testicular prostheses consented... AIM: To help clarifying the possibility of connective-tissue diseases in men with penile or testicular prostheses. METHODS: Eight patients underwent inflatable penile prostheses and 15, testicular prostheses consented to the study. Their medical records were reviewed and a follow-up interview and physical and serological examinations were performed. RESULTS: In patients with penile prostheses, there was no abnormal antinuclear antibody (ANA) or IgM elevation. The serum levels of the rheumatoid factor (RF), C4, IgA and IgG were abnormal in one patient, and the levels of erythrocyte sedimentation rate (ESR) and C3, abnormal in two. Four had elevated IgE. In patients with testicular prostheses, there was no abnormal RF, ANA or IgM. The serum levels of ESR and IgA were abnormal in two, and three had abnormal C4, ten abnormal C3, and eleven decreased IgG. All had increased IgE. Men with penile prostheses had higher serum levels of IgG and IgM than those with testicular prostheses (P=0.001, P=0.016, respectively). The rates of abnormal values of IgE and IgG were higher in men with testicular prostheses than in men with penile prostheses (P=0.008, P=0.009, respectively). Physical examination was normal in all patients and nobody had documented symptoms pertinent to connective-tissue diseases. CONCLUSION: Our findings suggest that the risk of connective-tissue diseases is not higher in patients wearing prostheses as the ANA is negative and there is no apparent manifestation suggestive of connective-tissue diseases. 展开更多
关键词 ADOLESCENT Adult Aged Aged 80 and over Blood Sedimentation Complement C3 Complement C4 Connective Tissue Diseases Humans Immunoglobulin A Immunoglobulin E Immunoglobulin G Immunoglobulin m male middle Aged Penile Prosthesis Pilot Projects Risk Factors Silicon
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ErbB-3结合蛋白—ebp1对ACC-M细胞生长的影响 被引量:11
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作者 余优成 张志愿 +5 位作者 陈万涛 周晓健 潘红芽 张萍 徐骎 叶冬霞 《中国临床医学》 北大核心 2005年第2期324-326,共3页
目的:探讨ErbB- 3结合蛋白—ebp1 对腺样囊性癌ACC M细胞生长增殖作用的影响。方法:通过免疫组化筛选到erbB 2/erbB -3双阳性的ACC M细胞系;转染pcDNA3.1 -ebp1 质粒至ACC M细胞,G418 筛选被转染的阳性细胞;RT- PCR检测转染后细胞中ebp... 目的:探讨ErbB- 3结合蛋白—ebp1 对腺样囊性癌ACC M细胞生长增殖作用的影响。方法:通过免疫组化筛选到erbB 2/erbB -3双阳性的ACC M细胞系;转染pcDNA3.1 -ebp1 质粒至ACC M细胞,G418 筛选被转染的阳性细胞;RT- PCR检测转染后细胞中ebp1的转录水平;细胞生长曲线及3H- TdR摄入法观察转染前后细胞生长增殖能力的改变。结果:ACC- M细胞同时表达erbB 2/erbB 3;RT -PCR显示转染后细胞中ebp1转录水平明显升高;ACC- M- ebp1 细胞生长曲线平缓,生长减慢,3H- TdR摄入量明显减少,细胞增殖能力减弱。结论:ebp1在体外能显著抑制ACC- M肿瘤细胞增殖。 展开更多
关键词 ACC erbB-2 线 PCDNA3 PCR m细胞 TdR ^3H RT
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Dark Energy Explained via the Hawking-Hartle Quantum Wave and the Topology of Cosmic Crystallography 被引量:1
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作者 Mohamed S. El Naschie Atef Helal 《International Journal of Astronomy and Astrophysics》 2013年第3期318-343,共26页
The aim of the present paper is to explain and accurately calculate the missing dark energy density of the cosmos by scaling the Planck scale and using the methodology of the relatively novel discipline of cosmic crys... The aim of the present paper is to explain and accurately calculate the missing dark energy density of the cosmos by scaling the Planck scale and using the methodology of the relatively novel discipline of cosmic crystallography and Hawking-Hartle quantum wave solution of Wheeler-DeWitt equation. Following this road we arrive at a modified version of Einstein’s energy mass relation E = mc2 which predicts a cosmological energy density in astonishing accord with the WMAP and supernova measurements and analysis. We develop non-constructively what may be termed super symmetric Penrose fractal tiling and find that the isomorphic length of this tiling is equal to the self affinity radius of a universe which resembles an 11 dimensional Hilbert cube or a fractal M-theory with a Hausdorff dimension where. It then turns out that the correct maximal quantum relativity energy-mass equation for intergalactic scales is a simple relativistic scaling, in the sense of Weyl-Nottale, of Einstein’s classical equation, namely EQR = (1/2)(1/) moc2 = 0.0450849 mc2 and that this energy is the ordinary measurable energy density of the quantum particle. This means that almost 95.5% of the energy of the cosmos is dark energy which by quantum particle-wave duality is the absolute value of the energy of the quantum wave and is proportional to the square of the curvature of the curled dimension of spacetime namely where and is Hardy’s probability of quantum entanglement. Because of the quantum wave collapse on measurement this energy cannot be measured using our current technologies. The same result is obtained by involving all the 17 Stein spaces corresponding to 17 types of the wallpaper groups as well as the 230-11=219 three dimensional crystallographic group which gives the number of the first level of massless particle-like states in Heterotic string theory. All these diverse subjects find here a unified view point leading to the same result regarding the missing dark energy of the universe, which turned out to by synonymous with the absolute value of the energy of the Hawking-Hartle quantum wave solution of Wheeler-DeWitt equation while ordinary energy is the energy of the quantum particle into which the Hawking-Hartle wave collapse at cosmic energy measurement. In other words it is in the very act of measurement which causes our inability to measure the “Dark energy of the quantum wave” in any direct way. The only hope if any to detect dark energy and utilize it in nuclear reactors is future development of sophisticated quantum wave non-demolition measurement instruments. 展开更多
关键词 Doubly SPECIAL RELATIVITY Weeks manifold Experimental Test of Einsteins RELATIVITY Wittens m-THEORY Ordinary Energy of the QUANTUm Particle Hawking-Hartle WAVE of Cosmos Crystallographic Symmetry Groups REVISING SPECIAL RELATIVITY
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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions
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作者 Yuxue Mu Ning Zhang +7 位作者 Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen 《Neural Regeneration Research》 SCIE CAS 2025年第7期2116-2128,共13页
A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to ... A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under microgravity.After 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic cells.To investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail suspension.The results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly upregulated.In addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated weightlessness.These findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness. 展开更多
关键词 glial fibrous acidic protein GLIOSIS müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness
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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease
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作者 Shengyang Zhou Ting Li +8 位作者 Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen 《Neural Regeneration Research》 SCIE CAS 2025年第8期2361-2372,共12页
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report... Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease. 展开更多
关键词 cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 m1 phenotype neurodegenerative disease NEUROINFLAmmATION Parkinsons disease RU521 STING type I interferon
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