阳性淋巴结比率对M_0期非小细胞肺癌患者的预后影响

目的研究阳性淋巴结比率对M_0期非小细胞肺癌的预后影响。方法分析2010—2015年间SEER数据库中M_0期非小细胞肺癌患者的临床数据,应用X-file软件选取阳性淋巴结比率的最佳截断值,运用Cox回归比例风险模型探讨阳性淋巴结比率在M_0期非小细胞肺癌患者中的预后价值,Kaplan-Meier法绘制生存曲线分析两组的生存情况。结果从数据库中提取37001例M_0期非小细胞肺癌患者的数据,X-file筛选出阳性淋巴结比率的最佳截断值为阳性淋巴结比率≤0.07和阳性淋巴结比率>0.07,通过Cox回归比例风险模型得到年龄、性别、人种、T分期、N分期、Grade分级、诊断到治疗的时间(月)、收入、肿瘤大小、肿瘤所在肺叶、有无系统治疗是同时影响M_0期非小细胞肺癌患者总体生存期和肿瘤特异性生存期的独立风险因素,Kaplan-Meier生存曲线显示阳性淋巴结比率≤0.07组的预后要明显优于阳性淋巴结比率>0.07组(P<0.05)。结论阳性淋巴结比率>0.07是M_0期非小细胞肺癌患者预后的独立危险因素,预后预测价值高。

经腹入路与经后腹腔入路腹腔镜肾部分切除术治疗T1aN0M0期肾癌的效果分析

目的对比经腹入路与经后腹腔入路腹腔镜肾部分切除术(LPN)治疗T1aN0M0期肾癌的效果,为临床提供参考。方法回顾性分析2021年1月至2024年1月徐州市肿瘤医院收治的100例进行LPN治疗的T1aN0M0肾癌患者的临床资料,根据手术方法的不同分为对照组(50例,接受经腹入路LPN治疗)和观察组(50例,接受经后腹腔入路LPN治疗)。比较两组患者围术期指标水平、应激指标水平和术后并发症发生情况。结果观察组患者手术时间与术后住院时间均短于对照组(均P<0.05);两组患者手术成功率、术中出血量比较,差异均无统计学意义(均P>0.05)。术后1 d,两组患者丙二醛(MDA)、皮质醇(Cor)水平均高于术前,但观察组均低于对照组(均P<0.05)。两组患者术后并发症总发生率比较,差异无统计学意义(P>0.05)。结论与经腹入路相比,经后腹腔入路LPN治疗T1aN0M0期肾癌在缩短手术时间和术后住院时间及减轻应激反应等方面具有优势,值得临床应用。

Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection:A retrospective study

BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.

Comparative efficacy and safety between endoscopic submucosal dissection,surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer

BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.

pT1N1M0早期胃癌术后辅助治疗临床意义的探索

背景:pT1N1M0分期胃癌术后辅助治疗目前各大指南无统一共识。本研究的目的是确定辅助放化疗对pT1N1M0胃癌根治术后患者有无生存获益,分析影响pT1N1M0胃癌患者预后的危险因素。方法:从SEER数据库中选择2004年至2019年胃切除术后pT1N1M0 GC患者319例。采用Kaplan-Meier法和log-rank检验分析总生存率。采用Cox比例风险回归模型对影响pT1N1M0胃癌根治性切除患者预后的因素进行单变量和多变量分析。结果:生存分析显示术后辅助化疗(5年OS:52.4% vs. 75.8%,p 0.05)。结论:术后辅助化疗及辅助放疗能够改善pT1N1M0 GC患者OS,年龄、辅助化疗、肿瘤部位、ELNC是pT1N1M0胃癌预后的独立影响因素。Background: Currently, there is no consensus on postoperative adjuvant therapy for pT1N1M0 gastric cancer in major guidelines. The aim of this study is to determine the survival benefit of adjuvant chemoradiotherapy in patients with pT1N1M0 gastric cancer after radical gastrectomy, and to analyze the risk factors affecting the prognosis of patients with pT1N1M0 gastric cancer. Methods: A total of 319 patients with pT1N1M0 GC after gastrectomy from 2004 to 2019 were selected from the SEER database. Kaplan-Meier method and log-rank test were used to analyze the overall survival rate. Univariate and multivariate analyses of prognostic factors of patients with pT1N1M0 gastric cancer after radical resection were performed using Cox proportional hazards regression model. Results: Survival analysis showed that postoperative adjuvant chemotherapy (5-year OS: 52.4% vs. 75.8%, p 0.05). Conclusions: Postoperative adjuvant chemotherapy and radiotherapy can improve the OS of patients with pT1N1M0 GC. Age, adjuvant chemotherapy, tumor location, and ELNC are independent prognostic factors for pT1N1M0 gastric cancer.

cT1N0M0期食管癌内镜下非治愈性切除的研究进展

随着消化内镜诊疗活动的广泛开展,内镜下切除已成为cT1N0M0期食管癌的标准治疗方案之一。然而,术后病理确认的非治愈性切除患者仍然面临复杂的后续管理选择。本文就cT1N0M0期食管癌内镜下非治愈性切除的国内外研究进展进行综述,指出现有指南有关非治愈性切除的定义尚存争议,同时针对这部分患者,应在临床实践中制定选择性的个体化管理策略。

Effects of O defects on adsorption of small Ag clusters on a MgO(001) surface

The interaction of Ag atoms with a defective MgO（001） surface is systematically studied based on density functional theory. The Ag clusters are deposited on neutral and charged oxygen vacancies of the MgO（001） surface. The structures of Ag clusters take the shape of simple models of two- or three-dimensional （2D and 3D） metal particles deposited on the MgO surface. When the nucleation of the metal clusters occurs in the Fs （missing neutral O） centre, the interaction with the substrate is considerably stronger than that in the Fs^＋ （missing O-） centre. The results show that the adsorption of Ag atoms on the MgO surface with oxygcn vacancy is stronger than on a clear MgO surface, thereby attracting more Ag atoms to cluster together, and forming atomic islands.

Electronic structure and infrared spectrum of a W_n C^(0,±) (n = 1-6) cluster

WnC0＇± （n= 1-6） clusters are investigated by using the density functional theory （DFT） at the B3LYP/LANL2DZ level. We find that the neutral, anionic and cationic ground state structures are similar within the same size, and constituted by substituting a C atom for one W atom in the structures of Wn＋1 clusters. The natural bond orbital （NBO） charge analyses indicate that the direction of electron transfer is from the W atom to the 2p orbital of the C atom. In addition, the calculated infrared spectra of the WnC0＇± （n= 2-6） clusters manifest that the vibrational frequencies of neutral, anionic and cationic clusters are similar in a range of 80 cm-1-864 cm-1. The high frequency, strong peak modes are found to be an almost stretched deformation of the carbide atom. Finally, the polarizabilities of WnC0＇± （n= 1-6） clusters are also discussed.

Geometries, stabilities, and electronic properties analysis in In_nNi^((0,±1)) clusters: Molecular modeling and DFT calculations

Density functional theory（DFT） with the B3 LYP method and the SDD basis set is selected to investigate In_nNi,In_nNi^-, and In_nNi~＋ （n = 1–14） clusters. For neutral and charged systems, several isomers and different multiplicities are studied with the aim to confirm the most stable structures. The structural evolution of neutral, cationic, and anionic In_nNi clusters, which favors the three-dimensional structures for n = 3–14. The main configurations of the In_nNi isomers are not affected by adding or removing an electron, the order of their stabilities is also nearly not affected. The obtained binding energy exhibits that the Ni-doped In_（13） cluster is the most stable species of all different sized clusters. The calculated fragmentation energy and the second-order energy difference as a function of the cluster size exhibit a pronounced even–odd alternation phenomenon. The electronic properties including energy gap（E_g）, adiabatic electron affinity（AEA）, vertical electron detachment energy（VDE）, adiabatic ionization potential energy（AIP）, and vertical ionization potential energy（VIP） are studied. The total magnetic moments show that the different magnetic moments depend on the number of the In atoms for charged In_nNi. Additionally, the natural population analysis of In_nNi^（（0,±1）clusters is also discussed.

Simulating the Dynamics of Bimetallic Clusters Deposited onto a Surface Using Molecular Dynamics

This paper examines the interface development between a single crystalline Ag matrix and core-shell AgnCom nanoclusters that have been deposited with energies varying between 0.25 eV and 1.5 eV per atom using computer modeling techniques. Clusters undergo deformation as a result of the slowing down;they may also become epitaxial with the substrate and maintain their core-shell structure. A detailed analysis of the effects of the cluster-surface interaction is conducted over a realistic size and energy range, and a model is created to show how clusters accumulate. It is discovered that both the silver shells and the cobalt cluster cores exhibit limited epitaxy with the substrate, and that the contact produced is only a few atomic layers thick. The effect is higher for Ag shells than for Co cores, and it is not very energy dependent.

新型产业用地(M0)设计探索——以衢州衢江区临港数智科创园为例

新型产业用地最早起源于深圳,此后诸多城市也出台了新型产业用地的相关政策,以推动新兴产业高质量发展,为创新型企业项目发展和创新人才的空间需求提供相关用地保障,但在目前新型产业园建筑设计方面缺少相关的系统研究。本文结合衢州衢江区临港数智科创园,对新型产业用地的设计进行分析和解读。

关于工业用地“标准地兼容M0”出让制度改革的探讨——以鞍山市为例

工业用地作为经济发展的重要支撑,其出让和利用方式直接关系到土地资源的优化配置和企业投资环境的改善。本文深入剖析鞍山市工业用地“标准地兼容M0”出让制度改革的实践经验,为完善和推广工业用地“标准地兼容M0”出让制度提供参考。

S1280 and S1284: Two Oscillating Blue Stragglers in the Open Cluster M67

We present results of a time-series CCD photometry of two blue stragglers in the open cluster M67 that are also oscillating variables, S1280 and S1284. The observations obtained on 11 nights confirmed the δ Scuti-like variability of the two stars. Four and five main pulsating frequencies are detected for S1280 and S1284, respectively, through a power spectral analysis. A preliminary mode identification indicates that the two stars are both in radial oscillation. Based on the nature of oscillation, the physical parameters of the two stars are determined, and their evolutionary status discussed.

PtnNim(n+m≤5,n,m≠0)团簇结构与性质的密度泛函理论研究

采用密度泛函理论(DFT)中B3LYP方法,在Lanl2dz水平下对Pt_nNi_m(n+m≤5,n,m≠0)团簇进行了结构优化,预测它们的基态几何结构,并对基态结构的平均结合能、磁性以及五个原子团簇的振动频率和光谱进行了分析.结果表明:Pt_nNi_m(n+m≤5,n,m≠0)团簇的基态结构趋向于立体结构,三个原子团簇的基态结构都为三角形,四个原子团簇的都为四面体,五个原子团簇都为船型;PtNi_n(n=2-4)团簇都具有弱的反铁磁性,其他团簇都呈铁磁性,并且我们所计算的Pt/Ni合金团簇的磁性具有Ni纯团簇的特征.它们的磁矩分为两个阶段:当2≤n+m≤4时团簇的磁矩为2μ_B,n+m=5时团簇的磁矩突增到4μ_B,且五个原子团簇的9个振动模式都既具有红外活性又具有拉曼活性.

M_6^(0,±)(M=Os,Ir,Pt)团簇结构与性质的密度泛函理论研究

采用密度泛函理论(DFT)中的杂化密度泛函(B3LYP)方法,在LANL2DZ基组水平上对M06,±(M=Os,Ir,Pt)团簇的各种可能构型进行了几何结构优化,得出各团簇的最稳定构型,并对其能量、振动频率、热力学性质、核独立化学位移(NICS)和极化率进行了理论研究.结果表明,M06,±(M=Os,Ir)团簇的基态都是三棱柱结构,Pt-6团簇的基态是平面三角形结构;M06,±(M=Os,Ir,Pt)团簇生成焓都为负值,热力学上是稳定的;NICS值都为负值,表明M06,±(M=Os,Ir,Pt)团簇都具有芳香性,其中Os-6团簇的芳香性最强;从光谱分析来看,Os6的IR和Raman谱的较强吸收峰的个数最多,Ir6的IR和Raman谱的最强吸收峰都只有一个,IR最强吸收峰在137.0和143.5 cm-1之间,Raman谱最强的吸收峰位于169.5 cm-1处;Pt6的IR和Raman谱的最强吸收峰分别位于50.2和194.7 cm-1处.

2013年4月20日四川芦山M7.0级地震介绍

2013年4月20日四川芦山M7.0级地震发生在龙门山断裂带南段,震源机制解为逆冲型.震后3天震区已发生3000多次余震,其中M5级余震4次,最大余震是4月21日17时05分芦山、邛崃交界M5.4级地震,余震区长轴约45km,短轴约20km.芦山M7.0级地震与2008年5月12日汶川M8.0级地震均位于龙门山断裂带,但汶川地震发生在该断裂带中-北段,两个地震的余震区存在约45km的间隔,芦山M7.0级地震不是汶川地震的余震,但两者密切相关.

反周期函数的2-周期(0,m)三角插值的收敛性

研究了以π为周期的反周期函数的2-周期(0,m)三角插值,得到了解存在的条件,并给出对应条件下解的显式表达式及收敛阶.

反周期函数(0,m)三角插值的收敛性

用一种不同的方法,研究了以π为周期的反周期函数的(0,m)三角插值问题,得到了解存在的条件,并给出了对应条件下解的显式表达式及其收敛阶.

pT3N0M0期胸段食管鳞癌根治术后的预后因素

目的探讨p T3N0M0期胸段食管鳞癌两野根治术后的预后及其影响因素。方法胸段食管鳞癌行胸腹两野食管癌根治术后、分期为p T3N0M0者249例,中位年龄60岁（33～78岁）;胸上段39例、胸中段166例、胸下段44例,病变中位长度5 cm（2～12 cm）;术中无粘连者35例、轻度粘连者90例、重度粘连者124例;术中清扫淋巴结中位数9枚（1～27枚）;98例单纯手术、151例行术后辅助治疗。结果 249例中1、3、5年总生存率（overall Survival,OS）和无进展生存率（progression-free survival,PFS）分别为90.0%、6 8.7%、5 5.2%和8 2.1%、6 1.7%、5 3.9%。单因素分析结果显示：性别、肿瘤位置、病理分化程度和术前血红蛋白水平与O S有关（P〈0.05）;年龄、肿瘤位置和术中粘连程度与PFS有关（P〈0.05）;多因素分析结果显示：肿瘤位置、术前血红蛋白水平、术前CT有纵隔小淋巴结（〈1 cm）和清扫淋巴结数目是OS独立影响因素,肿瘤位置是影响PFS独立危险因素。术后辅助治疗对OS和PFS均无明显影响;但术前CT纵隔有小淋巴结（〈1 cm）者,术后辅助治疗可以提高OS和PFS（P〈0.05）。结论 p T3N0M0期胸段食管鳞癌胸腹两野根治术后,肿瘤位置影响OS和PFS,胸下段癌预后最好,胸上段癌预后最差;术中清扫淋巴结数多、术前CT纵隔无淋巴结者预后较好,反之预后较差;术前血红蛋白高者生存率低;而术后辅助治疗的价值有待证实。

(Pt_nMn)^(±,0)(n=1～5)掺杂团簇结构与磁性的密度泛函研究

采用密度泛函理论(Density Function Theory)中的B3LYP方法,在Lanl2dz赝势基组水平上对(PtnMn)±,0(n=1~5)团簇的几何构型进行了全优化,并对基态的能级以及磁性进行了研究.结果表明:PtMn掺杂团簇的自旋多重度比较高,这种性质跟纯Mn团簇相似.并且发现一般情况下Mn原子参与成键数越多,结构越稳定,在成键数相同的情况下,成键的平均键长越短越稳定;其次(PtnMn)±,0团簇的所有稳定结构都表现为铁磁性耦合;掺杂一个Mn原子后的团簇磁性大大增强,磁矩主要来源于未满的d壳层电子,且Mn原子上的局域磁矩远大于Pt原子.随着Pt原子个数的增加,Mn原子的局域磁矩变化不大,但团簇的总磁矩渐渐增大.