The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Co...The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care.展开更多
Based on vibration analysis, single-layered graphene sheet （SLGS） with multiple attached nanoparticles is developed as nanoscale mass sensor in thermal environments. Graphene sensors are assumed to be in simplysuppo...Based on vibration analysis, single-layered graphene sheet （SLGS） with multiple attached nanoparticles is developed as nanoscale mass sensor in thermal environments. Graphene sensors are assumed to be in simplysupported configuration. Based on the nonlocal plate the- ory which incorporates size effects into the classical theory, closed-form expressions lot the frequencies and relative fre- quency shills of SLGS-based mass sensor are derived using the Galerkin method. The suggested model is justified by a good agreement between the results given by the present model and available data in literature. The effects of tem- perature difference, nonlocal parameter, the location of the nanoparticle and the number of nanoparticles on the relative frequency shift of the mass sensor are also elucidated. The obtained results show that the sensitivity of the SLGS- based mass sensor increases with increasing temperature difference.展开更多
The aim of this paper is to investigate the effect of nitrite intercalated Mg-Al layered double hydroxides(Mg-Al LDH-NO_(2))on mortar durability under the coexisting environment of Cl−and SO_(4)^(2-).Cl−and SO_(4)^(2-...The aim of this paper is to investigate the effect of nitrite intercalated Mg-Al layered double hydroxides(Mg-Al LDH-NO_(2))on mortar durability under the coexisting environment of Cl−and SO_(4)^(2-).Cl−and SO_(4)^(2-) binding properties of Mg-Al LDH-NO_(2) in simulated concrete pore solutions,Cl−and SO_(4)^(2-) diffusion properties of mortars with Mg-Al LDHNO 2 were examined.The steel corrosion and resistance of mortar against SO_(4)^(2-) attack were also evaluated.The results indicate that Mg-Al LDH-NO_(2) can effectively adsorb the Cl−and SO_(4)^(2-) in simulated concrete pore solution,and inhibit the diffusion of Cl−and SO_(4)^(2-) into cement mortars.The presence of SO_(4)^(2-) can greatly affect the uptake amount of Cl−,and there is a coupled effect of Cl−and SO_(4)^(2-) on their penetration into mortar specimens.In addition,Mg-Al LDH-NO_(2) can greatly upgrade the resistance of mortars against SO_(4)^(2-) attack and well prevent the steel from corrosion.However,Cl−will aggravate the SO_(4)^(2-) attack and SO_(4)^(2-) can initially decrease and then increase the steel corrosion.展开更多
This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-...This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-vironment for the casual-wear chain stores in HongKong.Julie Baker’s Three-category framework onstore environments namely ambient,design and socialfactors was adopted for investigation.The results indi-cated that the store environment was important in affect-ing consumers’selection of store for shopping.It alsorevealed that social factor was perceived relatively im-portant than ambient and design factors.Nine store ex-pectation dimensions were categorised and the resultdemonstrated that most respondents were concerned onthe social aspect in their expectation of having a satisfy-ing store environment.展开更多
To provide a theoretical basis for further improvement of Brassica napus yield, additive dominance with additive - by - additive epistatic effects （ ADAA） genetic model and a 6 X 8 partial dial- lel cross des...To provide a theoretical basis for further improvement of Brassica napus yield, additive dominance with additive - by - additive epistatic effects （ ADAA） genetic model and a 6 X 8 partial dial- lel cross design were used to analyze the genetic effects and correlations of five yield related traits of 14 excellent Brassica napus parental lines and their 46 and F2 populations. The results showed that silique density （SD） , siliques per plant （SPP） , seeds per silique （SPS） and thousand - seed weight （TSW） exhibited not only additive and dominant effects, but also significant epistatic effects. The dominant effects of all five yield - related traits were obviously greater than their additive effects and epistatic effects. Yield per plant （YPP） showed significant genetic correlation with SD, SPP and SPS, and the main component of the genetic correlation was the dominance correlation. SPP and SPS both showed a significant negative correlation with TSW. The SD of rapeseed was genetically correlated with all three components of yield to a certain extent, and there were different components of genetic effects positively correlated with the three yield components, indicating that SD is a potential trait to reconcile the conflict between TSW and SPP as well as SPS.展开更多
Based on the geological and hydrogeological conditions along with dynamic changes of groundwater level,this paper analyzes the hydrodynamic characteristics of saltwater intrusion in the study area.According to monitor...Based on the geological and hydrogeological conditions along with dynamic changes of groundwater level,this paper analyzes the hydrodynamic characteristics of saltwater intrusion in the study area.According to monitoring data of groundwater quality,the distribution characteristics of macro component are analyzed,and then fuzzy comprehensive evaluation method is adopted to evaluate the impact of saltwater intrusion on groundwater environment.Concerning the influence degree of groundwater environment,the study area is divided into brine area,seriously influenced area,moderately influenced zone,slightly influenced zone and uninfluenced zone.The results can offer references for prevention and control of saltwater intrusion as well as the protection of water resources.展开更多
The main objective of this paper is to evaluate the seismic response of buildings of typical reinforced concrete frames when concrete starts to deteriorate gradually and to make a comparison between the base shear and...The main objective of this paper is to evaluate the seismic response of buildings of typical reinforced concrete frames when concrete starts to deteriorate gradually and to make a comparison between the base shear and the displacement at different stages of earthquake loading. Typical 5, 15, 20 and 30-storey reinforced concrete frames have been designed for seismicity according to the recently adopted seismic code in Abu Dhabi, ACI 318-08/IBC 2009 code. A pushover analysis has been performed to these four buildings by using SAP 2000. Twenty-four models have been created (6 models for each building) by decreasing the concrete strength gradually from 4000 psi (281 kg/cm<sup>2</sup>) to 1500 psi (105 kg/cm<sup>2</sup>). This is to simulate the effect of harsh environment on the strength of concrete in existing buildings.展开更多
基金partly supported by Florida Department of Health Cancer Research Chair FundingNIH fund-ing (CA150190,HL 70567 and CA78383,and Mayo Clinic Pancreatic Cancer SPORE P50 CA102701 Pilot Project) to DMNCI training grant 1T32 CA148073 (to DM) Pre-doctoral fellowship to NJ
文摘The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care.
文摘Based on vibration analysis, single-layered graphene sheet （SLGS） with multiple attached nanoparticles is developed as nanoscale mass sensor in thermal environments. Graphene sensors are assumed to be in simplysupported configuration. Based on the nonlocal plate the- ory which incorporates size effects into the classical theory, closed-form expressions lot the frequencies and relative fre- quency shills of SLGS-based mass sensor are derived using the Galerkin method. The suggested model is justified by a good agreement between the results given by the present model and available data in literature. The effects of tem- perature difference, nonlocal parameter, the location of the nanoparticle and the number of nanoparticles on the relative frequency shift of the mass sensor are also elucidated. The obtained results show that the sensitivity of the SLGS- based mass sensor increases with increasing temperature difference.
基金Project(51478164)supported by the National Natural Science Foundation of ChinaProject(BK20181306)supported by Natural Science Foundation of Jiangsu Province,China。
文摘The aim of this paper is to investigate the effect of nitrite intercalated Mg-Al layered double hydroxides(Mg-Al LDH-NO_(2))on mortar durability under the coexisting environment of Cl−and SO_(4)^(2-).Cl−and SO_(4)^(2-) binding properties of Mg-Al LDH-NO_(2) in simulated concrete pore solutions,Cl−and SO_(4)^(2-) diffusion properties of mortars with Mg-Al LDHNO 2 were examined.The steel corrosion and resistance of mortar against SO_(4)^(2-) attack were also evaluated.The results indicate that Mg-Al LDH-NO_(2) can effectively adsorb the Cl−and SO_(4)^(2-) in simulated concrete pore solution,and inhibit the diffusion of Cl−and SO_(4)^(2-) into cement mortars.The presence of SO_(4)^(2-) can greatly affect the uptake amount of Cl−,and there is a coupled effect of Cl−and SO_(4)^(2-) on their penetration into mortar specimens.In addition,Mg-Al LDH-NO_(2) can greatly upgrade the resistance of mortars against SO_(4)^(2-) attack and well prevent the steel from corrosion.However,Cl−will aggravate the SO_(4)^(2-) attack and SO_(4)^(2-) can initially decrease and then increase the steel corrosion.
文摘This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-vironment for the casual-wear chain stores in HongKong.Julie Baker’s Three-category framework onstore environments namely ambient,design and socialfactors was adopted for investigation.The results indi-cated that the store environment was important in affect-ing consumers’selection of store for shopping.It alsorevealed that social factor was perceived relatively im-portant than ambient and design factors.Nine store ex-pectation dimensions were categorised and the resultdemonstrated that most respondents were concerned onthe social aspect in their expectation of having a satisfy-ing store environment.
基金This research was supported by the National Basic Research Program of China （ 973 Program, 2011CB109302）；the National High - Tech R＆D Pro-gram of China （863 Program, 2011AA10A104, 2012AA101107） ； Natural Science Foundation of Hu-bei Province （2015CFA103） ； Hubei Agricultural Science and Technology Innovation Center.
文摘To provide a theoretical basis for further improvement of Brassica napus yield, additive dominance with additive - by - additive epistatic effects （ ADAA） genetic model and a 6 X 8 partial dial- lel cross design were used to analyze the genetic effects and correlations of five yield related traits of 14 excellent Brassica napus parental lines and their 46 and F2 populations. The results showed that silique density （SD） , siliques per plant （SPP） , seeds per silique （SPS） and thousand - seed weight （TSW） exhibited not only additive and dominant effects, but also significant epistatic effects. The dominant effects of all five yield - related traits were obviously greater than their additive effects and epistatic effects. Yield per plant （YPP） showed significant genetic correlation with SD, SPP and SPS, and the main component of the genetic correlation was the dominance correlation. SPP and SPS both showed a significant negative correlation with TSW. The SD of rapeseed was genetically correlated with all three components of yield to a certain extent, and there were different components of genetic effects positively correlated with the three yield components, indicating that SD is a potential trait to reconcile the conflict between TSW and SPP as well as SPS.
基金supported by Shandong Land and Resources Department [2011.No. 14]
文摘Based on the geological and hydrogeological conditions along with dynamic changes of groundwater level,this paper analyzes the hydrodynamic characteristics of saltwater intrusion in the study area.According to monitoring data of groundwater quality,the distribution characteristics of macro component are analyzed,and then fuzzy comprehensive evaluation method is adopted to evaluate the impact of saltwater intrusion on groundwater environment.Concerning the influence degree of groundwater environment,the study area is divided into brine area,seriously influenced area,moderately influenced zone,slightly influenced zone and uninfluenced zone.The results can offer references for prevention and control of saltwater intrusion as well as the protection of water resources.
文摘The main objective of this paper is to evaluate the seismic response of buildings of typical reinforced concrete frames when concrete starts to deteriorate gradually and to make a comparison between the base shear and the displacement at different stages of earthquake loading. Typical 5, 15, 20 and 30-storey reinforced concrete frames have been designed for seismicity according to the recently adopted seismic code in Abu Dhabi, ACI 318-08/IBC 2009 code. A pushover analysis has been performed to these four buildings by using SAP 2000. Twenty-four models have been created (6 models for each building) by decreasing the concrete strength gradually from 4000 psi (281 kg/cm<sup>2</sup>) to 1500 psi (105 kg/cm<sup>2</sup>). This is to simulate the effect of harsh environment on the strength of concrete in existing buildings.
